Publications by authors named "Gert J Ossenkoppele"

100Publications

Oral Azacitidine Maintenance Therapy for Acute Myeloid Leukemia in First Remission.

N Engl J Med 2020 12;383(26):2526-2537

From the Department of Clinical Haematology, Alfred Hospital, and the Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia (A.H.W.); the Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany (H. Döhner); Kent and Canterbury Hospital, Canterbury, United Kingdom (C.P.); Centro de Investigación Biomédica en Red de Cáncer, Instituto Carlos III, Madrid, and Hospital Universitari i Politècnic La Fe, Valencia - both in Spain (P.M.); Raisa Gorbacheva Memorial Research Institute for Pediatric Oncology, Hematology, and Transplantation, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia (B.A.); the Department of Hematology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, and Institut de Recherche Saint-Louis, Université de Paris, Paris (H. Dombret); the Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston (F.R.); Indiana University Cancer Center, Indianapolis (H.S.); Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea (J.H.J.); Hospital District of Helsinki and Uusimaa (HUS) Comprehensive Cancer Center, Hematology Research Unit Helsinki and iCAN Digital Precision Cancer Center Medicine Flagship, University of Helsinki, Helsinki (K.P.); AZ Sint-Jan Brugge-Oostende AV, Bruges, Belgium (D.S.); University of Alberta Hospital, Edmonton, Canada (I.S.); Ondokuz Mayis University, Samsun (M.T.), and Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara (M.K.C.) - both in Turkey; Antonio e Biagio e Cesare Arrigo Hospital, Alessandria (V.G.), Città della Salute e della Scienza, Turin (C.F.), Ospedale San Gerardo Monza, Monza (L.B.), and Ospedale Policlinico San Martino, Genoa (G.B.) - all in Italy; Rambam Medical Center and Faculty of Medicine Technion, Haifa, Israel (Y.O.); Hospital dos Capuchos, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal (A.B.S.); Wroclaw Medical University, Wroclaw, Poland (J.R.); Ústav Hematologie a Krevní Transfuze, Prague, Czech Republic (J.C.); Amsterdam University Medical Center, Location VUMC (Vrije Universiteit Medical Center), Amsterdam (G.J.O.); Celgene (Bristol Myers Squibb), Boudry, Switzerland (I.L.T.); Bristol Myers Squibb, Princeton, NJ (B.S., K.K., Q.D., C.L.B.); University of Kansas Medical Center, Kansas City (B.S.); and Weill Cornell Medicine and New York Presbyterian Hospital, New York (G.J.R.).

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December 2020

Minimal residual disease and stem cell transplantation outcomes.

Hematology Am Soc Hematol Educ Program 2019 12;2019(1):617-625

Department of Medical and Molecular Genetics, King's College, London, United Kingdom.

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December 2019

TP53 mutations and relevance of expression of TP53 pathway genes in paediatric acute myeloid leukaemia.

Br J Haematol 2020 03 6;188(5):736-739. Epub 2019 Oct 6.

Department of Paediatric Oncology, Cancer Centre Amsterdam, Amsterdam UMC, VUMC, Amsterdam, The Netherlands.

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March 2020

Survival of early posthematopoietic stem cell transplantation relapse of myeloid malignancies.

Eur J Haematol 2019 Nov 14;103(5):491-499. Epub 2019 Aug 14.

Department of Hematology, Amsterdam University Medical Centers, Location AMC, Amsterdam, The Netherlands.

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November 2019

Hypomethylating agents in the treatment of acute myeloid leukemia: A guide to optimal use.

Crit Rev Oncol Hematol 2019 Aug 25;140:1-7. Epub 2019 May 25.

Department of Hematology, VU University Medical Center, Amsterdam, the Netherlands. Electronic address:

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August 2019

The non-erythroid myeloblast count rule in myelodysplastic syndromes: fruitful or futile?

