Gerhard Winter

Gerhard Winter

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Gerhard Winter

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Cellular uptake of self-assembled phytantriol-based hexosomes is independent of major endocytic machineries.

J Colloid Interface Sci 2019 Oct 19;553:820-833. Epub 2019 Jun 19.

Department of Integrative Medical Biology, Umeå University, Johan Bures väg 12, SE-901 87 Umeå, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jcis.2019.06.045DOI Listing
October 2019

Immunomodulatory asthma therapy in the equine animal model: A dose-response study and evaluation of a long-term effect.

Immun Inflamm Dis 2019 09 29;7(3):130-149. Epub 2019 May 29.

Department of Veterinary Medicine, Equine Clinic, Surgery and Radiology, Free University of Berlin, Berlin, Germany.

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http://dx.doi.org/10.1002/iid3.252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688086PMC
September 2019

Do interactions between protein and phospholipids influence the release behavior from lipid-based exenatide depot systems?

Eur J Pharm Biopharm 2019 Sep 10;142:61-69. Epub 2019 Jun 10.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München, Butenandtstraße 5, 81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.ejpb.2019.06.007DOI Listing
September 2019

Nonspherical Nanoparticle Shape Stability Is Affected by Complex Manufacturing Aspects: Its Implications for Drug Delivery and Targeting.

Adv Healthc Mater 2019 Sep 13;8(18):e1900352. Epub 2019 Aug 13.

Pharmaceutical Technology and Biopharmaceutics, Department of Pharmacy, Ludwig-Maximilians-Universität München, Butenandtstraße 5, 81377, Munich, Germany.

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http://dx.doi.org/10.1002/adhm.201900352DOI Listing
September 2019

Structure-based Discovery of a new Protein-Aggregation Breaking Excipient.

Eur J Pharm Biopharm 2019 Sep 12. Epub 2019 Sep 12.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://dx.doi.org/10.1016/j.ejpb.2019.09.010DOI Listing
September 2019

Application of interpretable artificial neural networks to early monoclonal antibodies development.

Eur J Pharm Biopharm 2019 Aug 18;141:81-89. Epub 2019 May 18.

Ludwig Maximilians-Universität München, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Butenandtstrasse 5, 81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.ejpb.2019.05.017DOI Listing
August 2019

Shape Characterization of Subvisible Particles Using Dynamic Imaging Analysis.

J Pharm Sci 2019 Aug 30. Epub 2019 Aug 30.

West Coast BioDesign, Santa Barbara, California, USA.

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http://dx.doi.org/10.1016/j.xphs.2019.08.023DOI Listing
August 2019

Evaluation of a 3D Human Artificial Lymph Node as Test Model for the Assessment of Immunogenicity of Protein Aggregates.

J Pharm Sci 2019 Jul 21;108(7):2358-2366. Epub 2019 Feb 21.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München, Butenandtstr.5, D-81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.xphs.2019.02.011DOI Listing
July 2019

Rapid sample-saving biophysical characterisation and long-term storage stability of liquid interferon alpha2a formulations: Is there a correlation?

Int J Pharm 2019 May 14;562:42-50. Epub 2019 Mar 14.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University, Butenandtstrasse 5-13, Munich D-81377, Germany.

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http://dx.doi.org/10.1016/j.ijpharm.2019.03.025DOI Listing
May 2019

The ReFOLD assay for protein formulation studies and prediction of protein aggregation during long-term storage.

Eur J Pharm Biopharm 2019 Apr 25;137:131-139. Epub 2019 Feb 25.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University, Butenandtstrasse 5-13, Munich D-81377, Germany.

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http://dx.doi.org/10.1016/j.ejpb.2019.02.018DOI Listing
April 2019

Silicone Oil-Free Polymer Syringes for the Storage of Therapeutic Proteins.

J Pharm Sci 2019 Mar 2;108(3):1148-1160. Epub 2018 Nov 2.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität Munich, Butenandtstr. 5-13, Munich D-81377, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S00223549183068
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http://dx.doi.org/10.1016/j.xphs.2018.10.049DOI Listing
March 2019

Comparison of ice fog methods and monitoring of controlled nucleation success after freeze-drying.

