Gert Schaart

Gert Schaart

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Gert Schaart

Publications by authors named "Gert Schaart"

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Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial.

EBioMedicine 2019 Nov 31;49:318-330. Epub 2019 Oct 31.

Department of Radiology and Nuclear Medicine, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, the Netherlands; Department of Nutrition and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945245PMC
November 2019

In vitro effects of sitosterol and sitostanol on mitochondrial respiration in human brown adipocytes, myotubes and hepatocytes.

Eur J Nutr 2019 Jul 17. Epub 2019 Jul 17.

Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, 6200 MD, The Netherlands.

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http://dx.doi.org/10.1007/s00394-019-02052-yDOI Listing
July 2019

Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete's paradox.

Mol Metab 2018 11 18;17:71-81. Epub 2018 Aug 18.

Department of Nutrition and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197504PMC
November 2018

Super-resolution microscopy localizes perilipin 5 at lipid droplet-mitochondria interaction sites and at lipid droplets juxtaposing to perilipin 2.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 11 31;1863(11):1423-1432. Epub 2018 Aug 31.

Department of Nutrition and Movement Sciences, Maastricht University Medical Centre+, 6200 MD Maastricht, the Netherlands; NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2018.08.016DOI Listing
November 2018

Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5?

J Physiol 2018 03 23;596(5):857-868. Epub 2017 Nov 23.

Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands.

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http://doi.wiley.com/10.1113/JP275182
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http://dx.doi.org/10.1113/JP275182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830434PMC
March 2018

Genetic Markers of Brown Adipose Tissue Identity and In Vitro Brown Adipose Tissue Activity in Humans.

Obesity (Silver Spring) 2018 01 27;26(1):135-140. Epub 2017 Nov 27.

Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/oby.22062DOI Listing
January 2018

Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South Asians.

Sci Rep 2017 02 14;7:42393. Epub 2017 Feb 14.

Department of Human Biology and Human Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, 6200 MD, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/srep42393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307956PMC
February 2017

Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial.

Diabetes Care 2016 Dec 6;39(12):2211-2217. Epub 2016 Oct 6.

Department of Human Biology and Human Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands

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http://dx.doi.org/10.2337/dc16-0499DOI Listing
December 2016

Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans.

Diabetes 2016 05 30;65(5):1179-89. Epub 2015 Dec 30.

Departments of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands

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http://dx.doi.org/10.2337/db15-1372DOI Listing
May 2016

Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans.

Diabetologia 2016 May 10;59(5):1040-8. Epub 2016 Feb 10.

Department of Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, 6200MD, Maastricht, the Netherlands.

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http://link.springer.com/10.1007/s00125-016-3865-z
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http://dx.doi.org/10.1007/s00125-016-3865-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826431PMC
May 2016

ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity.

Diabetologia 2016 May 17;59(5):1030-9. Epub 2016 Feb 17.

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, P. O. Box 616, 6200MD, Maastricht, the Netherlands.

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http://dx.doi.org/10.1007/s00125-016-3885-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826430PMC
May 2016

A genistein-enriched diet neither improves skeletal muscle oxidative capacity nor prevents the transition towards advanced insulin resistance in ZDF rats.

Sci Rep 2016 Mar 14;6:22854. Epub 2016 Mar 14.

Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/srep22854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789602PMC
March 2016

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity.

Cell Metab 2015 Sep 30;22(3):418-26. Epub 2015 Jul 30.

Department of Human Biology and Human Movement Sciences, NUTRIM, School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht 6200 MD, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.07.002DOI Listing
September 2015

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus.

Nat Med 2015 Aug 6;21(8):863-5. Epub 2015 Jul 6.

Department of Human Biology, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands.

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http://dx.doi.org/10.1038/nm.3891DOI Listing
August 2015

Cold acclimation affects immune composition in skeletal muscle of healthy lean subjects.

Physiol Rep 2015 Jul;3(7)

Department of Human Biology, NUTRIM, School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.14814/phy2.12394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552515PMC
July 2015

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain.