Haematologica 2019 12 19;104(12):e547-e550. Epub 2019 Apr 19.

Department of Hematology, Amsterdam UMC, location Vrije Universiteit Amsterdam, Cancer Center Amsterdam

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December 2019

Measurable residual disease in acute myeloid leukemia using flow cytometry: approaches for harmonization/standardization.

Expert Rev Hematol 2018 12;11(12):921-935

a Department of Hematology , VU University Medical Center , Amsterdam , Netherlands.

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December 2018

Prognostic and therapeutic role of CLEC12A in acute myeloid leukemia.

Blood Rev 2019 03 1;34:26-33. Epub 2018 Nov 1.

Department of Hematology, Amsterdam UMC, VU University Medical Center, Amsterdam, the Netherlands.

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March 2019

A novel allogeneic off-the-shelf dendritic cell vaccine for post-remission treatment of elderly patients with acute myeloid leukemia.

Cancer Immunol Immunother 2018 Oct 23;67(10):1505-1518. Epub 2018 Jul 23.

Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

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October 2018

Molecular Minimal Residual Disease in Acute Myeloid Leukemia.

N Engl J Med 2018 Mar;378(13):1189-1199

From the Department of Hematology (M.J.-L., T.G., F.G.K., A.H., A.Z., C.A.J.E.-V., M.A.S., B.L., P.J.M.V.) and HOVON Data Center, Department of Hematology (P.L.G., R.M.), Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, the Department of Hematology, VU University Medical Center (D.H., J.C., G.J.O., G.J.S.), and the Department of Hematology, Academic Medical Center (B.J.B.), Amsterdam, and Isala Hospital, Zwolle (M.M.K.) - all in the Netherlands; UCL Namur (Godinne), Yvoir (C.G.), and the Department of Hematology, Cliniques Universitaires Saint-Luc, Brussels (V.H.) - both in Belgium; and the Department of Hematology, University Hospital Zurich, Zurich (M.G.M.), University Hospital, Bern (T.P.), and the Division of Hematology, University Hospital Basel, Basel (J.R.P.) - all in Switzerland.

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March 2018

Validation of and proposals for refinements of the WHO 2016 classification for myelodysplastic syndromes.

Am J Hematol 2017 Nov 24;92(11):E631-E634. Epub 2017 Aug 24.

Department of Haematology, VU University Medical Center, Cancer Center Amsterdam, The Netherlands.

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November 2017

Specific Depletion of Leukemic Stem Cells: Can MicroRNAs Make the Difference?

Cancers (Basel) 2017 Jun 30;9(7). Epub 2017 Jun 30.

Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

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June 2017

The interference of genetic associations in establishing the prognostic value of the immunophenotype in acute myeloid leukemia.

Cytometry B Clin Cytom 2018 01 15;94(1):151-158. Epub 2017 Aug 15.

Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands.

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January 2018

Reduced CD62L Expression on T Cells and Increased Soluble CD62L Levels Predict Molecular Response to Tyrosine Kinase Inhibitor Therapy in Early Chronic-Phase Chronic Myelogenous Leukemia.

J Clin Oncol 2017 Jan 7;35(2):175-184. Epub 2016 Nov 7.

Sieghart Sopper, Günther Gastl, Matthias Baldauf, Zlatko Trajanoski, and Dominik Wolf, Medical University Innsbruck; Sieghart Sopper and Dominik Wolf, Tyrolean Cancer Research Institute; Matthias Baldauf, Oncotyrol, Innsbruck; Peter Valent, Medical University of Vienna, Vienna, Austria; Satu Mustjoki and Kimmo Porkka, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland; Deborah White and Timothy Hughes, South Australian Health and Medical Research Institute and University of Adelaide School of Medicine, Adelaide, South Australia, Australia; Andreas Burchert, Universitätsklinikum Gießen und Marburg and Philipps Universität Marburg, Marburg; Andreas Hochhaus, Thomas Ernst, and Thomas Schenk, Universitätsklinikum Jena, Jena; Dominik Wolf, University Hospital of Bonn, Bonn, Germany; Bjørn T. Gjertsen, University of Bergen, Bergen, Norway; Frank Giles, Northwestern University, Chicago, IL; and Jeroen J.W.M. Janssen and Gert J. Ossenkoppele, Vrije Universiteit Medical Center, Amsterdam, the Netherlands.

