Gert-Jan van Ommen

Gert-Jan van Ommen

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Gert-Jan van Ommen

Gert-Jan van Ommen

Publications by authors named "Gert-Jan van Ommen"

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Meeting report: the Human Genome Meeting (HGM) 2019 in Seoul, Korea.

Hum Genomics 2019 Aug 1;13(1):35. Epub 2019 Aug 1.

Australian Institute of Tropical Health and Medicine (AITHM), James Cook University, Smithfield, QLD 4878, Australia.

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http://dx.doi.org/10.1186/s40246-019-0218-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670184PMC
August 2019

Meeting report: The Human Genome Meeting (HGM) 2019 in Seoul, Korea.

Eur J Hum Genet 2019 Aug 1. Epub 2019 Aug 1.

Australian Institute of Tropical Health and Medicine (AITHM), James Cook University, Smithfield, QLD, 4878, Australia.

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http://dx.doi.org/10.1038/s41431-019-0461-yDOI Listing
August 2019

Role of Academic Biobanks in Public-Private Partnerships in the European Biobanking and BioMolecular Resources Research Infrastructure Community.

Biopreserv Biobank 2019 30;17(1):46-51. Epub 2018 Nov 30.

5 Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1089/bio.2018.0024DOI Listing
May 2019

Transnational access to large prospective cohorts in Europe: Current trends and unmet needs.

N Biotechnol 2019 Mar 17;49:98-103. Epub 2018 Oct 17.

Institute for Molecular Medicine Finland FIMM, University of Helsinki, Biomedicum 2U, Tukholmankati 8, 00290, Helsinki, Finland; National Institute for Health and Welfare (THL), Biomedicum 1, Haartmaninkatu 8, 00290, Helsinki, Finland; University of Tartu, Estonian Genome Center, Riia 23b, 51010, Tartu, Estonia.

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https://linkinghub.elsevier.com/retrieve/pii/S18716784183177
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http://dx.doi.org/10.1016/j.nbt.2018.10.001DOI Listing
March 2019

Chronic disease research in Europe and the need for integrated population cohorts.

Eur J Epidemiol 2017 09 6;32(9):741-749. Epub 2017 Oct 6.

Imperial College London, London, UK.

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http://dx.doi.org/10.1007/s10654-017-0315-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662668PMC
September 2017

The Pathogenesis and Therapy of Muscular Dystrophies.

Annu Rev Genomics Hum Genet 2015 4;16:281-308. Epub 2015 Jun 4.

Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy, and Genetics, University of Oxford, OX1 3PT Oxford, United Kingdom; email: ,

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http://dx.doi.org/10.1146/annurev-genom-090314-025003DOI Listing
May 2016

Therapeutic NOTCH3 cysteine correction in CADASIL using exon skipping: in vitro proof of concept.

Brain 2016 Apr 19;139(Pt 4):1123-35. Epub 2016 Feb 19.

Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands

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http://dx.doi.org/10.1093/brain/aww011DOI Listing
April 2016

The Complete Genome Sequence of the Murine Pathobiont Helicobacter typhlonius.

Front Microbiol 2015 8;6:1549. Epub 2016 Jan 8.

Leiden Genome Technology Center, Leiden University Medical CenterLeiden, Netherlands; Department of Human Genetics, Leiden University Medical CenterLeiden, Netherlands.

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http://dx.doi.org/10.3389/fmicb.2015.01549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705304PMC
January 2016

25 years of the EJHG!

Eur J Hum Genet 2016 01;25(1)

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http://dx.doi.org/10.1038/ejhg.2016.167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159777PMC
January 2016

IL7R gene expression network associates with human healthy ageing.

Immun Ageing 2015 11;12:21. Epub 2015 Nov 11.

Section of Molecular Epidemiology, Leiden University Medical Center, Zone S5-P, P.O. Box 9600, 2300 RC Leiden, The Netherlands ; Netherlands Consortium for Healthy Ageing, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1186/s12979-015-0048-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642670PMC
November 2015

Selection and characterization of llama single domain antibodies against N-terminal huntingtin.

Neurol Sci 2015 Mar 8;36(3):429-34. Epub 2014 Oct 8.

Department of Human Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s10072-014-1971-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341019PMC
March 2015

Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels.

Nat Commun 2015 Mar 9;6:6065. Epub 2015 Mar 9.

Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands.

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http://dx.doi.org/10.1038/ncomms7065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366498PMC
March 2015

Roux-en-Y gastric bypass surgery, but not calorie restriction, reduces plasma branched-chain amino acids in obese women independent of weight loss or the presence of type 2 diabetes.

Diabetes Care 2014 Dec 14;37(12):3150-6. Epub 2014 Oct 14.

Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, the Netherlands Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden, the Netherlands.

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http://dx.doi.org/10.2337/dc14-0195DOI Listing
December 2014

Innovating therapies for muscle diseases.

Handb Clin Neurol 2013 ;113:1497-501

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/B978-0-444-59565-2.00020-4DOI Listing
March 2014

Reproducibility of high-throughput mRNA and small RNA sequencing across laboratories.

Nat Biotechnol 2013 Nov 15;31(11):1015-22. Epub 2013 Sep 15.

1] Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. [2] Netherlands Bioinformatics Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/nbt.2702DOI Listing
November 2013

Familial resemblance for serum metabolite concentrations.

Twin Res Hum Genet 2013 Oct 28;16(5):948-61. Epub 2013 Aug 28.

Department of Biological Psychology, Faculty of Psychology and Education, VU University Amsterdam, The Netherlands.

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http://dx.doi.org/10.1017/thg.2013.59DOI Listing
October 2013

Patients would benefit from simplified ethical review and consent procedure.

Lancet Oncol 2013 May 21;14(6):451-3. Epub 2013 Mar 21.

Centre for Research Ethics & Bioethics, Department of Public Health and Caring Sciences, Uppsala University, PO Box 564, S-751 22 Uppsala, Sweden.

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http://dx.doi.org/10.1016/S1470-2045(13)70129-3DOI Listing
May 2013

Advances in therapeutic RNA-targeting.

N Biotechnol 2013 Mar 28;30(3):299-301. Epub 2013 Jan 28.

Department of Human Genetics, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S18716784130000
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http://dx.doi.org/10.1016/j.nbt.2013.01.005DOI Listing
March 2013

Cell-type specific regulation of myostatin signaling.

FASEB J 2012 Apr 27;26(4):1462-72. Epub 2011 Dec 27.

Center for Human and Clinical Genetics, Leiden University Medical Center, Postzone S4-P, PO Box 9600, 2300RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1096/fj.11-191189DOI Listing
April 2012

Interspecies translation of disease networks increases robustness and predictive accuracy.

PLoS Comput Biol 2011 Nov 3;7(11):e1002258. Epub 2011 Nov 3.

Center for Human and Clinical Genetics, Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1371/journal.pcbi.1002258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207951PMC
November 2011

Dual exon skipping in myostatin and dystrophin for Duchenne muscular dystrophy.

BMC Med Genomics 2011 Apr 20;4:36. Epub 2011 Apr 20.

Center for Human and Clinical Genetics, Leiden University Medical Center, Postzone S4-P, PO Box 9600, Leiden, 2300RC, the Netherlands.

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http://dx.doi.org/10.1186/1755-8794-4-36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107769PMC
April 2011

[Dutch government invests in existing biobanks].

Ned Tijdschr Geneeskd 2010 ;154:A2825

Leids Universitair Medisch Centrum, Afd. Humane Genetica, Leiden, the Netherlands.

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December 2010

New insights in gene-derived therapy: the example of Duchenne muscular dystrophy.

Ann N Y Acad Sci 2010 Dec 1;1214:199-212. Epub 2010 Dec 1.

Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/j.1749-6632.2010.05836.xDOI Listing
December 2010

