Publications by authors named "Gerhard Mittler"

40Publications

A Prion-like Domain in Transcription Factor EBF1 Promotes Phase Separation and Enables B Cell Programming of Progenitor Chromatin.

Authors:
Yuanting Wang Nikolay Zolotarev Cheng-Yuan Yang Angelika Rambold Gerhard Mittler Rudolf Grosschedl

Immunity 2020 Dec 6;53(6):1151-1167.e6. Epub 2020 Nov 6.

Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany. Electronic address:

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December 2020

ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue.

Authors:
Judit Carrasco Michael Rauer Barbara Hummel Dominika Grzejda Carlos Alfonso-Gonzalez Yeon Lee Qingqing Wang Monika Puchalska Gerhard Mittler Valérie Hilgers

Mol Cell 2020 10;80(1):156-163.e6

Max-Planck-Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany. Electronic address:

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October 2020

Heat-Shock Protein 90 Controls the Expression of Cell-Cycle Genes by Stabilizing Metazoan-Specific Host-Cell Factor HCFC1.

Authors:
Aneliya Antonova Barbara Hummel Ashkan Khavaran Desiree M Redhaber Fernando Aprile-Garcia Prashant Rawat Kathrin Gundel Megan Schneck Erik C Hansen Jan Mitschke Gerhard Mittler Cornelius Miething Ritwick Sawarkar

Cell Rep 2019 11;29(6):1645-1659.e9

Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany; CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany; MRC Toxicology Unit, University of Cambridge, Cambridge, UK. Electronic address:

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November 2019

The NSL complex maintains nuclear architecture stability via lamin A/C acetylation.

Authors:
Adam Karoutas Witold Szymanski Tobias Rausch Sukanya Guhathakurta Eva A Rog-Zielinska Remi Peyronnet Janine Seyfferth Hui-Ru Chen Rebecca de Leeuw Benjamin Herquel Hiroshi Kimura Gerhard Mittler Peter Kohl Ohad Medalia Jan O Korbel Asifa Akhtar

Nat Cell Biol 2019 10 1;21(10):1248-1260. Epub 2019 Oct 1.

Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

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October 2019

CAPRI enables comparison of evolutionarily conserved RNA interacting regions.

Authors:
Amol Panhale Florian M Richter Fidel Ramírez Maria Shvedunova Thomas Manke Gerhard Mittler Asifa Akhtar

Nat Commun 2019 06 18;10(1):2682. Epub 2019 Jun 18.

Max Planck Institute of Immunobiology and Epigenetics, 79108, Freiburg im Breisgau, Germany.

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June 2019

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.

Authors:
Daniel J Puleston Michael D Buck Ramon I Klein Geltink Ryan L Kyle George Caputa David O'Sullivan Alanna M Cameron Angela Castoldi Yaarub Musa Agnieszka M Kabat Ying Zhang Lea J Flachsmann Cameron S Field Annette E Patterson Stefanie Scherer Francesca Alfei Francesc Baixauli S Kyle Austin Beth Kelly Mai Matsushita Jonathan D Curtis Katarzyna M Grzes Matteo Villa Mauro Corrado David E Sanin Jing Qiu Nora Pällman Katelyn Paz Maria Elena Maccari Bruce R Blazar Gerhard Mittler Joerg M Buescher Dietmar Zehn Sabine Rospert Edward J Pearce Stefan Balabanov Erika L Pearce

Cell Metab 2019 08 23;30(2):352-363.e8. Epub 2019 May 23.

Max Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany. Electronic address:

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August 2019

Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2.

Authors:
David E Sanin Mai Matsushita Ramon I Klein Geltink Katarzyna M Grzes Nikki van Teijlingen Bakker Mauro Corrado Agnieszka M Kabat Michael D Buck Jing Qiu Simon J Lawless Alanna M Cameron Matteo Villa Francesc Baixauli Annette E Patterson Fabian Hässler Jonathan D Curtis Christina M O'Neill David O'Sullivan Duojiao Wu Gerhard Mittler Stanley Ching-Cheng Huang Erika L Pearce Edward J Pearce

Immunity 2018 12;49(6):1021-1033.e6

Department of Immunometabolism, Max Planck Institute of Epigenetics and Immunobiology, Freiburg im Breisgau, Germany; Faculty of Biology, University of Freiburg, Freiburg im Breisgau, Germany. Electronic address:

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December 2018

De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation.