Int J Pharm 2019 Mar 28;558:18-28. Epub 2018 Dec 28.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University, D-81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.ijpharm.2018.12.056DOI Listing
March 2019

Test models for the evaluation of immunogenicity of protein aggregates.

Int J Pharm 2019 Mar 18;559:192-200. Epub 2019 Jan 18.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximilians-Universität München, Butenandtstr. 5, D-81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.015DOI Listing
March 2019

Vesicular phospholipid gels as drug delivery systems for small molecular weight drugs, peptides and proteins: State of the art review.

Int J Pharm 2019 Feb 18;557:1-8. Epub 2018 Dec 18.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://dx.doi.org/10.1016/j.ijpharm.2018.12.030DOI Listing
February 2019

New studies on leachables in commercial scale protein drug filling lines using stir bar sorptive extraction coupled with TD-GC-MS and UPLC/QTOF-MS/MS analytics.

Int J Pharm 2019 Jan 27;555:404-419. Epub 2018 Nov 27.

Ludwig Maximilian University Munich, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Butenandtstr. 5, Building B, 81377 München, Germany.

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http://dx.doi.org/10.1016/j.ijpharm.2018.11.033DOI Listing
January 2019

A New Approach to Study the Physical Stability of Monoclonal Antibody Formulations-Dilution From a Denaturant.

J Pharm Sci 2018 12 16;107(12):3007-3013. Epub 2018 Aug 16.

Ludwig Maximilians-Universität München, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Butenandstr. 5, Munich 81377, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S00223549183050
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http://dx.doi.org/10.1016/j.xphs.2018.08.004DOI Listing
December 2018

A Comparison of Controlled Ice Nucleation Techniques for Freeze-Drying of a Therapeutic Antibody.

J Pharm Sci 2018 11 25;107(11):2748-2754. Epub 2018 Jul 25.

Ludwig-Maximilians-Universität München, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Butenandstr. 5, 81377 Munich, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S00223549183045
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http://dx.doi.org/10.1016/j.xphs.2018.07.019DOI Listing
November 2018

Expanding Bedside Filtration-A Powerful Tool to Protect Patients From Protein Aggregates.

J Pharm Sci 2018 11 27;107(11):2775-2788. Epub 2018 Jul 27.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität Munich, Butenandtstr. 5-13, Munich D-81377, Germany.

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http://dx.doi.org/10.1016/j.xphs.2018.07.022DOI Listing
November 2018

CONTAMINATION OF ANTI-VEGF DRUGS FOR INTRAVITREAL INJECTION: How Do Repackaging and Newly Developed Syringes Affect the Amount of Silicone Oil Droplets and Protein Aggregates?

Retina 2018 Oct;38(10):2088-2095

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1097/IAE.0000000000001809DOI Listing
October 2018

Significant Drying Time Reduction Using Microwave-Assisted Freeze-Drying for a Monoclonal Antibody.

J Pharm Sci 2018 10 8;107(10):2538-2543. Epub 2018 Jun 8.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München, Butenandstr. 5, 81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.xphs.2018.05.023DOI Listing
October 2018

New insights into process understanding of solid lipid extrusion (SLE) of extruded lipid implants for sustained protein delivery.

Eur J Pharm Biopharm 2018 Sep 18;130:11-21. Epub 2018 Jun 18.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University, Butenandtstrasse 5-13, D-81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.ejpb.2018.06.016DOI Listing
September 2018

Immune responses induced by nano-self-assembled lipid adjuvants based on a monomycoloyl glycerol analogue after vaccination with the Chlamydia trachomatis major outer membrane protein.

J Control Release 2018 09 28;285:12-22. Epub 2018 Jun 28.

Department of Pharmacy, Pharmaceutical Technology and Biopharmacy, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, DE-81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2018.06.028DOI Listing
September 2018

Progress in formulation development and sterilisation of freeze-dried oligodeoxynucleotide-loaded gelatine nanoparticles.

Eur J Pharm Biopharm 2018 Aug 16;129:10-20. Epub 2018 May 16.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2018.05.016DOI Listing
August 2018

Does controlled nucleation impact the properties and stability of lyophilized monoclonal antibody formulations?

