Publications by authors named "Gerwin Huls"

75Publications

The Association Between Anemia and Skin Autofluorescence, a Marker for Advanced Glycation End Product Accumulation.

Hemasphere 2020 Dec 26;4(6):e470. Epub 2020 Oct 26.

Department of Hematology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/HS9.0000000000000470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593064PMC
December 2020

The IL1-IL1RAP axis plays an important role in the inflammatory leukemic niche that favors acute myeloid leukemia proliferation over normal hematopoiesis.

Haematologica 2020 10 29;Online ahead of print. Epub 2020 Oct 29.

Department of Experimental Hematology, Cancer Research Centre Groningen, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2020.254987DOI Listing
October 2020

Transcription factor 4 (TCF4) expression predicts clinical outcome in RUNX1 mutated and translocated acute myeloid leukemia.

Haematologica 2020 Jun 5;105(9):e454-457. Epub 2020 Jun 5.

Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Centrer, Nijmegen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2019.232827DOI Listing
June 2020

The long road: improving outcome in elderly "unfit" AML?

Blood 2020 Jun;135(24):2114-2115

University Medical Center Groningen.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood.2020005651DOI Listing
June 2020

Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals.

Blood 2020 04;135(14):1161-1170

Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood.2019004362DOI Listing
April 2020

WEE1 Inhibition Enhances Anti-Apoptotic Dependency as a Result of Premature Mitotic Entry and DNA Damage.

Cancers (Basel) 2019 Nov 7;11(11). Epub 2019 Nov 7.

Department of Hematology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11111743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895818PMC
November 2019

Iron deficiency, elevated erythropoietin, fibroblast growth factor 23, and mortality in the general population of the Netherlands: A cohort study.

PLoS Med 2019 06 6;16(6):e1002818. Epub 2019 Jun 6.

Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pmed.1002818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553711PMC
June 2019

Multidimensional radar dot-plots, do we need it for the screening of acute promyelocytic leukemia?

Ann Hematol 2019 07 25;98(7):1793-1794. Epub 2019 Apr 25.

Department of Hematology, University Medical Centre Groningen, Hanzeplein 1, 9713, GZ, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00277-019-03693-zDOI Listing
July 2019

10-day vs 5-day decitabine: equivalence cannot be concluded.

Lancet Haematol 2019 04;6(4):e177

Department of Hematology, Freiburg University Hospital, Freiburg, Germany.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S23523026193002
Publisher Site
http://dx.doi.org/10.1016/S2352-3026(19)30024-9DOI Listing
April 2019

Cancer cell-expressed SLAMF7 is not required for CD47-mediated phagocytosis.

Nat Commun 2019 02 1;10(1):533. Epub 2019 Feb 1.

Department of Hematology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, GZ, 9713, The Netherlands.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41467-018-08013-z
Publisher Site
http://dx.doi.org/10.1038/s41467-018-08013-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358615PMC
February 2019

Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones.

Cancer Cell 2018 10 20;34(4):674-689.e8. Epub 2018 Sep 20.

Department of Experimental Hematology, Cancer Research Centre Groningen (CRCG), University Medical Centre Groningen, University of Groningen, Hanzeplein 1, DA13, 9700 RB Groningen, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2018.08.014DOI Listing
October 2018

Decitabine in combination with donor lymphocyte infusions can induce remissions in relapsed myeloid malignancies with higher leukemic burden after allogeneic hematopoietic cell transplantation.

Leuk Res 2018 09 7;72:20-26. Epub 2018 Jul 7.

Department of Hematology, Oncology and Stem Cell Transplantation, University of Freiburg Medical Center, Freiburg, Germany; German Cancer Consortium (DKTK), Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.leukres.2018.07.005DOI Listing
September 2018

DNA Methyltransferase Inhibition Promotes Th1 Polarization in Human CD4CD25 FOXP3 Regulatory T Cells but Does Not Affect Their Suppressive Capacity.

J Immunol Res 2018 15;2018:4973964. Epub 2018 Apr 15.

Department of Laboratory Medicine-Medical Immunology, Radboud University Medical Center (Radboudumc), Nijmegen, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/4973964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924998PMC
October 2018

Active Smoking and Hematocrit and Fasting Circulating Erythropoietin Concentrations in the General Population.

