Publications by authors named "Gerhard J Molderings"

55Publications

Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome.

Int J Infect Dis 2020 Nov 10;100:327-332. Epub 2020 Sep 10.

Institute of Human Genetics, University Hospital of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1016/j.ijid.2020.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529115PMC
November 2020

Mast Cell Activation Syndrome: A Primer for the Gastroenterologist.

Dig Dis Sci 2020 Apr 23. Epub 2020 Apr 23.

Institute of Human Genetics, University Hospital Bonn, 53127, Bonn, Germany.

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http://dx.doi.org/10.1007/s10620-020-06264-9DOI Listing
April 2020

Restless legs syndrome is associated with mast cell activation syndrome.

J Clin Sleep Med 2020 03 14;16(3):401-408. Epub 2020 Jan 14.

Institute of Human Genetics, University Hospital Bonn, Bonn, Germany.

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http://dx.doi.org/10.5664/jcsm.8216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075100PMC
March 2020

Case Report: Treatment of systemic mastocytosis with sunitinib.

F1000Res 2017 28;6:2182. Epub 2017 Dec 28.

Department of Oncology, Hematology and Palliative Care, Kreiskrankenhaus Waldbröl, Waldbröl, D-51545, Germany.

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http://dx.doi.org/10.12688/f1000research.13343.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946163PMC
December 2017

Mast Cell Activation Syndrome Mimicking Breast Cancer: Case Report With Pathophysiologic Considerations.

Clin Breast Cancer 2018 06 12;18(3):e271-e276. Epub 2017 Dec 12.

Klinik für Diagnostische und Interventionelle Radiologie, Uniklinik RWTH Aachen, Aachen, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S15268209173053
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http://dx.doi.org/10.1016/j.clbc.2017.12.004DOI Listing
June 2018

A Practical Guide for Treatment of Pain in Patients with Systemic Mast Cell Activation Disease.

Pain Physician 2017 09;20(6):E849-E861

Institute of Human Genetics, University Hospital of Bonn, Germany.

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September 2017

Siglec-8 as mast cell selective target: developing paradigms amidst inconvenient truths.

Naunyn Schmiedebergs Arch Pharmacol 2017 Nov 14;390(11):1173-1175. Epub 2017 Sep 14.

Institute of Human Genetics, University Hospital of Bonn, Sigmund-Freud-Strasse 25, 53127, Bonn, Germany.

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http://link.springer.com/10.1007/s00210-017-1425-9
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http://dx.doi.org/10.1007/s00210-017-1425-9DOI Listing
November 2017

Pharmacological treatment options for mast cell activation disease.

Naunyn Schmiedebergs Arch Pharmacol 2016 Jul 30;389(7):671-94. Epub 2016 Apr 30.

Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1007/s00210-016-1247-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903110PMC
July 2016

Often seen, rarely recognized: mast cell activation disease--a guide to diagnosis and therapeutic options.

Ann Med 2016 25;48(3):190-201. Epub 2016 Mar 25.

d Institute of Human Genetics , University Hospital of Bonn , Bonn , Germany.

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http://dx.doi.org/10.3109/07853890.2016.1161231DOI Listing
December 2016

Transgenerational transmission of systemic mast cell activation disease-genetic and epigenetic features.

Transl Res 2016 08 11;174:86-97. Epub 2016 Jan 11.

Institute of Human Genetics, University Hospital of Bonn, Sigmund-Freud-Strasse 25, D-53127 Bonn, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19315244160000
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http://dx.doi.org/10.1016/j.trsl.2016.01.001DOI Listing
August 2016

Cardiovascular symptoms in patients with systemic mast cell activation disease.

Transl Res 2016 08 28;174:23-32.e1. Epub 2015 Dec 28.

Institute of Human Genetics, University Hospital of Bonn, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2015.12.012DOI Listing
August 2016

Mast cell activation disease: An underappreciated cause of neurologic and psychiatric symptoms and diseases.

Brain Behav Immun 2015 Nov 8;50:314-321. Epub 2015 Jul 8.

Institute of Human Genetics, University Hospital of Bonn, Bonn, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08891591150023
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http://dx.doi.org/10.1016/j.bbi.2015.07.002DOI Listing
November 2015

Successful treatment of mast cell activation syndrome with sunitinib.

Eur J Haematol 2015 Dec 25;95(6):595-7. Epub 2015 Jun 25.

Institute for Human Genetics, University of Bonn, Bonn, Germany.

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http://doi.wiley.com/10.1111/ejh.12606
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http://dx.doi.org/10.1111/ejh.12606DOI Listing
December 2015

The genetic basis of mast cell activation disease - looking through a glass darkly.

Crit Rev Oncol Hematol 2015 Feb 28;93(2):75-89. Epub 2014 Sep 28.

Institute of Human Genetics, University Hospital of Bonn, Sigmund-Freud-Str. 25, D-53127 Bonn, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10408428140014
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http://dx.doi.org/10.1016/j.critrevonc.2014.09.001DOI Listing
February 2015

Evidence for contribution of epigenetic mechanisms in the pathogenesis of systemic mast cell activation disease.