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Authors:
Iris M Heid Anne U Jackson Joshua C Randall Thomas W Winkler Lu Qi Valgerdur Steinthorsdottir Gudmar Thorleifsson M Carola Zillikens Elizabeth K Speliotes Reedik Mägi Tsegaselassie Workalemahu Charles C White Nabila Bouatia-Naji Tamara B Harris Sonja I Berndt Erik Ingelsson Cristen J Willer Michael N Weedon Jian'an Luan Sailaja Vedantam Tõnu Esko Tuomas O Kilpeläinen Zoltán Kutalik Shengxu Li Keri L Monda Anna L Dixon Christopher C Holmes Lee M Kaplan Liming Liang Josine L Min Miriam F Moffatt Cliona Molony George Nicholson Eric E Schadt Krina T Zondervan Mary F Feitosa Teresa Ferreira Hana Lango Allen Robert J Weyant Eleanor Wheeler Andrew R Wood Karol Estrada Michael E Goddard Guillaume Lettre Massimo Mangino Dale R Nyholt Shaun Purcell Albert Vernon Smith Peter M Visscher Jian Yang Steven A McCarroll James Nemesh Benjamin F Voight Devin Absher Najaf Amin Thor Aspelund Lachlan Coin Nicole L Glazer Caroline Hayward Nancy L Heard-Costa Jouke-Jan Hottenga Asa Johansson Toby Johnson Marika Kaakinen Karen Kapur Shamika Ketkar Joshua W Knowles Peter Kraft Aldi T Kraja Claudia Lamina Michael F Leitzmann Barbara McKnight Andrew P Morris Ken K Ong John R B Perry Marjolein J Peters Ozren Polasek Inga Prokopenko Nigel W Rayner Samuli Ripatti Fernando Rivadeneira Neil R Robertson Serena Sanna Ulla Sovio Ida Surakka Alexander Teumer Sophie van Wingerden Veronique Vitart Jing Hua Zhao Christine Cavalcanti-Proença Peter S Chines Eva Fisher Jennifer R Kulzer Cecile Lecoeur Narisu Narisu Camilla Sandholt Laura J Scott Kaisa Silander Klaus Stark Mari-Liis Tammesoo Tanya M Teslovich Nicholas John Timpson Richard M Watanabe Ryan Welch Daniel I Chasman Matthew N Cooper John-Olov Jansson Johannes Kettunen Robert W Lawrence Niina Pellikka Markus Perola Liesbeth Vandenput Helene Alavere Peter Almgren Larry D Atwood Amanda J Bennett Reiner Biffar Lori L Bonnycastle Stefan R Bornstein Thomas A Buchanan Harry Campbell Ian N M Day Mariano Dei Marcus Dörr Paul Elliott Michael R Erdos Johan G Eriksson Nelson B Freimer Mao Fu Stefan Gaget Eco J C Geus Anette P Gjesing Harald Grallert Jürgen Grässler Christopher J Groves Candace Guiducci Anna-Liisa Hartikainen Neelam Hassanali Aki S Havulinna Karl-Heinz Herzig Andrew A Hicks Jennie Hui Wilmar Igl Pekka Jousilahti Antti Jula Eero Kajantie Leena Kinnunen Ivana Kolcic Seppo Koskinen Peter Kovacs Heyo K Kroemer Vjekoslav Krzelj Johanna Kuusisto Kirsti Kvaloy Jaana Laitinen Olivier Lantieri G Mark Lathrop Marja-Liisa Lokki Robert N Luben Barbara Ludwig Wendy L McArdle Anne McCarthy Mario A Morken Mari Nelis Matt J Neville Guillaume Paré Alex N Parker John F Peden Irene Pichler Kirsi H Pietiläinen Carl G P Platou Anneli Pouta Martin Ridderstråle Nilesh J Samani Jouko Saramies Juha Sinisalo Jan H Smit Rona J Strawbridge Heather M Stringham Amy J Swift Maris Teder-Laving Brian Thomson Gianluca Usala Joyce B J van Meurs Gert-Jan van Ommen Vincent Vatin Claudia B Volpato Henri Wallaschofski G Bragi Walters Elisabeth Widen Sarah H Wild Gonneke Willemsen Daniel R Witte Lina Zgaga Paavo Zitting John P Beilby Alan L James Mika Kähönen Terho Lehtimäki Markku S Nieminen Claes Ohlsson Lyle J Palmer Olli Raitakari Paul M Ridker Michael Stumvoll Anke Tönjes Jorma Viikari Beverley Balkau Yoav Ben-Shlomo Richard N Bergman Heiner Boeing George Davey Smith Shah Ebrahim Philippe Froguel Torben Hansen Christian Hengstenberg Kristian Hveem Bo Isomaa Torben Jørgensen Fredrik Karpe Kay-Tee Khaw Markku Laakso Debbie A Lawlor Michel Marre Thomas Meitinger Andres Metspalu Kristian Midthjell Oluf Pedersen Veikko Salomaa Peter E H Schwarz Tiinamaija Tuomi Jaakko Tuomilehto Timo T Valle Nicholas J Wareham Alice M Arnold Jacques S Beckmann Sven Bergmann Eric Boerwinkle Dorret I Boomsma Mark J Caulfield Francis S Collins Gudny Eiriksdottir Vilmundur Gudnason Ulf Gyllensten Anders Hamsten Andrew T Hattersley Albert Hofman Frank B Hu Thomas Illig Carlos Iribarren Marjo-Riitta Jarvelin W H Linda Kao Jaakko Kaprio Lenore J Launer Patricia B Munroe Ben Oostra Brenda W Penninx Peter P Pramstaller Bruce M Psaty Thomas Quertermous Aila Rissanen Igor Rudan Alan R Shuldiner Nicole Soranzo Timothy D Spector Ann-Christine Syvanen Manuela Uda André Uitterlinden Henry Völzke Peter Vollenweider James F Wilson Jacqueline C Witteman Alan F Wright Gonçalo R Abecasis Michael Boehnke Ingrid B Borecki Panos Deloukas Timothy M Frayling Leif C Groop Talin Haritunians David J Hunter Robert C Kaplan Kari E North Jeffrey R O'Connell Leena Peltonen David Schlessinger David P Strachan Joel N Hirschhorn Themistocles L Assimes H-Erich Wichmann Unnur Thorsteinsdottir Cornelia M van Duijn Kari Stefansson L Adrienne Cupples Ruth J F Loos Inês Barroso Mark I McCarthy Caroline S Fox Karen L Mohlke Cecilia M Lindgren

Nat Genet 2010 Nov 10;42(11):949-60. Epub 2010 Oct 10.

Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, Regensburg, Germany.

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http://dx.doi.org/10.1038/ng.685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000924PMC
November 2010

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Authors:
Elizabeth K Speliotes Cristen J Willer Sonja I Berndt Keri L Monda Gudmar Thorleifsson Anne U Jackson Hana Lango Allen Cecilia M Lindgren Jian'an Luan Reedik Mägi Joshua C Randall Sailaja Vedantam Thomas W Winkler Lu Qi Tsegaselassie Workalemahu Iris M Heid Valgerdur Steinthorsdottir Heather M Stringham Michael N Weedon Eleanor Wheeler Andrew R Wood Teresa Ferreira Robert J Weyant Ayellet V Segrè Karol Estrada Liming Liang James Nemesh Ju-Hyun Park Stefan Gustafsson Tuomas O Kilpeläinen Jian Yang Nabila Bouatia-Naji Tõnu Esko Mary F Feitosa Zoltán Kutalik Massimo Mangino Soumya Raychaudhuri Andre Scherag Albert Vernon Smith Ryan Welch Jing Hua Zhao Katja K Aben Devin M Absher Najaf Amin Anna L Dixon Eva Fisher Nicole L Glazer Michael E Goddard Nancy L Heard-Costa Volker Hoesel Jouke-Jan Hottenga Asa Johansson Toby Johnson Shamika Ketkar Claudia Lamina Shengxu Li Miriam F Moffatt Richard H Myers Narisu Narisu John R B Perry Marjolein J Peters Michael Preuss Samuli Ripatti Fernando Rivadeneira Camilla Sandholt Laura J Scott Nicholas J Timpson Jonathan P Tyrer Sophie van Wingerden Richard M Watanabe Charles C White Fredrik Wiklund Christina Barlassina Daniel I Chasman Matthew N Cooper John-Olov Jansson Robert W Lawrence Niina Pellikka Inga Prokopenko Jianxin Shi Elisabeth Thiering Helene Alavere Maria T S Alibrandi Peter Almgren Alice M Arnold Thor Aspelund Larry D Atwood Beverley Balkau Anthony J Balmforth Amanda J Bennett Yoav Ben-Shlomo Richard N Bergman Sven Bergmann Heike Biebermann Alexandra I F Blakemore Tanja Boes Lori L Bonnycastle Stefan R Bornstein Morris J Brown Thomas A Buchanan Fabio Busonero Harry Campbell Francesco P Cappuccio Christine Cavalcanti-Proença Yii-Der Ida Chen Chih-Mei Chen Peter S Chines Robert Clarke Lachlan Coin John Connell Ian N M Day Martin den Heijer Jubao Duan Shah Ebrahim Paul Elliott Roberto Elosua Gudny Eiriksdottir Michael R Erdos Johan G Eriksson Maurizio F Facheris Stephan B Felix Pamela Fischer-Posovszky Aaron R Folsom Nele Friedrich Nelson B Freimer Mao Fu Stefan Gaget Pablo V Gejman Eco J C Geus Christian Gieger Anette P Gjesing Anuj Goel Philippe Goyette Harald Grallert Jürgen Grässler Danielle M Greenawalt Christopher J Groves Vilmundur Gudnason Candace Guiducci Anna-Liisa Hartikainen Neelam Hassanali Alistair S Hall Aki S Havulinna Caroline Hayward Andrew C Heath Christian Hengstenberg Andrew A Hicks Anke Hinney Albert Hofman Georg Homuth Jennie Hui Wilmar Igl Carlos Iribarren Bo Isomaa Kevin B Jacobs Ivonne Jarick Elizabeth Jewell Ulrich John Torben Jørgensen Pekka Jousilahti Antti Jula Marika Kaakinen Eero Kajantie Lee M Kaplan Sekar Kathiresan Johannes Kettunen Leena Kinnunen Joshua W Knowles Ivana Kolcic Inke R König Seppo Koskinen Peter Kovacs Johanna Kuusisto Peter Kraft Kirsti Kvaløy Jaana Laitinen Olivier Lantieri Chiara Lanzani