Mayo Clin Proc 2018 03;93(3):337-343

Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mayocp.2018.01.005DOI Listing
March 2018

Combined PD-1 and JAK1/2 inhibition in refractory primary mediastinal B-cell lymphoma.

Ann Hematol 2018 May 11;97(5):905-907. Epub 2018 Jan 11.

Department of Pathology and Medical Biology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00277-018-3233-9DOI Listing
May 2018

Apoptosis-Related Gene Expression Profiling in Hematopoietic Cell Fractions of MDS Patients.

PLoS One 2016 30;11(11):e0165582. Epub 2016 Nov 30.

Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center (Radboudumc), Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165582PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130187PMC
September 2017

Overexpression of TP53 is associated with poor survival, but not with reduced response to hypomethylating agents in older patients with acute myeloid leukaemia.

Br J Haematol 2017 09 19;178(5):810-812. Epub 2016 Jul 19.

Department of Haematology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.14166DOI Listing
September 2017

Severe Ankyrin-R deficiency results in impaired surface retention and lysosomal degradation of RhAG in human erythroblasts.

Haematologica 2016 09 31;101(9):1018-27. Epub 2016 May 31.

School of Biochemistry, University of Bristol, UK National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Red Blood Cell Products, University of Bristol, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2016.146209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5060018PMC
September 2016

Addition of 10-Day Decitabine to Fludarabine/Total Body Irradiation Conditioning is Feasible and Induces Tumor-Associated Antigen-Specific T Cell Responses.

Biol Blood Marrow Transplant 2016 06 6;22(6):1000-1008. Epub 2016 Feb 6.

Department of Hematology, Radboudumc, Nijmegen, the Netherlands; Department of Laboratory Medicine, Laboratory of Hematology, Radboudumc, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2016.02.003DOI Listing
June 2016

Azacitidine in AML: a treatment option?

Authors:
Gerwin Huls

Blood 2015 Jul;126(3):283-4

RADBOUD UNIVERSITY MEDICAL CENTER.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2015-06-648071DOI Listing
July 2015

High expression of transcription factor 4 (TCF4) is an independent adverse prognostic factor in acute myeloid leukemia that could guide treatment decisions.

Haematologica 2014 Dec 22;99(12):e257-9. Epub 2014 Aug 22.

Department of Laboratory medicine, Laboratory of Hematology, RadboudUMC; and Department of Hematology, RadboudUMC, Nijmegen, The Netherlands

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2014.110437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258745PMC
December 2014

Characterization of acute myeloid leukemia based on levels of global hydroxymethylation.

Blood 2014 Aug 1;124(7):1110-8. Epub 2014 Jul 1.

Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2013-08-518514DOI Listing
August 2014

Aging impairs long-term hematopoietic regeneration after autologous stem cell transplantation.

Biol Blood Marrow Transplant 2014 Jun 7;20(6):865-71. Epub 2014 Mar 7.

Department of Experimental Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10838791140015
Publisher Site
http://dx.doi.org/10.1016/j.bbmt.2014.03.001DOI Listing
June 2014

Absence of aberrant myeloid progenitors by flow cytometry is associated with favorable response to azacitidine in higher risk myelodysplastic syndromes.

Cytometry B Clin Cytom 2014 May 28;86(3):207-15. Epub 2014 Jan 28.

Department of Hematology, VU Institute of Cancer and Immunology (V-ICI), Cancer Center Amsterdam (CCA), VU University Medical Center, Amsterdam, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cyto.b.21160DOI Listing
May 2014

Absence of aberrant myeloid progenitors by flow cytometry is associated with favorable response to azacitidine in higher risk myelodysplastic syndromes.

Cytometry B Clin Cytom 2014 Jan 15. Epub 2014 Jan 15.

Department of Hematology, VU Institute of Cancer and Immunology (V-ICI), Cancer Center Amsterdam (CCA), VU University Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cytob.21160DOI Listing
January 2014

Clinical Results of Hypomethylating Agents in AML Treatment.

J Clin Med 2014 Dec 25;4(1):1-17. Epub 2014 Dec 25.

Department of Hematology, Radboud University Medical Center, PO Box 9191, 6500 HB Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm4010001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470235PMC
December 2014

A dominant-negative GFI1B mutation in the gray platelet syndrome.

N Engl J Med 2014 Jan 10;370(3):245-53. Epub 2013 Dec 10.

