Gesine Bug

Gesine Bug

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Gesine Bug

Publications by authors named "Gesine Bug"

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Clearance of Hematologic Malignancies by Allogeneic Cytokine-Induced Killer Cell or Donor Lymphocyte Infusions.

Biol Blood Marrow Transplant 2019 07 13;25(7):1281-1292. Epub 2019 Mar 13.

Division of Stem Cell Transplantation and Immunology, Department of Children and Adolescents, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2019.03.004DOI Listing
July 2019

Functional Dominance of CHIP-Mutated Hematopoietic Stem Cells in Patients Undergoing Autologous Transplantation.

Cell Rep 2019 05;27(7):2022-2028.e3

Department of Medicine II, Hematology/Oncology, Goethe University Hospital, Frankfurt am Main 60590, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193053
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http://dx.doi.org/10.1016/j.celrep.2019.04.064DOI Listing
May 2019

CMR imaging biosignature of cardiac involvement due to cancer-related treatment by T1 and T2 mapping.

Int J Cardiol 2019 Jan 11;275:179-186. Epub 2018 Oct 11.

Institute of Experimental and Translational Cardiac Imaging, DZHK Centre for Cardiovascular Imaging, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany; Department of Cardiology, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany; Department of Cardiology, Guys and St Thomas' NHS Trust, London, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183499
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http://dx.doi.org/10.1016/j.ijcard.2018.10.023DOI Listing
January 2019

Enhanced labile plasma iron and outcome in acute myeloid leukaemia and myelodysplastic syndrome after allogeneic haemopoietic cell transplantation (ALLIVE): a prospective, multicentre, observational trial.

Lancet Haematol 2018 May 5;5(5):e201-e210. Epub 2018 Apr 5.

Medizinische Fakultät Carl-Gustav-Carus der Technischen Universität, Medizinische Klinik und Poliklinik I, University Hospital Carl-Gustav-Carus, Dresden, Germany; National Center for Tumor Diseases (NCT)-Partner Site Dresden, Dresden, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, Germany.

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http://dx.doi.org/10.1016/S2352-3026(18)30036-XDOI Listing
May 2018

Establishment and Characterization of Long-Term Cultures Derived from Primary Acute Myeloid Leukemia Cells for HDAC Inhibitor Research.

Methods Mol Biol 2017 ;1510:127-148

Department of Medicine II, Hematology and Oncology, University Hospital Frankfurt, Goethe-University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/978-1-4939-6527-4_10DOI Listing
January 2018

CD19-CAR engineered NK-92 cells are sufficient to overcome NK cell resistance in B-cell malignancies.

J Cell Mol Med 2016 07 23;20(7):1287-94. Epub 2016 Mar 23.

Institute for Transfusion Medicine and Immunohematology, J.W. Goethe University Frankfurt/Main, Red Cross Blood Donor Service Baden-Württemberg-Hessen, Dresden, Germany.

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http://dx.doi.org/10.1111/jcmm.12810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929308PMC
July 2016

Mismatched unrelated hematopoietic stem cell transplantation with post-transplant cyclophosphamide for high-risk acute myeloid leukemia.

Ann Hematol 2016 May 8;95(6):1023-5. Epub 2016 Apr 8.

Department of Medicine II, Hematology and Oncology, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/s00277-016-2652-8DOI Listing
May 2016

FLT3-ITD and TLR9 use Bruton tyrosine kinase to activate distinct transcriptional programs mediating AML cell survival and proliferation.

Blood 2015 Mar 20;125(12):1936-47. Epub 2015 Jan 20.

Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany; German Cancer Consortium, Heidelberg, Germany; German Cancer Research Center, Heidelberg, Germany;

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http://dx.doi.org/10.1182/blood-2014-06-585216DOI Listing
March 2015

Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1.

Mol Oncol 2015 Jan 11;9(1):140-54. Epub 2014 Aug 11.

Department of Gynecology, School of Medicine, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528686PMC
January 2015

Unstimulated leukapheresis in patients and donors: comparison of two apheresis systems.

