Gervaise Loirand

Gervaise Loirand

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Gervaise Loirand

Gervaise Loirand

Publications by authors named "Gervaise Loirand"

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Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats.

Oxid Med Cell Longev 2019 13;2019:2567198. Epub 2019 May 13.

L'institut du thorax, INSERM, CNRS, UNIV Nantes, Nantes, France.

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http://dx.doi.org/10.1155/2019/2567198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535829PMC
December 2019

Synthesis and biological evaluation of 3-amino-, 3-alkoxy- and 3-aryloxy-6-(hetero)arylpyridazines as potent antitumor agents.

Bioorg Med Chem Lett 2019 03 23;29(5):755-760. Epub 2018 Dec 23.

Plate-Forme ImPACcell, Structure Fédérative de Recherche BIOSIT, Université de Rennes 1, Campus de Villejean, 2 Avenue du Pr. Leon Bernard CS34317, F-35043 Rennes Cedex, France.

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http://dx.doi.org/10.1016/j.bmcl.2018.12.050DOI Listing
March 2019

[New protagonists in asthma pathophysiology].

Presse Med 2019 Mar 8;48(3 Pt 1):255-261. Epub 2019 Mar 8.

INRA, UR1268 BIA, rue de la Géraudière, BP 71627, 44316 Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.lpm.2019.01.004DOI Listing
March 2019

Targeting of Rac1 prevents bronchoconstriction and airway hyperresponsiveness.

J Allergy Clin Immunol 2018 09 16;142(3):824-833.e3. Epub 2017 Nov 16.

NSERM, CNRS, UNIV Nantes, l'institut du thorax, Nantes, France; CHU Nantes, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.09.049DOI Listing
September 2018

Seeds Attenuate Vascular Oxidative and Nitrosative Stresses in Spontaneously Hypertensive Rats.

Oxid Med Cell Longev 2017 20;2017:4129459. Epub 2017 Jun 20.

INSERM, CNRS, Université de Nantes, l'institut du thorax, 44000 Nantes, France.

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http://dx.doi.org/10.1155/2017/4129459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496124PMC
April 2018

In Vitro and In Vivo Approaches to Assess Rho Kinase Activity.

Methods Mol Biol 2017 ;1527:213-218

INSERM, CNRS, UNIV Nantes, l'institut du thorax, 8 Quai Moncousu, BP 70721, 44007, Nantes Cedex 1, France.

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http://dx.doi.org/10.1007/978-1-4939-6625-7_17DOI Listing
January 2018

Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1.

J Am Soc Nephrol 2017 Apr 13;28(4):1216-1226. Epub 2017 Jan 13.

Unité Mixte de Recherche Scientifique 1138, Team 1, Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Pierre et Marie Curie University, Paris Descartes University, Paris, France;

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http://dx.doi.org/10.1681/ASN.2016040477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373452PMC
April 2017

Cardiac Protective Effects of Moringa oleifera Seeds in Spontaneous Hypertensive Rats.

Am J Hypertens 2016 07 10;29(7):873-81. Epub 2016 Feb 10.

INSERM, UMR S1087-CNRS UMR C6291, Nantes, France; Université de Nantes, Nantes, France;

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http://dx.doi.org/10.1093/ajh/hpw001DOI Listing
July 2016

Rho Kinases in Health and Disease: From Basic Science to Translational Research.

Authors:
Gervaise Loirand

Pharmacol Rev 2015 Oct;67(4):1074-95

Institut National de la Santé et de la Recherche Médicale UMR1087, Université de Nantes, CHU Nantes, l'institut du thorax, Nantes, France

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http://pharmrev.aspetjournals.org/cgi/doi/10.1124/pr.115.010
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http://dx.doi.org/10.1124/pr.115.010595DOI Listing
October 2015

Involvement of Rho GTPases and their regulators in the pathogenesis of hypertension.

Small GTPases 2014 31;5(4):1-10. Epub 2014 Oct 31.

a INSERM; U1087; l'institut du thorax ; Nantes , France.

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http://dx.doi.org/10.4161/sgtp.28846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205133PMC
August 2015

Prime role of IL-17A in neutrophilia and airway smooth muscle contraction in a house dust mite-induced allergic asthma model.

J Allergy Clin Immunol 2015 Jun 30;135(6):1643-1643.e3. Epub 2015 Jan 30.

