Gert-Jan B van Ommen

Gert-Jan B van Ommen

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Gert-Jan B van Ommen

Gert-Jan B van Ommen

Publications by authors named "Gert-Jan B van Ommen"

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Role of Academic Biobanks in Public-Private Partnerships in the European Biobanking and BioMolecular Resources Research Infrastructure Community.

Biopreserv Biobank 2019 30;17(1):46-51. Epub 2018 Nov 30.

5 Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1089/bio.2018.0024DOI Listing
May 2019

The Pathogenesis and Therapy of Muscular Dystrophies.

Annu Rev Genomics Hum Genet 2015 4;16:281-308. Epub 2015 Jun 4.

Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy, and Genetics, University of Oxford, OX1 3PT Oxford, United Kingdom; email: ,

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http://dx.doi.org/10.1146/annurev-genom-090314-025003DOI Listing
May 2016

Therapeutic NOTCH3 cysteine correction in CADASIL using exon skipping: in vitro proof of concept.

Brain 2016 Apr 19;139(Pt 4):1123-35. Epub 2016 Feb 19.

Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands

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http://dx.doi.org/10.1093/brain/aww011DOI Listing
April 2016

The Complete Genome Sequence of the Murine Pathobiont Helicobacter typhlonius.

Front Microbiol 2015 8;6:1549. Epub 2016 Jan 8.

Leiden Genome Technology Center, Leiden University Medical CenterLeiden, Netherlands; Department of Human Genetics, Leiden University Medical CenterLeiden, Netherlands.

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http://dx.doi.org/10.3389/fmicb.2015.01549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705304PMC
January 2016

25 years of the EJHG!

Eur J Hum Genet 2016 01;25(1)

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http://dx.doi.org/10.1038/ejhg.2016.167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159777PMC
January 2016

IL7R gene expression network associates with human healthy ageing.

Immun Ageing 2015 11;12:21. Epub 2015 Nov 11.

Section of Molecular Epidemiology, Leiden University Medical Center, Zone S5-P, P.O. Box 9600, 2300 RC Leiden, The Netherlands ; Netherlands Consortium for Healthy Ageing, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1186/s12979-015-0048-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642670PMC
November 2015

Selection and characterization of llama single domain antibodies against N-terminal huntingtin.

Neurol Sci 2015 Mar 8;36(3):429-34. Epub 2014 Oct 8.

Department of Human Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s10072-014-1971-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341019PMC
March 2015

Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels.

Nat Commun 2015 Mar 9;6:6065. Epub 2015 Mar 9.

Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000 CA, The Netherlands.

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http://dx.doi.org/10.1038/ncomms7065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366498PMC
March 2015

Reproducibility of high-throughput mRNA and small RNA sequencing across laboratories.

Nat Biotechnol 2013 Nov 15;31(11):1015-22. Epub 2013 Sep 15.

1] Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. [2] Netherlands Bioinformatics Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/nbt.2702DOI Listing
November 2013

Familial resemblance for serum metabolite concentrations.

Twin Res Hum Genet 2013 Oct 28;16(5):948-61. Epub 2013 Aug 28.

Department of Biological Psychology, Faculty of Psychology and Education, VU University Amsterdam, The Netherlands.

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http://dx.doi.org/10.1017/thg.2013.59DOI Listing
October 2013

Advances in therapeutic RNA-targeting.

N Biotechnol 2013 Mar 28;30(3):299-301. Epub 2013 Jan 28.

Department of Human Genetics, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S18716784130000
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http://dx.doi.org/10.1016/j.nbt.2013.01.005DOI Listing
March 2013

Interspecies translation of disease networks increases robustness and predictive accuracy.

PLoS Comput Biol 2011 Nov 3;7(11):e1002258. Epub 2011 Nov 3.

Center for Human and Clinical Genetics, Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1371/journal.pcbi.1002258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207951PMC
November 2011

Dual exon skipping in myostatin and dystrophin for Duchenne muscular dystrophy.

BMC Med Genomics 2011 Apr 20;4:36. Epub 2011 Apr 20.