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January 2017

Prognostic relevance of morphological classification models for myelodysplastic syndromes in an era of the revised International Prognostic Scoring System.

Eur J Cancer 2016 Mar 19;56:10-20. Epub 2016 Jan 19.

Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:

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March 2016

Multiparameter flow cytometry is instrumental to distinguish myelodysplastic syndromes from non-neoplastic cytopenias.

Eur J Cancer 2016 Feb 22;54:49-56. Epub 2015 Dec 22.

Department of Hematology, VU University Medical Center, Cancer Center Amsterdam (VUmc CCA), De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. Electronic address:

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February 2016

Primary acute myeloid leukemia cells with overexpression of EVI-1 are sensitive to all-trans retinoic acid.

Blood 2016 Jan 18;127(4):458-63. Epub 2015 Nov 18.

Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands; and.

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January 2016

Application of flow cytometry for myelodysplastic syndromes: Pitfalls and technical considerations.

Cytometry B Clin Cytom 2016 07 14;90(4):358-67. Epub 2015 Dec 14.

Department of Hematology, Cancer Center Amsterdam (CCA), VU University Medical Center, Amsterdam, The Netherlands.

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July 2016

A Human Cell Line Model for Interferon-α Driven Dendritic Cell Differentiation.

PLoS One 2015 7;10(8):e0135219. Epub 2015 Aug 7.

Dept of Hematology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands.

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May 2016

Differential capacity of human interleukin-4 and interferon-α monocyte-derived dendritic cells for cross-presentation of free versus cell-associated antigen.

Cancer Immunol Immunother 2015 Nov 28;64(11):1419-27. Epub 2015 Jul 28.

Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, De Boelelaan 1117, 1081HV, Amsterdam, The Netherlands.

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November 2015

Empiric definition of eligibility criteria for clinical trials in relapsed/refractory acute myeloid leukemia: analysis of 1,892 patients from HOVON/SAKK and SWOG.

Haematologica 2015 Oct 9;100(10):e409-11. Epub 2015 Jul 9.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Department of Medicine, Division of Hematology, University of Washington, Seattle, WA, USA.

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October 2015

Absence of leukaemic CD34 cells in acute myeloid leukaemia is of high prognostic value: a longstanding controversy deciphered.

Br J Haematol 2015 Oct 24;171(2):227-238. Epub 2015 Jun 24.

Department of Haematology, VU University Medical Centre, Cancer Centre Amsterdam, Amsterdam, The Netherlands.

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October 2015

Immunophenotyping for diagnosis and prognosis in MDS: ready for general application?

Best Pract Res Clin Haematol 2015 Mar 11;28(1):14-21. Epub 2014 Nov 11.

Department of Hematology, VU University Medical Center, Cancer Center Amsterdam (VUmc CCA), Amsterdam, The Netherlands. Electronic address:

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March 2015

loading of skin dendritic cells with apoptotic bleb-derived antigens for the induction of tumor-directed immunity.

Oncoimmunology 2014;3(7):e946360. Epub 2014 Jul 3.

Department of Medical Oncology; VU University Medical Center; Cancer Center Amsterdam ; Amsterdam, The Netherlands.

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July 2014

MRD in AML: it is time to change the definition of remission.

Best Pract Res Clin Haematol 2014 Sep-Dec;27(3-4):265-71. Epub 2014 Oct 15.

Department of Hematology, VU University Medical Center Amsterdam, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.

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July 2015

Genomic amplification of MYC as double minutes in a patient with APL-like leukemia.