Toxicol Lett 2015 Apr 19;234(2):139-50. Epub 2015 Feb 19.

Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.toxlet.2015.02.012DOI Listing
April 2015

Reduced incorporation of fatty acids into triacylglycerol in myotubes from obese individuals with type 2 diabetes.

Diabetes 2014 May 31;63(5):1583-1593. Epub 2014 Jan 31.

Department of Human Biology, NUTRIM-School for Nutrition, Toxicology and Metabolism, Departments of Human Biology, Maastricht University Medical Center, Maastricht, the Netherlands.

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db13
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http://dx.doi.org/10.2337/db13-1123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023412PMC
May 2014

Increased oxygen consumption in human adipose tissue from the "brown adipose tissue" region.

J Clin Endocrinol Metab 2013 Jul 19;98(7):E1230-4. Epub 2013 Jun 19.

Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, the Netherlands.

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http://dx.doi.org/10.1210/jc.2013-1348DOI Listing
July 2013

Steep increase in myonuclear domain size during infancy.

Anat Rec (Hoboken) 2013 Feb 4;296(2):192-7. Epub 2012 Dec 4.

Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, the Netherlands.

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http://dx.doi.org/10.1002/ar.22631DOI Listing
February 2013

Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels.

Diabetes 2012 Nov 17;61(11):2679-90. Epub 2012 Jul 17.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://dx.doi.org/10.2337/db11-1402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478528PMC
November 2012

High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance.

Diabetes 2012 Oct 10;61(10):2472-8. Epub 2012 Jul 10.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.2337/db11-1832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447923PMC
October 2012

Reduced hexokinase II impairs muscle function 2 wk after ischemia-reperfusion through increased cell necrosis and fibrosis.

J Appl Physiol (1985) 2012 Aug 21;113(4):608-18. Epub 2012 Jun 21.

Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands.

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http://www.physiology.org/doi/10.1152/japplphysiol.01494.201
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http://dx.doi.org/10.1152/japplphysiol.01494.2011DOI Listing
August 2012

Hibernoma with metabolic impact?

BMJ Case Rep 2012 Aug 21;2012. Epub 2012 Aug 21.

Department of Human Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://dx.doi.org/10.1136/bcr-2012-006325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543389PMC
August 2012

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria.

Histochem Cell Biol 2012 Feb 30;137(2):205-16. Epub 2011 Nov 30.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://dx.doi.org/10.1007/s00418-011-0888-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262136PMC
February 2012

Three weeks on a high-fat diet increases intrahepatic lipid accumulation and decreases metabolic flexibility in healthy overweight men.

J Clin Endocrinol Metab 2011 Apr 20;96(4):E691-5. Epub 2011 Jan 20.

Department of Human Biology, NUTRIM School for Nutrition, Toxicology, and Metabolism, Maastricht University Medical Centre, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1210/jc.2010-2243DOI Listing
April 2011

Adaptations in mitochondrial function parallel, but fail to rescue, the transition to severe hyperglycemia and hyperinsulinemia: a study in Zucker diabetic fatty rats.

Obesity (Silver Spring) 2010 Jun 29;18(6):1100-7. Epub 2009 Oct 29.

NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://doi.wiley.com/10.1038/oby.2009.372
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http://dx.doi.org/10.1038/oby.2009.372DOI Listing
June 2010

The use of statins potentiates the insulin-sensitizing effect of exercise training in obese males with and without Type 2 diabetes.

Clin Sci (Lond) 2010 Jun 25;119(7):293-301. Epub 2010 Jun 25.

Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://dx.doi.org/10.1042/CS20100153DOI Listing
June 2010

Partial hexokinase II knockout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice.

Pflugers Arch 2010 Apr 25;459(5):705-12. Epub 2010 Feb 25.

Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anaesthesiology, Academic Medical Center, Meibergdreef 9, 1105 Amsterdam, The Netherlands.

