Gerrit K J Hooijer

CCAAT/Enhancer-Binding Protein Delta (C/EBPδ): A Previously Unrecognized Tumor Suppressor that Limits the Oncogenic Potential of Pancreatic Ductal Adenocarcinoma Cells.

Authors:

Leonie Hartl JanWillem Duitman Hella L Aberson Kan Chen Frederike Dijk Joris J T H Roelofs Mark P G Dings Gerrit K J Hooijer Pratika Y Hernanda Qiunwei Pan Olivier R Busch Marc G H Besselink Ton Boerman Maikel P Peppelenbosch Maarten F Bijlsma C Arnold Spek

Cancers (Basel) 2020 Sep 7;12(9). Epub 2020 Sep 7.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam University Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

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September 2020

Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation.

Authors:

Cansu Tekin Hella L Aberson Cynthia Waasdorp Gerrit K J Hooijer Onno J de Boer Frederike Dijk Maarten F Bijlsma C Arnold Spek

Cell Oncol (Dordr) 2020 Dec 18;43(6):1161-1174. Epub 2020 Aug 18.

Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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December 2020

Characterization of gut-homing molecules in non-endstage livers of patients with primary sclerosing cholangitis and inflammatory bowel disease.

Authors:

Manon de Krijger Thijmen Visseren Manon E Wildenberg Gerrit K J Hooijer Monique M A Verstegen Luc J W van der Laan Wouter J de Jonge Joanne Verheij Cyriel Y Ponsioen

J Transl Autoimmun 2020 9;3:100054. Epub 2020 Apr 9.

Department of Gastroenterology and Hepatology Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.

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April 2020

Pathological validation and prognostic potential of quantitative MRI in the characterization of pancreas cancer: preliminary experience.

Authors:

Remy Klaassen Anne Steins Oliver J Gurney-Champion Maarten F Bijlsma Geertjan van Tienhoven Marc R W Engelbrecht Casper H J van Eijck Mustafa Suker Johanna W Wilmink Marc G Besselink Olivier R Busch Onno J de Boer Marc J van de Vijver Gerrit K J Hooijer Joanne Verheij Jaap Stoker Aart J Nederveen Hanneke W M van Laarhoven

Mol Oncol 2020 09 23;14(9):2176-2189. Epub 2020 Jun 23.

Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, The Netherlands.

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September 2020

Comprehensive evaluation of methods to assess overall and cell-specific immune infiltrates in breast cancer.

Breast Cancer Res 2019 12 26;21(1):151. Epub 2019 Dec 26.

Department of Oncology, Laboratory for Translational Breast Cancer Research, KU Leuven, Leuven, Belgium.

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December 2019

Multicentre study on the consistency of PD-L1 immunohistochemistry as predictive test for immunotherapy in non-small cell lung cancer.

Authors:

Rogier Butter Nils A 't Hart Gerrit K J Hooijer Kim Monkhorst Ernst-Jan Speel Paul Theunissen Erik Thunnissen Jan H Von der Thüsen Wim Timens Marc J van de Vijver

J Clin Pathol 2020 Jul 10;73(7):423-430. Epub 2019 Dec 10.

Department of Pathology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

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July 2020

Phase I Dose Escalation Study with Expansion Cohort of the Addition of Nab-Paclitaxel to Capecitabine and Oxaliplatin (CapOx) as First-Line Treatment of Metastatic Esophagogastric Adenocarcinoma (ACTION Study).

Authors:

Sandor Schokker Stephanie O van der Woude Jessy Joy van Kleef Daan J van Zoen Martijn G H van Oijen Banafsche Mearadji Ludo F M Beenen Charlotte I Stroes Cynthia Waasdorp R Aarti Jibodh Aafke Creemers Sybren L Meijer Gerrit K J Hooijer Cornelis J A Punt Maarten F Bijlsma Hanneke W M van Laarhoven

Cancers (Basel) 2019 Jun 14;11(6). Epub 2019 Jun 14.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands.

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June 2019

A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma.

Authors:

Tim van Groningen Nurdan Akogul Ellen M Westerhout Alvin Chan Nancy E Hasselt Danny A Zwijnenburg Marloes Broekmans Peter Stroeken Franciska Haneveld Gerrit K J Hooijer C Dilara Savci-Heijink Arjan Lakeman Richard Volckmann Peter van Sluis Linda J Valentijn Jan Koster Rogier Versteeg Johan van Nes

Nat Commun 2019 04 4;10(1):1530. Epub 2019 Apr 4.

Department of Oncogenomics, Amsterdam UMC University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

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April 2019

Stromal-derived interleukin 6 drives epithelial-to-mesenchymal transition and therapy resistance in esophageal adenocarcinoma.