Mol Cytogenet 2014 22;7(1):67. Epub 2014 Oct 22.

Department of Haematology, VU University Medical Center, Amsterdam, The Netherlands.

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November 2014

Attenuation of microRNA-126 expression that drives CD34+38- stem/progenitor cells in acute myeloid leukemia leads to tumor eradication.

Cancer Res 2014 Apr 29;74(7):2094-105. Epub 2014 Jan 29.

Authors' Affiliation: Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands.

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April 2014

Absence of aberrant myeloid progenitors by flow cytometry is associated with favorable response to azacitidine in higher risk myelodysplastic syndromes.

Cytometry B Clin Cytom 2014 May 28;86(3):207-15. Epub 2014 Jan 28.

Department of Hematology, VU Institute of Cancer and Immunology (V-ICI), Cancer Center Amsterdam (CCA), VU University Medical Center, Amsterdam, Netherlands.

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May 2014

Absence of aberrant myeloid progenitors by flow cytometry is associated with favorable response to azacitidine in higher risk myelodysplastic syndromes.

Cytometry B Clin Cytom 2014 Jan 15. Epub 2014 Jan 15.

Department of Hematology, VU Institute of Cancer and Immunology (V-ICI), Cancer Center Amsterdam (CCA), VU University Medical Center, Amsterdam, The Netherlands.

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January 2014

Apoptotic blebs from leukemic cells as a preferred source of tumor-associated antigen for dendritic cell-based vaccines.

Cancer Immunol Immunother 2014 Apr 3;63(4):335-45. Epub 2014 Jan 3.

Department of Hematology, Cancer Center Amsterdam, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

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April 2014

High prognostic impact of flow cytometric minimal residual disease detection in acute myeloid leukemia: data from the HOVON/SAKK AML 42A study.

J Clin Oncol 2013 Nov 23;31(31):3889-97. Epub 2013 Sep 23.

Monique Terwijn, Angèle Kelder, Peter C. Huijgens, Angelika M. Dräger, Yvonne J.M. Oussoren, Willemijn J. Scholten, Alexander N. Snel, Gert J. Ossenkoppele, and Gerrit J. Schuurhuis, VU University Medical Centre; Bart J. Biemond, Academic Medical Centre, Amsterdam; Wim L.J. van Putten, Vincent H.J. van der Velden, Georgine E. de Greef, Peter J.M. Valk, Mojca Jongen-Lavrecic, and Bob Löwenberg, Erasmus University Medical Centre; Rik A. Brooimans, Jan W. Gratama, Erasmus University Medical Centre/Daniel den Hoed Cancer Centre, Rotterdam; Frank W.M.B. Preijers, Radboud University Nijmegen Medical Center, Nijmegen; Michel van Gelder, University Medical Centre, Maastricht; Pierre Wijermans, Haga Hospital, The Hague; Marie-Cecile Legdeur and Jennita Slomp, Medisch Spectrum Twente, Enschede; Jurgen Kuball, University Medical Center Utrecht; Okke de Weerdt, St. Antonius Hospital, Nieuwegein; Leo F. Verdonck, Isala Clinics, Zwolle, the Netherlands; Thomas Pabst, Bern University Hospital, Bern; Urs Schanz, University Hospital, Zürich; Jakob R. Passweg, Basel University Hospital, Basel; Mario Bargetzi, Kantonspital, Aarau; Yves Chalandon, University Hospital of Geneva, Geneva; Urs Hess, Kantonsspital, St. Gallen, Switzerland; Johan Maertens, University Hospital Gasthuisberg; Nancy Boeckx, University Hospitals Leuven and Katholieke Universiteit Leuven, Leuven; Carlos Graux, Cliniques Universitaires-Université Catholique de Louvain, Mont-Godinne, Yvoir; and Marie-Christiane Vekemans, St. Luc Hospital, Brussels, Belgium.