Center for Human and Clinical Genetics, Leiden University Medical Center, Postzone S4-P, PO Box 9600, Leiden, 2300RC, the Netherlands.

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http://dx.doi.org/10.1186/1755-8794-4-36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107769PMC
April 2011

[Dutch government invests in existing biobanks].

Ned Tijdschr Geneeskd 2010 ;154:A2825

Leids Universitair Medisch Centrum, Afd. Humane Genetica, Leiden, the Netherlands.

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December 2010

New insights in gene-derived therapy: the example of Duchenne muscular dystrophy.

Ann N Y Acad Sci 2010 Dec 1;1214:199-212. Epub 2010 Dec 1.

Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/j.1749-6632.2010.05836.xDOI Listing
December 2010

Genome-wide assessment of differential roles for p300 and CBP in transcription regulation.

Nucleic Acids Res 2010 Sep 30;38(16):5396-408. Epub 2010 Apr 30.

Department of Molecular Cell Biology, Leiden University Medical Center, Postzone S4-0P, PO Box 9600, 2300 RC Leiden, The Netherlands.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkq184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938195PMC
September 2010

Progress in therapeutic antisense applications for neuromuscular disorders.

Eur J Hum Genet 2010 Feb 7;18(2):146-53. Epub 2009 Oct 7.

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.nature.com/articles/ejhg2009160
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http://dx.doi.org/10.1038/ejhg.2009.160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987179PMC
February 2010

Novel protein-protein interactions inferred from literature context.

PLoS One 2009 Nov 18;4(11):e7894. Epub 2009 Nov 18.

Biosemantics Association, Department of Human Genetics, Leiden University Medical Center, Leiden, and Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007894PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774517PMC
November 2009

Less is more: therapeutic exon skipping for Duchenne muscular dystrophy.

Lancet Neurol 2009 Oct 25;8(10):873-5. Epub 2009 Aug 25.

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http://dx.doi.org/10.1016/S1474-4422(09)70229-7DOI Listing
October 2009

Development of antisense-mediated exon skipping as a treatment for duchenne muscular dystrophy.

Ann N Y Acad Sci 2009 Sep;1175:71-9

Duchenne Muscular Dystrophy Genetic Therapy Group, Department of Human Genetics, Leiden University, Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/j.1749-6632.2009.04973.xDOI Listing
September 2009

Integrated analysis of DNA copy number and gene expression microarray data using gene sets.

BMC Bioinformatics 2009 Jun 29;10:203. Epub 2009 Jun 29.

Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1471-2105-10-203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753845PMC
June 2009

Cost-effective HRMA pre-sequence typing of clone libraries; application to phage display selection.

BMC Biotechnol 2009 May 22;9:50. Epub 2009 May 22.

Center for Human and Clinical Genetics, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1472-6750-9-50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694173PMC
May 2009

Assessment of the feasibility of exon 45-55 multiexon skipping for Duchenne muscular dystrophy.

BMC Med Genet 2008 Dec 1;9:105. Epub 2008 Dec 1.

DMD Genetic Therapy Group, Department of Human Genetics, Leiden University, Medical Center, Postzone S4-P, PO Box 9600, 2300RC, Leiden, The Netherlands.

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http://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2350-9-105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2611974PMC
December 2008

CORE_TF: a user-friendly interface to identify evolutionary conserved transcription factor binding sites in sets of co-regulated genes.

BMC Bioinformatics 2008 Nov 26;9:495. Epub 2008 Nov 26.

The Center for Human and Clinical Genetics, Leiden University Medical Center, Postzone S4-0P, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://bmcbioinformatics.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/1471-2105-9-495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613159PMC
November 2008

Literature-aided meta-analysis of microarray data: a compendium study on muscle development and disease.

BMC Bioinformatics 2008 Jun 24;9:291. Epub 2008 Jun 24.

Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/1471-2105-9-291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2459190PMC
June 2008

Serum protein profiling in mice: identification of Factor XIIIa as a potential biomarker for muscular dystrophy.

