Publications by authors named "Gerda Egger"

60Publications

Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK-driven lymphomagenesis.

Authors:
Elisa Redl Raheleh Sheibani-Tezerji Crhistian de Jesus Cardona Patricia Hamminger Gerald Timelthaler Melanie Rosalia Hassler Maša Zrimšek Sabine Lagger Thomas Dillinger Lorena Hofbauer Kristina Draganić Andreas Tiefenbacher Michael Kothmayer Charles H Dietz Bernard H Ramsahoye Lukas Kenner Christoph Bock Christian Seiser Wilfried Ellmeier Gabriele Schweikert Gerda Egger

Life Sci Alliance 2021 02 11;4(2). Epub 2020 Dec 11.

Department of Pathology, Medical University of Vienna, Vienna, Austria

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February 2021

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis.

Authors:
Ilaria Guccini Ajinkya Revandkar Mariantonietta D'Ambrosio Manuel Colucci Emiliano Pasquini Simone Mosole Martina Troiani Daniela Brina Raheleh Sheibani-Tezerji Angela Rita Elia Andrea Rinaldi Nicolò Pernigoni Jan Hendrik Rüschoff Susanne Dettwiler Angelo M De Marzo Emmanuel S Antonarakis Costanza Borrelli Andreas E Moor Ramon Garcia-Escudero Abdullah Alajati Giuseppe Attanasio Marco Losa Holger Moch Peter Wild Gerda Egger Andrea Alimonti

Cancer Cell 2021 Jan 12;39(1):68-82.e9. Epub 2020 Nov 12.

Institute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), Bellinzona 6500, Switzerland; Università della Svizzera Italiana, Lugano 6900, Switzerland; Department of Medicine, University of Padua, Padua 35128, Italy; Department of Health Sciences and Technology (D-HEST) ETH Zurich, Zurich 8093, Switzerland. Electronic address:

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January 2021

ALK-transformed mature T lymphocytes restore early thymus progenitor features.

Authors:
Annabelle Congras Coralie Hoareau-Aveilla Nina Caillet Marie Tosolini Patrick Villarese Agata Cieslak Laura Rodriguez Vahid Asnafi Elisabeth Macintyre Gerda Egger Pierre Brousset Laurence Lamant Fabienne Meggetto

J Clin Invest 2020 Dec;130(12):6395-6408

INSERM, UMR1037 CRCT, F-31000, Toulouse, France.

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December 2020

Thyroid and androgen receptor signaling are antagonized by μ-Crystallin in prostate cancer.

Authors:
Osman Aksoy Jan Pencik Markus Hartenbach Ali A Moazzami Michaela Schlederer Theresa Balber Adam Varady Cecile Philippe Pascal A Baltzer Bismoy Mazumder Jonathan B Whitchurch Christopher J Roberts Andrea Haitel Merima Herac Martin Susani Markus Mitterhauser Rodrig Marculescu Judith Stangl-Kremser Melanie R Hassler Gero Kramer Shahrokh F Shariat Suzanne D Turner Boris Tichy Jan Oppelt Sarka Pospisilova Sabrina Hartenbach Simone Tangermann Gerda Egger Heidi A Neubauer Richard Moriggl Zoran Culig Georg Greiner Gregor Hoermann Marcus Hacker David M Heery Olaf Merkel Lukas Kenner

Int J Cancer 2021 Feb 31;148(3):731-747. Epub 2020 Oct 31.

Department of Pathology, Medical University Vienna, Vienna, Austria.

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February 2021

Discovery of Molecular DNA Methylation-Based Biomarkers through Genome-Wide Analysis of Response Patterns to BCG for Bladder Cancer.

Authors:
Dafina Ilijazi Walter Pulverer Iris E Ertl Ursula Lemberger Shoji Kimura Mohammad Abufaraj David D'Andrea Benjamin Pradere Andreas Bruchbacher Anna Graf Francesco Soria Martin Susani Andrea Haitel Luca Molinaro Armin Pycha Evi Comploj Stephan Pabinger Andreas Weinhäusel Gerda Egger Shahrokh F Shariat Melanie R Hassler

Cells 2020 08 5;9(8). Epub 2020 Aug 5.

Department of Urology, Medical University of Vienna, 1090 Vienna, Austria.

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August 2020

Attenuation of canonical NF-κB signaling maintains function and stability of human Treg.

Authors:
Liesa S Ziegler Marlene C Gerner Ralf L J Schmidt Doris Trapin Peter Steinberger Winfried F Pickl Christian Sillaber Gerda Egger Ilse Schwarzinger Klaus G Schmetterer

FEBS J 2021 Jan 28;288(2):640-662. Epub 2020 May 28.

Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.

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January 2021

Vorinostat in the acute neuroinflammatory form of X-linked adrenoleukodystrophy.

Authors:
Bettina Zierfuss Isabelle Weinhofer Jörn-Sven Kühl Wolfgang Köhler Annette Bley Katharina Zauner Johannes Binder Ksenija Martinović Christian Seiser Christoph Hertzberg Stephan Kemp Gerda Egger Gerda Leitner Jan Bauer Christoph Wiesinger Markus Kunze Sonja Forss-Petter Johannes Berger

Ann Clin Transl Neurol 2020 05 2;7(5):639-652. Epub 2020 May 2.

Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Vienna, Austria.

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May 2020

STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer.

