Gesine Bug

Gesine Bug

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Gesine Bug

Publications by authors named "Gesine Bug"

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Valproate and Retinoic Acid in Combination With Decitabine in Elderly Nonfit Patients With Acute Myeloid Leukemia: Results of a Multicenter, Randomized, 2 × 2, Phase II Trial.

Authors:
Michael Lübbert Olga Grishina Claudia Schmoor Richard F Schlenk Edgar Jost Martina Crysandt Michael Heuser Felicitas Thol Helmut R Salih Marcus M Schittenhelm Ulrich Germing Andrea Kuendgen Katharina S Götze Hans-Walter Lindemann Carsten Müller-Tidow Gerhard Heil Sebastian Scholl Gesine Bug Carsten Schwaenen Aristoteles Giagounidis Andreas Neubauer Jürgen Krauter Wolfram Brugger Maike De Wit Ralph Wäsch Heiko Becker Annette M May Justus Duyster Konstanze Döhner Arnold Ganser Björn Hackanson Hartmut Döhner

J Clin Oncol 2020 Jan 3;38(3):257-270. Epub 2019 Dec 3.

University Hospital of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1200/JCO.19.01053DOI Listing
January 2020

External Validation of Models for KIR2DS1/KIR3DL1-informed Selection of Hematopoietic Cell Donors fails.

Authors:
Johannes Schetelig Henning Baldauf Falk Heidenreich Carolin Massalski Sandra Frank Jürgen Sauter Matthias Stelljes Francis Ayuk Wolfgang Andreas Bethge Gesine Bug Stefan Klein Sarah Wendler Vinzenz Lange Liesbeth C de Wreede Daniel Fuerst Guido Kobbe Hellmut D Ottinger Dietrich W Beelen Joannis Mytilineos Katharina Fleischhauer Alexander H Schmidt Martin Bornhauser

Blood 2020 Jan 13. Epub 2020 Jan 13.

University Hospital Dresden, Dresden, Germany.

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http://dx.doi.org/10.1182/blood.2019002887DOI Listing
January 2020

Redefining and measuring transplant conditioning intensity in current era: a study in acute myeloid leukemia patients.

Authors:
Alexandros Spyridonidis Myriam Labopin Bipin N Savani Riitta Niittyvuopio Didier Blaise Charles Craddock Gerard Socié Uwe Platzbecker Dietrich Beelen Noel Milpied Jan J Cornelissen Arnold Ganser Anne Huynh Laimonas Griskevicius Sebastian Giebel Eolia Brissot Florent Malard Jordi Esteve Zinaida Peric Frédéric Baron Annalisa Ruggeri Christoph Schmid Maria Gilleece Norbert-Claude Gorin Francesco Lanza Roni Shouval Jurjen Versluis Gesine Bug Yngvar Fløisand Fabio Ciceri Jamie Sanz Ali Bazarbachi Arnon Nagler Mohamad Mohty

Bone Marrow Transplant 2020 Jan 29. Epub 2020 Jan 29.

Service d' Hématologie Clinique et Thérapie Cellulaire, Hospital Saint-Antoine, Sorbonne Université, Centre de Recherche Saint-Antoine (CRSA), Paris, France.

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http://dx.doi.org/10.1038/s41409-020-0803-yDOI Listing
January 2020

Children and Adults with Refractory Acute Graft-versus-Host Disease Respond to Treatment with the Mesenchymal Stromal Cell Preparation "MSC-FFM"-Outcome Report of 92 Patients.

Authors:
Halvard Bonig Zyrafete Kuçi Selim Kuçi Shahrzad Bakhtiar Oliver Basu Gesine Bug Mike Dennis Johann Greil Aniko Barta Krisztián M Kállay Peter Lang Giovanna Lucchini Raj Pol Ansgar Schulz Karl-Walter Sykora Irene Teichert von Luettichau Grit Herter-Sprie Mohammad Ashab Uddin Phil Jenkin Abdulrahman Alsultan Jochen Buechner Jerry Stein Agnes Kelemen Andrea Jarisch Jan Soerensen Emilia Salzmann-Manrique Martin Hutter Richard Schäfer Erhard Seifried Shankara Paneesha Igor Novitzky-Basso Aharon Gefen Neta Nevo Gernot Beutel Paul-Gerhardt Schlegel Thomas Klingebiel Peter Bader

Cells 2019 Dec 5;8(12). Epub 2019 Dec 5.

Department for Children and Adolescents, Division for Stem Cell Transplantation and Immunology, University Hospital Frankfurt, Frankfurt am Main, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.3390/cells8121577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952775PMC
December 2019

HDAC3 Activity is Essential for Human Leukemic Cell Growth and the Expression of β-catenin, MYC, and WT1.

Authors:
Mandy Beyer Annette Romanski Al-Hassan M Mustafa Miriam Pons Iris Büchler Anja Vogel Andrea Pautz Andreas Sellmer Günter Schneider Gesine Bug Oliver H Krämer

Cancers (Basel) 2019 Sep 26;11(10). Epub 2019 Sep 26.

Department of Toxicology, University Medical Center, 55131 Mainz, Germany.

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http://dx.doi.org/10.3390/cancers11101436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826998PMC
September 2019

Clearance of Hematologic Malignancies by Allogeneic Cytokine-Induced Killer Cell or Donor Lymphocyte Infusions.

Authors:
Michael Merker Emilia Salzmann-Manrique Verena Katzki Sabine Huenecke Melanie Bremm Shahrzad Bakhtiar Andre Willasch Andrea Jarisch Jan Soerensen Ansgar Schulz Roland Meisel Gesine Bug Halvard Bonig Thomas Klingebiel Peter Bader Eva Rettinger

Biol Blood Marrow Transplant 2019 07 13;25(7):1281-1292. Epub 2019 Mar 13.

Division of Stem Cell Transplantation and Immunology, Department of Children and Adolescents, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2019.03.004DOI Listing
July 2019

LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML.

Authors:
Jessica Barth Khalil Abou-El-Ardat Denis Dalic Nina Kurrle Anna-Maria Maier Sebastian Mohr Judith Schütte Lothar Vassen Gabriele Greve Johannes Schulz-Fincke Martin Schmitt Milica Tosic Eric Metzger Gesine Bug Cyrus Khandanpour Sebastian A Wagner Michael Lübbert Manfred Jung Hubert Serve Roland Schüle Tobias Berg

Leukemia 2019 06 24;33(6):1411-1426. Epub 2019 Jan 24.

Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1038/s41375-018-0375-7DOI Listing
June 2019

Correction: LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML.

Authors:
Jessica Barth Khalil Abou-El-Ardat Denis Dalic Nina Kurrle Anna-Maria Maier Sebastian Mohr Judith Schütte Lothar Vassen Gabriele Greve Johannes Schulz-Fincke Martin Schmitt Milica Tosic Eric Metzger Gesine Bug Cyrus Khandanpour Sebastian A Wagner Michael Lübbert Manfred Jung Hubert Serve Roland Schüle Tobias Berg

Leukemia 2019 Jun;33(6):1541

Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1038/s41375-019-0415-yDOI Listing
June 2019

A phase I trial investigating the Aurora B kinase inhibitor BI 811283 in combination with cytarabine in patients with acute myeloid leukaemia.