Proteomics 2008 Apr;8(8):1552-63

Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/pmic.200700857DOI Listing
April 2008

Generation and characterization of transgenic mice with the full-length human DMD gene.

J Biol Chem 2008 Feb 13;283(9):5899-907. Epub 2007 Dec 13.

Center for Human and Clinical Genetics, Leiden University Medical Center, Postal Zone S4-P, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M709410200
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http://dx.doi.org/10.1074/jbc.M709410200DOI Listing
February 2008

Popper revisited: GWAS here, last year.

Eur J Hum Genet 2008 Jan;16(1):1-2

Center for Human and Clinical Genetics, Leiden University Medical Center PO Box 9600, 2300 RC Leiden NL.

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http://dx.doi.org/10.1038/sj.ejhg.5201970DOI Listing
January 2008

Antisense-mediated exon skipping: a versatile tool with therapeutic and research applications.

RNA 2007 Oct 7;13(10):1609-24. Epub 2007 Aug 7.

DMD genetic therapy group, Department of Human Genetics, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1261/rna.653607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1986821PMC
October 2007

Longitudinal evaluation of "presymptomatic" carriers of Huntington's disease.

J Neuropsychiatry Clin Neurosci 2007 ;19(3):310-7

Leiden University Medical Center, Department of Neurology, Section Neuropsychology J3-R, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1176/jnp.2007.19.3.310DOI Listing
October 2007

Antisense-induced exon skipping for duplications in Duchenne muscular dystrophy.

BMC Med Genet 2007 Jul 5;8:43. Epub 2007 Jul 5.

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1471-2350-8-43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1931584PMC
July 2007

Diagnosis of genetic abnormalities in developmentally delayed patients: a new strategy combining MLPA and array-CGH.

Am J Med Genet A 2007 Mar;143A(6):610-4

Center for Human and Clinical Genetics, Leiden University Medical Center, RC Leiden, The Netherlands.

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http://dx.doi.org/10.1002/ajmg.a.31593DOI Listing
March 2007

Exploring the frontiers of therapeutic exon skipping for Duchenne muscular dystrophy by double targeting within one or multiple exons.

Mol Ther 2006 Sep 6;14(3):401-7. Epub 2006 Jun 6.

DMD Genetic Therapy Group, Center for Human and Clinical Genetics, Leiden University Medical Center, RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.ymthe.2006.02.022DOI Listing
September 2006

Entries in the Leiden Duchenne muscular dystrophy mutation database: an overview of mutation types and paradoxical cases that confirm the reading-frame rule.

Muscle Nerve 2006 Aug;34(2):135-44

Leiden University Medical Center, Department of Human Genetics, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://doi.wiley.com/10.1002/mus.20586
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http://dx.doi.org/10.1002/mus.20586DOI Listing
August 2006

Gene expression profiling highlights defective myogenesis in DMD patients and a possible role for bone morphogenetic protein 4.

Neurobiol Dis 2006 Jul 6;23(1):228-36. Epub 2006 May 6.

Center for Human and Clinical Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.nbd.2006.03.004DOI Listing
July 2006

Small N-terminal mutant huntingtin fragments, but not wild type, are mainly present in monomeric form: Implications for pathogenesis.

Exp Neurol 2006 Jun 27;199(2):257-64. Epub 2005 Dec 27.

CBG-Center of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.expneurol.2005.11.008DOI Listing
June 2006

Gene expression profiling to monitor therapeutic and adverse effects of antisense therapies for Duchenne muscular dystrophy.

Pharmacogenomics 2006 Apr;7(3):281-97

Leiden University Medical Center, Center for Human and Clinical Genetics, Room S-04-003, Postbus 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.2217/14622416.7.3.281DOI Listing
April 2006

Mutant huntingtin represses CBP, but not p300, by binding and protein degradation.

Mol Cell Neurosci 2005 Dec;30(4):560-71

CBG-Center of Human and Clinical Genetics, Leiden University Medical Center, The Netherlands, and Department of Neurology, The second affiliated hospital of China Medical University, Shenyang, China.