Eur J Pharm Biopharm 2018 Aug 22;129:134-144. Epub 2018 May 22.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University, D-81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.ejpb.2018.05.025DOI Listing
August 2018

Application of water-soluble polyvinyl alcohol-based film patches on laser microporated skin facilitates intradermal macromolecule and nanoparticle delivery.

Eur J Pharm Biopharm 2018 Jul 13;128:119-130. Epub 2018 Apr 13.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximilians-University Munich, Butenandtstr. 5, Haus B, D-81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2018.04.008DOI Listing
July 2018

A pilot study using a novel pyrotechnically driven prototype applicator for epidermal powder immunization in piglets.

Int J Pharm 2018 Jul 20;545(1-2):215-228. Epub 2018 Apr 20.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximilians-University Munich, Butenandtstr. 5, D-81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.ijpharm.2018.04.039DOI Listing
July 2018

Engineered hybrid spider silk particles as delivery system for peptide vaccines.

Biomaterials 2018 07 21;172:105-115. Epub 2018 Apr 21.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximilians-University Munich, Butenandtstrasse 5, 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2018.04.008DOI Listing
July 2018

Binding of HSA to Macromolecular pHPMA Based Nanoparticles for Drug Delivery: An Investigation Using Fluorescence Methods.

Langmuir 2018 07 27;34(27):7998-8006. Epub 2018 Jun 27.

Physik-Department, Physik weicher Materie , Technische Universität München , James-Franck-Str. 1 , 85748 Garching , Germany.

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http://dx.doi.org/10.1021/acs.langmuir.8b01015DOI Listing
July 2018

Zn-triggered self-assembly of Gonadorelin [6-D-Phe] to produce nanostructures and fibrils.

Sci Rep 2018 07 26;8(1):11280. Epub 2018 Jul 26.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximilians-Universitaet, Butenandtstrasse 5, 81377, Muenchen, Germany.

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http://dx.doi.org/10.1038/s41598-018-29529-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062538PMC
July 2018

Isothermal chemical denaturation as a complementary tool to overcome limitations of thermal differential scanning fluorimetry in predicting physical stability of protein formulations.

Eur J Pharm Biopharm 2018 Apr 9;125:106-113. Epub 2018 Jan 9.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Munich D-81377, Germany.

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http://dx.doi.org/10.1016/j.ejpb.2018.01.004DOI Listing
April 2018

Evaluation of stir-bar sorptive extraction coupled with thermal desorption GC-MS for the detection of leachables from polymer single use systems to drugs.

J Pharm Biomed Anal 2018 Apr 3;152:66-73. Epub 2018 Feb 3.

Ludwig Maximilian University Munich, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, 81377 München, Butenandtstr. 5, Building B, Germany.

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http://dx.doi.org/10.1016/j.jpba.2018.01.045DOI Listing
April 2018

A comparison of nanoparticullate CpG immunotherapy with and without allergens in spontaneously equine asthma-affected horses, an animal model.

Immun Inflamm Dis 2018 03 1;6(1):81-96. Epub 2017 Nov 1.

Department of Veterinary Medicine, Equine Clinic, Surgery and Radiology, Free University of Berlin, Berlin, Germany.

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http://dx.doi.org/10.1002/iid3.198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818452PMC
March 2018

Thermo-Optical Protein Characterization for Straightforward Preformulation Development.

J Pharm Sci 2017 10 15;106(10):2955-2958. Epub 2017 Jun 15.

Ludwig-Maximilians-Universität München, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Butenandtstrasse 5, Munich 81377, Germany.

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http://dx.doi.org/10.1016/j.xphs.2017.06.002DOI Listing
October 2017

Impact of plasma protein binding on cargo release by thermosensitive liposomes probed by fluorescence correlation spectroscopy.

Eur J Pharm Biopharm 2017 Oct 23;119:215-223. Epub 2017 Jun 23.

Department of Physics and Center for NanoScience (CeNS), Ludwig-Maximilians-Universität, Geschwister-Scholl-Platz 1, 80539 München, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2017.06.022DOI Listing
October 2017

Scale-up of water-based spider silk film casting using a film applicator.