Lenore J Launer Cecile Lecoeur Terho Lehtimäki Guillaume Lettre Jianjun Liu Marja-Liisa Lokki Mattias Lorentzon Robert N Luben Barbara Ludwig Paolo Manunta Diana Marek Michel Marre Nicholas G Martin Wendy L McArdle Anne McCarthy Barbara McKnight Thomas Meitinger Olle Melander David Meyre Kristian Midthjell Grant W Montgomery Mario A Morken Andrew P Morris Rosanda Mulic Julius S Ngwa Mari Nelis Matt J Neville Dale R Nyholt Christopher J O'Donnell Stephen O'Rahilly Ken K Ong Ben Oostra Guillaume Paré Alex N Parker Markus Perola Irene Pichler Kirsi H Pietiläinen Carl G P Platou Ozren Polasek Anneli Pouta Suzanne Rafelt Olli Raitakari Nigel W Rayner Martin Ridderstråle Winfried Rief Aimo Ruokonen Neil R Robertson Peter Rzehak Veikko Salomaa Alan R Sanders Manjinder S Sandhu Serena Sanna Jouko Saramies Markku J Savolainen Susann Scherag Sabine Schipf Stefan Schreiber Heribert Schunkert Kaisa Silander Juha Sinisalo David S Siscovick Jan H Smit Nicole Soranzo Ulla Sovio Jonathan Stephens Ida Surakka Amy J Swift Mari-Liis Tammesoo Jean-Claude Tardif Maris Teder-Laving Tanya M Teslovich John R Thompson Brian Thomson Anke Tönjes Tiinamaija Tuomi Joyce B J van Meurs Gert-Jan van Ommen Vincent Vatin Jorma Viikari Sophie Visvikis-Siest Veronique Vitart Carla I G Vogel Benjamin F Voight Lindsay L Waite Henri Wallaschofski G Bragi Walters Elisabeth Widen Susanna Wiegand Sarah H Wild Gonneke Willemsen Daniel R Witte Jacqueline C Witteman Jianfeng Xu Qunyuan Zhang Lina Zgaga Andreas Ziegler Paavo Zitting John P Beilby I Sadaf Farooqi Johannes Hebebrand Heikki V Huikuri Alan L James Mika Kähönen Douglas F Levinson Fabio Macciardi Markku S Nieminen Claes Ohlsson Lyle J Palmer Paul M Ridker Michael Stumvoll Jacques S Beckmann Heiner Boeing Eric Boerwinkle Dorret I Boomsma Mark J Caulfield Stephen J Chanock Francis S Collins L Adrienne Cupples George Davey Smith Jeanette Erdmann Philippe Froguel Henrik Grönberg Ulf Gyllensten Per Hall Torben Hansen Tamara B Harris Andrew T Hattersley Richard B Hayes Joachim Heinrich Frank B Hu Kristian Hveem Thomas Illig Marjo-Riitta Jarvelin Jaakko Kaprio Fredrik Karpe Kay-Tee Khaw Lambertus A Kiemeney Heiko Krude Markku Laakso Debbie A Lawlor Andres Metspalu Patricia B Munroe Willem H Ouwehand Oluf Pedersen Brenda W Penninx Annette Peters Peter P Pramstaller Thomas Quertermous Thomas Reinehr Aila Rissanen Igor Rudan Nilesh J Samani Peter E H Schwarz Alan R Shuldiner Timothy D Spector Jaakko Tuomilehto Manuela Uda André Uitterlinden Timo T Valle Martin Wabitsch Gérard Waeber Nicholas J Wareham Hugh Watkins James F Wilson Alan F Wright M Carola Zillikens Nilanjan Chatterjee Steven A McCarroll Shaun Purcell Eric E Schadt Peter M Visscher Themistocles L Assimes Ingrid B Borecki Panos Deloukas Caroline S Fox Leif C Groop Talin Haritunians David J Hunter Robert C Kaplan Karen L Mohlke Jeffrey R O'Connell Leena Peltonen David Schlessinger David P Strachan Cornelia M van Duijn H-Erich Wichmann Timothy M Frayling Unnur Thorsteinsdottir Gonçalo R Abecasis Inês Barroso Michael Boehnke Kari Stefansson Kari E North Mark I McCarthy Joel N Hirschhorn Erik Ingelsson Ruth J F Loos