INSERM, U1087, l'institut du thorax, Nantes, France; CNRS, U6291, Nantes, France; Université de Nantes, Nantes, France; CHU Nantes, l'institut du thorax, Service de Pneumologie, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.12.1872DOI Listing
June 2015

Angiotensin II activates the RhoA exchange factor Arhgef1 in humans.

Hypertension 2015 Jun 13;65(6):1273-8. Epub 2015 Apr 13.

From Inserm UMR 1087, CNRS UMR 6291 and University of Nantes, Nantes, France (M.L.C., J.B., G.C., P.P., G.L.); CHU Nantes, l'Institut du Thorax, Nantes, France (P.P., G.L.); Inserm, UMR 970, Paris Cardiovascular Research Center, Paris, France (N.D, X.J.); Université Paris Descartes, Sorbonne Paris Cité, Paris, France (A.B., M.A., X.J.); Assistance Publique, Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France (A.B., M.A., X.J.); Inserm CIC 1418, Paris, France (A.B., M.A.); and Laboratorio di Genomica e Proteomica funzionale, Universta di Bari, Bari, Italy (M.L.C.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.05065DOI Listing
June 2015

PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension.

Atherosclerosis 2015 Mar 19;239(1):252-9. Epub 2015 Jan 19.

INSERM, UMR1087-CNRS UMR6291, l'Institut du Thorax, F-44000 Nantes, France; Université de Nantes, Institut du Thorax, F-44000 Nantes, France; Department of Endocrinology, University Hospital of Nantes, F-44000 Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.01.012DOI Listing
March 2015

Smooth muscle specific Rac1 deficiency induces hypertension by preventing p116RIP3-dependent RhoA inhibition.

J Am Heart Assoc 2014 Jun 17;3(3):e000852. Epub 2014 Jun 17.

Inserm UMR_S1087, CNRS UMR_C6291, l'institut du thorax, Nantes, F-44000, France (G.A., J.E.S., G.T., M.R.D., G.L., V.S.) Université de Nantes, Nantes, F-44000, France (G.A., J.E.S., G.T., M.R.D., G.L., V.S.) CHU Nantes, l'institut du thorax, Nantes, F-44000, France (G.L., V.S.).

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http://dx.doi.org/10.1161/JAHA.114.000852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309079PMC
June 2014

Electrografting of a biodegradable layer as a primer adhesion coating onto a metallic stent: in vitro and in vivo evaluations.

J Mater Sci Mater Med 2013 Dec 1;24(12):2729-39. Epub 2013 Aug 1.

Equipe Systèmes Polymères Complexes, Institut de Chimie et des Matériaux Paris-Est-UMR 7182, CNRS, Université Paris-Est Créteil Val-de-Marne, 2 rue Henri Dunant, 94320, Thiais, France,

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http://link.springer.com/content/pdf/10.1007/s10856-013-5015
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http://link.springer.com/10.1007/s10856-013-5015-1
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http://dx.doi.org/10.1007/s10856-013-5015-1DOI Listing
December 2013

Shear stress regulates endothelial microparticle release.

Circ Res 2013 May 27;112(10):1323-33. Epub 2013 Mar 27.

INSERM, U970, Paris Cardiovascular Research Center PARCC, Paris, France.

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http://dx.doi.org/10.1161/CIRCRESAHA.112.300818DOI Listing
May 2013

AMPK alpha 1-induced RhoA phosphorylation mediates vasoprotective effect of estradiol.

Arterioscler Thromb Vasc Biol 2011 Nov;31(11):2634-42

Institut National de la Santé et de la Recherche Médicale, UMR915, Institut du Thorax, Nantes, France.

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http://dx.doi.org/10.1161/ATVBAHA.111.228304DOI Listing
November 2011

WNK1 regulates vasoconstriction and blood pressure response to α 1-adrenergic stimulation in mice.

Hypertension 2011 Sep 18;58(3):439-45. Epub 2011 Jul 18.

INSERM U970, Paris Cardiovascular Research Center PARCC, 56 rue Leblanc, 75015 Paris, France.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.172429DOI Listing
September 2011

The role of Rho protein signaling in hypertension.

Nat Rev Cardiol 2010 Nov 31;7(11):637-47. Epub 2010 Aug 31.

Inserm UMR915, IRT-UN, 8 Quai Moncousu, BP 70721, 44007 Nantes cedex 1, France.

