Gergely L Lukacs

Gergely L Lukacs

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Gergely L Lukacs

Publications by authors named "Gergely L Lukacs"

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Differential Scanning Fluorimetry and Hydrogen Deuterium Exchange Mass Spectrometry to Monitor the Conformational Dynamics of NBD1 in Cystic Fibrosis.

Methods Mol Biol 2019 ;1873:53-67

Department of Physiology, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1007/978-1-4939-8820-4_4DOI Listing
May 2019

Identification of Allosteric Inhibitors against Active Caspase-6.

Sci Rep 2019 Apr 2;9(1):5504. Epub 2019 Apr 2.

Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Ch. Cote Ste-Catherine, Montreal, Quebec, H3T 1E2, Canada.

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http://dx.doi.org/10.1038/s41598-019-41930-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445123PMC
April 2019

Single Cell Fluorescence Ratio Image Analysis for Studying ESCRT Function in Receptor Trafficking.

Methods Mol Biol 2019 ;1998:93-103

Department of Biochemistry, McGill University, Montréal, QC, Canada.

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http://dx.doi.org/10.1007/978-1-4939-9492-2_7DOI Listing
January 2019

Publisher Correction: Mechanism of parkin activation by phosphorylation.

Nat Struct Mol Biol 2018 Aug;25(8):744

Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/s41594-018-0105-xDOI Listing
August 2018

Mechanism of parkin activation by phosphorylation.

Nat Struct Mol Biol 2018 Jul 2;25(7):623-630. Epub 2018 Jul 2.

Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/s41594-018-0088-7DOI Listing
July 2018

Extracellular oxidation in cystic fibrosis airway epithelium causes enhanced EGFR/ADAM17 activity.

Am J Physiol Lung Cell Mol Physiol 2018 04 14;314(4):L555-L568. Epub 2017 Dec 14.

Cell Biology, Erasmus MC, Rotterdam , The Netherlands.

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http://dx.doi.org/10.1152/ajplung.00458.2017DOI Listing
April 2018

PINK1 autophosphorylation is required for ubiquitin recognition.

EMBO Rep 2018 04 23;19(4). Epub 2018 Feb 23.

Department of Pharmacology & Therapeutics and Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montréal, QC, Canada

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http://dx.doi.org/10.15252/embr.201744981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891426PMC
April 2018

Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase.

Dev Cell 2018 03 1;44(6):694-708.e7. Epub 2018 Mar 1.

Department of Physiology, McGill University, 3655 Promenade Sir-William-Osler, Montréal, QC H3G 1Y6, Canada; Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada; Department of GRASP, McGill University, Montréal, QC H3G 1Y6, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15345807183009
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http://dx.doi.org/10.1016/j.devcel.2018.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447300PMC
March 2018

Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator.

MAbs 2016 Aug-Sep;8(6):1167-76. Epub 2016 May 16.

a Donnelly Center for Cellular and Biomolecular Research , University of Toronto , Toronto , Ontario , Canada.

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http://dx.doi.org/10.1080/19420862.2016.1186320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968092PMC
December 2017

Leukoencephalopathy-causing CLCN2 mutations are associated with impaired Cl channel function and trafficking.

J Physiol 2017 11 9;595(22):6993-7008. Epub 2017 Oct 9.

Unitat de Fisiología, Departament de Ciències Fisiològiques, IDIBELL-Institute of Neurosciences, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain.

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http://dx.doi.org/10.1113/JP275087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685823PMC
November 2017

Epithelial Anion Transport as Modulator of Chemokine Signaling.

Mediators Inflamm 2016 12;2016:7596531. Epub 2016 Jun 12.

Department of Physiology, McGill University, Montréal, QC, Canada H3G 1Y6.

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http://dx.doi.org/10.1155/2016/7596531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921137PMC
May 2017

A Christianson syndrome-linked deletion mutation (∆(287)ES(288)) in SLC9A6 disrupts recycling endosomal function and elicits neurodegeneration and cell death.