Nat Genet 2010 Nov 10;42(11):937-48. Epub 2010 Oct 10.

Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.

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http://www.genome.gov/pages/research/dir/bmistudy.pdf
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http://www.nature.com/doifinder/10.1038/ng.686
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http://dx.doi.org/10.1038/ng.686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014648PMC
November 2010

Hundreds of variants clustered in genomic loci and biological pathways affect human height.

Authors:
Hana Lango Allen Karol Estrada Guillaume Lettre Sonja I Berndt Michael N Weedon Fernando Rivadeneira Cristen J Willer Anne U Jackson Sailaja Vedantam Soumya Raychaudhuri Teresa Ferreira Andrew R Wood Robert J Weyant Ayellet V Segrè Elizabeth K Speliotes Eleanor Wheeler Nicole Soranzo Ju-Hyun Park Jian Yang Daniel Gudbjartsson Nancy L Heard-Costa Joshua C Randall Lu Qi Albert Vernon Smith Reedik Mägi Tomi Pastinen Liming Liang Iris M Heid Jian'an Luan Gudmar Thorleifsson Thomas W Winkler Michael E Goddard Ken Sin Lo Cameron Palmer Tsegaselassie Workalemahu Yurii S Aulchenko Asa Johansson M Carola Zillikens Mary F Feitosa Tõnu Esko Toby Johnson Shamika Ketkar Peter Kraft Massimo Mangino Inga Prokopenko Devin Absher Eva Albrecht Florian Ernst Nicole L Glazer Caroline Hayward Jouke-Jan Hottenga Kevin B Jacobs Joshua W Knowles Zoltán Kutalik Keri L Monda Ozren Polasek Michael Preuss Nigel W Rayner Neil R Robertson Valgerdur Steinthorsdottir Jonathan P Tyrer Benjamin F Voight Fredrik Wiklund Jianfeng Xu Jing Hua Zhao Dale R Nyholt Niina Pellikka Markus Perola John R B Perry Ida Surakka Mari-Liis Tammesoo Elizabeth L Altmaier Najaf Amin Thor Aspelund Tushar Bhangale Gabrielle Boucher Daniel I Chasman Constance Chen Lachlan Coin Matthew N Cooper Anna L Dixon Quince Gibson Elin Grundberg Ke Hao M Juhani Junttila Lee M Kaplan Johannes Kettunen Inke R König Tony Kwan Robert W Lawrence Douglas F Levinson Mattias Lorentzon Barbara McKnight Andrew P Morris Martina Müller Julius Suh Ngwa Shaun Purcell Suzanne Rafelt Rany M Salem Erika Salvi Serena Sanna Jianxin Shi Ulla Sovio John R Thompson Michael C Turchin Liesbeth Vandenput Dominique J Verlaan Veronique Vitart Charles C White Andreas Ziegler Peter Almgren Anthony J Balmforth Harry Campbell Lorena Citterio Alessandro De Grandi Anna Dominiczak Jubao Duan Paul Elliott Roberto Elosua Johan G Eriksson Nelson B Freimer Eco J C Geus Nicola Glorioso Shen Haiqing Anna-Liisa Hartikainen Aki S Havulinna Andrew A Hicks Jennie Hui Wilmar Igl Thomas Illig Antti Jula Eero Kajantie Tuomas O Kilpeläinen Markku Koiranen Ivana Kolcic Seppo Koskinen Peter Kovacs Jaana Laitinen Jianjun Liu Marja-Liisa Lokki Ana Marusic Andrea Maschio Thomas Meitinger Antonella Mulas Guillaume Paré Alex N Parker John F Peden Astrid Petersmann Irene Pichler Kirsi H Pietiläinen Anneli Pouta Martin Ridderstråle Jerome I Rotter Jennifer G Sambrook Alan R Sanders Carsten Oliver Schmidt Juha Sinisalo Jan H Smit Heather M Stringham G Bragi Walters Elisabeth Widen Sarah H Wild Gonneke Willemsen Laura Zagato Lina Zgaga Paavo Zitting Helene Alavere Martin Farrall Wendy L McArdle Mari Nelis Marjolein J Peters Samuli Ripatti Joyce B J van Meurs Katja K Aben Kristin G Ardlie Jacques S Beckmann John P Beilby Richard N Bergman Sven Bergmann Francis S Collins Daniele Cusi Martin den Heijer Gudny Eiriksdottir Pablo V Gejman Alistair S Hall Anders Hamsten Heikki V Huikuri Carlos Iribarren Mika Kähönen Jaakko Kaprio Sekar Kathiresan Lambertus Kiemeney Thomas Kocher Lenore J Launer Terho Lehtimäki Olle Melander Tom H Mosley Arthur W Musk Markku S Nieminen Christopher J O'Donnell Claes Ohlsson Ben Oostra Lyle J Palmer Olli Raitakari Paul M Ridker John D Rioux Aila Rissanen Carlo Rivolta Heribert Schunkert Alan R Shuldiner David S Siscovick Michael Stumvoll Anke Tönjes Jaakko Tuomilehto Gert-Jan van Ommen Jorma Viikari Andrew C Heath Nicholas G Martin Grant W Montgomery Michael A Province Manfred Kayser Alice M Arnold Larry D Atwood Eric Boerwinkle Stephen J Chanock Panos Deloukas Christian Gieger Henrik Grönberg Per Hall Andrew T Hattersley Christian Hengstenberg Wolfgang Hoffman G Mark Lathrop Veikko Salomaa Stefan Schreiber Manuela Uda Dawn Waterworth Alan F Wright Themistocles L Assimes Inês Barroso Albert Hofman Karen L Mohlke Dorret I Boomsma Mark J Caulfield L Adrienne Cupples Jeanette Erdmann Caroline S Fox Vilmundur Gudnason Ulf Gyllensten Tamara B Harris Richard B Hayes Marjo-Riitta Jarvelin Vincent Mooser Patricia B Munroe Willem H Ouwehand Brenda W Penninx Peter P Pramstaller Thomas Quertermous Igor Rudan Nilesh J Samani Timothy D Spector Henry Völzke Hugh Watkins James F Wilson Leif C Groop Talin Haritunians Frank B Hu Robert C Kaplan Andres Metspalu Kari E North David Schlessinger Nicholas J Wareham David J Hunter Jeffrey R O'Connell David P Strachan H-Erich Wichmann Ingrid B Borecki Cornelia M van Duijn Eric E Schadt Unnur Thorsteinsdottir Leena Peltonen André G Uitterlinden Peter M Visscher Nilanjan Chatterjee Ruth J F Loos Michael Boehnke Mark I McCarthy Erik Ingelsson Cecilia M Lindgren Gonçalo R Abecasis Kari Stefansson Timothy M Frayling Joel N Hirschhorn