Int J Pharm 2017 Oct 24;532(1):13-20. Epub 2017 Aug 24.

Ludwig-Maximilians-University, Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Butenandtstr. 5, D-81377, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2017.08.090DOI Listing
October 2017

Long-term release and stability of pharmaceutical proteins delivered from solid lipid implants.

Eur J Pharm Biopharm 2017 Aug 22;117:244-255. Epub 2017 Apr 22.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University, Butenandtstrasse 5-13, Munich D-81377, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2017.04.017DOI Listing
August 2017

Trends on Analytical Characterization of Polysorbates and Their Degradation Products in Biopharmaceutical Formulations.

J Pharm Sci 2017 07 14;106(7):1722-1735. Epub 2017 Mar 14.

Coriolis Pharma Research GmbH, Martinsried, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2017.03.001DOI Listing
July 2017

Lyophilized Drug Product Cake Appearance: What Is Acceptable?

J Pharm Sci 2017 07 22;106(7):1706-1721. Epub 2017 Mar 22.

Drug Product Development, Janssen R&D, Malvern, Pennsylvania 19355.

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http://dx.doi.org/10.1016/j.xphs.2017.03.014DOI Listing
July 2017

Evaluation of Heat Flux Measurement as a New Process Analytical Technology Monitoring Tool in Freeze Drying.

J Pharm Sci 2017 05 4;106(5):1249-1257. Epub 2017 Jan 4.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University, Munich 81377, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2016.12.030DOI Listing
May 2017

Twin-screw extruded lipid implants containing TRP2 peptide for tumour therapy.

Eur J Pharm Biopharm 2017 May 16;114:79-87. Epub 2017 Jan 16.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University Munich, Butenandtstr. 5, D-81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2016.12.033DOI Listing
May 2017

Needle-Free Injection of Vesicular Phospholipid Gels-A Novel Approach to Overcome an Administration Hurdle for Semisolid Depot Systems.

J Pharm Sci 2017 04 29;106(4):968-972. Epub 2016 Dec 29.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University, Munich 81377, Germany.

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http://dx.doi.org/10.1016/j.xphs.2016.12.020DOI Listing
April 2017

cmRNA/lipoplex encapsulation in PLGA microspheres enables transfection via calcium phosphate cement (CPC)/PLGA composites.

J Control Release 2017 03 2;249:143-149. Epub 2017 Feb 2.

Technische Universität München, Institute of Molecular Immunology & Experimental Oncology, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.01.045DOI Listing
March 2017

Optimisation of one-step desolvation and scale-up of gelatine nanoparticle production.

J Microencapsul 2016 Nov 7;33(7):595-604. Epub 2016 Sep 7.

a Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics , Ludwig-Maximilians Universität München , Munich , Germany.

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http://dx.doi.org/10.1080/02652048.2016.1228706DOI Listing
November 2016

Characterization of Lipid-Based Hexosomes as Versatile Vaccine Carriers.

Mol Pharm 2016 11 27;13(11):3945-3954. Epub 2016 Sep 27.

Department of Pharmacy, Pharmaceutical Technology and Biopharmacy, Ludwig-Maximilians-Universität München , Butenandtstraße 5-13, DE-81377 Munich, Germany.

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http://dx.doi.org/10.1021/acs.molpharmaceut.6b00716DOI Listing
November 2016

Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality.

N Biotechnol 2016 Sep 17;33(5 Pt A):574-81. Epub 2015 Dec 17.

Division of Functional Genome Analysis, Deutsches Krebsforschungszentrum (DKFZ) , Im Neuenheimer Feld 580, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.nbt.2015.12.003DOI Listing
September 2016

Origin of Aggregate Formation in Antibody Crystal Suspensions Containing PEG.

J Pharm Sci 2016 Mar 2;105(3):1059-65. Epub 2016 Feb 2.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximillians-University Munich, Munich, Germany.

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http://dx.doi.org/10.1016/j.xphs.2015.12.014DOI Listing
March 2016

Calcium alginate gels as stem cell matrix-making paracrine stem cell activity available for enhanced healing after surgery.