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http://dx.doi.org/10.1038/nrcardio.2010.136DOI Listing
November 2010

[The exchange factor Arhgef1: a new target in hypertension].

Med Sci (Paris) 2010 Jun-Jul;26(6-7):561-3

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http://dx.doi.org/10.1051/medsci/2010266-7561DOI Listing
September 2010

Angiotensin II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells.

Am J Physiol Cell Physiol 2009 Nov 19;297(5):C1062-70. Epub 2009 Aug 19.

Institut National de la Santé et de la Recherche Médicale, UMR915, l'institut du thorax, 44322 Nantes cedex 3, France.

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http://dx.doi.org/10.1152/ajpcell.00174.2009DOI Listing
November 2009

RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling.

Am J Respir Crit Care Med 2009 Jun 19;179(12):1151-8. Epub 2009 Mar 19.

INSERM U915, Faculté de médecine, 4 rue Gaston Veil, Nantes cedex 1, France.

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http://dx.doi.org/10.1164/rccm.200805-691OCDOI Listing
June 2009

RhoE Is required for keratinocyte differentiation and stratification.

Mol Biol Cell 2009 Jan 15;20(1):452-63. Epub 2008 Oct 15.

Molecular Medicine, National Heart and Lung Institute, Imperial College London., United Kingdom.

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http://www.molbiolcell.org/doi/10.1091/mbc.e07-11-1197
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http://dx.doi.org/10.1091/mbc.e07-11-1197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613104PMC
January 2009

Urotensin II and atherosclerosis.

Peptides 2008 May 2;29(5):778-82. Epub 2007 Sep 2.

Inserm U533, Nantes F-44000, France.

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http://dx.doi.org/10.1016/j.peptides.2007.08.024DOI Listing
May 2008

Ste20-related kinase SLK phosphorylates Ser188 of RhoA to induce vasodilation in response to angiotensin II Type 2 receptor activation.

Circ Res 2008 May 17;102(10):1265-74. Epub 2008 Apr 17.

Inserm U915, Faculté des Sciences, l'nstitut du thorax, 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.

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http://dx.doi.org/10.1161/CIRCRESAHA.107.164764DOI Listing
May 2008

Rho exchange factors in the cardiovascular system.

Curr Opin Pharmacol 2008 Apr 28;8(2):174-80. Epub 2008 Jan 28.

Inserm, U915, Nantes F-44000, France.

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http://dx.doi.org/10.1016/j.coph.2007.12.006DOI Listing
April 2008

Direct stenting limits sirolimus-eluting stent edge neointimal thickening.

J Vasc Surg 2007 Aug;46(2):354-9

Inserm, U533, l'institut du thorax, Université de Nantes, Nantes, France.

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http://dx.doi.org/10.1016/j.jvs.2007.04.063DOI Listing
August 2007

Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes.

J Immunol 2007 Jul;179(2):901-9

Institut National de la Recherche Agronomique, Unité Mixte de Recherche 1280-Physiologie des Adaptations Nutritionnelles, Nantes, France.

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http://dx.doi.org/10.4049/jimmunol.179.2.901DOI Listing
July 2007

Transglutaminase-dependent RhoA activation and depletion by serotonin in vascular smooth muscle cells.

J Biol Chem 2007 Feb 2;282(5):2918-28. Epub 2006 Dec 2.

INSERM U533 Institut du Thorax, Université de Nantes, 44322 Nantes cedex 3, France.

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http://dx.doi.org/10.1074/jbc.M604195200DOI Listing
February 2007

Hyaluronan induces vascular smooth muscle cell migration through RHAMM-mediated PI3K-dependent Rac activation.

Cardiovasc Res 2006 Nov 29;72(2):339-48. Epub 2006 Jul 29.

Inserm, Université de Nantes, U533, l'institut du thorax, Nantes, F-44000, France.

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http://dx.doi.org/10.1016/j.cardiores.2006.07.017DOI Listing
November 2006

Regulation of Rho proteins by phosphorylation in the cardiovascular system.

Trends Cardiovasc Med 2006 Aug;16(6):199-204

INSERM U533 Institut du Thorax, Université de Nantes, F-44000 Nantes, France.

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http://dx.doi.org/10.1016/j.tcm.2006.03.010DOI Listing
August 2006

Rho kinases in cardiovascular physiology and pathophysiology.