Immunogenetics 2014 May 14;66(5):287-97. Epub 2014 Mar 14.

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

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http://dx.doi.org/10.1007/s00251-014-0768-3DOI Listing
May 2014

Familial occurrence of systemic mast cell activation disease.

PLoS One 2013 30;8(9):e76241. Epub 2013 Sep 30.

Institute of Human Genetics, University Hospital of Bonn, Bonn, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076241PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787002PMC
June 2014

Intravenous infusion of ascorbic acid decreases serum histamine concentrations in patients with allergic and non-allergic diseases.

Naunyn Schmiedebergs Arch Pharmacol 2013 Sep 11;386(9):789-93. Epub 2013 May 11.

Functional Tissue Diagnostics, Department of Medicine I, University Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.

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http://dx.doi.org/10.1007/s00210-013-0880-1DOI Listing
September 2013

The 1,4-benzodiazepine Ro5-4864 (4-chlorodiazepam) suppresses multiple pro-inflammatory mast cell effector functions.

Cell Commun Signal 2013 Feb 20;11(1):13. Epub 2013 Feb 20.

Medical Faculty, Institute of Biochemistry and Molecular Immunology, RWTH Aachen University, Pauwelsstr, 30, 52074, Aachen, Germany.

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http://dx.doi.org/10.1186/1478-811X-11-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598916PMC
February 2013

Investigation into mechanisms mediating the inhibitory effect of 1,4-benzodiazepines on mast cells by gene expression profiling.

Life Sci 2013 Mar 24;92(6-7):345-51. Epub 2013 Jan 24.

Institute of Human Genetics, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1016/j.lfs.2013.01.010DOI Listing
March 2013

Inhibitory effects of benzodiazepines on the adenosine A(2B) receptor mediated secretion of interleukin-8 in human mast cells.

Eur J Pharmacol 2013 Jan 22;700(1-3):152-8. Epub 2012 Dec 22.

Pharma Center Bonn, Department of Pharmacology and Toxicology, Biomedical Research Center, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.

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https://www.karger.com/Article/FullText/443960
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https://www.karger.com/Article/Abstract/443960
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https://linkinghub.elsevier.com/retrieve/pii/S00142999120100
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http://dx.doi.org/10.1016/j.ejphar.2012.12.003DOI Listing
January 2013

Agmatine (decarboxylated L-arginine): physiological role and therapeutic potential.

Pharmacol Ther 2012 Mar 22;133(3):351-65. Epub 2011 Dec 22.

Institute of Human Genetics, University Hospital of Bonn, Sigmund-Freud-Str. 25, D-53127 Bonn, Germany.

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http://dx.doi.org/10.1016/j.pharmthera.2011.12.005DOI Listing
March 2012

Omalizumab treatment of systemic mast cell activation disease: experiences from four cases.

Intern Med 2011 15;50(6):611-5. Epub 2011 Mar 15.

Institute of Human Genetics, University Hospital of Bonn, Germany.

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http://dx.doi.org/10.2169/internalmedicine.50.4640DOI Listing
February 2012

Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options.

J Hematol Oncol 2011 Mar 22;4:10. Epub 2011 Mar 22.

Institute of Human Genetics, University Hospital of Bonn, Germany.

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http://dx.doi.org/10.1186/1756-8722-4-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069946PMC
March 2011

Toward a global classification of mast cell activation diseases.

J Allergy Clin Immunol 2011 May 8;127(5):1311; author reply 1311-2. Epub 2011 Feb 8.

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http://dx.doi.org/10.1016/j.jaci.2010.12.1113DOI Listing
May 2011

Comparative analysis of mutation of tyrosine kinase kit in mast cells from patients with systemic mast cell activation syndrome and healthy subjects.

Immunogenetics 2010 Dec 14;62(11-12):721-7. Epub 2010 Sep 14.

Institute of Human Genetics, University Hospital of Bonn, Sigmund-Freud-Strasse 25, Bonn, Germany.

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http://link.springer.com/10.1007/s00251-010-0474-8
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http://dx.doi.org/10.1007/s00251-010-0474-8DOI Listing
December 2010

[Systemic mastocytosis--definition of an internal disease].

Med Klin (Munich) 2010 Aug 8;105(8):544-53. Epub 2010 Sep 8.

Abteilung für Innere Medizin, Evangelisches Waldkrankenhaus, Bonn, Germany.

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http://dx.doi.org/10.1007/s00063-010-1093-8DOI Listing
August 2010

Therapy-refractory gastrointestinal motility disorder in a child with c-kit mutations.

World J Gastroenterol 2010 Sep;16(34):4363-6

Department of General Pediatrics, University Children's Hospital, Moorenstr. 5, 40225 Düsseldorf, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937119PMC
http://dx.doi.org/10.3748/wjg.v16.i34.4363DOI Listing
September 2010

Ureteral stones due to systemic mastocytosis: diagnostic and therapeutic characteristics.

Urol Res 2009 Aug 10;37(4):227-9. Epub 2009 Jun 10.