Authors:
Hartmut Döhner Carsten Müller-Tidow Michael Lübbert Walter Fiedler Alwin Krämer Jörg Westermann Gesine Bug Richard F Schlenk Utz Krug Rainer-Georg Goeldner James Hilbert Tillmann Taube Oliver G Ottmann

Br J Haematol 2019 May 19;185(3):583-587. Epub 2018 Nov 19.

Department of Medicine, Haematology/Oncology, Goethe University, Frankfurt/Main, Germany.

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http://doi.wiley.com/10.1111/bjh.15563
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http://dx.doi.org/10.1111/bjh.15563DOI Listing
May 2019

Functional Dominance of CHIP-Mutated Hematopoietic Stem Cells in Patients Undergoing Autologous Transplantation.

Authors:
Christina A Ortmann Lena Dorsheimer Khalil Abou-El-Ardat Jennifer Hoffrichter Birgit Assmus Halvard Bonig Anica Scholz Heike Pfeifer Hans Martin Tobias Schmid Bernhard Brüne Sebastian Scheich Björn Steffen Julia Riemann Stella Hermann Alexandra Dukat Gesine Bug Christian H Brandts Sebastian Wagner Hubert Serve Michael A Rieger

Cell Rep 2019 05;27(7):2022-2028.e3

Department of Medicine II, Hematology/Oncology, Goethe University Hospital, Frankfurt am Main 60590, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193053
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http://dx.doi.org/10.1016/j.celrep.2019.04.064DOI Listing
May 2019

Biology-Driven Approaches to Prevent and Treat Relapse of Myeloid Neoplasia after Allogeneic Hematopoietic Stem Cell Transplantation.

Authors:
Robert Zeiser Dietrich W Beelen Wolfgang Bethge Martin Bornhäuser Gesine Bug Andreas Burchert Maximilian Christopeit Justus Duyster Jürgen Finke Armin Gerbitz Jan Henning Klusmann Guido Kobbe Michael Lübbert Carsten Müller-Tidow Uwe Platzbecker Wolf Rösler Martin Sauer Christoph Schmid Thomas Schroeder Mathias Stelljes Nicolaus Kröger Lutz P Müller

Biol Blood Marrow Transplant 2019 04 15;25(4):e128-e140. Epub 2019 Jan 15.

Department of Internal Medicine IV, Hematology and Oncology, University Hospital Halle, Martin-Luther-University Halle-Wittenberg, Halle, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S10838791193006
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http://dx.doi.org/10.1016/j.bbmt.2019.01.016DOI Listing
April 2019

Phase I dose-escalation trial investigating volasertib as monotherapy or in combination with cytarabine in patients with relapsed/refractory acute myeloid leukaemia.

Authors:
Oliver G Ottmann Carsten Müller-Tidow Alwin Krämer Richard F Schlenk Michael Lübbert Gesine Bug Utz Krug Tilmann Bochtler Florian Voss Tillmann Taube Dan Liu Pilar Garin-Chesa Hartmut Döhner

Br J Haematol 2019 03 8;184(6):1018-1021. Epub 2018 Jun 8.

Department of Internal Medicine III, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1111/bjh.15204DOI Listing
March 2019

Prophylactic donor lymphocyte infusion after allogeneic stem cell transplantation in acute leukaemia - a matched pair analysis by the Acute Leukaemia Working Party of EBMT.

Authors:
Christoph Schmid Myriam Labopin Nicolaas Schaap Hendrik Veelken Michael Schleuning Michael Stadler Juergen Finke Erin Hurst Frederic Baron Olle Ringden Gesine Bug Didier Blaise Johanna Tischer Adrian Bloor Jordi Esteve Sebastian Giebel Bipin Savani Norbert-Claude Gorin Fabio Ciceri Mohamad Mohty Arnon Nagler

Br J Haematol 2019 03 22;184(5):782-787. Epub 2018 Nov 22.

Chaim Sheba Medical Centre, Tel-Hashomer, Israel.

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http://doi.wiley.com/10.1111/bjh.15691
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http://dx.doi.org/10.1111/bjh.15691DOI Listing
March 2019

Stenotrophomonas maltophilia colonization during allogeneic hematopoietic stem cell transplantation is associated with impaired survival.

Authors:
Sebastian Scheich Rosalie Koenig Anne C Wilke Sarah Lindner Claudia Reinheimer Thomas A Wichelhaus Michael Hogardt Volkhard A J Kempf Johanna Kessel Sarah Weber Hans Martin Gesine Bug Hubert Serve Björn Steffen

PLoS One 2018 19;13(7):e0201169. Epub 2018 Jul 19.

Department of Hematology and Oncology, Johann Wolfgang Goethe University of Frankfurt, Frankfurt am Main, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201169PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053200PMC
January 2019

CMR imaging biosignature of cardiac involvement due to cancer-related treatment by T1 and T2 mapping.

Authors:
Jasmin D Haslbauer Sarah Lindner Silvia Valbuena-Lopez Hafisyatul Zainal Hui Zhou Tommaso D'Angelo Faraz Pathan Christophe A Arendt Gesine Bug Hubert Serve Thomas J Vogl Andreas M Zeiher Gerry Carr-White Eike Nagel Valentina O Puntmann

Int J Cardiol 2019 Jan 11;275:179-186. Epub 2018 Oct 11.

Institute of Experimental and Translational Cardiac Imaging, DZHK Centre for Cardiovascular Imaging, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany; Department of Cardiology, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany; Department of Cardiology, Guys and St Thomas' NHS Trust, London, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183499
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http://dx.doi.org/10.1016/j.ijcard.2018.10.023DOI Listing
January 2019

Measurable residual disease-guided treatment with azacitidine to prevent haematological relapse in patients with myelodysplastic syndrome and acute myeloid leukaemia (RELAZA2): an open-label, multicentre, phase 2 trial.

Authors:
Uwe Platzbecker Jan Moritz Middeke Katja Sockel Regina Herbst Dominik Wolf Claudia D Baldus Uta Oelschlägel Anke Mütherig Lars Fransecky Richard Noppeney Gesine Bug Katharina S Götze Alwin Krämer Tilmann Bochtler Matthias Stelljes Christoph Groth Antje Schubert Marika Mende Friedrich Stölzel Christine Borkmann Anne Sophie Kubasch Malte von Bonin Hubert Serve Mathias Hänel Ulrich Dührsen Johannes Schetelig Christoph Röllig Michael Kramer Gerhard Ehninger Martin Bornhäuser Christian Thiede

Lancet Oncol 2018 12 12;19(12):1668-1679. Epub 2018 Nov 12.

Universitätsklinikum "Carl Gustav Carus" der Technischen Universität Dresden, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), and National Center for Tumor Diseases (NCT) Dresden, Dresden, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183058
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http://dx.doi.org/10.1016/S1470-2045(18)30580-1DOI Listing
December 2018

Effective treatment of steroid and therapy-refractory acute graft-versus-host disease with a novel mesenchymal stromal cell product (MSC-FFM).

