Publications by authors named "Germana Castelli"

44Publications

Genetic Alterations of Metastatic Colorectal Cancer.

Biomedicines 2020 Oct 13;8(10). Epub 2020 Oct 13.

Department of Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/biomedicines8100414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601984PMC
October 2020

Cancer stem cell targeted therapies.

Ann Ist Super Sanita 2020 Jul-Sep;56(3):336-350

Dipartimento di Oncologia, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.4415/ANN_20_03_12DOI Listing
September 2020

Isocitrate Dehydrogenase Mutations in Myelodysplastic Syndromes and in Acute Myeloid Leukemias.

Cancers (Basel) 2020 Aug 26;12(9). Epub 2020 Aug 26.

Department of Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/cancers12092427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564409PMC
August 2020

Genetic Alterations in Renal Cancers: Identification of The Mechanisms Underlying Cancer Initiation and Progression and of Therapeutic Targets.

Medicines (Basel) 2020 Jul 29;7(8). Epub 2020 Jul 29.

Department of Oncology, Istituto Superiore di Sanità, Vaile Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/medicines7080044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459851PMC
July 2020

Endothelial Progenitors in the Tumor Microenvironment.

Adv Exp Med Biol 2020 ;1263:85-115

Department of Oncology, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1007/978-3-030-44518-8_7DOI Listing
July 2020

Breast Cancer: A Molecularly Heterogenous Disease Needing Subtype-Specific Treatments.

Med Sci (Basel) 2020 Mar 23;8(1). Epub 2020 Mar 23.

Department of Oncology, Istituto Superiore di Sanità, Regina Elena 299, 00161 Rome,Italy.

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http://dx.doi.org/10.3390/medsci8010018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151639PMC
March 2020

Understanding mechanisms of cancer initiation and development supports the need for an implementation of primary and secondary cancer prevention.

Ann Ist Super Sanita 2019 Oct-Dec;55(4):371-379

Dipartimento oncologia e medicina molecolare, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.4415/ANN_19_04_11DOI Listing
May 2020

CD123 as a Therapeutic Target in the Treatment of Hematological Malignancies.

Cancers (Basel) 2019 Sep 12;11(9). Epub 2019 Sep 12.

Department of Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/cancers11091358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769702PMC
September 2019

Cellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications.

Medicines (Basel) 2019 Jul 30;6(3). Epub 2019 Jul 30.

Department of Oncology, Istituto Superiore di Sanità, Vaile Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/medicines6030082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789661PMC
July 2019

Emerging Therapies for Acute Myelogenus Leukemia Patients Targeting Apoptosis and Mitochondrial Metabolism.

Cancers (Basel) 2019 Feb 22;11(2). Epub 2019 Feb 22.

Department of Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/cancers11020260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406361PMC
February 2019

Genetic Abnormalities, Clonal Evolution, and Cancer Stem Cells of Brain Tumors.

Med Sci (Basel) 2018 Oct 2;6(4). Epub 2018 Oct 2.

Department of Oncology, Istituto Superiore di Sanità, 00161 Rome, Italy.

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http://www.mdpi.com/2076-3271/6/4/85
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http://dx.doi.org/10.3390/medsci6040085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313628PMC
October 2018

Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells.

Cancers (Basel) 2018 Jul 27;10(8). Epub 2018 Jul 27.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/cancers10080248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116004PMC
July 2018

miR-146 and miR-155: Two Key Modulators of Immune Response and Tumor Development.

Noncoding RNA 2017 Jun 26;3(3). Epub 2017 Jun 26.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/ncrna3030022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831915PMC
June 2017

Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells.

Med Sci (Basel) 2018 Apr 13;6(2). Epub 2018 Apr 13.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/medsci6020031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024750PMC
April 2018

Ovarian Cancers: Genetic Abnormalities, Tumor Heterogeneity and Progression, Clonal Evolution and Cancer Stem Cells.

Medicines (Basel) 2018 Feb 1;5(1). Epub 2018 Feb 1.

Department of Oncology and Molecular Medicine, Core Facilities, Istituto Superiore di Sanità, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/medicines5010016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874581PMC
February 2018

Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.

Onco Targets Ther 2018 28;11:131-155. Epub 2017 Dec 28.

Department of Oncology, Istituto Superiore di Sanità, Rome, Italy.

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https://www.dovepress.com/targeting-histone-methyltransferas
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http://dx.doi.org/10.2147/OTT.S145971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749389PMC
December 2017

Melanoma: Genetic Abnormalities, Tumor Progression, Clonal Evolution and Tumor Initiating Cells.

Med Sci (Basel) 2017 Nov 20;5(4). Epub 2017 Nov 20.

Department of Oncology, Istituto Superiore di Sanità, 00161 Rome, Italy.

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http://dx.doi.org/10.3390/medsci5040028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753657PMC
November 2017

Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells.

Biomedicines 2017 Nov 18;5(4). Epub 2017 Nov 18.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome 00135, Italy.

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http://dx.doi.org/10.3390/biomedicines5040065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744089PMC
November 2017

Mechanisms of anti-cancer effects of ascorbate: Cytotoxic activity and epigenetic modulation.

Blood Cells Mol Dis 2018 03 21;69:57-64. Epub 2017 Sep 21.