Nature 2010 Oct 29;467(7317):832-8. Epub 2010 Sep 29.

Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX1 2LU, UK.

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http://dx.doi.org/10.1038/nature09410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955183PMC
October 2010

Genome-wide assessment of differential roles for p300 and CBP in transcription regulation.

Nucleic Acids Res 2010 Sep 30;38(16):5396-408. Epub 2010 Apr 30.

Department of Molecular Cell Biology, Leiden University Medical Center, Postzone S4-0P, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1093/nar/gkq184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938195PMC
September 2010

Therapeutic exon skipping for dysferlinopathies?

Eur J Hum Genet 2010 Aug 10;18(8):889-94. Epub 2010 Feb 10.

Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/ejhg.2010.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987387PMC
August 2010

A 3 months mild functional test regime does not affect disease parameters in young mdx mice.

Neuromuscul Disord 2010 Apr 21;20(4):273-80. Epub 2010 Mar 21.

Department of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.nmd.2010.02.004DOI Listing
April 2010

Progress in therapeutic antisense applications for neuromuscular disorders.

Eur J Hum Genet 2010 Feb 7;18(2):146-53. Epub 2009 Oct 7.

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.nature.com/articles/ejhg2009160
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http://dx.doi.org/10.1038/ejhg.2009.160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987179PMC
February 2010

Novel protein-protein interactions inferred from literature context.

PLoS One 2009 Nov 18;4(11):e7894. Epub 2009 Nov 18.

Biosemantics Association, Department of Human Genetics, Leiden University Medical Center, Leiden, and Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007894PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774517PMC
November 2009

Less is more: therapeutic exon skipping for Duchenne muscular dystrophy.

Lancet Neurol 2009 Oct 25;8(10):873-5. Epub 2009 Aug 25.

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http://dx.doi.org/10.1016/S1474-4422(09)70229-7DOI Listing
October 2009

Development of antisense-mediated exon skipping as a treatment for duchenne muscular dystrophy.

Ann N Y Acad Sci 2009 Sep;1175:71-9

Duchenne Muscular Dystrophy Genetic Therapy Group, Department of Human Genetics, Leiden University, Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/j.1749-6632.2009.04973.xDOI Listing
September 2009

Integrated analysis of DNA copy number and gene expression microarray data using gene sets.

BMC Bioinformatics 2009 Jun 29;10:203. Epub 2009 Jun 29.

Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1471-2105-10-203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753845PMC
June 2009

Cost-effective HRMA pre-sequence typing of clone libraries; application to phage display selection.

BMC Biotechnol 2009 May 22;9:50. Epub 2009 May 22.

Center for Human and Clinical Genetics, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1472-6750-9-50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694173PMC
May 2009

Theoretic applicability of antisense-mediated exon skipping for Duchenne muscular dystrophy mutations.

Hum Mutat 2009 Mar;30(3):293-9

Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/humu.20918DOI Listing
March 2009

Assessment of the feasibility of exon 45-55 multiexon skipping for Duchenne muscular dystrophy.

BMC Med Genet 2008 Dec 1;9:105. Epub 2008 Dec 1.