Authors:
M Felicia Basilicata Ange-Line Bruel Giuseppe Semplicio Claudia Isabelle Keller Valsecchi Tuğçe Aktaş Yannis Duffourd Tobias Rumpf Jenny Morton Iben Bache Witold G Szymanski Christian Gilissen Olivier Vanakker Katrin Õunap Gerhard Mittler Ineke van der Burgt Salima El Chehadeh Megan T Cho Rolph Pfundt Tiong Yang Tan Maria Kirchhoff Björn Menten Sarah Vergult Kristin Lindstrom André Reis Diana S Johnson Alan Fryer Victoria McKay Richard B Fisher Christel Thauvin-Robinet David Francis Tony Roscioli Sander Pajusalu Kelly Radtke Jaya Ganesh Han G Brunner Meredith Wilson Laurence Faivre Vera M Kalscheuer Julien Thevenon Asifa Akhtar

Nat Genet 2018 10 17;50(10):1442-1451. Epub 2018 Sep 17.

Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.

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October 2018

Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response.

Authors:
Benedetto Daniele Giaimo Francesca Ferrante Diana M Vallejo Kerstin Hein Irene Gutierrez-Perez Andrea Nist Thorsten Stiewe Gerhard Mittler Susanne Herold Tobias Zimmermann Marek Bartkuhn Peggy Schwarz Franz Oswald Maria Dominguez Tilman Borggrefe

Nucleic Acids Res 2018 09;46(16):8197-8215

Institute of Biochemistry, University of Giessen, Friedrichstrasse 24, 35392 Giessen, Germany.

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September 2018

Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors.

Authors:
José Miguel Ramos Pittol Agata Oruba Gerhard Mittler Simona Saccani Dominic van Essen

PLoS Biol 2018 05 29;16(5):e2004526. Epub 2018 May 29.

Institute for Research on Cancer and Aging, Nice, Nice, France.

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May 2018

Comprehensive Proteomic Investigation of Ebf1 Heterozygosity in Pro-B Lymphocytes Utilizing Data Independent Acquisition.

Authors:
Yaarub R Musa Sören Boller Monika Puchalska Rudolf Grosschedl Gerhard Mittler

J Proteome Res 2018 01 11;17(1):76-85. Epub 2017 Dec 11.

Proteomics Facility, ‡Department of Molecular and Cellular Immunology, Max Planck Institute of Immunobiology and Epigenetics , D-79108 Freiburg, Germany.

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January 2018

Histone propionylation is a mark of active chromatin.

Authors:
Adam F Kebede Anna Nieborak Lara Zorro Shahidian Stephanie Le Gras Florian Richter Diana Aguilar Gómez Marijke P Baltissen Gergo Meszaros Helena de Fatima Magliarelli Aaron Taudt Raphael Margueron Maria Colomé-Tatché Romeo Ricci Sylvain Daujat Michiel Vermeulen Gerhard Mittler Robert Schneider

Nat Struct Mol Biol 2017 Dec 23;24(12):1048-1056. Epub 2017 Oct 23.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.

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December 2017

DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome.

Authors:
Tuğçe Aktaş İbrahim Avşar Ilık Daniel Maticzka Vivek Bhardwaj Cecilia Pessoa Rodrigues Gerhard Mittler Thomas Manke Rolf Backofen Asifa Akhtar

Nature 2017 04 29;544(7648):115-119. Epub 2017 Mar 29.

Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

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April 2017

Interaction of CCR4-NOT with EBF1 regulates gene-specific transcription and mRNA stability in B lymphopoiesis.

