Publications by authors named "Gerda Egger"

60Publications

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis.

Cancer Cell 2021 Jan 12;39(1):68-82.e9. Epub 2020 Nov 12.

Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), Bellinzona 6500, Switzerland; Università della Svizzera Italiana, Lugano 6900, Switzerland; Department of Medicine, University of Padua, Padua 35128, Italy; Department of Health Sciences and Technology (D-HEST) ETH Zurich, Zurich 8093, Switzerland. Electronic address:

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January 2021

Histone deacetylase inhibitors valproic acid and vorinostat enhance trastuzumab-mediated antibody-dependent cell-mediated phagocytosis.

J Immunother Cancer 2020 01 2;8(1). Epub 2020 Jan 2.

Division of General Surgery, Department of Surgery, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria

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January 2020

The Transcriptional Roles of ALK Fusion Proteins in Tumorigenesis.

Cancers (Basel) 2019 Jul 30;11(8). Epub 2019 Jul 30.

Department of Pathology, Medical University Vienna, 1090 Vienna, Austria.

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July 2019

Epigenetic biomarkers in cancer.

Authors:
Gerda Egger

ESMO Open 2018 3;3(5):e000416. Epub 2018 Aug 3.

Department of Pathology, Medical University of Vienna and Ludwig Boltzmann Institute Applied Diagnostics, Wien, Austria.

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August 2018

Progressive tissue biomarker profiling in non-muscle-invasive bladder cancer.

Expert Rev Anticancer Ther 2018 07 9;18(7):695-703. Epub 2018 May 9.

a Department of Urology , Medical University of Vienna , Vienna , Austria.

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July 2018

New avenues for targeted therapies and biomarkers in anaplastic large cell lymphoma.

Epigenomics 2017 02 18;9(2):97-100. Epub 2017 Jan 18.

Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Lab Block Level 3, Addenbrooke's Hospital, Cambridge CB20QQ, UK.

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February 2017

Insights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation Profiling.

Cell Rep 2016 10;17(2):596-608

Clinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria; European Research Initiative on ALK-Related Malignancies (ERIA), Cambridge CB2 0QQ, UK. Electronic address:

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October 2016

The role of AP-1 and epigenetics in ALCL.

Front Biosci (Schol Ed) 2015 Jun 1;7:226-35. Epub 2015 Jun 1.

Clinical Institute of Pathology, Medical University of Vienna, Wahringer Gürtel 18-20, A-1090 Vienna, Austria,

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June 2015

Brain-derived neurotrophic factor (BDNF)-epigenetic regulation in unipolar and bipolar affective disorder.

J Affect Disord 2014 Oct 19;168:399-406. Epub 2014 Jul 19.

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria; Zentrum für Seelische Gesundheit LEOpoldau, Vienna, Austria. Electronic address:

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October 2014

Cytosine 5-Hydroxymethylation of the LZTS1 Gene Is Reduced in Breast Cancer.

Transl Oncol 2013 Dec 1;6(6):715-21. Epub 2013 Dec 1.

Molecular Diagnostics Unit, Health and Environment Department, Austrian Institute of Technology, Vienna, Austria.

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December 2013

Combating the epigenome: epigenetic drugs against non-Hodgkin's lymphoma.

Epigenomics 2013 Aug;5(4):397-415

Clinical Institute of Pathology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

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August 2013

Epigenetics.

Biochimie 2012 Nov 11;94(11):2191-2. Epub 2012 Sep 11.

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November 2012

Antineoplastic activity of the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine in anaplastic large cell lymphoma.

Biochimie 2012 Nov 9;94(11):2297-307. Epub 2012 Jun 9.

Clinical Institute of Pathology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

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November 2012

Epigenomics of cancer - emerging new concepts.

Biochimie 2012 Nov 17;94(11):2219-30. Epub 2012 May 17.

Clinical Institute of Pathology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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November 2012

DNA methylation testing and marker validation using PCR: diagnostic applications.

Expert Rev Mol Diagn 2012 Jan;12(1):75-92

Clinical Institute of Pathology, Medical University of Vienna, Austria.

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January 2012

Identification of differential and functionally active miRNAs in both anaplastic lymphoma kinase (ALK)+ and ALK- anaplastic large-cell lymphoma.