Authors:
Peter Bader Zyrafete Kuçi Shahrzad Bakhtiar Oliver Basu Gesine Bug Michael Dennis Johann Greil Aniko Barta Krisztián M Kállay Peter Lang Giovanna Lucchini Raj Pol Ansgar Schulz Karl-Walter Sykora Irene von Luettichau Grit Herter-Sprie Mohammad Ashab Uddin Phil Jenkin Abdulrahman Alsultan Jochen Buechner Jerry Stein Agnes Kelemen Andrea Jarisch Jan Soerensen Emilia Salzmann-Manrique Martin Hutter Richard Schäfer Erhard Seifried Thomas Klingebiel Halvard Bonig Selim Kuçi

Bone Marrow Transplant 2018 07 29;53(7):852-862. Epub 2018 Jan 29.

Department for Children and Adolescents, Division for Stem Cell Transplantation and Immunology, University Hospital Frankfurt, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1038/s41409-018-0102-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039391PMC
July 2018

Timepoints of vancomycin-resistant Enterococcus colonization predict outcomes of acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplantation.

Authors:
Sebastian Scheich Sarah Weber Rosalie König Anne C Wilke Sarah Lindner Claudia Reinheimer Thomas A Wichelhaus Michael Hogardt Volkhard A J Kempf Johanna Kessel Hans Martin Gesine Bug Hubert Serve Björn Steffen

Eur J Haematol 2018 Jul 26. Epub 2018 Jul 26.

Department of Hematology and Oncology, University Hospital Frankfurt, Frankfurt am Main, Germany.

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http://doi.wiley.com/10.1111/ejh.13151
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http://dx.doi.org/10.1111/ejh.13151DOI Listing
July 2018

A Modified Post-Transplant Cyclophosphamide Regimen, for Unmanipulated Haploidentical Marrow Transplantation, in Acute Myeloid Leukemia: A Multicenter Study.

Authors:
Patrizia Chiusolo Gesine Bug Attilio Olivieri Mats Brune Nicola Mordini Paolo Emilio Alessandrino Alida Dominietto Anna Maria Raiola Carmen Di Grazia Francesca Gualandi Maria Teresa Van Lint Felicetto Ferrara Olimpia Finizio Emanuele Angelucci Andrea Bacigalupo

Biol Blood Marrow Transplant 2018 06 5;24(6):1243-1249. Epub 2018 Feb 5.

Istituto di Ematologia, Policlinico Universitario A Gemelli, Università Cattolica, Roma, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2018.01.031DOI Listing
June 2018

Enhanced labile plasma iron and outcome in acute myeloid leukaemia and myelodysplastic syndrome after allogeneic haemopoietic cell transplantation (ALLIVE): a prospective, multicentre, observational trial.

Authors:
Martin Wermke Julia Eckoldt Katharina S Götze Stefan A Klein Gesine Bug Liesbeth C de Wreede Michael Kramer Friedrich Stölzel Malte von Bonin Johannes Schetelig Michael Laniado Verena Plodeck Wolf-Karsten Hofmann Gerhard Ehninger Martin Bornhäuser Dominik Wolf Igor Theurl Uwe Platzbecker

Lancet Haematol 2018 May 5;5(5):e201-e210. Epub 2018 Apr 5.

Medizinische Fakultät Carl-Gustav-Carus der Technischen Universität, Medizinische Klinik und Poliklinik I, University Hospital Carl-Gustav-Carus, Dresden, Germany; National Center for Tumor Diseases (NCT)-Partner Site Dresden, Dresden, Germany; German Cancer Consortium (DKTK), Partner Site Dresden, Germany.

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http://dx.doi.org/10.1016/S2352-3026(18)30036-XDOI Listing
May 2018

Treatment of relapsed AML and MDS after allogeneic stem cell transplantation with decitabine and DLI-a retrospective multicenter analysis on behalf of the German Cooperative Transplant Study Group.

Authors:
Thomas Schroeder Christina Rautenberg William Krüger Uwe Platzbecker Gesine Bug Juliane Steinmann Stefan Klein Olaf Hopfer Kathrin Nachtkamp Mustafa Kondakci Stefanie Geyh Rainer Haas Ulrich Germing Martin Bornhäuser Guido Kobbe

Ann Hematol 2018 Feb 18;97(2):335-342. Epub 2017 Nov 18.

Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.

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http://dx.doi.org/10.1007/s00277-017-3185-5DOI Listing
February 2018

Establishment and Characterization of Long-Term Cultures Derived from Primary Acute Myeloid Leukemia Cells for HDAC Inhibitor Research.

Authors:
Annette Romanski Gesine Bug

Methods Mol Biol 2017 ;1510:127-148

Department of Medicine II, Hematology and Oncology, University Hospital Frankfurt, Goethe-University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/978-1-4939-6527-4_10DOI Listing
January 2018

Clinical impact of colonization with multidrug-resistant organisms on outcome after allogeneic stem cell transplantation in patients with acute myeloid leukemia.

Authors:
Sebastian Scheich Sarah Lindner Rosalie Koenig Claudia Reinheimer Thomas A Wichelhaus Michael Hogardt Silke Besier Volkhard A J Kempf Johanna Kessel Hans Martin Anne C Wilke Hubert Serve Gesine Bug Björn Steffen

Cancer 2018 01 28;124(2):286-296. Epub 2017 Sep 28.

Department of Hematology and Oncology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1002/cncr.31045DOI Listing
January 2018

Dasatinib and Azacitidine Followed by Haploidentical Stem Cell Transplant for Chronic Myeloid Leukemia with Evolving Myelodysplasia: A Case Report and Review of Treatment Options.

Authors:
Fabian Lang Lydia Wunderle Heike Pfeifer Susanne Schnittger Gesine Bug Oliver G Ottmann

Am J Case Rep 2017 Oct 16;18:1099-1109. Epub 2017 Oct 16.

Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652250PMC
http://dx.doi.org/10.12659/ajcr.904956DOI Listing
October 2017

Long-Term Follow-Up and Impact of Comorbidity before Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Relapsed or Refractory Acute Myeloid Leukemia-Lessons Learned from the Prospective BRIDGE Trial.

Authors:
Jan Moritz Middeke Regina Herbst Stefani Parmentier Gesine Bug Mathias Hänel Gernot Stuhler Kerstin Schäfer-Eckart Wolf Rösler Stefan Klein Wolfgang Bethge Ulrich Bitz Bozena Büttner Holger Knoth Nael Alakel Markus Schaich Anke Morgner Michael Kramer Katja Sockel Malte von Bonin Friedrich Stölzel Uwe Platzbecker Christoph Röllig Christian Thiede Gerhard Ehninger Martin Bornhäuser Johannes Schetelig

Biol Blood Marrow Transplant 2017 Sep 17;23(9):1491-1497. Epub 2017 May 17.

Universitätsklinikum Carl Gustav Carus der TU Dresden, Medizinische Klinik und Poliklinik I, Dresden, Germany; DKMS German Bone Marrow Donor Center, Dresden, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S10838791173046
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http://dx.doi.org/10.1016/j.bbmt.2017.05.014DOI Listing
September 2017

Accurate quantification of chromosomal lesions via short tandem repeat analysis using minimal amounts of DNA.

