Gert van Zyl

Gert van Zyl

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Gert van Zyl

Publications by authors named "Gert van Zyl"

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PhyloPi: An affordable, purpose built phylogenetic pipeline for the HIV drug resistance testing facility.

PLoS One 2019 5;14(3):e0213241. Epub 2019 Mar 5.

Division of Virology, University of the Free State and National Health Laboratory Service (NHLS), Bloemfontein, South Africa.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213241PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400384PMC
December 2019

Evaluation of the Performance of Three Biomarker Assays for Recent HIV Infection Using a Well-Characterized HIV-1 Subtype C Incidence Cohort.

AIDS Res Hum Retroviruses 2019 07 13;35(7):615-627. Epub 2019 May 13.

2 DST-NRF Center of Excellence in Epidemiological Modeling and Analysis (SACEMA), Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.

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http://dx.doi.org/10.1089/AID.2019.0033DOI Listing
July 2019

Lessons in diagnostic virology: expected and unexpected sources of error.

Rev Med Virol 2019 07 30;29(4):e2052. Epub 2019 May 30.

Division of Medical Virology, Department Pathology, Stellenbosch University, Faculty of Medicine and Health Sciences, Parow, South Africa.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/rmv.2052
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http://dx.doi.org/10.1002/rmv.2052DOI Listing
July 2019

Rapid emergence of resistance to antiretroviral treatment after undisclosed prior exposure: A case report.

South Afr J HIV Med 2019 30;20(1):965. Epub 2019 Jul 30.

Division of Medical Virology, Stellenbosch University and National Health Laboratory Service, Bellville, South Africa.

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http://dx.doi.org/10.4102/sajhivmed.v20i1.965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676989PMC
July 2019

Pharmacogenetics and pharmacokinetics of CNS penetration of efavirenz and its metabolites.

J Antimicrob Chemother 2019 03;74(3):699-709

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1093/jac/dky481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376850PMC
March 2019

Pooled PCR testing of dried blood spots for infant HIV diagnosis is cost efficient and accurate.

BMC Infect Dis 2019 Feb 11;19(1):136. Epub 2019 Feb 11.

The DST/NRF Centre of Excellence in Epidemiological Modelling and Analysis (SACEMA), Stellenbosch University, Stellenbosch, South Africa.

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3767-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371519PMC
February 2019

The effect of interventions on the transmission and spread of HIV in South Africa: a phylodynamic analysis.

Sci Rep 2019 02 25;9(1):2640. Epub 2019 Feb 25.

Emerging Pathogens Institute, University of Florida, Gainesville, Florida, 32608, United States of America.

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http://dx.doi.org/10.1038/s41598-018-37749-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389914PMC
February 2019

Paper-based detection of HIV-1 drug resistance using isothermal amplification and an oligonucleotide ligation assay.

Anal Biochem 2018 03 8;544:64-71. Epub 2017 Dec 8.

Department of Bioengineering, Rice University, 6100 Main St MS-142, Houston, TX 77005, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2017.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854266PMC
March 2018

HIV evolution and diversity in ART-treated patients.

Retrovirology 2018 01 30;15(1):14. Epub 2018 Jan 30.

HIV Dynamic and Replication Program, Center for Cancer Research, National Cancer Institute at Frederick, 1050 Boyles Street, Building 535, Room 109, Frederick, MD, 21702-1201, USA.

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http://dx.doi.org/10.1186/s12977-018-0395-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789667PMC
January 2018

Late-Onset Hiv Encephalopathy In Children With Long-Standing Virologic Suppression Followed By Slow Spontaneous Recovery Despite no Change In Antiretroviral Therapy: 4 Case Reports.

Pediatr Infect Dis J 2017 Nov;36(11):e264-e267

From the *Children's Infectious Diseases Clinical Research Unit (KID-CRU), Stellenbosch University, and †Department of Paediatrics and Child Health, Tygerberg Children's Hospital, Cape Town, South Africa; ‡Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Soweto, South Africa; and §Division of Medical Virology, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa.

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http://dx.doi.org/10.1097/INF.0000000000001694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638699PMC
November 2017

Moderate levels of pre-therapy drug resistance (PDR) in a generalised epidemic: time for better first-line ART?

AIDS 2017 11 28;31(17):2387-2391. Epub 2017 Aug 28.

aSouth African Medical Research Council Collaborating Centre TygHIVLab, Division of Medical Virology, Stellenbosch University, South Africa bNational Health Laboratory Service, Tygerberg Business Unit, South Africa cANOVA Health Institute dDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, South Africa.