Authors:
Cheng-Yuan Yang Senthilkumar Ramamoorthy Sören Boller Marc Rosenbaum Alfonso Rodriguez Gil Gerhard Mittler Yumiko Imai Keiji Kuba Rudolf Grosschedl

Genes Dev 2016 Oct 2;30(20):2310-2324. Epub 2016 Nov 2.

Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.

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October 2016

Biochemical and cellular characterization of transcription factors binding to the hyperconserved core promoter-associated M4 motif.

Authors:
Ngo Tat Trung Elisabeth Kremmer Gerhard Mittler

BMC Genomics 2016 08 30;17:693. Epub 2016 Aug 30.

Department of Cellular and Molecular Immunology, Proteomics Core Facility, Max-Planck-Institute of Immunobiology and Epigenetics, D-79108, Freiburg, Germany.

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August 2016

Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation.

Authors:
Sarantis Chlamydas Herbert Holz Maria Samata Tomasz Chelmicki Plamen Georgiev Vicent Pelechano Friederike Dündar Pouria Dasmeh Gerhard Mittler Filipe Tavares Cadete Fidel Ramírez Thomas Conrad Wu Wei Sunil Raja Thomas Manke Nicholas M Luscombe Lars M Steinmetz Asifa Akhtar

Nat Struct Mol Biol 2016 06 16;23(6):580-9. Epub 2016 May 16.

Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.

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June 2016

A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes.

Authors:
Franz Oswald Patrick Rodriguez Benedetto Daniele Giaimo Zeus A Antonello Laura Mira Gerhard Mittler Verena N Thiel Kelly J Collins Nassif Tabaja Wiebke Cizelsky Melanie Rothe Susanne J Kühl Michael Kühl Francesca Ferrante Kerstin Hein Rhett A Kovall Maria Dominguez Tilman Borggrefe

Nucleic Acids Res 2016 06 23;44(10):4703-20. Epub 2016 Feb 23.

Institute of Biochemistry, University of Giessen, Friedrichstrasse 24, 35392 Giessen, Germany

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June 2016

Corrigendum: IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity.

Authors:
Idan Cohen Peleg Rider Elena Vornov Martin Tomas Cicerone Tudor Mareike Wegner Lydia Brondani Marina Freudenberg Gerhard Mittler Elisa Ferrando-May Charles A Dinarello Ron N Apte Robert Schneider

Sci Rep 2016 Jan 11;6:19100. Epub 2016 Jan 11.

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January 2016

IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity.

Authors:
Idan Cohen Cohen Idan Peleg Rider Rider Peleg Elena Vornov Voronov Elena Martin Tomas Tomas Martin Cicerone Tudor Tudor Cicerone Mareike Wegner Wegner Mareike Lydia Brondani Brondani Lydia Marina Freudenberg Freudenberg Marina Gerhard Mittler Mittler Gerhard Elisa Ferrando-May Ferrando-May Elisa Charles A Dinarello Ron N Apte Apte N Ron Robert Schneider Schneider Robert

Sci Rep 2015 Oct 6;5:14756. Epub 2015 Oct 6.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104, INSERM U 964, Université de Strasbourg, 67404 Illkirch, France.

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October 2015

Effective Eradication of Glioblastoma Stem Cells by Local Application of an AC133/CD133-Specific T-cell-Engaging Antibody and CD8 T Cells.

Authors:
Shruthi Prasad Simone Gaedicke Marcia Machein Gerhard Mittler Friederike Braun Michael Hettich Elke Firat Kerstin Klingner Julia Schüler Dagmar Wider Ralph M Wäsch Christel Herold-Mende Ursula Elsässer-Beile Gabriele Niedermann

Cancer Res 2015 Jun 3;75(11):2166-76. Epub 2015 Apr 3.

Department of Radiation Oncology, University Hospital Freiburg, Freiburg, Germany. German Cancer Consortium (DKTK), Freiburg, and German Cancer Research Center (DKFZ), Heidelberg, Germany.

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June 2015