PLoS One 2015 20;10(3):e0118937. Epub 2015 Mar 20.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University Munich, Butenandtstr. 5, Haus B, D-81377 Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118937PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368733PMC
December 2015

Particle contamination of parenteralia and in-line filtration of proteinaceous drugs.

Int J Pharm 2015 Dec 7;496(2):250-67. Epub 2015 Nov 7.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximilians-University Munich, Butenandtstr. 5, D-81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.ijpharm.2015.10.082DOI Listing
December 2015

Freeze-drying of HESylated IFNα-2b: Effect of HESylation on storage stability in comparison to PEGylation.

Int J Pharm 2015 Nov 24;495(1):608-611. Epub 2015 Sep 24.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximillians-University Munich, Butenandtstr. 5-8, 81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.ijpharm.2015.09.031DOI Listing
November 2015

Protein stability in pulmonary drug delivery via nebulization.

Adv Drug Deliv Rev 2015 Oct 12;93:79-94. Epub 2014 Oct 12.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig Maximilians-Universitaet Muenchen, Butenandtstr. 5, 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2014.10.003DOI Listing
October 2015

Recent insights into cutaneous immunization: How to vaccinate via the skin.

Vaccine 2015 Sep 23;33(37):4663-74. Epub 2015 May 23.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximilians-University Munich, Butenandtstr. 5, Haus B, D-81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2015.05.012DOI Listing
September 2015

Water-based preparation of spider silk films as drug delivery matrices.

J Control Release 2015 Sep 20;213:134-141. Epub 2015 Jun 20.

Ludwig-Maximilians-University, Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Butenandtstr. 5, D-81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2015.06.025DOI Listing
September 2015

Impact of implant composition of twin-screw extruded lipid implants on the release behavior.

Int J Pharm 2015 Sep 15;493(1-2):102-10. Epub 2015 Jul 15.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität München, Butenandtstr. 5, D-81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2015.06.052DOI Listing
September 2015

Influence of particle size, an elongated particle geometry, and adjuvants on dendritic cell activation.

Eur J Pharm Biopharm 2015 Aug 26;94:542-9. Epub 2015 Jun 26.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximilians-University Munich, Butenandtstr. 5, D-81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2015.06.015DOI Listing
August 2015

Thermosensitive liposomal drug delivery systems: state of the art review.

Int J Nanomedicine 2014 16;9:4387-98. Epub 2014 Sep 16.

Department of Internal Medicine III, University Hospital Munich, Germany.

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http://dx.doi.org/10.2147/IJN.S49297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172103PMC
June 2015

The "New Polyethylene Glycol Dilemma": Polyethylene Glycol Impurities and Their Paradox Role in mAb Crystallization.

J Pharm Sci 2015 Jun 21;104(6):1938-1945. Epub 2015 Mar 21.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximillians-University Munich, Munich D-81377, Germany.

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http://dx.doi.org/10.1002/jps.24424DOI Listing
June 2015

CMC determination of nonionic surfactants in protein formulations using ultrasonic resonance technology.

Eur J Pharm Biopharm 2015 May 12;92:8-14. Epub 2015 Feb 12.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University Munich, Munich, Germany.

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http://dx.doi.org/10.1016/j.ejpb.2015.02.005DOI Listing
May 2015

Dose levels in particulate-containing formulations impact anti-drug antibody responses to murine monoclonal antibody in mice.

J Pharm Sci 2015 May 3;104(5):1610-21. Epub 2015 Mar 3.

Department of Chemical and Biological Engineering, Center for Pharmaceutical Biotechnology, University of Colorado, Boulder, Colorado, 80303.

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https://linkinghub.elsevier.com/retrieve/pii/S00223549153011
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http://dx.doi.org/10.1002/jps.24413DOI Listing
May 2015

Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics.

Proc Natl Acad Sci U S A 2015 May 27;112(19):5997-6002. Epub 2015 Apr 27.

