Gerhard Multhaup

Gerhard Multhaup

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Gerhard Multhaup

Gerhard Multhaup

Publications by authors named "Gerhard Multhaup"

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19Publications

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Label-free distribution of anti-amyloid D-AIP in Drosophila melanogaster: prevention of Aβ42-induced toxicity without side effects in transgenic flies.

J Neurochem 2019 May 11. Epub 2019 May 11.

Department of Pharmacology & Therapeutics, Life Sciences Complex, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1111/jnc.14720DOI Listing
May 2019

Amyloid Precursor Protein Dimerisation Reduces Neurite Outgrowth.

Mol Neurobiol 2019 Jan 19;56(1):13-28. Epub 2018 Apr 19.

Department of Pathology, The University of Melbourne, Melbourne, VIC, 3010, Australia.

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http://dx.doi.org/10.1007/s12035-018-1070-4DOI Listing
January 2019

Neurodegenerative Disease-Related Proteins within the Epidermal Layer of the Human Skin.

J Alzheimers Dis 2019 ;69(2):463-478

Department of Pharmacology & Therapeutics, Life Sciences Complex, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.3233/JAD-181191DOI Listing
January 2019

Hyperbranched Polyglycerol Derivatives as Prospective Copper Nanotransporter Candidates.

Molecules 2018 May 26;23(6). Epub 2018 May 26.

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin 14195, Germany.

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http://dx.doi.org/10.3390/molecules23061281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100100PMC
May 2018

APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding.

Sci Rep 2018 01 30;8(1):1916. Epub 2018 Jan 30.

Institut für Chemie und Biochemie, Freie Universität Berlin, Thielallee 63, 14195, Berlin, Germany.

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http://dx.doi.org/10.1038/s41598-018-19530-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789831PMC
January 2018

Direct evidence of amyloid precursor-like protein 1 interactions in cell-cell adhesion platforms investigated via fluorescence fluctuation spectroscopy.

Mol Biol Cell 2017 Dec 11;28(25):3609-3620. Epub 2017 Oct 11.

Institute of Biochemistry and Biology, University of Potsdam, 14476 Potsdam, Germany

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http://dx.doi.org/10.1091/mbc.E17-07-0459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706989PMC
December 2017

Evidence for Heterodimerization and Functional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS.

Hypertension 2017 06 1;69(6):1128-1135. Epub 2017 May 1.

From the Center for Cardiovascular Research, Charité-Medical Faculty Berlin, Germany (J.L., D.C.V., M.M., S.K., P.N., K.L., V.B., N.D., T.U., U.M.S.); The Integrated Research and Treatment Center for Sepsis Control and Care (CSCC) and Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Germany (J.L.); Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil (D.C.V., R.A.S.); Faculty of Medicine, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, Brazil (D.C.V.); Leibniz-Institut für Molekulare Pharmakologie (FMP), Berlin, Germany (A.T., R.S.); Institut für Chemie und Biochemie, Free University Berlin, Germany (L.-M.M., M.C.M., G.M.); Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada (L.-M.M., G.M.); CARIM, Maastricht University, The Netherlands (P.N., T.U.); Max-Delbrück-Center for Molecular Medicine, Berlin-Buch, Germany (N.A., M.B.); Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Japan (M.H., M.I.); and IMM-Department of Cardiovascular and Renal Research, University of Southern Denmark, Odense (U.M.S.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08814DOI Listing
June 2017

Alzheimer amyloid peptide aβ42 regulates gene expression of transcription and growth factors.

J Alzheimers Dis 2015 ;44(2):613-24

Institut fuer Chemie und Biochemie, Freie Universitaet Berlin, Berlin, Germany Department of Pharmacology & Therapeutics, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.3233/JAD-141902DOI Listing
September 2015

Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles.

J Biol Chem 2015 Sep 21;290(39):23515-22. Epub 2015 Aug 21.

the Jean Pierre Aubert Research Centre, Alzheimer & Tauopathies, INSERM, CHU-Lille, UMR-S 1172, University of Lille, F-59000 Lille, France.

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http://dx.doi.org/10.1074/jbc.R115.677211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583011PMC
September 2015

Impact of amyloid precursor protein hydrophilic transmembrane residues on amyloid-beta generation.

Biochemistry 2015 May 23;54(17):2777-84. Epub 2015 Apr 23.

†Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, H3G 1Y6 Montréal, Canada.

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http://dx.doi.org/10.1021/acs.biochem.5b00217DOI Listing
May 2015

Polyglycerol based coatings to reduce non-specific protein adsorption in sample vials and on SPR sensors.

Anal Chim Acta 2015 Mar 10;867:47-55. Epub 2015 Feb 10.

Freie Universität Berlin, Institute of Chemistry and Biochemistry, Takustr. 3, 14195 Berlin, Germany.

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http://dx.doi.org/10.1016/j.aca.2015.01.048DOI Listing
March 2015

Novel zinc-binding site in the E2 domain regulates amyloid precursor-like protein 1 (APLP1) oligomerization.

J Biol Chem 2014 Jul 22;289(27):19019-30. Epub 2014 May 22.

From the Institut für Chemie und Biochemie, Freie Universität Berlin, Thielallee 63, 14195 Berlin, Germany, the Department of Pharmacology and Therapeutics, McGill University Montreal, Montreal, Quebec H3G 1Y6, Canada,

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http://dx.doi.org/10.1074/jbc.M114.570382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081940PMC
July 2014

Nuclear translocation uncovers the amyloid peptide Aβ42 as a regulator of gene transcription.

J Biol Chem 2014 Jul 30;289(29):20182-91. Epub 2014 May 30.

From the Institut fuer Chemie und Biochemie, Freie Universitaet Berlin, 14195 Berlin, Germany, the Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, Quebec H3G 0B1, Canada,

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http://dx.doi.org/10.1074/jbc.M114.564690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106333PMC
July 2014