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December 2005

Epitope mapping of monoclonal antibody 4C8 recognizing the protein huntingtin.

Hybridoma (Larchmt) 2005 Oct;24(5):231-5

Center of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1089/hyb.2005.24.231DOI Listing
October 2005

Mutant huntingtin represses CBP, but not p300, by binding and protein degradation.

Mol Cell Neurosci 2005 Sep;30(1):12-23

CBG-Center of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.mcn.2005.05.003DOI Listing
September 2005

Frequency of new copy number variation in humans.

Nat Genet 2005 Apr;37(4):333-4

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http://www.nature.com/articles/ng0405-333
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http://dx.doi.org/10.1038/ng0405-333DOI Listing
April 2005

Genomics: the human genome, revisited.

Eur J Hum Genet 2005 Mar;13(3):265-7

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http://www.nature.com/articles/5201348
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http://dx.doi.org/10.1038/sj.ejhg.5201348DOI Listing
March 2005

Large-scale gene expression analysis of human skeletal myoblast differentiation.

Neuromuscul Disord 2004 Sep;14(8-9):507-18

Center for Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S096089660400092
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http://dx.doi.org/10.1016/j.nmd.2004.03.008DOI Listing
September 2004

Gene expression variation between mouse inbred strains.

BMC Genomics 2004 Aug 18;5(1):57. Epub 2004 Aug 18.

Center for Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, Nederland.

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http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2164-5-57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC516769PMC
August 2004

Embryonic expression patterns of the Drosophila dystrophin-associated glycoprotein complex orthologs.

Gene Expr Patterns 2004 Mar;4(2):153-9

Laboratory of Developmental Neurobiology, Department of Molecular and Cell Biology, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.modgep.2003.09.004DOI Listing
March 2004

Intensity-based analysis of two-colour microarrays enables efficient and flexible hybridization designs.

Nucleic Acids Res 2004 Feb 24;32(4):e41. Epub 2004 Feb 24.

Center for Human and Clinical Genetics, Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1093/nar/gnh038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC390313PMC
February 2004

Antisense-induced multiexon skipping for Duchenne muscular dystrophy makes more sense.

Am J Hum Genet 2004 Jan 16;74(1):83-92. Epub 2003 Dec 16.

Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1181915PMC
http://dx.doi.org/10.1086/381039DOI Listing
January 2004

Hypomethylation of D4Z4 in 4q-linked and non-4q-linked facioscapulohumeral muscular dystrophy.

Nat Genet 2003 Dec 23;35(4):315-7. Epub 2003 Nov 23.

Department of Human Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, P.O. Box 9502, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1038/ng1262DOI Listing
December 2003

Advances in Duchenne muscular dystrophy gene therapy.

Nat Rev Genet 2003 Oct;4(10):774-83

Center for Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands.

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http://www.nature.com/articles/nrg1180
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http://dx.doi.org/10.1038/nrg1180DOI Listing
October 2003

GeneHopper: a web-based search engine to link gene-expression platforms through GenBank accession numbers.

Genome Biol 2003 25;4(5):R35. Epub 2003 Apr 25.

Center for Human and Clinical Genetics/Leiden Genome Technology Center, Leiden University Medical Center, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC156591PMC
http://dx.doi.org/10.1186/gb-2003-4-5-r35DOI Listing
July 2003

Cognitive and motor functioning in gene carriers for Huntington's disease: a baseline study.

J Neuropsychiatry Clin Neurosci 2003 ;15(1):7-16

Leiden University Medical Center, Department of Neurology, Leiden, The Netherlands.

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http://dx.doi.org/10.1176/jnp.15.1.7DOI Listing
April 2003

Therapeutic antisense-induced exon skipping in cultured muscle cells from six different DMD patients.

Hum Mol Genet 2003 Apr;12(8):907-14

Center for Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands.

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http://dx.doi.org/10.1093/hmg/ddg100DOI Listing
April 2003