Authors:
Johann-Christoph Jann Daniel Nowak Florian Nolte Stephanie Fey Verena Nowak Julia Obländer Jovita Pressler Iris Palme Christina Xanthopoulos Alice Fabarius Uwe Platzbecker Aristoteles Giagounidis Katharina Götze Anne Letsch Detlef Haase Richard Schlenk Gesine Bug Michael Lübbert Arnold Ganser Ulrich Germing Claudia Haferlach Wolf-Karsten Hofmann Maximilian Mossner

J Med Genet 2017 09 9;54(9):640-650. Epub 2017 Jun 9.

III Medizinische Klinik, Hämatologie und Onkologie, Universitätsmedizin Mannheim, Mannheim, Germany.

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http://dx.doi.org/10.1136/jmedgenet-2017-104528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574397PMC
September 2017

Erythrocyte depletion from bone marrow: performance evaluation after 50 clinical-scale depletions with Spectra Optia BMC.

Authors:
Soo-Zin Kim-Wanner Gesine Bug Juliane Steinmann Salem Ajib Nadine Sorg Carolin Poppe Milica Bunos Eva Wingenfeld Christiane Hümmer Beate Luxembourg Erhard Seifried Halvard Bonig

J Transl Med 2017 08 11;15(1):174. Epub 2017 Aug 11.

Institute Frankfurt, German Red Cross Blood Service Baden-Württemberg-Hessen, Sandhofstr. 1, 60528, Frankfurt, Germany.

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http://dx.doi.org/10.1186/s12967-017-1277-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553998PMC
August 2017

Peripheral blood cytogenetics allows treatment monitoring and early identification of treatment failure to lenalidomide in MDS patients: results of the LE-MON-5 trial.

Authors:
Friederike Braulke Xenia Schulz Ulrich Germing Esther Schuler Uwe Platzbecker Florian Nolte Wolf-Karsten Hofmann Aristoteles Giagounidis Katharina Götze Michael Lübbert Richard F Schlenk Julie Schanz Ulrike Bacher Arnold Ganser Guntram Büsche Anne Letsch Philippe Schafhausen Gesine Bug Tim H Brümmendorf Rainer Haas Lorenz Trümper Katayoon Shirneshan Detlef Haase

Ann Hematol 2017 Jun 3;96(6):887-894. Epub 2017 Apr 3.

Department of Hematology and Medical Oncology, University Medicine of Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany.

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http://dx.doi.org/10.1007/s00277-017-2983-0DOI Listing
June 2017

CD19-CAR engineered NK-92 cells are sufficient to overcome NK cell resistance in B-cell malignancies.

Authors:
Annette Romanski Christoph Uherek Gesine Bug Erhard Seifried Hans Klingemann Winfried S Wels Oliver G Ottmann Torsten Tonn

J Cell Mol Med 2016 07 23;20(7):1287-94. Epub 2016 Mar 23.

Institute for Transfusion Medicine and Immunohematology, J.W. Goethe University Frankfurt/Main, Red Cross Blood Donor Service Baden-Württemberg-Hessen, Dresden, Germany.

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http://dx.doi.org/10.1111/jcmm.12810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929308PMC
July 2016

Mismatched unrelated hematopoietic stem cell transplantation with post-transplant cyclophosphamide for high-risk acute myeloid leukemia.

Authors:
Sarah Lindner Tobias Berg Julia Riemann Salem Ajib Zuzana Jedlickova Saskia Gueller Fabian Lang Hans Martin Hubert Serve Andrea Bacigalupo Gesine Bug

Ann Hematol 2016 May 8;95(6):1023-5. Epub 2016 Apr 8.

Department of Medicine II, Hematology and Oncology, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/s00277-016-2652-8DOI Listing
May 2016

Interleukin-15-activated cytokine-induced killer cells may sustain remission in leukemia patients after allogeneic stem cell transplantation: feasibility, safety and first insights on efficacy.

Authors:
Eva Rettinger Sabine Huenecke Halvard Bonig Michael Merker Andrea Jarisch Jan Soerensen Andre Willasch Gesine Bug Ansgar Schulz Thomas Klingebiel Peter Bader

Haematologica 2016 Apr 14;101(4):e153-6. Epub 2016 Jan 14.

JW Goethe University Frankfurt, Hospital for Children and Adolescents, Department of Stem Cell Transplantation and Immunology, Germany

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http://dx.doi.org/10.3324/haematol.2015.138016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004389PMC
April 2016

Treatment of acute myeloid leukemia or myelodysplastic syndrome relapse after allogeneic stem cell transplantation with azacitidine and donor lymphocyte infusions--a retrospective multicenter analysis from the German Cooperative Transplant Study Group.

Authors:
Thomas Schroeder Elena Rachlis Gesine Bug Matthias Stelljes Stefan Klein Nina Kristin Steckel Dominik Wolf Mark Ringhoffer Akos Czibere Kathrin Nachtkamp Ariane Dienst Mustafa Kondakci Michael Stadler Uwe Platzbecker Lutz Uharek Thomas Luft Roland Fenk Ulrich Germing Martin Bornhäuser Nicolaus Kröger Dietrich W Beelen Rainer Haas Guido Kobbe

Biol Blood Marrow Transplant 2015 Apr 23;21(4):653-60. Epub 2014 Dec 23.

Department of Hematology, Oncology and Clinical Immunology, University of Duesseldorf, Medical Faculty, Duesseldorf, Germany.

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http://dx.doi.org/10.1016/j.bbmt.2014.12.016DOI Listing
April 2015

Clinical and functional implications of microRNA mutations in a cohort of 935 patients with myelodysplastic syndromes and acute myeloid leukemia.

Authors:
Felicitas Thol Michaela Scherr Aylin Kirchner Rabia Shahswar Karin Battmer Sofia Kade Anuhar Chaturvedi Christian Koenecke Michael Stadler Uwe Platzbecker Christian Thiede Thomas Schroeder Guido Kobbe Gesine Bug Oliver Ottmann Wolf-Karsten Hofmann Nicolaus Kröger Walter Fiedler Richard Schlenk Konstanze Döhner Hartmut Döhner Jürgen Krauter Matthias Eder Arnold Ganser Michael Heuser

Haematologica 2015 Apr 31;100(4):e122-4. Epub 2014 Dec 31.

Department of Hematology, Hemostasis, Oncology and HSCT, Hannover Medical School, Hannover.

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http://dx.doi.org/10.3324/haematol.2014.120345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380731PMC
April 2015

FLT3-ITD and TLR9 use Bruton tyrosine kinase to activate distinct transcriptional programs mediating AML cell survival and proliferation.

Authors:
Thomas Oellerich Sebastian Mohr Jasmin Corso Julia Beck Carmen Döbele Helene Braun Anjali Cremer Silvia Münch Johannes Wicht Mark F Oellerich Gesine Bug Hanibal Bohnenberger Christina Perske Ekkehard Schütz Henning Urlaub Hubert Serve

Blood 2015 Mar 20;125(12):1936-47. Epub 2015 Jan 20.

Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany; German Cancer Consortium, Heidelberg, Germany; German Cancer Research Center, Heidelberg, Germany;

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http://dx.doi.org/10.1182/blood-2014-06-585216DOI Listing
March 2015

Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1.

Authors:
Monika Raab Andrea Krämer Stephanie Hehlgans Mourad Sanhaji Elisabeth Kurunci-Csacsko Christina Dötsch Gesine Bug Oliver Ottmann Sven Becker Fiona Pachl Bernhard Kuster Klaus Strebhardt

Mol Oncol 2015 Jan 11;9(1):140-54. Epub 2014 Aug 11.

Department of Gynecology, School of Medicine, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528686PMC
January 2015

STAT activation status differentiates leukemogenic from non-leukemogenic stem cells in AML and is suppressed by arsenic in t(6;9)-positive AML.

Authors:
Claudia Oancea Brigitte Rüster Boris Brill Jessica Roos Maria Heinssmann Gesine Bug Afsar Ali Mian Nathalie Andrea Guillen Steven M Kornblau Reinhard Henschler Martin Ruthardt

Genes Cancer 2014 Nov;5(11-12):378-92

Department of Hematology, Goethe University, Frankfurt, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279436PMC
http://dx.doi.org/10.18632/genesandcancer.39DOI Listing
November 2014

Unstimulated leukapheresis in patients and donors: comparison of two apheresis systems.

Authors:
Miriam Schulz Heike Bialleck Kristin Thorausch Gesine Bug Ulrich Dünzinger Erhard Seifried Halvard Bönig

Transfusion 2014 Jun 3;54(6):1622-9. Epub 2013 Dec 3.

German Red Cross Blood Service Baden-Württemberg-Hessen and Institute for Transfusion Medicine and Immunohematology, Goethe University Hospital, Frankfurt, Germany.

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http://dx.doi.org/10.1111/trf.12506DOI Listing
June 2014

Immunomagnetic selection or irradiation eliminates alloreactive cells but also reduces anti-tumor potential of cytokine-induced killer cells: implications for unmanipulated cytokine-induced killer cell infusion.

Authors:
Eva Rettinger Hermann Kreyenberg Michael Merker Selim Kuçi Andre Willasch Gesine Bug Evelyn Ullrich Winfried S Wels Halvard Bonig Thomas Klingebiel Peter Bader

Cytotherapy 2014 Jun 28;16(6):835-44. Epub 2014 Feb 28.

University Hospital Frankfurt/Main, Department for Children and Adolescents Medicine, Division of Stem Cell Transplantation and Immunology, Goethe-University Frankfurt/Main, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1016/j.jcyt.2014.01.003DOI Listing
June 2014

Outcome of patients with abnl(17p) acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation.

Authors:
Jan M Middeke Min Fang Jan J Cornelissen Brigitte Mohr Frederick R Appelbaum Michael Stadler Jaime Sanz Herrad Baurmann Gesine Bug Kerstin Schäfer-Eckart Ute Hegenbart Tilmann Bochtler Christoph Röllig Friedrich Stölzel Roland B Walter Gerhard Ehninger Martin Bornhäuser Bob Löwenberg Johannes Schetelig

Blood 2014 May 20;123(19):2960-7. Epub 2014 Mar 20.

Universitätsklinikum Carl Gustav Carus der Technische Universität Dresden, Medizinische Klinik und Poliklinik I, Dresden, Germany;

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http://dx.doi.org/10.1182/blood-2013-12-544957DOI Listing
May 2014

Long-term results of a prospective randomized trial evaluating G-CSF priming in intensive induction chemotherapy followed by autologous stem cell transplantation in elderly patients with acute myeloid leukemia.

Authors:
Gesine Bug Steffen Koschmieder Juergen Krauter Michael Heuser Felicitas Thol Stefanie Wiebe Wolf-Karsten Hofmann Stefan A Klein Gerd Wegener Gudrun Göhring Wolfgang Heit Dieter Hoelzer Arnold Ganser Oliver G Ottmann

Ann Hematol 2014 Feb 27;93(2):193-202. Epub 2013 Aug 27.

Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s00277-013-1873-3DOI Listing
February 2014

Treatment of patients with advanced cancer with the natural killer cell line NK-92.

Authors:
Torsten Tonn Dirk Schwabe Hans G Klingemann Sven Becker Ruth Esser Ulrike Koehl Meinolf Suttorp Erhard Seifried Oliver G Ottmann Gesine Bug

Cytotherapy 2013 Dec 1;15(12):1563-70. Epub 2013 Oct 1.

Institute for Transfusion Medicine and Immunohematology, Goethe University Hospital, Frankfurt am Main, Germany; German Red Cross Blood Donation Service, Baden-Württemberg-Hessen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2013.06.017DOI Listing
December 2013

A randomized, open-label, phase I/II trial to investigate the maximum tolerated dose of the Polo-like kinase inhibitor BI 2536 in elderly patients with refractory/relapsed acute myeloid leukaemia.

Authors:
Carsten Müller-Tidow Gesine Bug Michael Lübbert Alwin Krämer Jürgen Krauter Peter Valent David Nachbaur Wolfgang E Berdel Oliver G Ottmann Holger Fritsch Gerd Munzert Pilar Garin-Chesa Frank Fleischer Tillmann Taube Hartmut Döhner

Br J Haematol 2013 Oct 16;163(2):214-22. Epub 2013 Aug 16.

Department of Medicine, Haematology and Oncology, University of Münster, Münster, Germany.

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http://dx.doi.org/10.1111/bjh.12518DOI Listing
October 2013

Molecular cytogenetic monitoring from CD34+ peripheral blood cells in myelodysplastic syndromes: first results from a prospective multicenter German diagnostic study.

Authors:
Friederike Braulke Klaus Jung Julie Schanz Katharina Götze Catharina Müller-Thomas Uwe Platzbecker Ulrich Germing Tim H Brümmendorf Gesine Bug Oliver Ottmann Aristoteles A N Giagounidis Michael Stadler Wolf-Karsten Hofmann Philippe Schafhausen Michael Lübbert Richard F Schlenk Igor W Blau Christina Ganster Sebastian Pfeiffer Katayoon Shirneshan Michael Metz Sven Detken Jörg Seraphin Kathleen Jentsch-Ullrich Angelika Böhme Burkhard Schmidt Lorenz Trümper Detlef Haase

Leuk Res 2013 Aug 25;37(8):900-6. Epub 2013 Apr 25.

Department of Hematology and Oncology, University of Goettingen, Germany.

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http://dx.doi.org/10.1016/j.leukres.2013.03.019DOI Listing
August 2013

Feasibility of azacitidine added to standard chemotherapy in older patients with acute myeloid leukemia--a randomised SAL pilot study.