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November 2013

Targeting the acute myeloid leukemic stem cell compartment by enhancing tumor cell-based vaccines.

Immunotherapy 2013 Aug;5(8):859-68

Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands.

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August 2013

How to assess minimal residual disease in pediatric and adult acute myeloid leukemia?

Transl Pediatr 2013 Apr;2(2):80-3

1 Department of Haematology, 2 Department of Haematology and Pediatric Oncology/Haematology, Cancer Center Amsterdam, VU Institute for Cancer and Immunology, VU University Medical Center, Amsterdam, The Netherlands.

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April 2013

Autologous Stem Cell Transplantation in elderly Acute Myeloid Leukemia.

Mediterr J Hematol Infect Dis 2013 16;5(1):e2013018. Epub 2013 Feb 16.

Department of Haematology, VU. University Medical Center, Amsterdam, the Netherlands.

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March 2013

A threshold of 10% for myeloperoxidase by flow cytometry is valid to classify acute leukemia of ambiguous and myeloid origin.

Cytometry B Clin Cytom 2013 Mar 16;84(2):114-8. Epub 2013 Jan 16.

Department of Hematology, Cancer Centre Amsterdam, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

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March 2013

Raynaud-like phenomenon in two patients on nilotinib.

Br J Haematol 2012 Aug 5;158(4):431. Epub 2012 Jul 5.

Department of Internal Medicine, Medisch Spectrum Twente, Enschede, The Netherlands.

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August 2012

Tumor immune escape in acute myeloid leukemia: Class II-associated invariant chain peptide expression as result of deficient antigen presentation.

Oncoimmunology 2012 Mar;1(2):211-213

Department of Hematology; Cancer Center Amsterdam; VU Institute for Cancer and Immunology; VU University Medical Center; Amsterdam, The Netherlands ; Department of Immunopathology; Sanquin Research and Landsteiner Laboratory; Academic Medical Center; University of Amsterdam; Amsterdam, The Netherlands.

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March 2012

Azacitidine differentially affects CD4(pos) T-cell polarization in vitro and in vivo in high risk myelodysplastic syndromes.

Leuk Res 2012 Jul 14;36(7):921-30. Epub 2012 Apr 14.

Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands.

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July 2012

Class II-associated invariant chain peptide expression represents a novel parameter for flow cytometric detection of acute promyelocytic leukemia.

Am J Pathol 2011 Nov 9;179(5):2157-61. Epub 2011 Sep 9.

Department of Hematology, Cancer Center Amsterdam, VU Institute for Cancer and Immunology, VU University Medical Center, Amsterdam, The Netherlands.

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November 2011

Pancreatic pseudocyst in an adult patient after treatment with pegylated asparaginase.

Br J Haematol 2011 Mar 14;152(6):676. Epub 2011 Jan 14.

Department of Haematology, VU University Medical Centre, Boelelaan 1118, 1081 HV Amsterdam, the Netherlands.

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March 2011

Role of immune responses in the pathogenesis of low-risk MDS and high-risk MDS: implications for immunotherapy.

Br J Haematol 2011 Jun 13;153(5):568-81. Epub 2011 Apr 13.

Department of Haematology, VU Institute for Cancer and Immunology, VU University Medical Centre, Amsterdam, the Netherlands.

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June 2011

Chronic myeloid leukemia lysate-loaded dendritic cells induce T-cell responses towards leukemia progenitor cells.

Immunotherapy 2011 Apr;3(4):569-76

Department of Hematology, Cancer Center Amsterdam/VUmc Institute for Cancer & Immunology, VU University Medical Center, Amsterdam, The Netherlands.

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April 2011

Review of the relevance of aberrant antigen expression by flow cytometry in myeloid neoplasms.

Br J Haematol 2011 May 9;153(4):421-36. Epub 2011 Mar 9.

Department of Haematology, VU University Medical Center, De Boelelaan 1117, Amsterdam, the Netherlands.

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May 2011