Mol Neurodegener 2016 09 2;11(1):63. Epub 2016 Sep 2.

Department of Physiology, McGill University, Bellini Life Sciences Bldg., Rm, 166, 3649 Promenade Sir-William-Osler, Montreal, QC, H3G 0B1, Canada.

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http://dx.doi.org/10.1186/s13024-016-0129-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010692PMC
September 2016

Proteostasis: Chaperoning for hearing loss.

Authors:
Gergely L Lukacs

Nat Chem Biol 2016 05;12(6):388-9

Department of Physiology and Biochemistry, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/nchembio.2091DOI Listing
May 2016

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.

Mol Biol Cell 2016 Feb;27(3):424-33

Department of Physiology, McGill University, Montréal, QC H3G 1Y6, Canada Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada GRASP, McGill University, Montréal, QC H3G 1Y6, Canada

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http://dx.doi.org/10.1091/mbc.E14-04-0935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751594PMC
February 2016

Potentiators of Defective ΔF508-CFTR Gating that Do Not Interfere with Corrector Action.

Mol Pharmacol 2015 Oct 5;88(4):791-9. Epub 2015 Aug 5.

Departments of Medicine and Physiology (P.-W.P., J.A.T., A.S.V.) and Department of Pathology (W.E.F.), University of California, San Francisco, California; Department of Physiology and Groupe de Recherche Axé sur la Structure des Protéine (G.V., G.L.L.) and Department of Biochemistry (G.L.L.), McGill University, Montreal, Quebec, Canada

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.115.09
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http://dx.doi.org/10.1124/mol.115.099689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576684PMC
October 2015

Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration.

Cell Rep 2015 Oct 8;13(3):599-609. Epub 2015 Oct 8.

Department of Biochemistry, Goodman Cancer Research Centre, McGill University, Montreal, Canada, H3G 1Y6. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.09.024DOI Listing
October 2015

Degradation mechanism of a Golgi-retained distal renal tubular acidosis mutant of the kidney anion exchanger 1 in renal cells.

Am J Physiol Cell Physiol 2014 Aug 11;307(3):C296-307. Epub 2014 Jun 11.

Department of Physiology, University of Alberta, Edmonton, Alberta, Canada; and

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http://dx.doi.org/10.1152/ajpcell.00310.2013DOI Listing
August 2014

Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy.

Mol Pharmacol 2014 Jul 15;86(1):42-51. Epub 2014 Apr 15.

Departments of Medicine and Physiology (P.-W.P., J.T., A.S.V.) and Department of Pathology (W.E.F.), University of California, San Francisco, California; and Groupe de Recherche Axé sur la Structure des Protéine and Departments of Physiology (G.V., A.R., G.L.L.) and Biochemistry (G.L.L.), McGill University, Montreal, Quebec, Canada

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http://molpharm.aspetjournals.org/content/86/1/42.full.pdf
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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.114.09
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http://dx.doi.org/10.1124/mol.114.092478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054004PMC
July 2014

Protein homeostasis at the plasma membrane.

Physiology (Bethesda) 2014 Jul;29(4):265-77

Department of Physiology and Research Group Focused on Protein Structure (GRASP), McGill University, Montreal, Quebec, Canada; and Department of Biochemistry, McGill University, Montreal, Quebec, Canada

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http://dx.doi.org/10.1152/physiol.00058.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103059PMC
July 2014

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.

Sci Transl Med 2014 Jul;6(246):246ra97

Department of Physiology, McGill University, Montréal, Quebec H3G 1Y6, Canada. Department of Biochemistry, McGill University, Montréal, Quebec H3G 1Y6, Canada. Groupe de Recherche Axé sur la Structure des Protéines (GRASP), McGill University, Montréal, Quebec H3G 1Y6, Canada.

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http://dx.doi.org/10.1126/scitranslmed.3008889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467693PMC
July 2014

Ubiquitin-dependent sorting in endocytosis.

Cold Spring Harb Perspect Biol 2014 Jan 1;6(1). Epub 2014 Jan 1.

Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242.

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http://dx.doi.org/10.1101/cshperspect.a016808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941215PMC
January 2014

Ubiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane.

Mol Biol Cell 2013 Dec 23;24(24):3787-804. Epub 2013 Oct 23.

Department of Physiology and Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montréal, QC H3E 1Y6, Canada.

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http://dx.doi.org/10.1091/mbc.E13-07-0417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861077PMC
December 2013

Reduced PDZ interactions of rescued ΔF508CFTR increases its cell surface mobility.

J Biol Chem 2012 Dec 31;287(52):43630-8. Epub 2012 Oct 31.

Department of Medicine, University of California, San Francisco, California 94143-0521, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.421172
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http://dx.doi.org/10.1074/jbc.M112.421172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527949PMC
December 2012

Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia.

Mol Biol Cell 2012 Nov 12;23(21):4188-202. Epub 2012 Sep 12.

Department of Physiology and Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montréal, QC H3G 1Y6, Canada.

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http://www.molbiolcell.org/content/23/21/4188.full.pdf
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http://www.molbiolcell.org/cgi/doi/10.1091/mbc.E12-06-0424
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http://dx.doi.org/10.1091/mbc.E12-06-0424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484098PMC
November 2012

Fixing cystic fibrosis by correcting CFTR domain assembly.

J Cell Biol 2012 Oct;199(2):199-204

Department of Physiology, McGill University, Montréal, Quebec, Canada.

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http://dx.doi.org/10.1083/jcb.201208083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471238PMC
October 2012

CFTR: folding, misfolding and correcting the ΔF508 conformational defect.

Trends Mol Med 2012 Feb 3;18(2):81-91. Epub 2011 Dec 3.

Department of Physiology and GRASP, McGill University, Montréal, Quebec H3E 1Y6, Canada.

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http://dx.doi.org/10.1016/j.molmed.2011.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643519PMC
February 2012

Introduction to section III: biochemical methods to study CFTR protein.

Methods Mol Biol 2011 ;741:213-8

Faculty of Sciences, BioFiG-Centre for Biodiversity and Functional and Integrative Genomics, University of Lisboa, Lisboa, Portugal.

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http://dx.doi.org/10.1007/978-1-61779-117-8_14DOI Listing
September 2011

Protein quality control at the plasma membrane.

Curr Opin Cell Biol 2011 Aug 14;23(4):483-91. Epub 2011 May 14.

Department of Physiology and Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montréal, Quebec H3G 1Y6, Canada.

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http://dx.doi.org/10.1016/j.ceb.2011.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148424PMC
August 2011

Quality control for unfolded proteins at the plasma membrane.

J Cell Biol 2010 Nov 25;191(3):553-70. Epub 2010 Oct 25.

Department of Physiology, McGill University, Montréal, Quebec, Canada.

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http://dx.doi.org/10.1083/jcb.201006012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003321PMC
November 2010

Peripheral protein quality control removes unfolded CFTR from the plasma membrane.

Science 2010 Aug 1;329(5993):805-10. Epub 2010 Jul 1.

Department of Physiology, and Groupe de Recherche Axé sur la Structure des Protéine (GRASP) McGill University, Montreal, Quebec H3G 1Y6, Canada.

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http://dx.doi.org/10.1126/science.1191542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026491PMC
August 2010

Cooperative assembly and misfolding of CFTR domains in vivo.

Mol Biol Cell 2009 Apr 28;20(7):1903-15. Epub 2009 Jan 28.

Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6.

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http://dx.doi.org/10.1091/mbc.e08-09-0950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663924PMC
April 2009

N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic.

J Cell Biol 2009 Mar;184(6):847-62

Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1083/jcb.200808124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699153PMC
March 2009

Polyubiquitination of prolactin receptor stimulates its internalization, postinternalization sorting, and degradation via the lysosomal pathway.

Mol Cell Biol 2008 Sep 23;28(17):5275-87. Epub 2008 Jun 23.

Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, 380 S. Philadelphia, PA 19104-4539, USA.

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http://dx.doi.org/10.1128/MCB.00350-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519723PMC
September 2008

Analysis of endocytic trafficking by single-cell fluorescence ratio imaging.

Curr Protoc Cell Biol 2008 Sep;Chapter 15:Unit 15.13

McGill University, Department of Physiology, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/0471143030.cb1513s40DOI Listing
September 2008

Molecular proximity of cystic fibrosis transmembrane conductance regulator and epithelial sodium channel assessed by fluorescence resonance energy transfer.

J Biol Chem 2007 Dec 3;282(50):36481-8. Epub 2007 Oct 3.

Department of Physiology & Biophysics, Gregory Fleming James Cystic Fibrosis Research Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294-0005, USA.

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http://dx.doi.org/10.1074/jbc.M708089200DOI Listing
December 2007

Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis.

J Cell Biol 2007 Dec;179(5):935-50

Department of Animal Biology and 2Mari Lowe Center for Comparative Oncology Research, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1083/jcb.200706034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2099190PMC
December 2007

Plasticity of polyubiquitin recognition as lysosomal targeting signals by the endosomal sorting machinery.

Mol Biol Cell 2007 Oct 8;18(10):3952-65. Epub 2007 Aug 8.

Hospital for Sick Children Research Institute, Department of Biochemistry and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, M5G 1X8.

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http://dx.doi.org/10.1091/mbc.e07-07-0678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995726PMC
October 2007

Cell surface dynamics of CFTR: the ins and outs.

Biochim Biophys Acta 2007 Apr 19;1773(4):476-9. Epub 2007 Jan 19.

Hospital for Sick Children Research Institutes, Cell Biology, 555 University Av., Toronto, Ontario, Canada M5G 1X8.

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http://dx.doi.org/10.1016/j.bbamcr.2007.01.004DOI Listing
April 2007

Decoding ubiquitin sorting signals for clathrin-dependent endocytosis by CLASPs.

J Cell Sci 2007 Feb;120(Pt 4):543-53

Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, PA 15261, USA, and Program in Cell and Lung Biology, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1242/jcs.03385DOI Listing
February 2007

Importin 13 regulates nuclear import of the glucocorticoid receptor in airway epithelial cells.

Am J Respir Cell Mol Biol 2006 Dec 29;35(6):668-80. Epub 2006 Jun 29.

McGill University-Montreal Children's Hospital Research Institute, Montreal, PQ, Canada.

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http://dx.doi.org/10.1165/rcmb.2006-0073OCDOI Listing
December 2006

Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions.

Mol Biol Cell 2006 Dec 20;17(12):4937-45. Epub 2006 Sep 20.

Department of Medicine and Physiology, University of California, San Francisco, San Francisco, CA 94143-0521, USA.

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http://dx.doi.org/10.1091/mbc.e06-08-0670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1679663PMC
December 2006

Nucleocytoplasmic transport of plasmid DNA: a perilous journey from the cytoplasm to the nucleus.

Hum Gene Ther 2006 Sep;17(9):882-9

Hospital for Sick Children, Program in Cell and Lung Biology, Department of Biochemistry and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, M5G 1X8 Canada.

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http://www.liebertpub.com/doi/10.1089/hum.2006.17.882
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http://dx.doi.org/10.1089/hum.2006.17.882DOI Listing
September 2006

CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis.

Curr Pharm Des 2006 ;12(18):2235-47

Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143-0521, USA.

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July 2006

The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.

Mol Biol Cell 2006 Jun 22;17(6):2513-23. Epub 2006 Mar 22.

Department of Biochemistry, Institute for Cancer Research, Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway.

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http://dx.doi.org/10.1091/mbc.e05-10-0915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474783PMC
June 2006

Molecular basis of oligoubiquitin-dependent internalization of membrane proteins in Mammalian cells.

Traffic 2006 Mar;7(3):282-97

Program in Cell and Lung Biology, Hospital for Sick Children Research Institute, Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada M5G 1X8.