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http://link.springer.com/10.1007/s00424-010-0787-3
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http://dx.doi.org/10.1007/s00424-010-0787-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842566PMC
April 2010

Adipocyte differentiation-related protein and OXPAT in rat and human skeletal muscle: involvement in lipid accumulation and type 2 diabetes mellitus.

J Clin Endocrinol Metab 2009 Oct 14;94(10):4077-85. Epub 2009 Jul 14.

NUTRIM School for Nutrition, Toxicology, and Metabolism, Department of Human Movement Sciences, Maastricht University Medical Center+, NL-6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1210/jc.2009-0352DOI Listing
October 2009

Cardiotin localization in mitochondria of cardiomyocytes in vivo and in vitro and its down-regulation during dedifferentiation.

Cardiovasc Pathol 2009 Jan-Feb;18(1):19-27. Epub 2008 Feb 20.

Department of Molecular Cell Biology, School for Cardiovascular Diseases (CARIM), University of Maastricht, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.carpath.2007.12.008DOI Listing
December 2008

Both type 1 and type 2a muscle fibers can respond to enzyme therapy in Pompe disease.

Muscle Nerve 2008 Feb;37(2):251-5

Department of Movement Sciences, Nutrition, Toxicology Research Institute Maastricht, Maastricht University, P.O. Box 616, NL 6200 MD Maastricht, The Netherlands.

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http://doi.wiley.com/10.1002/mus.20896
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http://dx.doi.org/10.1002/mus.20896DOI Listing
February 2008

Mitochondrial function, content and ROS production in rat skeletal muscle: effect of high-fat feeding.

FEBS Lett 2008 Feb 28;582(4):510-6. Epub 2008 Jan 28.

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.febslet.2008.01.013DOI Listing
February 2008

Arachidonic acid but not eicosapentaenoic acid (EPA) and oleic acid activates NF-kappaB and elevates ICAM-1 expression in Caco-2 cells.

Lipids 2007 Aug 3;42(8):687-98. Epub 2007 Jul 3.

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://doi.wiley.com/10.1007/s11745-007-3071-3
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http://dx.doi.org/10.1007/s11745-007-3071-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039812PMC
August 2007

Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly.

Am J Physiol Endocrinol Metab 2007 Jan 22;292(1):E151-7. Epub 2006 Aug 22.

Dept. of Movement Sciences, Faculty of Health Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1152/ajpendo.00278.2006DOI Listing
January 2007

UCP3 in muscle wasting, a role in modulating lipotoxicity?

FEBS Lett 2006 Oct 5;580(22):5172-6. Epub 2006 Sep 5.

Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, NUTRIM, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.febslet.2006.08.066DOI Listing
October 2006

Regional variations in intramyocellular lipid concentration correlate with muscle fiber type distribution in rat tibialis anterior muscle.

Magn Reson Med 2006 Jul;56(1):19-25

Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.

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http://dx.doi.org/10.1002/mrm.20924DOI Listing
July 2006

Age-related morphological changes in skeletal muscle cells of acid alpha-glucosidase knockout mice.

Muscle Nerve 2006 Apr;33(4):505-13

Department of Movement Sciences, Cardiovascular Research Institute Maastricht, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/mus.20482DOI Listing
April 2006

Reduced skeletal muscle uncoupling protein-3 content in prediabetic subjects and type 2 diabetic patients: restoration by rosiglitazone treatment.

J Clin Endocrinol Metab 2006 Apr 29;91(4):1520-5. Epub 2005 Dec 29.

Nutrition and Toxicology Research Institute Maastricht, Department of Human Biology, Maastricht University, P.O. Box 616, NL-6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1210/jc.2005-1572DOI Listing
April 2006

The effect of high-fat feeding on intramuscular lipid and lipid peroxidation levels in UCP3-ablated mice.

FEBS Lett 2006 Feb 26;580(5):1371-5. Epub 2006 Jan 26.