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http://dx.doi.org/10.1097/QAD.0000000000001629DOI Listing
November 2017

Trends in Genotypic HIV-1 Antiretroviral Resistance between 2006 and 2012 in South African Patients Receiving First- and Second-Line Antiretroviral Treatment Regimens.

PLoS One 2013 26;8(6):e67188. Epub 2013 Jun 26.

National Health Laboratory Service, Tygerberg, Coastal Branch, South Africa ; Division of Medical Virology, Stellenbosch University, Faculty of Medicine and Health Sciences, Parow, South Africa.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067188PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694021PMC
October 2017

Barriers to HIV remission research in low- and middle-income countries.

J Int AIDS Soc 2017 06;20(1):21521

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.7448/IAS.20.1.21521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515034PMC
June 2017

Future technologies for monitoring HIV drug resistance and cure.

Curr Opin HIV AIDS 2017 03;12(2):182-189

aDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA bDivision of Medical Virology, Stellenbosch University and NHLS Tygerberg, Cape Town, South Africa.

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http://dx.doi.org/10.1097/COH.0000000000000344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738332PMC
March 2017

Tabula viva chirurgic: a living surgical document.

Cardiovasc J Afr 2016 May/Jun;27(3):170-176

Dean, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.

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http://dx.doi.org/10.5830/CVJA-2015-081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125284PMC
February 2017

Is HIV-1C a risk factor for protease inhibitor failure?

Lancet HIV 2016 Apr 14;3(4):e149-51. Epub 2016 Mar 14.

Division of Clinical Pharmacology, Department Medicine, Stellenbosch University, Faculty of Medicine and Health Sciences, Parow, Cape Town, South Africa.

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http://dx.doi.org/10.1016/S2352-3018(16)00040-0DOI Listing
April 2016

CD4 count-based failure criteria combined with viral load monitoring may trigger worse switch decisions than viral load monitoring alone.

Trop Med Int Health 2016 Feb 10;21(2):219-23. Epub 2015 Dec 10.

National Health Laboratory Service, Tygerberg, Cape Town, South Africa.

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http://dx.doi.org/10.1111/tmi.12639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717435PMC
February 2016

Mutational Heterogeneity in p6 Gag Late Assembly (L) Domains in HIV-1 Subtype C Viruses from South Africa.

AIDS Res Hum Retroviruses 2016 Jan 9;32(1):80-4. Epub 2015 Oct 9.

1 Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet , Stockholm, Sweden .

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http://dx.doi.org/10.1089/AID.2015.0266DOI Listing
January 2016

Virologic failure among children taking lopinavir/ritonavir-containing first-line antiretroviral therapy in South Africa.

Pediatr Infect Dis J 2015 Feb;34(2):175-9

From the *Department of Paediatrics, Chris Hani Baragwanath Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; †Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; ‡Division of Epidemiology and Biostatistics, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China; §Empilweni Services and Research Unit (ESRU), Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; and ¶Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University and National Health Laboratory Service, Tygerberg, South Africa.

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http://dx.doi.org/10.1097/INF.0000000000000544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352713PMC
February 2015

Next generation sequencing improves detection of drug resistance mutations in infants after PMTCT failure.

J Clin Virol 2015 Jan 20;62:48-53. Epub 2014 Nov 20.

Division of Medical Virology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zilj Drive, Parow 7500, South Africa; National Health Laboratory Service, Tygerberg, Francie van Zijl Drive, Parow 7500, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.jcv.2014.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279108PMC
January 2015

Emerging antiretroviral drug resistance in sub-Saharan Africa: novel affordable technologies are needed to provide resistance testing for individual and public health benefits.

AIDS 2014 Nov;28(18):2643-8

aDivision of Medical Virology, Department of Pathology, Stellenbosch University and National Health Laboratory Service Tygerberg, Cape Town, South Africa bDepartments of Pediatrics, Laboratory Medicine and Global Health, University of Washington, and Seattle Children's Research Institute cDepartments of Global Health, Medicine, and Epidemiology, University of Washington, Seattle, Washington, USA dDepartment of Medicine and Center for Infectious Diseases, Stellenbosch University Faculty of Medicine and Health Sciences, Cape Town, South Africa eDepartments of International Health and Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland fDivision of Infectious Diseases, Department of Medicine gDepartment of Epidemiology, Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1097/QAD.0000000000000502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784963PMC
November 2014

Southern African Treatment Resistance Network (SATuRN) RegaDB HIV drug resistance and clinical management database: supporting patient management, surveillance and research in southern Africa.

Database (Oxford) 2014 6;2014:bat082. Epub 2014 Feb 6.