Authors:
Utz Krug Anja Koschmieder Daniela Schwammbach Joachim Gerss Nicola Tidow Björn Steffen Gesine Bug Christian H Brandts Markus Schaich Christoph Röllig Christian Thiede Richard Noppeney Matthias Stelljes Thomas Büchner Steffen Koschmieder Ulrich Dührsen Hubert Serve Gerhard Ehninger Wolfgang E Berdel Carsten Müller-Tidow

PLoS One 2012 31;7(12):e52695. Epub 2012 Dec 31.

Department of Medicine A, University Hospital, Muenster, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052695PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534078PMC
June 2013

β2 integrin-derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis.

Authors:
Thomas Oellerich Mark F Oellerich Michael Engelke Silvia Münch Sebastian Mohr Marika Nimz He-Hsuan Hsiao Jasmin Corso Jing Zhang Hanibal Bohnenberger Tobias Berg Michael A Rieger Jürgen Wienands Gesine Bug Christian Brandts Henning Urlaub Hubert Serve

Blood 2013 May 18;121(19):3889-99, S1-66. Epub 2013 Mar 18.

Department of Hematology/Oncology, Johann Wolfgang Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1182/blood-2012-09-457887DOI Listing
May 2013

Influence of molecular subgroups on outcome of acute myeloid leukemia with normal karyotype in 141 patients undergoing salvage allogeneic stem cell transplantation in primary induction failure or beyond first relapse.

Authors:
Tim Pfeiffer Michael Schleuning Jiri Mayer Karl-Heinz Haude Johanna Tischer Stefanie Buchholz Donald Bunjes Gesine Bug Ernst Holler Ralf G Meyer Hildegard Greinix Christof Scheid Maximilian Christopeit Susanne Schnittger Jan Braess Günter Schlimok Karsten Spiekermann Arnold Ganser Hans-Jochem Kolb Christoph Schmid

Haematologica 2013 Apr 14;98(4):518-25. Epub 2012 Sep 14.

Department of Hematology and Oncology, Klinikum Augsburg, Germany.

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http://dx.doi.org/10.3324/haematol.2012.070235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659981PMC
April 2013

Breakdown of the FLT3-ITD/STAT5 axis and synergistic apoptosis induction by the histone deacetylase inhibitor panobinostat and FLT3-specific inhibitors.

Authors:
Kristin Pietschmann Hella Anna Bolck Marc Buchwald Steffi Spielberg Harald Polzer Karsten Spiekermann Gesine Bug Thorsten Heinzel Frank-Dietmar Böhmer Oliver H Krämer

Mol Cancer Ther 2012 Nov 31;11(11):2373-83. Epub 2012 Aug 31.

Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine, Friedrich-Schiller University, Hans-Knöll-Str. 2, Jena 07745, Germany.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-0129DOI Listing
November 2012

Outcome of high-risk acute myeloid leukemia after allogeneic hematopoietic cell transplantation: negative impact of abnl(17p) and -5/5q-.

Authors:
Jan M Middeke Dietrich Beelen Michael Stadler Gudrun Göhring Brigitte Schlegelberger Herrad Baurmann Gesine Bug Frauke Bellos Brigitte Mohr Stefanie Buchholz Rainer Schwerdtfeger Hans Martin Ute Hegenbart Gerhard Ehninger Martin Bornhäuser Johannes Schetelig

Blood 2012 Sep 31;120(12):2521-8. Epub 2012 Jul 31.

Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden, Dresden, Germany.

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http://dx.doi.org/10.1182/blood-2012-03-417972DOI Listing
September 2012

Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells.

Authors:
Annette Romanski Kerstin Schwarz Maren Keller Sarah Wietbrauk Anja Vogel Jessica Roos Claudia Oancea Boris Brill Oliver H Krämer Hubert Serve Martin Ruthardt Gesine Bug

Cell Cycle 2012 Sep 16;11(17):3219-26. Epub 2012 Aug 16.

Department of Medicine II, Hematology and Oncology, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany.

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http://dx.doi.org/10.4161/cc.21565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466521PMC
September 2012

Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes.

Authors:
Felicitas Thol Haiyang Yun Ann-Kathrin Sonntag Frederik Damm Eva M Weissinger Jürgen Krauter Katharina Wagner Michael Morgan Martin Wichmann Gudrun Göhring Gesine Bug Oliver Ottmann Wolf-Karsten Hofmann Axel Schambach Brigitte Schlegelberger Torsten Haferlach David Bowen Ken Mills Arnold Ganser Michael Heuser

Ann Hematol 2012 Aug 10;91(8):1221-33. Epub 2012 Apr 10.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany.

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http://link.springer.com/10.1007/s00277-012-1457-7
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http://dx.doi.org/10.1007/s00277-012-1457-7DOI Listing
August 2012

Polo-like kinases in AML.

Authors:
Tobias Berg Gesine Bug Oliver G Ottmann Klaus Strebhardt

Expert Opin Investig Drugs 2012 Aug 6;21(8):1069-74. Epub 2012 Jun 6.

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http://dx.doi.org/10.1517/13543784.2012.691163DOI Listing
August 2012

Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes.

Authors:
Felicitas Thol Sofia Kade Carola Schlarmann Patrick Löffeld Michael Morgan Jürgen Krauter Marcin W Wlodarski Britta Kölking Martin Wichmann Kerstin Görlich Gudrun Göhring Gesine Bug Oliver Ottmann Charlotte M Niemeyer Wolf-Karsten Hofmann Brigitte Schlegelberger Arnold Ganser Michael Heuser

Blood 2012 Apr 2;119(15):3578-84. Epub 2012 Mar 2.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1182/blood-2011-12-399337DOI Listing
April 2012

Antifungal management and resource use in patients with acute myeloid leukaemia after chemotherapy--retrospective analysis of changes over 3 yr in a German hospital.

Authors:
Angelika Böhme Johannes Atta Sabine Mousset Birgit Ehlken Margarita Shlaen Gesine Bug Hubert Serve Dieter Hoelzer

Eur J Haematol 2012 Jan 13;88(1):68-77. Epub 2011 Oct 13.

Department of Medicine, Hematology/Oncology, Goethe-University, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1111/j.1600-0609.2011.01704.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267047PMC
January 2012

The cytotoxic potential of interleukin-15-stimulated cytokine-induced killer cells against leukemia cells.

Authors:
Eva Rettinger Selim Kuçi Ivonne Naumann Petra Becker Hermann Kreyenberg Martina Anzaghe Andre Willasch Ulrike Koehl Gesine Bug Martin Ruthardt Thomas Klingebiel Simone Fulda Peter Bader

Cytotherapy 2012 Jan 6;14(1):91-103. Epub 2011 Oct 6.

University Children's Hospital of Frankfurt/Main and Department of Pediatric Hematology, Oncology and Hemostaseology, Goethe-University Frankfurt/Main, Frankfurt/Main, Germany.

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http://dx.doi.org/10.3109/14653249.2011.613931DOI Listing
January 2012

Enhanced immune response after a second dose of an AS03-adjuvanted H1N1 influenza A vaccine in patients after hematopoietic stem cell transplantation.

Authors:
Saskia Gueller Regina Allwinn Sabine Mousset Hans Martin Imke Wieters Eva Herrmann Hubert Serve Markus Bickel Gesine Bug

Biol Blood Marrow Transplant 2011 Oct 13;17(10):1546-50. Epub 2011 Feb 13.