Large Molecule Bioanalytical Research and Development, Pharmaceutical Sciences,

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http://www.pnas.org/lookup/doi/10.1073/pnas.1408766112
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http://dx.doi.org/10.1073/pnas.1408766112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434771PMC
May 2015

Stability of collapse lyophilized influenza vaccine formulations.

Int J Pharm 2015 Apr 7;483(1-2):131-41. Epub 2015 Feb 7.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximilians-University Munich, Butenandtstr. 5, D-81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2015.01.053DOI Listing
April 2015

Growth factor release by vesicular phospholipid gels: in-vitro results and application for rotator cuff repair in a rat model.

BMC Musculoskelet Disord 2015 Apr 10;16:82. Epub 2015 Apr 10.

Department of Orthopaedic Sports Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaningerstr., 81675, Munich, Germany.

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http://dx.doi.org/10.1186/s12891-015-0542-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417541PMC
April 2015

Non-spherical micro- and nanoparticles: fabrication, characterization and drug delivery applications.

Expert Opin Drug Deliv 2015 Mar 18;12(3):481-92. Epub 2014 Oct 18.

Pharmacist, PhD Student,Ludwig-Maximillians-University Munich, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics , Butenandtstr. 5, D-81377 Munich , Germany.

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http://dx.doi.org/10.1517/17425247.2015.963055DOI Listing
March 2015

The effect of steam sterilization on recombinant spider silk particles.

Int J Pharm 2015 Mar 14;481(1-2):125-31. Epub 2015 Jan 14.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University Munich, Butenandtstr. 5, D-81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2015.01.024DOI Listing
March 2015

Investigation of the immunogenicity of different types of aggregates of a murine monoclonal antibody in mice.

Pharm Res 2015 Feb 15;32(2):430-44. Epub 2014 Aug 15.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximilians-University Munich, Butenandtstr. 5, D-81377, Munich, Germany.

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http://dx.doi.org/10.1007/s11095-014-1472-6DOI Listing
February 2015

Head to head comparison of the formulation and stability of concentrated solutions of HESylated versus PEGylated anakinra.

J Pharm Sci 2015 Feb 1;104(2):515-26. Epub 2014 Dec 1.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximillians-University Munich, Munich, 81377, Germany.

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http://dx.doi.org/10.1002/jps.24253DOI Listing
February 2015

Two decades of publishing excellence in pharmaceutical biotechnology.

J Pharm Sci 2015 Feb 1;104(2):290-300. Epub 2014 Dec 1.

Department of Pharmaceutical Chemistry, Macromolecule and Vaccine Stabilization Center, University of Kansas, Lawrence, Kansas, 66047, USA.

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http://dx.doi.org/10.1002/jps.24285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826475PMC
February 2015

Characterization and compatibility of hydroxyethyl starch-polyethylenimine copolymers for DNA delivery.

J Biomater Sci Polym Ed 2014 2;25(9):855-71. Epub 2014 May 2.

a Department of Pharmacy , Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universität , Butenandtstrasse 5-13, Munich D-81377 , Germany.

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http://dx.doi.org/10.1080/09205063.2014.910152DOI Listing
January 2015

Quantitative detection of drug dose and spatial distribution in the lung revealed by Cryoslicing Imaging.

J Pharm Biomed Anal 2015 Jan 8;102:129-36. Epub 2014 Sep 8.

Comprehensive Pneumology Center, Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377 Munich, Germany; Institute of Lung Biology and Disease, Helmholtz Zentrum München, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2014.09.001DOI Listing
January 2015

Novel microscale approaches for easy, rapid determination of protein stability in academic and commercial settings.

Biochim Biophys Acta 2014 Dec 28;1844(12):2241-50. Epub 2014 Sep 28.

School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2014.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332417PMC
December 2014

Encapsulation of antigen-loaded silica nanoparticles into microparticles for intradermal powder injection.

Eur J Pharm Sci 2014 Oct 17;63:154-66. Epub 2014 Jul 17.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximilians-University Munich, Butenandtstrasse 5, D-81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2014.07.004DOI Listing
October 2014

In vivo investigation of twin-screw extruded lipid implants for vaccine delivery.