Transfusion 2014 Jun 3;54(6):1622-9. Epub 2013 Dec 3.

German Red Cross Blood Service Baden-Württemberg-Hessen and Institute for Transfusion Medicine and Immunohematology, Goethe University Hospital, Frankfurt, Germany.

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http://dx.doi.org/10.1111/trf.12506DOI Listing
June 2014

Immunomagnetic selection or irradiation eliminates alloreactive cells but also reduces anti-tumor potential of cytokine-induced killer cells: implications for unmanipulated cytokine-induced killer cell infusion.

Cytotherapy 2014 Jun 28;16(6):835-44. Epub 2014 Feb 28.

University Hospital Frankfurt/Main, Department for Children and Adolescents Medicine, Division of Stem Cell Transplantation and Immunology, Goethe-University Frankfurt/Main, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1016/j.jcyt.2014.01.003DOI Listing
June 2014

Treatment of patients with advanced cancer with the natural killer cell line NK-92.

Cytotherapy 2013 Dec 1;15(12):1563-70. Epub 2013 Oct 1.

Institute for Transfusion Medicine and Immunohematology, Goethe University Hospital, Frankfurt am Main, Germany; German Red Cross Blood Donation Service, Baden-Württemberg-Hessen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2013.06.017DOI Listing
December 2013

Breakdown of the FLT3-ITD/STAT5 axis and synergistic apoptosis induction by the histone deacetylase inhibitor panobinostat and FLT3-specific inhibitors.

Mol Cancer Ther 2012 Nov 31;11(11):2373-83. Epub 2012 Aug 31.

Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine, Friedrich-Schiller University, Hans-Knöll-Str. 2, Jena 07745, Germany.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-0129DOI Listing
November 2012

Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells.

Cell Cycle 2012 Sep 16;11(17):3219-26. Epub 2012 Aug 16.

Department of Medicine II, Hematology and Oncology, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany.

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http://dx.doi.org/10.4161/cc.21565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466521PMC
September 2012

Polo-like kinases in AML.

Expert Opin Investig Drugs 2012 Aug 6;21(8):1069-74. Epub 2012 Jun 6.

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http://dx.doi.org/10.1517/13543784.2012.691163DOI Listing
August 2012

The cytotoxic potential of interleukin-15-stimulated cytokine-induced killer cells against leukemia cells.

Cytotherapy 2012 Jan 6;14(1):91-103. Epub 2011 Oct 6.

University Children's Hospital of Frankfurt/Main and Department of Pediatric Hematology, Oncology and Hemostaseology, Goethe-University Frankfurt/Main, Frankfurt/Main, Germany.

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http://dx.doi.org/10.3109/14653249.2011.613931DOI Listing
January 2012

Enhanced immune response after a second dose of an AS03-adjuvanted H1N1 influenza A vaccine in patients after hematopoietic stem cell transplantation.

Biol Blood Marrow Transplant 2011 Oct 13;17(10):1546-50. Epub 2011 Feb 13.

Department of Medicine, Hematology/Oncology, Goethe-University of Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.bbmt.2011.02.004DOI Listing
October 2011

Therapy of sclerodermatous chronic graft-versus-host disease with mammalian target of rapamycin inhibitors.

Biol Blood Marrow Transplant 2011 May 7;17(5):657-63. Epub 2010 Aug 7.

Centre for Bone Marrow and Blood Stem Cell Transplantation, Deutsche Klinik für Diagnostik, Wiesbaden, Germany.

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http://dx.doi.org/10.1016/j.bbmt.2010.07.025DOI Listing
May 2011

The deacetylase inhibitor LAQ824 induces notch signalling in haematopoietic progenitor cells.

Leuk Res 2011 Jan 31;35(1):119-25. Epub 2010 Jul 31.

Department of Medicine II, Hematology and Oncology, Goethe Universität Frankfurt, Theodor-Stern-Kai 7, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.leukres.2010.06.024DOI Listing
January 2011

The DAC system and associations with acute leukemias and myelodysplastic syndromes.

Invest New Drugs 2010 Dec 14;28 Suppl 1:S36-49. Epub 2010 Dec 14.