Department of Oncology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcmd.2017.09.005DOI Listing
March 2018

Esophageal Cancer: Genomic and Molecular Characterization, Stem Cell Compartment and Clonal Evolution.

Medicines (Basel) 2017 Sep 14;4(3). Epub 2017 Sep 14.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00141 Rome, Italy.

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http://dx.doi.org/10.3390/medicines4030067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622402PMC
September 2017

Liver Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells.

Cancers (Basel) 2017 Sep 20;9(9). Epub 2017 Sep 20.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome 00141, Italy.

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http://dx.doi.org/10.3390/cancers9090127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615342PMC
September 2017

Targeted therapies in the treatment of adult acute myeloid leukemias: current status and future perspectives.

Int J Hematol Oncol 2016 Dec 7;5(4):143-164. Epub 2017 Feb 7.

Department of Hematology, Oncology & Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.

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https://www.futuremedicine.com/doi/10.2217/ijh-2016-0011
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http://dx.doi.org/10.2217/ijh-2016-0011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172000PMC
December 2016

Conditioned medium from human umbilical vein endothelial cells markedly improves the proliferation and differentiation of circulating endothelial progenitors.

Blood Cells Mol Dis 2016 10 18;61:58-65. Epub 2016 Aug 18.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 200, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2016.07.007DOI Listing
October 2016

Endothelial progenitor cells in hematologic malignancies.

Stem Cell Investig 2016 1;3:26. Epub 2016 Jul 1.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.21037/sci.2016.06.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981702PMC
September 2016

Oxidative stress and hypoxia in normal and leukemic stem cells.

Exp Hematol 2016 07 12;44(7):540-60. Epub 2016 May 12.

Departement of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1016/j.exphem.2016.04.012DOI Listing
July 2016

Targeting LSCs through membrane antigens selectively or preferentially expressed on these cells.

Blood Cells Mol Dis 2015 Dec 26;55(4):336-46. Epub 2015 Jul 26.

Department of Hematology, Oncology and Molecular Medicine, Istituto Suepriore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2015.07.015DOI Listing
December 2015

Experimental and investigational therapies for chemotherapy-induced anemia.

Expert Opin Investig Drugs 2015 10;24(11):1433-45. Epub 2015 Sep 10.

a Istituto Superiore di Sanità, Department of Hematology, Oncology and Molecular Medicine , Viale Regina Elena 299, Rome, Italy

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http://dx.doi.org/10.1517/13543784.2015.1085505DOI Listing
May 2016

Cytotoxic effects of high concentrations of sodium ascorbate on human myeloid cell lines.

Ann Hematol 2015 Nov 12;94(11):1807-16. Epub 2015 Aug 12.

Department of Medical, Surgical and Neurological Sciences, University of Siena, Polo Scientifico San Miniato, Via A. Moro 2, 53100, Siena, Italy.

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http://dx.doi.org/10.1007/s00277-015-2464-2DOI Listing
November 2015

miR-21 is overexpressed in NPM1-mutant acute myeloid leukemias.

Leuk Res 2015 Feb 18;39(2):221-8. Epub 2014 Nov 18.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2014.11.001DOI Listing
February 2015

Human cord blood-derived hemogenic endothelium generates mast cells.

Blood Cells Mol Dis 2015 Feb 15;54(2):195-7. Epub 2014 Nov 15.

Department of Hmatology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2014.11.002DOI Listing
February 2015

Endothelial progenitors.

Blood Cells Mol Dis 2014 Apr 9;52(4):186-94. Epub 2013 Dec 9.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcmd.2013.11.004DOI Listing
April 2014

Chronic HIV-infected patients show an impaired dendritic cells differentiation of bone marrow CD34⁺ cells.

J Acquir Immune Defic Syndr 2013 Dec;64(4):342-4

*Laboratory of Cellular Immunology, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy; †Clinical Department, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy; ‡Department of Haematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy; and §Virology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy.

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http://pdfs.journals.lww.com/jaids/2013/12010/Chronic_HIV_In
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/QAI.0b013e3182a40ff7DOI Listing
December 2013

Human umbilical cord is a unique and safe source of various types of stem cells suitable for treatment of hematological diseases and for regenerative medicine.

Blood Cells Mol Dis 2012 Jun 23;49(1):20-8. Epub 2012 Mar 23.

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Italy.

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http://dx.doi.org/10.1016/j.bcmd.2012.02.007DOI Listing
June 2012

Immunophenotypic features of acute myeloid leukaemia patients exhibiting high FLT3 expression not associated with mutations.

Br J Haematol 2011 Apr 20;153(1):33-42. Epub 2011 Feb 20.

Department of Haematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1111/j.1365-2141.2011.08577.xDOI Listing
April 2011

MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis.

Haematologica 2009 Apr 10;94(4):479-86. Epub 2009 Mar 10.

Dept. of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

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http://dx.doi.org/10.3324/haematol.2008.002345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663611PMC
April 2009

Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.

Exp Hematol 2008 Aug 27;36(8):1035-46. Epub 2008 May 27.

Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1016/j.exphem.2008.03.004DOI Listing
August 2008

Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt.

J Biol Chem 2003 Nov 16;278(48):47622-8. Epub 2003 Sep 16.

Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry New Jersey, New Jersey Medical School, Newark, New Jersey 07101-1709, USA.

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http://dx.doi.org/10.1074/jbc.M305909200DOI Listing
November 2003