Circ Res 2006 Feb;98(3):322-34

INSERM U-533-Institut du Thorax, Faculté des Sciences, Nantes, France.

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http://dx.doi.org/10.1161/01.RES.0000201960.04223.3cDOI Listing
February 2006

Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension.

Br J Pharmacol 2005 Dec;146(7):1010-8

INSERM U533, Université de Nantes, Institut du Thorax, Faculté des Sciences, 2 rue de la Houssiniere, BP 92208, 44322 Nantes cedex 3, France.

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http://dx.doi.org/10.1038/sj.bjp.0706408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751229PMC
December 2005

Regulation of Rho signaling pathways in interleukin-2-stimulated human T-lymphocytes.

FASEB J 2005 Nov 7;19(13):1911-3. Epub 2005 Sep 7.

Inserm U461, Faculté de Pharmacie Paris-XI, Chatenay-Malabry, France.

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http://dx.doi.org/10.1096/fj.05-4030fjeDOI Listing
November 2005

Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome-mediated degradation in vascular smooth muscle cells.

Circ Res 2005 Jun 12;96(11):1152-60. Epub 2005 May 12.

INSERM U-533, Faculté des Sciences, 2 rue de la Houssinière, BP 92208, 44322 Nantes cedex 3, France.

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http://dx.doi.org/10.1161/01.RES.0000170084.88780.eaDOI Listing
June 2005

RhoA and resistance artery remodeling.

Am J Physiol Heart Circ Physiol 2005 Mar;288(3):H1051-6

Institut National de la Santé et de la Recherche Médicale U-533, Institut du Thorax, Nantes, France.

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http://dx.doi.org/10.1152/ajpheart.00710.2004DOI Listing
March 2005

Stent implantation activates RhoA in human arteries: inhibitory effect of rapamycin.

J Vasc Res 2005 Jan-Feb;42(1):21-8. Epub 2004 Dec 21.

INSERM U 533, Faculté des Sciences, Nantes, France.

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http://dx.doi.org/10.1159/000082873DOI Listing
February 2005

Expression of sialyl-Tn epitopes on beta1 integrin alters epithelial cell phenotype, proliferation and haptotaxis.

J Cell Sci 2004 Oct 21;117(Pt 21):5059-69. Epub 2004 Sep 21.

INSERM U601, Institut de Biologie, 9 quai Moncousu, 44093 Nantes CEDEX, France.

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http://dx.doi.org/10.1242/jcs.01350DOI Listing
October 2004

Sildenafil prevents change in RhoA expression induced by chronic hypoxia in rat pulmonary artery.

Circ Res 2003 Oct 28;93(7):630-7. Epub 2003 Aug 28.

Inserm U-533, Faculté des Sciences, Nantes, France.

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http://dx.doi.org/10.1161/01.RES.0000093220.90027.D9DOI Listing
October 2003

Rho-associated protein kinase contributes to early atherosclerotic lesion formation in mice.

Circ Res 2003 Oct 2;93(9):884-8. Epub 2003 Oct 2.

Institut National de la Santé et de la Recherche Médicale U541, Hôpital Lariboisière, Paris, France.

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http://dx.doi.org/10.1161/01.RES.0000099062.55042.9ADOI Listing
October 2003

Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis.

Gastroenterology 2003 May;124(5):1180-7

INSERM U-539, Department of Gastroenterology, and Centre d'Investigation Clinique, Centre Hospitalier Universitaire, Hotel Dieu, Nantes, France.

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http://dx.doi.org/10.1016/s0016-5085(03)00283-xDOI Listing
May 2003

RhoA expression is controlled by nitric oxide through cGMP-dependent protein kinase activation.

J Biol Chem 2003 Mar 9;278(11):9472-80. Epub 2003 Jan 9.

INSERM U-533, Faculté des Sciences, 44322 Nantes Cedex 3, France.

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http://dx.doi.org/10.1074/jbc.M212776200DOI Listing
March 2003

Rho-kinase inhibitors: pharmacomodulations on the lead compound Y-32885.

J Enzyme Inhib Med Chem 2002 Dec;17(6):381-90

Laboratoire de Chimie Thérapeutique, Faculté des Sciences Pharmaceutiques et Biologiques, BP 83, 59006 Lille Cedex, France.

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http://dx.doi.org/10.1080/1475636021000005659DOI Listing
December 2002