Department of Medicine, Hematology/Oncology, Goethe-University of Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.bbmt.2011.02.004DOI Listing
October 2011

Advanced flowcytometric analysis of regulatory T cells: CD127 downregulation early post stem cell transplantation and altered Treg/CD3(+)CD4(+)-ratio in severe GvHD or relapse.

Authors:
Melanie Bremm Sabine Huenecke Thomas Lehrnbecher Eva Ponstingl Regine Mueller Annekathrin Heinze Gesine Bug Andrea Quaiser Michael Kapinsky Claudia Brehm Peter Bader Gisbert Schneider Thomas Klingebiel Ulrike Koehl

J Immunol Methods 2011 Oct 3;373(1-2):36-44. Epub 2011 Aug 3.

Pediatric Hematology and Oncology, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.jim.2011.07.018DOI Listing
October 2011

Treatment of poor-risk myelodysplastic syndromes and acute myeloid leukemia with a combination of 5-azacytidine and valproic acid.

Authors:
Andrea Kuendgen Gesine Bug Oliver G Ottmann Detlef Haase Julie Schanz Barbara Hildebrandt Kathrin Nachtkamp Judith Neukirchen Ariane Dienst Rainer Haas Ulrich Germing Norbert Gattermann

Clin Epigenetics 2011 Aug 8;2(2):389-99. Epub 2011 Apr 8.

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http://dx.doi.org/10.1007/s13148-011-0031-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365387PMC
August 2011

Long term outcome of patients with steroid-refractory acute intestinal graft versus host disease after treatment with pentostatin.

Authors:
Stefan A Klein Gesine Bug Sabine Mousset Wolf-Karsten Hofmann Dieter Hoelzer Hans Martin

Br J Haematol 2011 Jul 8;154(1):143-6. Epub 2011 Apr 8.

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http://dx.doi.org/10.1111/j.1365-2141.2010.08495.xDOI Listing
July 2011

Prognostic significance of ASXL1 mutations in patients with myelodysplastic syndromes.

Authors:
Felicitas Thol Inna Friesen Frederik Damm Haiyang Yun Eva M Weissinger Jürgen Krauter Katharina Wagner Anuhar Chaturvedi Amit Sharma Martin Wichmann Gudrun Göhring Christiane Schumann Gesine Bug Oliver Ottmann Wolf-Karsten Hofmann Brigitte Schlegelberger Michael Heuser Arnold Ganser

J Clin Oncol 2011 Jun 16;29(18):2499-506. Epub 2011 May 16.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany.

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http://jco.ascopubs.org/content/early/2011/05/16/JCO.2010.33
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2010.33.4938
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June 2011

Therapy of sclerodermatous chronic graft-versus-host disease with mammalian target of rapamycin inhibitors.

Authors:
Zuzana Jedlickova Irina Burlakova Gesine Bug Herrad Baurmann Rainer Schwerdtfeger Michael Schleuning

Biol Blood Marrow Transplant 2011 May 7;17(5):657-63. Epub 2010 Aug 7.

Centre for Bone Marrow and Blood Stem Cell Transplantation, Deutsche Klinik für Diagnostik, Wiesbaden, Germany.

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http://dx.doi.org/10.1016/j.bbmt.2010.07.025DOI Listing
May 2011

Increased HDAC1 deposition at hematopoietic promoters in AML and its association with patient survival.

Authors:
Lara Tickenbrock Hans-Ulrich Klein Cristina Trento Antje Hascher Stefanie Göllner Nicole Bäumer Robert Kuss Shuchi Agrawal Gesine Bug Hubert Serve Christian Thiede Gerhard Ehninger Udo Zur Stadt Michael McClelland Yipeng Wang Anke Becker Steffen Koschmieder Wolfgang E Berdel Martin Dugas Carsten Müller-Tidow

Leuk Res 2011 May 22;35(5):620-5. Epub 2010 Dec 22.

Department of Medicine A, Hematology and Oncology, University of Münster, Münster, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S01452126100053
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http://dx.doi.org/10.1016/j.leukres.2010.11.006DOI Listing
May 2011

The deacetylase inhibitor LAQ824 induces notch signalling in haematopoietic progenitor cells.

Authors:
Kerstin Schwarz Annette Romanski Elena Puccetti Sarah Wietbrauk Anja Vogel Maren Keller Jeffrey W Scott Hubert Serve Gesine Bug

Leuk Res 2011 Jan 31;35(1):119-25. Epub 2010 Jul 31.

Department of Medicine II, Hematology and Oncology, Goethe Universität Frankfurt, Theodor-Stern-Kai 7, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.leukres.2010.06.024DOI Listing
January 2011

The DAC system and associations with acute leukemias and myelodysplastic syndromes.

Authors:
Gesine Bug Oliver G Ottmann

Invest New Drugs 2010 Dec 14;28 Suppl 1:S36-49. Epub 2010 Dec 14.

Medizinische Klinik II, Abteilung für Hämatologie und Onkologie der, Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s10637-010-9595-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003828PMC
December 2010

IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis.

Authors:
Felicitas Thol Eva M Weissinger Jürgen Krauter Katharina Wagner Frederik Damm Martin Wichmann Gudrun Göhring Christiane Schumann Gesine Bug Oliver Ottmann Wolf-Karsten Hofmann Brigitte Schlegelberger Arnold Ganser Michael Heuser

Haematologica 2010 Oct 21;95(10):1668-74. Epub 2010 May 21.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Strasse 1, Hannover, Germany.

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http://dx.doi.org/10.3324/haematol.2010.025494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948091PMC
October 2010

[Valproic acid as a histone deacetylase inhibitor. New application for a well-known drug].

Authors:
Julia Mareike Wagner Gesine Bug Manfred Jung

Pharm Unserer Zeit 2010 May;39(3):197-203

Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104 Freiburg.

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http://dx.doi.org/10.1002/pauz.201000366DOI Listing
May 2010

Monitoring of donor chimerism in sorted CD34+ peripheral blood cells allows the sensitive detection of imminent relapse after allogeneic stem cell transplantation.

Authors:
Martin Bornhäuser Uta Oelschlaegel Uwe Platzbecker Gesine Bug Karin Lutterbeck Michael G Kiehl Johannes Schetelig Alexander Kiani Thomas Illmer Markus Schaich Catrin Theuser Brigitte Mohr Cornelia Brendel Axel A Fauser Stefan Klein Hans Martin Gerhard Ehninger Christian Thiede

Haematologica 2009 Nov;94(11):1613-7

Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany.

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http://dx.doi.org/10.3324/haematol.2009.007765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770975PMC
November 2009

Impact of leukapheresis on early death rate in adult acute myeloid leukemia presenting with hyperleukocytosis.

Authors:
Gesine Bug Konstantinos Anargyrou Torsten Tonn Heike Bialleck Erhard Seifried Dieter Hoelzer Oliver G Ottmann

Transfusion 2007 Oct;47(10):1843-50

Department of Internal Medicine II, University Hospital, Johann Wolfgang Goethe-University, Theodor Stern-Kai 7, D-60590 Frankfurt am Main, Germany.

