Publications by authors named "German Sosa"

2 Publications

  • Page 1 of 1

Case report of renal tubular acidosis and misdiagnosed.

Nefrologia 2016 May-Jun;36(3):323-5. Epub 2016 Feb 5.

Laboratorio de Investigación en Nefrología y Metabolismo Mineral Óseo, Hospital Infantil de México Federico Gómez, México, D.F., México.

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December 2017

Urinary MCP-1/creatinine in Henoch-Schönlein purpura and its relationship with nephritis.

Pediatr Nephrol 2014 Jun 12;29(6):1047-52. Epub 2014 Jan 12.

Laboratorio de Investigación en Nefrología, Hospital Infantil de México Federico Gómez, Calle Dr. Márquez 162, Col. Doctores, Deleg. Cuauhtémoc, C. P. 06720, México, D. F., México,

Background: Monocyte chemotactic protein-1 (MCP-1) plays a direct role in the infiltration of macrophages and monocytes during the early stages of Henoch-Schönlein purpura (HSP) nephritis. The aim of this study was to compare the urinary MCP-1/creatinine levels in children with and without HSP nephritis and determine if they are associated with the severity of renal lesions.

Methods: We included 77 patients with HSP and 25 healthy control children. Levels of serum creatinine, urinalysis, and 12-h proteinuria assessments were performed. Urinary MCP-1 levels were determined by ELISA.

Results: Fifty-seven patients had nephritis (74 %). Urinary MCP-1/creatinine levels were significantly higher in patients with HSP nephritis (median, 653 pg/mg) compared to those with HSP without nephritis (median, 269 pg/mg) or healthy children (191 pg/mg). In addition, higher MCP-1/creatinine levels were observed in HSP patients who had renal biopsy (median, 1,412 pg/mg) in comparison to HSP patients without renal biopsy (median, 302 pg/mg). The urinary MCP-1 cut-off value of 530 pg/mg could be used to distinguish patients who undergo renal biopsy with a sensitivity of 81 % and specificity of 77 %.

Conclusions: Urinary MCP-1/creatinine levels are elevated in the early stages of severe HSP nephritis and can be used as a biomarker for HSP nephritis.
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June 2014