Africa Centre for Health and Population Studies, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Mtubatuba, South Africa, Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK, Immunology department, University of Pretoria, Pretoria, South Africa, Infectious Diseases, Internal Medicine, University of the Free State School of Medicine, Bloemfontein, South Africa and Division of Medical Virology, Stellenbosch University, Stellenbosch, South Africa, National Health Laboratory Service Tygerberg, Cape Town, South Africa, Department of Virology, National Health Laboratory Service, University of KwaZulu-Natal, Durban, South Africa, The Brighton Doctoral College, Brighton and Sussex Medical School, UK, Academic Unit of primary Care and Population Science, Division of Social Statistics and Geography, University of Southampton, Southampton, UK, Jembi Health Systems, Cape Town, South Africa, School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, Westville, South Africa and Research Department of Infection, University College of London (UCL), London, UK.

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http://dx.doi.org/10.1093/database/bat082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630899PMC
August 2014

A qualitative PCR minipool strategy to screen for virologic failure and antiretroviral drug resistance in South African patients on first-line antiretroviral therapy.

J Clin Virol 2014 Aug 29;60(4):387-91. Epub 2014 May 29.

Division of Medical Virology, Department of Pathology, National Health Laboratory Service (NHLS), Tygerberg and Stellenbosch University, Cape Town, Western Cape, South Africa.

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http://dx.doi.org/10.1016/j.jcv.2014.05.011DOI Listing
August 2014

Developing a strategic research framework for sport and exercise medicine.

Br J Sports Med 2014 Jul 20;48(14):1120-6. Epub 2014 Mar 20.

Division Health Sciences Education, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.

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http://dx.doi.org/10.1136/bjsports-2013-093252DOI Listing
July 2014

Irreproducible positive results on the Cobas AmpliPrep/Cobas TaqMan HIV-1 Qual test are different qualitatively from confirmed positive results.

J Med Virol 2014 Jan 17;86(1):82-7. Epub 2013 Oct 17.

Division of Medical Virology, Department of Pathology, Stellenbosch University Faculty of Medicine and Health Sciences and National Health Laboratory Service, Cape Town, South Africa.

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http://dx.doi.org/10.1002/jmv.23811DOI Listing
January 2014

Establishing diagnostic cut-off criteria for the COBAS AmpliPrep/COBAS TaqMan HIV-1 Qualitative test through validation against the Amplicor DNA test v1.5 for infant diagnosis using dried blood spots.

J Clin Virol 2012 Feb 21;53(2):106-9. Epub 2011 Dec 21.

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, Stellenbosch University and National Health Laboratory Service Tygerberg, P.O. Box 19063, Tygerberg 7505, South Africa.

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http://dx.doi.org/10.1016/j.jcv.2011.12.002DOI Listing
February 2012

Antiretroviral resistance patterns and factors associated with resistance in adult patients failing NNRTI-based regimens in the Western Cape, South Africa.

J Med Virol 2011 Oct;83(10):1764-9

Division of Medical Virology, Stellenbosch University, Tygerberg, Cape Town, South Africa.

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http://dx.doi.org/10.1002/jmv.22189DOI Listing
October 2011

Acute extrapyramidal dysfunction in two HIV-infected children.

J Trop Pediatr 2011 Jun 13;57(3):227-31. Epub 2010 Sep 13.

Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa.

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http://dx.doi.org/10.1093/tropej/fmq080DOI Listing
June 2011

HIV treatment adherence, drug resistance, virologic failure: evolving concepts.

Infect Disord Drug Targets 2011 Apr;11(2):167-74

Departments of International Health and Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072419PMC
http://dx.doi.org/10.2174/187152611795589663DOI Listing
April 2011

Young age a predictor of weak reactivity in a rapid antibody test in infants infected with HIV.

J Med Virol 2010 Aug;82(8):1314-7

Division of Medical Virology, Department of Pathology, National Health Laboratory Service, University of Stellenbosch, Cape Town, South Africa.

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http://dx.doi.org/10.1002/jmv.21832DOI Listing
August 2010

Surveillance of transmitted resistance to antiretroviral drug classes among young children in the Western Cape Province of South Africa.

Pediatr Infect Dis J 2010 Apr;29(4):370-1

Division of Medical Virology, Stellenbosch University, Tygerberg, South Africa.

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http://dx.doi.org/10.1097/INF.0b013e3181c4dadaDOI Listing
April 2010

Protease inhibitor resistance in South African children with virologic failure.

Pediatr Infect Dis J 2009 Dec;28(12):1125-7

Centre for Infectious Diseases, Division of Medical Virology, Tygerberg and Stellenbosch University, Cape Town, South Africa.

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http://dx.doi.org/10.1097/INF.0b013e3181af829dDOI Listing
December 2009