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http://doi.wiley.com/10.1111/j.1537-2995.2007.01406.x
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http://dx.doi.org/10.1111/j.1537-2995.2007.01406.xDOI Listing
October 2007

Current status of growth factors in the treatment of acute myeloid and lymphoblastic leukemia.

Authors:
Oliver G Ottmann Gesine Bug Jürgen Krauter

Semin Hematol 2007 Jul;44(3):183-92

Department of Hematology and Oncology, Johann Wolfgang Goethe University, Frankfurt/Main, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S003719630700070
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http://dx.doi.org/10.1053/j.seminhematol.2007.04.007DOI Listing
July 2007

Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia.

Authors:
Gesine Bug Kerstin Schwarz Claudia Schoch Manuela Kampfmann Reinhard Henschler Dieter Hoelzer Oliver G Ottmann Martin Ruthardt

Haematologica 2007 Apr;92(4):542-5

Medizinische Klinik II, Abt. Hämatologie/Onkologie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, Frankfurt, Germany.

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http://dx.doi.org/10.3324/haematol.10758DOI Listing
April 2007

Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RARalpha-positive leukemic stem cells.

Authors:
Xiaomin Zheng Anita Seshire Brigitte Rüster Gesine Bug Tim Beissert Elena Puccetti Dieter Hoelzer Reinhard Henschler Martin Ruthardt

Haematologica 2007 Mar;92(3):323-31

Laboratory of Tumor Stem Cell Biology, Department of Hematology, J.W. Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.3324/haematol.10541DOI Listing
March 2007

Long-term survival in refractory acute myeloid leukemia after sequential treatment with chemotherapy and reduced-intensity conditioning for allogeneic stem cell transplantation.

Authors:
Christoph Schmid Michael Schleuning Rainer Schwerdtfeger Bernd Hertenstein Eva Mischak-Weissinger Donald Bunjes Stephanie V Harsdorf Christoph Scheid Udo Holtick Hildegard Greinix Felix Keil Barbara Schneider Michael Sandherr Gesine Bug Johanna Tischer Georg Ledderose Michael Hallek Wolfgang Hiddemann Hans-Jochem Kolb

Blood 2006 Aug 21;108(3):1092-9. Epub 2006 Mar 21.

Department of Internal Medicine III, José Carreras Unit for Hematopoietic Stem Cell Transplantation, Ludwig-Maximilians-University Hospital, Marchioninistr 15, 81379 Munich, Germany.

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http://dx.doi.org/10.1182/blood-2005-10-4165DOI Listing
August 2006

Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia.

Authors:
Gesine Bug Markus Ritter Barbara Wassmann Claudia Schoch Thorsten Heinzel Kerstin Schwarz Annette Romanski Oliver H Kramer Manuela Kampfmann Dieter Hoelzer Andreas Neubauer Martin Ruthardt Oliver G Ottmann

Cancer 2005 Dec;104(12):2717-25

Department of Internal Medicine II, University Hospital, JW Goethe-University Frankfurt, Germany.

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http://dx.doi.org/10.1002/cncr.21589DOI Listing
December 2005

Transplantation of human acute myeloid leukemia (AML) cells in immunodeficient mice reveals altered cell surface phenotypes and expression of human endothelial markers.

Authors:
Reinhard Henschler Stephan Göttig Ilse Junghahn Gesine Bug Erhard Seifried Albrecht M Müller Iduna Fichtner

Leuk Res 2005 Oct;29(10):1191-9

Institute of Transfusion Medicine and Immune Hematology, German Red Cross Blood Center, Johann Wolfgang Goethe University, Sandhofstrasse 1, D-60528 Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.leukres.2005.03.019DOI Listing
October 2005

High-dose melphalan is an effective salvage therapy in acute myeloid leukaemia patients with refractory relapse and relapse after autologous stem cell transplantation.

Authors:
Gesine Bug Johannes Atta Stefan A Klein Bernd Hertenstein Lothar Bergmann Simone Boehrer Sabine Mousset Dieter Hoelzer Hans Martin

Ann Hematol 2005 Oct 7;84(11):748-54. Epub 2005 Jul 7.

Medizinische Klinik II, Klinikum der J.W. Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany,

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http://dx.doi.org/10.1007/s00277-005-1075-8DOI Listing
October 2005

Early molecular response to posttransplantation imatinib determines outcome in MRD+ Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL).

Authors:
Barbara Wassmann Heike Pfeifer Michael Stadler Martin Bornhaüser Gesine Bug Urban J Scheuring Patrick Brück Matthias Stelljes Rainer Schwerdtfeger Nadezda Basara Jolanta Perz Donald Bunjes Georg Ledderose Rolf Mahlberg Anja Binckebanck Harald Gschaidmeier Dieter Hoelzer Oliver G Ottmann

Blood 2005 Jul 7;106(2):458-63. Epub 2005 Apr 7.

Departments of Hematology/Oncology of University Hospitals Frankfurt, Hannover, Dresden, Münster, Ulm, Heidelberg, Munich, Germany.

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http://dx.doi.org/10.1182/blood-2004-05-1746DOI Listing
July 2005

Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells.

Authors:
Gesine Bug Hilal Gül Kerstin Schwarz Heike Pfeifer Manuela Kampfmann Xiaomin Zheng Tim Beissert Simone Boehrer Dieter Hoelzer Oliver Gerhard Ottmann Martin Ruthardt

Cancer Res 2005 Apr;65(7):2537-41

Medizinische Klinik II/Abteilung Hämatologie, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3011DOI Listing
April 2005

Mechanisms of resistance to natural killer cell-mediated cytotoxicity in acute lymphoblastic leukemia.

Authors:
Annette Romanski Gesine Bug Sven Becker Manuela Kampfmann Erhard Seifried Dieter Hoelzer Oliver G Ottmann Torsten Tonn

Exp Hematol 2005 Mar;33(3):344-52

Center for Internal Medicine, Department of Hematology/Oncology, Johann Wolfgang Goethe University, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1016/j.exphem.2004.11.006DOI Listing
March 2005

Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia.

Authors:
Annette Romanski Biserka Bacic Gesine Bug Heike Pfeifer Hilal Gul Stacy Remiszewski Dieter Hoelzer Peter Atadja Martin Ruthardt Oliver G Ottmann

Haematologica 2004 Apr;89(4):419-26

Med. Klinik III/Abtl. Hämatologie, Johann Wolfgang Goethe-Universität, 60590 Frankfurt, Germany.

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April 2004

Chimaerism and erythroid marker expression after microinjection of human acute myeloid leukaemia cells into murine blastocysts.

Authors:
Michael Dürr Friedrich Harder Angela Merkel Gesine Bug Reinhard Henschler Albrecht M Müller

Oncogene 2003 Dec;22(57):9185-91

Institute of Medical Radiation and Cell Research (MSZ), University of Würzburg, Versbacherstr 5, D-2 97078 Würzburg, Germany.

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http://www.nature.com/articles/1207134
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http://dx.doi.org/10.1038/sj.onc.1207134DOI Listing
December 2003