DMD Genetic Therapy Group, Department of Human Genetics, Leiden University, Medical Center, Postzone S4-P, PO Box 9600, 2300RC, Leiden, The Netherlands.

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http://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2350-9-105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2611974PMC
December 2008

CORE_TF: a user-friendly interface to identify evolutionary conserved transcription factor binding sites in sets of co-regulated genes.

BMC Bioinformatics 2008 Nov 26;9:495. Epub 2008 Nov 26.

The Center for Human and Clinical Genetics, Leiden University Medical Center, Postzone S4-0P, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://bmcbioinformatics.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/1471-2105-9-495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613159PMC
November 2008

Literature-aided meta-analysis of microarray data: a compendium study on muscle development and disease.

BMC Bioinformatics 2008 Jun 24;9:291. Epub 2008 Jun 24.

Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/1471-2105-9-291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2459190PMC
June 2008

The therapeutic potential of antisense-mediated exon skipping.

Curr Opin Mol Ther 2008 Apr;10(2):140-9

Leiden University Medical Center, Department of Human Genetics, Zone S4-P, PO Box 9600, 2300 RC Leiden, the Netherlands.

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April 2008

Serum protein profiling in mice: identification of Factor XIIIa as a potential biomarker for muscular dystrophy.

Proteomics 2008 Apr;8(8):1552-63

Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/pmic.200700857DOI Listing
April 2008

Generation and characterization of transgenic mice with the full-length human DMD gene.

J Biol Chem 2008 Feb 13;283(9):5899-907. Epub 2007 Dec 13.

Center for Human and Clinical Genetics, Leiden University Medical Center, Postal Zone S4-P, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M709410200
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February 2008

Biobanking for Europe.

Brief Bioinform 2008 Jan 23;9(1):14-24. Epub 2007 Oct 23.

The University of Manchester, School of Translational Medicine, CIGMR Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1093/bib/bbm050DOI Listing
January 2008

Popper revisited: GWAS here, last year.

Eur J Hum Genet 2008 Jan;16(1):1-2

Center for Human and Clinical Genetics, Leiden University Medical Center PO Box 9600, 2300 RC Leiden NL.

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http://dx.doi.org/10.1038/sj.ejhg.5201970DOI Listing
January 2008

Antisense-mediated exon skipping: a versatile tool with therapeutic and research applications.

RNA 2007 Oct 7;13(10):1609-24. Epub 2007 Aug 7.

DMD genetic therapy group, Department of Human Genetics, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1261/rna.653607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1986821PMC
October 2007

Longitudinal evaluation of "presymptomatic" carriers of Huntington's disease.

J Neuropsychiatry Clin Neurosci 2007 ;19(3):310-7

Leiden University Medical Center, Department of Neurology, Section Neuropsychology J3-R, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1176/jnp.2007.19.3.310DOI Listing
October 2007

Antisense-induced exon skipping for duplications in Duchenne muscular dystrophy.

BMC Med Genet 2007 Jul 5;8:43. Epub 2007 Jul 5.

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1471-2350-8-43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1931584PMC
July 2007

Diagnosis of genetic abnormalities in developmentally delayed patients: a new strategy combining MLPA and array-CGH.

Am J Med Genet A 2007 Mar;143A(6):610-4

Center for Human and Clinical Genetics, Leiden University Medical Center, RC Leiden, The Netherlands.

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http://dx.doi.org/10.1002/ajmg.a.31593DOI Listing
March 2007

Exploring the frontiers of therapeutic exon skipping for Duchenne muscular dystrophy by double targeting within one or multiple exons.

Mol Ther 2006 Sep 6;14(3):401-7. Epub 2006 Jun 6.

DMD Genetic Therapy Group, Center for Human and Clinical Genetics, Leiden University Medical Center, RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.ymthe.2006.02.022DOI Listing
September 2006

Entries in the Leiden Duchenne muscular dystrophy mutation database: an overview of mutation types and paradoxical cases that confirm the reading-frame rule.

Muscle Nerve 2006 Aug;34(2):135-44

Leiden University Medical Center, Department of Human Genetics, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://doi.wiley.com/10.1002/mus.20586
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August 2006

Gene expression profiling highlights defective myogenesis in DMD patients and a possible role for bone morphogenetic protein 4.

Neurobiol Dis 2006 Jul 6;23(1):228-36. Epub 2006 May 6.

Center for Human and Clinical Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.nbd.2006.03.004DOI Listing
July 2006

Gene expression profiling to monitor therapeutic and adverse effects of antisense therapies for Duchenne muscular dystrophy.

Pharmacogenomics 2006 Apr;7(3):281-97

Leiden University Medical Center, Center for Human and Clinical Genetics, Room S-04-003, Postbus 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.2217/14622416.7.3.281DOI Listing
April 2006