Proc Natl Acad Sci U S A 2010 Sep 30;107(37):16228-33. Epub 2010 Aug 30.

Laboratory for Immunological and Molecular Cancer Research, Third Medical Department with Hematology, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.

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September 2010

Epigenetic regulation of a murine retrotransposon by a dual histone modification mark.

PLoS Genet 2010 Apr 29;6(4):e1000927. Epub 2010 Apr 29.

Max F. Perutz Laboratories, Medical University of Vienna, Vienna Biocenter, Vienna, Austria.

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April 2010

The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation.

Mol Cell Biol 2010 Mar 22;30(5):1171-81. Epub 2009 Dec 22.

Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, Vienna Biocenter, Dr. Bohr-Gasse 9/2, A-1030 Vienna, Austria.

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March 2010

Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling.

Proc Natl Acad Sci U S A 2009 Dec 16;106(48):20423-8. Epub 2009 Nov 16.

Institute of Clinical Pathology, Department of Internal Medicine III, Medical University of Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria.

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December 2009

Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA.

Mol Cell Biol 2009 Oct 20;29(19):5366-76. Epub 2009 Jul 20.

Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center Keck School of Medicine, University of Southern California, NOR 8302L, 9181, Los Angeles, CA 90089-9181, USA.

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October 2009

Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice.

Cancer Prev Res (Phila) 2008 Sep 19;1(4):233-40. Epub 2008 Mar 19.

Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033-9181, USA.

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September 2008

Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells.

Biochem Biophys Res Commun 2009 Feb 29;379(3):726-31. Epub 2008 Dec 29.

Department of Urology, Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089-9181, USA.

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February 2009

Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line.

Proc Natl Acad Sci U S A 2008 Sep 27;105(35):12979-84. Epub 2008 Aug 27.

Department of Urology, Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9181, USA.

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September 2008

Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island.

Cancer Cell 2007 Nov;12(5):432-44

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

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November 2007

Cancer epigenetics: modifications, screening, and therapy.

Annu Rev Med 2008 ;59:267-80

Department of Urology, Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles 90089, USA.

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May 2008

Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides.

Cancer Res 2007 Jul;67(13):6400-8

Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

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July 2007

Inhibition of histone deacetylation does not block resilencing of p16 after 5-aza-2'-deoxycytidine treatment.

Cancer Res 2007 Jan;67(1):346-53

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA.

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January 2007

Constitutive nucleosome depletion and ordered factor assembly at the GRP78 promoter revealed by single molecule footprinting.

PLoS Genet 2006 Sep;2(9):e160

Department of Urology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

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September 2006

Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival.

Proc Natl Acad Sci U S A 2006 Sep 8;103(38):14080-5. Epub 2006 Sep 8.

Norris Comprehensive Cancer Center, Departments of Urology and Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA.

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September 2006

Negative and positive regulation of gene expression by mouse histone deacetylase 1.

Mol Cell Biol 2006 Nov 28;26(21):7913-28. Epub 2006 Aug 28.

Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, A-1030 Vienna, Austria.

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November 2006

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells.

Cancer Cell 2006 Jun;9(6):435-43

Department of Urology, Biochemistry, and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA.

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June 2006

Footprinting of mammalian promoters: use of a CpG DNA methyltransferase revealing nucleosome positions at a single molecule level.

Nucleic Acids Res 2005 Nov 27;33(20):e176. Epub 2005 Nov 27.

Department of Urology, Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California Los Angeles, CA 90089-9181, USA.

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November 2005

Single inner cell masses yield embryonic stem cell lines differing in lifr expression and their developmental potential.

Biochem Biophys Res Commun 2005 Jun;331(4):1577-86

Max F. Perutz Laboratories, University Institutes at the Vienna Biocenter, Department of Medical Biochemistry, Division of Molecular Cell Biology, Medical University of Vienna, Dr. Bohrgasse 9, A1030 Vienna, Austria.

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June 2005

Epigenetics in human disease and prospects for epigenetic therapy.

Nature 2004 May;429(6990):457-63

Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, Room 8302L, Los Angeles, California 90089-9181, USA.

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May 2004

Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome.

Proc Natl Acad Sci U S A 2004 May 3;101(19):7357-62. Epub 2004 May 3.

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, MS 8302L, Los Angeles, CA 90089-9181.

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May 2004