From the Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen Center for Molecular Life Sciences (D.M., A.E.M., S.M.B., H.V., G.H., F.P., W.V.H., J.H.J., B.A.V.R.) and the Departments of Pathology (K.M.H., B.W.), Hematology (B.A.P.L.G., M.A.M., G.H.), Cardiology (A.L.D.), and Human Genetics (S.S., M.J.E.K.), Radboud University Medical Center - all in Nijmegen, the Netherlands; the Department of Medical Genetics, Antwerp University Hospital and University of Antwerp (N.A.B., E.F., G.V.C., B.L.L., L.V.L.) and the Statua Center for Statistics, University of Antwerp (E.F.), Antwerp, Belgium; and the Department of Hematology, University Hospital, Essen, Germany (C.K., L.B.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1308130DOI Listing
January 2014

Therapy refractory angioimmunoblastic T-cell lymphoma in complete remission with lenalidomide.

Eur J Haematol 2013 Feb 7;90(2):162-3. Epub 2013 Jan 7.

Department of Hematology, University Medical Center Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejh.12053DOI Listing
February 2013

Role of the mycobiome in human acute graft-versus-host disease.

Biol Blood Marrow Transplant 2013 Feb 15;19(2):329-32. Epub 2012 Nov 15.

Department of Hematology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2012.11.008DOI Listing
February 2013

[Calcium suppletion for patients who use gastric acid inhibitors: calcium citrate or calcium carbonate?].

Ned Tijdschr Geneeskd 2012 ;156(34):A4343

Universitair Medisch Centrum Groningen, Afd. Interne Geneeskunde, the Netherlands.

View Article

Download full-text PDF

Source
May 2013

A review on CXCR4/CXCL12 axis in oncology: no place to hide.

Eur J Cancer 2013 Jan 9;49(1):219-30. Epub 2012 Jun 9.

Department of Medical Oncology, University Medical Centre Groningen, University of Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2012.05.005DOI Listing
January 2013

The combination of valproic acid and lithium delays hematopoietic stem/progenitor cell differentiation.

Blood 2012 Mar 10;119(13):3050-9. Epub 2012 Feb 10.

Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2011-08-375386DOI Listing
March 2012

Treatment with high-dose simvastatin inhibits geranylgeranylation in AML blast cells in a subset of AML patients.

Exp Hematol 2012 Mar 25;40(3):177-186.e6. Epub 2011 Nov 25.

Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2011.11.008DOI Listing
March 2012

Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects?

Curr Opin Immunol 2011 Aug 12;23(4):512-7. Epub 2011 Jun 12.

Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09527915110006
Publisher Site
http://dx.doi.org/10.1016/j.coi.2011.05.006DOI Listing
August 2011

Prognostic impact of white blood cell count in intermediate risk acute myeloid leukemia: relevance of mutated NPM1 and FLT3-ITD.

Haematologica 2011 Sep 23;96(9):1310-7. Epub 2011 May 23.

Division of Pediatric Oncology/Hematology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2011.040592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166101PMC
September 2011

Efficacy of single-agent lenalidomide in patients with JAK2 (V617F) mutated refractory anemia with ring sideroblasts and thrombocytosis.

Blood 2010 Jul 1;116(2):180-2. Epub 2010 Mar 1.

Department of Hematology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2010-01-263087DOI Listing
July 2010

Paradoxical down-regulation of p16 mRNA with advancing age in acute myeloid leukemia.

Aging (Albany NY) 2009 Oct 23;1(11):949-53. Epub 2009 Oct 23.

Division of Pediatric Oncology/Hematology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815746PMC
http://dx.doi.org/10.18632/aging.100096DOI Listing
October 2009

AML at older age: age-related gene expression profiles reveal a paradoxical down-regulation of p16INK4A mRNA with prognostic significance.

Blood 2009 Oct 10;114(14):2869-77. Epub 2009 Aug 10.

Division of Pediatric Oncology/Hematology, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-03-21
Publisher Site
http://dx.doi.org/10.1182/blood-2009-03-212688DOI Listing
October 2009

Resistant Microascus cirrosus pneumonia can be treated with a combination of surgery, multiple anti-fungal agents and a growth factor.

Mycopathologia 2006 Oct;162(4):299-302

The Department of Internal Medicine, Section of Hematology/Oncology, Medical College of Georgia, 1120 15th Street, BAA-5407, Augusta, GA 30912-3125, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11046-006-0067-0DOI Listing
October 2006