Institute of Human Genetics, University Hospital of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1007/s00240-009-0198-0DOI Listing
August 2009

Commentary: Condition is often overlooked.

BMJ 2009 Mar 9;338:b799. Epub 2009 Mar 9.

Institute of Human Genetics, University Hospital of Bonn, D-53111 Bonn, Germany.

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http://dx.doi.org/10.1136/bmj.b799DOI Listing
March 2009

Regulatory mechanisms underlying agmatine homeostasis in humans.

Am J Physiol Gastrointest Liver Physiol 2008 Nov 2;295(5):G1104-10. Epub 2008 Oct 2.

Inst. of Human Genetics, Univ. Hospital of Bonn, D-53111 Bonn, Germany.

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http://dx.doi.org/10.1152/ajpgi.90374.2008DOI Listing
November 2008

New aspects of liver abnormalities as part of the systemic mast cell activation syndrome.

Liver Int 2009 Feb 23;29(2):181-6. Epub 2008 Jul 23.

Evangelische Kliniken, Waldkrankenhaus, Department for Internal Medicine, Bonn, Germany.

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http://dx.doi.org/10.1111/j.1478-3231.2008.01839.xDOI Listing
February 2009

Characterization of an antiproliferative effect of imidazoline receptor ligands on PC12 cells.

Pharmacol Rep 2007 Nov-Dec;59(6):789-94

Institute of Pharmacology and Toxicology, University of Bonn, Reuterstrasse 2b, D-53113 Bonn, Germany.

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September 2008

S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligands.

Neurochem Int 2007 Dec 7;51(8):476-85. Epub 2007 May 7.

University of Bonn, Institute of Pharmacology and Toxicology, Reuterstr. 2b, D-53113 Bonn, Germany.

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http://dx.doi.org/10.1016/j.neuint.2007.04.022DOI Listing
December 2007

Cardiac mast cells: implications for heart failure.

J Am Coll Cardiol 2007 Mar 23;49(10):1107; author reply 1107-8. Epub 2007 Feb 23.

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http://dx.doi.org/10.1016/j.jacc.2006.12.018DOI Listing
March 2007

Functional and molecular identification of 5-hydroxytryptamine receptors in rabbit pulmonary artery: involvement in complex regulation of noradrenaline release.

Pharmacol Rep 2006 Mar-Apr;58(2):188-99

Institute of Pharmacology and Toxicology, University of Bonn, Reuterstr. 2b, D-53113 Bonn, Germany.

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October 2006

[Dysferlinopathy as an extrahepatic cause for the elevation of serum transaminases].

Med Klin (Munich) 2004 Jun;99(6):326-9

Institut für Pharmakologie und Toxikologie, Universität Bonn, Bonn.

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http://link.springer.com/10.1007/s00063-004-1046-1
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http://dx.doi.org/10.1007/s00063-004-1046-1DOI Listing
June 2004

Alpha(2A)-adrenergic versus imidazoline receptor controversy in rilmenidine's action: alpha(2A)-antagonism in humans versus alpha(2A)-agonism in rabbits.

Ann N Y Acad Sci 2003 Dec;1009:279-82

University of Bonn, Institute of Pharmacology and Toxicology, Bonn, Germany.

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http://dx.doi.org/10.1196/annals.1304.036DOI Listing
December 2003

Identification and pharmacological characterization of a specific agmatine transport system in human tumor cell lines.

Ann N Y Acad Sci 2003 Dec;1009:75-81

Institute of Pharmacology and Toxicology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1196/annals.1304.008DOI Listing
December 2003

Gastrointestinal uptake of agmatine: distribution in tissues and organs and pathophysiologic relevance.

Ann N Y Acad Sci 2003 Dec;1009:44-51

Institute of Pharmacology and Toxicology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1196/annals.1304.005DOI Listing
December 2003

Agmatine (decarboxylated arginine), a modulator of liver cell homeostasis and proliferation.

Naunyn Schmiedebergs Arch Pharmacol 2004 Feb 15;369(2):160-5. Epub 2004 Jan 15.

Institute of Pharmacology and Toxicology, University of Bonn, Reuterstrasse 2B, 53113 Bonn, Germany.

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http://dx.doi.org/10.1007/s00210-003-0859-4DOI Listing
February 2004

Exposure of rat isolated stomach and rats in vivo to [(14)C]agmatine: accumulation in the stomach wall and distribution in various tissues.

Fundam Clin Pharmacol 2002 Jun;16(3):219-25

Institut für Pharmakologie und Toxikologie, Universität Bonn, Reuterstr. 2b, D-53113 Bonn, Germany.

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http://dx.doi.org/10.1046/j.1472-8206.2002.00073.xDOI Listing
June 2002

[Physiologic and therapeutic importance of serotonin and the serotonergic system].

Arzneimittelforschung 2002 ;52(3):145-54

Institut für Pharmakologie und Toxikologie, Universität Bonn.

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http://dx.doi.org/10.1055/s-0031-1299872DOI Listing
May 2002