Eur J Pharm Biopharm 2014 Jul 4;87(2):338-46. Epub 2014 Mar 4.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University Munich, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2014.02.014DOI Listing
July 2014

That's cool!--Nebulization of thermolabile proteins with a cooled vibrating mesh nebulizer.

Eur J Pharm Biopharm 2014 Jul 15;87(2):357-65. Epub 2014 Mar 15.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig Maximilian University Munich, Munich, Germany.

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http://dx.doi.org/10.1016/j.ejpb.2014.03.001DOI Listing
July 2014

Protein HESylation for half-life extension: synthesis, characterization and pharmacokinetics of HESylated anakinra.

Eur J Pharm Biopharm 2014 Jul 27;87(2):378-85. Epub 2014 Mar 27.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximillians-University Munich, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2014.03.010DOI Listing
July 2014

Prediction of protein degradation during vibrating mesh nebulization via a high throughput screening method.

Eur J Pharm Biopharm 2014 Jul 4;87(2):386-94. Epub 2014 Apr 4.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig Maximilian University Munich, Munich, Germany.

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http://dx.doi.org/10.1016/j.ejpb.2014.03.020DOI Listing
July 2014

Stability and activity of hydroxyethyl starch-coated polyplexes in frozen solutions or lyophilizates.

Int J Pharm 2014 Jul 13;469(1):50-8. Epub 2014 Apr 13.

Pharmaceutical Technology and Biopharmaceutics, Department of Pharmacy, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, D-81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2014.04.020DOI Listing
July 2014

Influence of particle geometry and PEGylation on phagocytosis of particulate carriers.

Int J Pharm 2014 Apr 21;465(1-2):159-64. Epub 2014 Feb 21.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximillians-University Munich, Butenandtstr. 5-8 D-81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2014.02.037DOI Listing
April 2014

Toward intradermal vaccination: preparation of powder formulations by collapse freeze-drying.

Pharm Dev Technol 2014 Mar 25;19(2):213-22. Epub 2013 Feb 25.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University , Munich , Germany.

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http://dx.doi.org/10.3109/10837450.2013.769567DOI Listing
March 2014

High throughput prediction of the long-term stability of pharmaceutical macromolecules from short-term multi-instrument spectroscopic data.

J Pharm Sci 2014 Mar 13;103(3):828-39. Epub 2014 Jan 13.

Department of Pharmaceutical Chemistry, Macromolecule and Vaccine Stabilization Center, University of Kansas, Lawrence, Kansas; Department of Physics and Astronomy, University of Kansas, Lawrence, Kansas.

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http://dx.doi.org/10.1002/jps.23849DOI Listing
March 2014

Comparison of the lateral tail vein and the retro-orbital venous sinus routes of antibody administration in pharmacokinetic studies.

Lab Anim (NY) 2014 Mar;43(3):95-9

Department of Large Molecule Bioanalytical Research & Development, Pharmaceutical Sciences, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany.

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http://dx.doi.org/10.1038/laban.481DOI Listing
March 2014

Label-free flow cytometry analysis of subvisible aggregates in liquid IgG1 antibody formulations.

J Pharm Sci 2014 Jan 11;103(1):90-9. Epub 2013 Nov 11.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig Maximilian University Munich, Munich, 81377, Germany.

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http://dx.doi.org/10.1002/jps.23782DOI Listing
January 2014

Antibody responses in mice to particles formed from adsorption of a murine monoclonal antibody onto glass microparticles.

J Pharm Sci 2014 Jan 13;103(1):78-89. Epub 2013 Nov 13.

Department of Chemical and Biological Engineering, Center for Pharmaceutical Biotechnology, University of Colorado, Boulder, Colorado, 80303.

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http://dx.doi.org/10.1002/jps.23772DOI Listing
January 2014

Pharmaceutical feasibility of sub-visible particle analysis in parenterals with reduced volume light obscuration methods.

Eur J Pharm Biopharm 2013 Nov 27;85(3 Pt B):1084-7. Epub 2013 Feb 27.

Coriolis Pharma, Biopharmaceutical Research and Development, Martinsried, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09396411130005
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http://dx.doi.org/10.1016/j.ejpb.2013.02.004DOI Listing
November 2013

Weak antibody-cyclodextrin interactions determined by quartz crystal microbalance and dynamic/static light scattering.