Authors:

Eva A Ebbing Amber P van der Zalm Anne Steins Aafke Creemers Simone Hermsen Rosa Rentenaar Michelle Klein Cynthia Waasdorp Gerrit K J Hooijer Sybren L Meijer Kausilia K Krishnadath Cornelis J A Punt Mark I van Berge Henegouwen Suzanne S Gisbertz Otto M van Delden Maarten C C M Hulshof Jan Paul Medema Hanneke W M van Laarhoven Maarten F Bijlsma

Proc Natl Acad Sci U S A 2019 02 22;116(6):2237-2242. Epub 2019 Jan 22.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, 1105 AZ Amsterdam, The Netherlands;

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February 2019

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Authors:

Serena Nik-Zainal Helen Davies Johan Staaf Manasa Ramakrishna Dominik Glodzik Xueqing Zou Inigo Martincorena Ludmil B Alexandrov Sancha Martin David C Wedge Peter Van Loo Young Seok Ju Marcel Smid Arie B Brinkman Sandro Morganella Miriam R Aure Ole Christian Lingjærde Anita Langerød Markus Ringnér Sung-Min Ahn Sandrine Boyault Jane E Brock Annegien Broeks Adam Butler Christine Desmedt Luc Dirix Serge Dronov Aquila Fatima John A Foekens Moritz Gerstung Gerrit K J Hooijer Se Jin Jang David R Jones Hyung-Yong Kim Tari A King Savitri Krishnamurthy Hee Jin Lee Jeong-Yeon Lee Yilong Li Stuart McLaren Andrew Menzies Ville Mustonen Sarah O'Meara Iris Pauporté Xavier Pivot Colin A Purdie Keiran Raine Kamna Ramakrishnan F Germán Rodríguez-González Gilles Romieu Anieta M Sieuwerts Peter T Simpson Rebecca Shepherd Lucy Stebbings Olafur A Stefansson Jon Teague Stefania Tommasi Isabelle Treilleux Gert G Van den Eynden Peter Vermeulen Anne Vincent-Salomon Lucy Yates Carlos Caldas Laura Van't Veer Andrew Tutt Stian Knappskog Benita Kiat Tee Tan Jos Jonkers Åke Borg Naoto T Ueno Christos Sotiriou Alain Viari P Andrew Futreal Peter J Campbell Paul N Span Steven Van Laere Sunil R Lakhani Jorunn E Eyfjord Alastair M Thompson Ewan Birney Hendrik G Stunnenberg Marc J van de Vijver John W M Martens Anne-Lise Børresen-Dale Andrea L Richardson Gu Kong Gilles Thomas Michael R Stratton

Nature 2019 02;566(7742):E1

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

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February 2019

Assessment of PD-L1 expression across breast cancer molecular subtypes, in relation to mutation rate, -like status, tumor-infiltrating immune cells and survival.

Oncoimmunology 2018;7(12):e1509820. Epub 2018 Sep 11.

Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

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September 2018

The dynamics of HER2 status in esophageal adenocarcinoma.

Authors:

Aafke Creemers Eva A Ebbing Gerrit K J Hooijer Lisanne Stap Rajni A Jibodh-Mulder Susanne S Gisbertz Mark I van Berge Henegouwen Maurits L van Montfoort Maarten C C M Hulshof Kausilia K Krishnadath Martijn G H van Oijen Maarten F Bijlsma Sybren L Meijer Hanneke W M van Laarhoven

Oncotarget 2018 Jun 1;9(42):26787-26799. Epub 2018 Jun 1.

Center for Experimental and Molecular Medicine, Laboratory of Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Academic Medical Center, Amsterdam, The Netherlands.

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June 2018

Direct inhibition of STAT signaling by platinum drugs contributes to their anti-cancer activity.

Authors:

Stanleyson V Hato Carl G Figdor Susumu Takahashi Anja E Pen Altuna Halilovic Kalijn F Bol Angela Vasaturo Yukie Inoue Nienke de Haas Dagmar Verweij Carla M L Van Herpen Johannes H Kaanders Johan H J M van Krieken Hanneke W M Van Laarhoven Gerrit K J Hooijer Cornelis J A Punt Akira Asai I Jolanda M de Vries W Joost Lesterhuis

Oncotarget 2017 08 7;8(33):54434-54443. Epub 2017 May 7.

Department of Tumor Immunology, Radboud University Medical Centre and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.

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August 2017

Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry.

Authors:

Anne Trinh Kari Trumpi Felipe De Sousa E Melo Xin Wang Joan H de Jong Evelyn Fessler Peter J K Kuppen Marlies S Reimers Marloes Swets Miriam Koopman Iris D Nagtegaal Marnix Jansen Gerrit K J Hooijer George J A Offerhaus Onno Kranenburg Cornelis J Punt Jan Paul Medema Florian Markowetz Louis Vermeulen

Clin Cancer Res 2017 Jan 26;23(2):387-398. Epub 2016 Jul 26.

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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January 2017

Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype.

J Natl Cancer Inst 2016 11 13;108(11). Epub 2016 Jun 13.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver General Hospital and BC Cancer Agency, Vancouver, Canada (MKM, HMH, AT, WY, NR, CBG, DGH); Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (AF, LUK, SB, MA); Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland (AF, LUK, SB, MA); Centre of Gynaecologic Oncology Amsterdam (HSvM, MRB, GGK) and Department of Pathology (JBGH, GKJH, MJvdV, MCGB), Academic Medical Center, Amsterdam, the Netherlands; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland (NA, MH); Department of Obstetrics and Gynaecology, Tübingen University Hospital, Department of Women's Health, Tübingen, Germany (KZ, SYB, BK, SK); Department of Pathology (RB) and Department of Clinical Chemistry and Hematology (MA), Helsinki University Hospital, University of Helsinki and HUSLAB, Helsinki, Finland; Institute of Pathology, Tübingen University Hospital, Tübingen, Germany (AS); Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO (MH); Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada (DGH); Department of Human Genetics, Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada (MKM)

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November 2016