Medizinische Klinik II, Abteilung für Hämatologie und Onkologie der, Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s10637-010-9595-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003828PMC
December 2010

IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis.

Haematologica 2010 Oct 21;95(10):1668-74. Epub 2010 May 21.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Strasse 1, Hannover, Germany.

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http://dx.doi.org/10.3324/haematol.2010.025494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948091PMC
October 2010

[Valproic acid as a histone deacetylase inhibitor. New application for a well-known drug].

Pharm Unserer Zeit 2010 May;39(3):197-203

Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104 Freiburg.

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http://dx.doi.org/10.1002/pauz.201000366DOI Listing
May 2010

Impact of leukapheresis on early death rate in adult acute myeloid leukemia presenting with hyperleukocytosis.

Transfusion 2007 Oct;47(10):1843-50

Department of Internal Medicine II, University Hospital, Johann Wolfgang Goethe-University, Theodor Stern-Kai 7, D-60590 Frankfurt am Main, Germany.

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http://doi.wiley.com/10.1111/j.1537-2995.2007.01406.x
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http://dx.doi.org/10.1111/j.1537-2995.2007.01406.xDOI Listing
October 2007

Current status of growth factors in the treatment of acute myeloid and lymphoblastic leukemia.

Semin Hematol 2007 Jul;44(3):183-92

Department of Hematology and Oncology, Johann Wolfgang Goethe University, Frankfurt/Main, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S003719630700070
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http://dx.doi.org/10.1053/j.seminhematol.2007.04.007DOI Listing
July 2007

Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia.

Haematologica 2007 Apr;92(4):542-5

Medizinische Klinik II, Abt. Hämatologie/Onkologie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, Frankfurt, Germany.

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http://dx.doi.org/10.3324/haematol.10758DOI Listing
April 2007

Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RARalpha-positive leukemic stem cells.

Haematologica 2007 Mar;92(3):323-31

Laboratory of Tumor Stem Cell Biology, Department of Hematology, J.W. Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.3324/haematol.10541DOI Listing
March 2007

Transplantation of human acute myeloid leukemia (AML) cells in immunodeficient mice reveals altered cell surface phenotypes and expression of human endothelial markers.

Leuk Res 2005 Oct;29(10):1191-9

Institute of Transfusion Medicine and Immune Hematology, German Red Cross Blood Center, Johann Wolfgang Goethe University, Sandhofstrasse 1, D-60528 Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.leukres.2005.03.019DOI Listing
October 2005

High-dose melphalan is an effective salvage therapy in acute myeloid leukaemia patients with refractory relapse and relapse after autologous stem cell transplantation.

Ann Hematol 2005 Oct 7;84(11):748-54. Epub 2005 Jul 7.

Medizinische Klinik II, Klinikum der J.W. Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany,

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http://dx.doi.org/10.1007/s00277-005-1075-8DOI Listing
October 2005

Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells.

Cancer Res 2005 Apr;65(7):2537-41

Medizinische Klinik II/Abteilung Hämatologie, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3011DOI Listing
April 2005

Mechanisms of resistance to natural killer cell-mediated cytotoxicity in acute lymphoblastic leukemia.

Exp Hematol 2005 Mar;33(3):344-52

Center for Internal Medicine, Department of Hematology/Oncology, Johann Wolfgang Goethe University, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1016/j.exphem.2004.11.006DOI Listing
March 2005

Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia.

Haematologica 2004 Apr;89(4):419-26

Med. Klinik III/Abtl. Hämatologie, Johann Wolfgang Goethe-Universität, 60590 Frankfurt, Germany.

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April 2004

Chimaerism and erythroid marker expression after microinjection of human acute myeloid leukaemia cells into murine blastocysts.

Oncogene 2003 Dec;22(57):9185-91

Institute of Medical Radiation and Cell Research (MSZ), University of Würzburg, Versbacherstr 5, D-2 97078 Würzburg, Germany.

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http://www.nature.com/articles/1207134
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http://dx.doi.org/10.1038/sj.onc.1207134DOI Listing
December 2003