Eur J Pharm Biopharm 2013 Nov 17;85(3 Pt A):781-9. Epub 2013 May 17.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1016/j.ejpb.2013.04.021DOI Listing
November 2013

Can controlled ice nucleation improve freeze-drying of highly-concentrated protein formulations?

J Pharm Sci 2013 Nov 20;102(11):3915-9. Epub 2013 Aug 20.

Department of Pharmacy, Ludwig Maximilians University of Munich, Munich, 81377, Germany.

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http://dx.doi.org/10.1002/jps.23704DOI Listing
November 2013

Influence of hydroxypropyl-Beta-cyclodextrin on the stability of dilute and highly concentrated immunoglobulin g formulations.

J Pharm Sci 2013 Nov 19;102(11):4121-31. Epub 2013 Sep 19.

Pharmaceutical Technology and Biopharmaceutics, Department of Pharmacy, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, Munich, D-81377, Germany.

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http://dx.doi.org/10.1002/jps.23729DOI Listing
November 2013

Recent advances and further challenges in lyophilization.

Eur J Pharm Biopharm 2013 Oct 7;85(2):162-9. Epub 2013 Jun 7.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany.

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http://dx.doi.org/10.1016/j.ejpb.2013.05.019DOI Listing
October 2013

Meeting the challenges in freeze-drying of pharmaceuticals and biologicals.

Eur J Pharm Biopharm 2013 Oct 29;85(2):161. Epub 2013 Jun 29.

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http://dx.doi.org/10.1016/j.ejpb.2013.06.025DOI Listing
October 2013

In vitro effects of CpG oligodeoxynucleotides delivered by gelatin nanoparticles on canine peripheral blood mononuclear cells of atopic and healthy dogs - a pilot study.

Vet Dermatol 2013 Oct 5;24(5):494-e117. Epub 2013 Jul 5.

Vetsuisse Faculty University of Zurich, Clinic for Small Animal Internal Medicine, 8057, Zurich, Switzerland; Small Animal Medicine Clinic, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University, 80539, Munich, Germany.

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http://dx.doi.org/10.1111/vde.12056DOI Listing
October 2013

Quality control of protein crystal suspensions using microflow imaging and flow cytometry.

J Pharm Sci 2013 Oct 30;102(10):3860-6. Epub 2013 Jul 30.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximilians-University of Munich, Munich, Germany.

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http://dx.doi.org/10.1002/jps.23677DOI Listing
October 2013

Application of different analytical methods for the characterization of non-spherical micro- and nanoparticles.

Int J Pharm 2013 Sep 29;453(2):620-9. Epub 2013 May 29.

Department of Pharmacy, Pharmaceutical Technology & Biopharmaceutics, Ludwig-Maximillians-University Munich, Butenandstr. 5-13, D-81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.ijpharm.2013.05.046DOI Listing
September 2013

A critical evaluation of microcalorimetry as a predictive tool for long term stability of liquid protein formulations: granulocyte colony stimulating factor (GCSF).

Eur J Pharm Biopharm 2013 May 18;84(1):145-55. Epub 2013 Jan 18.

Department of Pharmaceutical Technology, Ludwig Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1016/j.ejpb.2012.12.017DOI Listing
May 2013

How subvisible particles become invisible-relevance of the refractive index for protein particle analysis.

J Pharm Sci 2013 May 5;102(5):1434-46. Epub 2013 Mar 5.

Coriolis Pharma, 82152 Martinsried-Munich, Germany.

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http://dx.doi.org/10.1002/jps.23479DOI Listing
May 2013

The effect of molar mass and degree of hydroxyethylation on the controlled shielding and deshielding of hydroxyethyl starch-coated polyplexes.

Biomaterials 2013 Mar 11;34(10):2530-8. Epub 2013 Jan 11.

Pharmaceutical Technology and Biopharmaceutics, Department of Pharmacy, Ludwig-Maximilians-Universität, Munich, Germany.

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http://dx.doi.org/10.1016/j.biomaterials.2012.12.025DOI Listing
March 2013