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.febslet.2006.01.059DOI Listing
February 2006

Effect of a 2-day very low-energy diet on skeletal muscle insulin sensitivity in obese type 2 diabetic patients on insulin therapy.

Metabolism 2005 Dec;54(12):1669-78

Department of General Internal Medicine C-4-66, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S002604950500267
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http://dx.doi.org/10.1016/j.metabol.2005.06.017DOI Listing
December 2005

A modified PAS stain combined with immunofluorescence for quantitative analyses of glycogen in muscle sections.

Histochem Cell Biol 2004 Aug 3;122(2):161-9. Epub 2004 Aug 3.

Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.

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http://link.springer.com/10.1007/s00418-004-0690-0
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http://dx.doi.org/10.1007/s00418-004-0690-0DOI Listing
August 2004

Investigation of the expression and localization of glucose transporter 4 and fatty acid translocase/CD36 in equine skeletal muscle.

Am J Vet Res 2004 Jul;65(7):951-6

Department of Equine Sciences (Medicine Section), Faculty of Veterinary Medicine, Utrecht University, Yalelaan 16, NL-3584 CM Utrecht, The Netherlands.

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http://dx.doi.org/10.2460/ajvr.2004.65.951DOI Listing
July 2004

Subcellular immunolocalisation of fatty acid translocase (FAT)/CD36 in human type-1 and type-2 skeletal muscle fibres.

Histochem Cell Biol 2004 Feb 23;121(2):101-7. Epub 2004 Jan 23.

Department of Movement Sciences, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

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http://link.springer.com/10.1007/s00418-003-0615-3
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http://dx.doi.org/10.1007/s00418-003-0615-3DOI Listing
February 2004

Immunohistochemical identification and fiber type specific localization of protein kinase C isoforms in equine skeletal muscle.

Am J Vet Res 2004 Jan;65(1):69-73

Department of Equine Sciences, Discipline of Internal Medicine, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.2460/ajvr.2004.65.69DOI Listing
January 2004

Uncoupling protein 3 as a mitochondrial fatty acid anion exporter.

FASEB J 2003 Dec 2;17(15):2272-4. Epub 2003 Oct 2.

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht , Maastricht University, The Netherlands.

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http://dx.doi.org/10.1096/fj.03-0515fjeDOI Listing
December 2003

Differential response of UCP3 to medium versus long chain triacylglycerols; manifestation of a functional adaptation.

FEBS Lett 2003 Dec;555(3):631-7

Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/s0014-5793(03)01343-7DOI Listing
December 2003

Influence of prolonged endurance cycling and recovery diet on intramuscular triglyceride content in trained males.

Am J Physiol Endocrinol Metab 2003 Oct 3;285(4):E804-11. Epub 2003 Jun 3.

Department of Human Biology, Nutrition Research Institute Maastricht, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://ajpendo.physiology.org/content/ajpendo/285/4/E804.ful
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http://ajpendo.physiology.org/content/ajpendo/early/2003/06/
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http://ajpendo.physiology.org/lookup/doi/10.1152/ajpendo.001
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http://dx.doi.org/10.1152/ajpendo.00112.2003DOI Listing
October 2003

Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo.

J Clin Invest 2003 Feb;111(4):479-86

Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1172/JCI16653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152374PMC
February 2003

Etomoxir-induced increase in UCP3 supports a role of uncoupling protein 3 as a mitochondrial fatty acid anion exporter.

FASEB J 2002 Oct 21;16(12):1688-90. Epub 2002 Aug 21.

Nutrition and Toxicology Research Institute Maastricht, Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1096/fj.02-0275fjeDOI Listing
October 2002

Impaired performance of skeletal muscle in alpha-glucosidase knockout mice.

Muscle Nerve 2002 Jun;25(6):873-83

Department of Movement Sciences, Cardiovascular Research Institute, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands.

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http://doi.wiley.com/10.1002/mus.10125
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http://dx.doi.org/10.1002/mus.10125DOI Listing
June 2002