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http://dx.doi.org/10.1111/j.1600-0854.2006.00384.xDOI Listing
March 2006

Oligomerization state of the DNA fragmentation factor in normal and apoptotic cells.

J Biol Chem 2005 Dec 3;280(48):40216-25. Epub 2005 Oct 3.

Program in Cell and Lung Biology, Hospital for Sick Children Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5G 1X8, Canada.

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http://www.jbc.org/content/280/48/40216.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M502220200
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http://dx.doi.org/10.1074/jbc.M502220200DOI Listing
December 2005

Intracellular routing of plasmid DNA during non-viral gene transfer.

Adv Drug Deliv Rev 2005 Apr;57(5):755-67

Hospital for Sick Children, Program in Cell and Lung Biology and Department of Laboratory Medicine and Pathobiology, University of Toronto, 555 University Av., Toronto, Ontario, Canada M5G 1X8.

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http://dx.doi.org/10.1016/j.addr.2004.12.008DOI Listing
April 2005

Destabilization of the transmembrane domain induces misfolding in a phenotypic mutant of cystic fibrosis transmembrane conductance regulator.

J Biol Chem 2005 Feb 10;280(6):4968-74. Epub 2004 Nov 10.

Division of Structural Biology and Biochemistry and Program in Cell and Lung Biology, Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1074/jbc.M410069200DOI Listing
February 2005

The DeltaF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR.

Nat Struct Mol Biol 2005 Jan 26;12(1):17-25. Epub 2004 Dec 26.

Hospital for Sick Children Research Institute, Program in Cell and Lung Biology, University of Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1038/nsmb882DOI Listing
January 2005

Contrasting nuclear dynamics of the caspase-activated DNase (CAD) in dividing and apoptotic cells.

J Cell Biol 2004 Dec 29;167(5):851-62. Epub 2004 Nov 29.

Hospital for Sick Children Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1083/jcb.200404105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172457PMC
December 2004

Proteomics techniques for cystic fibrosis research.

J Cyst Fibros 2004 Aug;3 Suppl 2:85-9

Centre of Human Genetics, National Institute of Health, Lisboa, Portugal.

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http://dx.doi.org/10.1016/j.jcf.2004.05.019DOI Listing
August 2004

Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects.

Science 2004 Apr;304(5670):600-2

Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, Post Office Box 208026, New Haven, CT 06520-8026, USA.

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http://dx.doi.org/10.1126/science.1093941DOI Listing
April 2004

Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes.

J Cell Biol 2004 Mar 8;164(6):923-33. Epub 2004 Mar 8.

Hospital for Sick Children, Program in Cell and Lung Biology, 555 University Ave., Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1083/jcb.200312018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172283PMC
March 2004

Pharmacologic approaches to correcting the basic defect in cystic fibrosis.

N Engl J Med 2003 Oct;349(15):1401-4

Program in Cell Biology, Research Institute, Hospital for Sick Children, Toronto.

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http://dx.doi.org/10.1056/NEJMp038113DOI Listing
October 2003

Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating.

J Biol Chem 2003 Sep 27;278(37):35079-85. Epub 2003 Jun 27.

Department of Medicine, University of California, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1074/jbc.M303098200DOI Listing
September 2003

CFTR folding and maturation in cells.

Methods Mol Med 2002 ;70:229-43

Program in Lung and Cell Biology, Hospital for Sick Children, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://link.springer.com/content/pdf/10.1385/1-59259-187-6:2
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http://link.springer.com/10.1385/1-59259-187-6:229
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http://dx.doi.org/10.1385/1-59259-187-6:229DOI Listing
September 2002

Intracellular barriers to non-viral gene transfer.

Curr Gene Ther 2002 May;2(2):183-94

Hospital for Sick Children, Program in Cell and Lung Biology, Department of Laboratory Medicine and Pathobiology, University of Toronto, 555 University Av., Toronto, Ontario, Canada, M5G 1X8.

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May 2002