Authors:
Monika Oberhuber Matteo Pecoraro Mate Rusz Georg Oberhuber Maritta Wieselberg Peter Haslinger Elisabeth Gurnhofer Michaela Schlederer Tanja Limberger Sabine Lagger Jan Pencik Petra Kodajova Sandra Högler Georg Stockmaier Sandra Grund-Gröschke Fritz Aberger Marco Bolis Jean-Philippe Theurillat Robert Wiebringhaus Theresa Weiss Andrea Haitel Marc Brehme Wolfgang Wadsak Johannes Griss Thomas Mohr Alexandra Hofer Anton Jäger Jürgen Pollheimer Gerda Egger Gunda Koellensperger Matthias Mann Brigitte Hantusch Lukas Kenner

Mol Syst Biol 2020 04;16(4):e9247

Department of Pathology, Medical University of Vienna, Vienna, Austria.

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April 2020

Histone deacetylase inhibitors valproic acid and vorinostat enhance trastuzumab-mediated antibody-dependent cell-mediated phagocytosis.

Authors:
Johannes Laengle Julijan Kabiljo Leah Hunter Jakob Homola Sophie Prodinger Gerda Egger Michael Bergmann

J Immunother Cancer 2020 01 2;8(1). Epub 2020 Jan 2.

Division of General Surgery, Department of Surgery, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria

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January 2020

The Transcriptional Roles of ALK Fusion Proteins in Tumorigenesis.

Authors:
Stephen P Ducray Karthikraj Natarajan Gavin D Garland Suzanne D Turner Gerda Egger

Cancers (Basel) 2019 Jul 30;11(8). Epub 2019 Jul 30.

Department of Pathology, Medical University Vienna, 1090 Vienna, Austria.

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July 2019

Radiopharmaceutical Evidence for MCHR1 Binding Sites in Murine Brown Adipocytes.

Authors:
Theresa Balber Katarína Benčurová Florian Wolfgang Kiefer Oana Cristina Kulterer Eva-Maria Klebermass Gerda Egger Loan Tran Karl-Heinz Wagner Helmut Viernstein Katharina Pallitsch Helmut Spreitzer Marcus Hacker Wolfgang Wadsak Markus Mitterhauser Cécile Philippe

Front Endocrinol (Lausanne) 2019 11;10:324. Epub 2019 Jun 11.

Division of Nuclear Medicine, Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.

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June 2019

Genome amplification and cellular senescence are hallmarks of human placenta development.

Authors:
Philipp Velicky Gudrun Meinhardt Kerstin Plessl Sigrid Vondra Tamara Weiss Peter Haslinger Thomas Lendl Karin Aumayr Mario Mairhofer Xiaowei Zhu Birgit Schütz Roberta L Hannibal Robert Lindau Beatrix Weil Jan Ernerudh Jürgen Neesen Gerda Egger Mario Mikula Clemens Röhrl Alexander E Urban Julie Baker Martin Knöfler Jürgen Pollheimer

PLoS Genet 2018 10 12;14(10):e1007698. Epub 2018 Oct 12.

Department of Obstetrics and Gynaecology, Reproductive Biology Unit, Medical University of Vienna, Vienna, Austria.

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October 2018

Epigenetic biomarkers in cancer.

Authors:
Gerda Egger

ESMO Open 2018 3;3(5):e000416. Epub 2018 Aug 3.

Department of Pathology, Medical University of Vienna and Ludwig Boltzmann Institute Applied Diagnostics, Wien, Austria.

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August 2018

Progressive tissue biomarker profiling in non-muscle-invasive bladder cancer.

Authors:
David D'Andrea Melanie R Hassler Mohammad Abufaraj Francesco Soria Iris E Ertl Dafina Ilijazi Andrea Mari Beat Foerster Gerda Egger Shahrokh F Shariat

Expert Rev Anticancer Ther 2018 07 9;18(7):695-703. Epub 2018 May 9.

a Department of Urology , Medical University of Vienna , Vienna , Austria.

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July 2018

Hepatocyte specific expression of an oncogenic variant of β-catenin results in lethal metabolic dysfunction in mice.

Authors:
Ursula J Lemberger Claudia D Fuchs Christian Schöfer Andrea Bileck Christopher Gerner Tatjana Stojakovic Makoto M Taketo Michael Trauner Gerda Egger Christoph H Österreicher

Oncotarget 2018 Feb 30;9(13):11243-11257. Epub 2018 Jan 30.

Institute of Pharmacology, Medical University Vienna, Vienna, Austria.

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February 2018

New avenues for targeted therapies and biomarkers in anaplastic large cell lymphoma.

Authors:
Gerda Egger Suzanne D Turner

Epigenomics 2017 02 18;9(2):97-100. Epub 2017 Jan 18.

Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Lab Block Level 3, Addenbrooke's Hospital, Cambridge CB20QQ, UK.

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February 2017

Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease.

Authors:
Ursula J Lemberger Claudia D Fuchs Matthias Karer Stefanie Haas Tatjana Stojakovic Christian Schöfer Hanns-Ulrich Marschall Fritz Wrba Makoto M Taketo Gerda Egger Michael Trauner Christoph H Österreicher

Oncotarget 2016 Dec;7(52):86985-86998

Institute of Pharmacology, Medical University of Vienna, Vienna, Austria.

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December 2016

Insights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation Profiling.

Authors:
Melanie R Hassler Walter Pulverer Ranjani Lakshminarasimhan Elisa Redl Julia Hacker Gavin D Garland Olaf Merkel Ana-Iris Schiefer Ingrid Simonitsch-Klupp Lukas Kenner Daniel J Weisenberger Andreas Weinhaeusel Suzanne D Turner Gerda Egger

Cell Rep 2016 10;17(2):596-608

Clinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria; European Research Initiative on ALK-Related Malignancies (ERIA), Cambridge CB2 0QQ, UK. Electronic address:

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October 2016

Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis.

Authors:
Jan Pencik Michaela Schlederer Wolfgang Gruber Christine Unger Steven M Walker Athena Chalaris Isabelle J Marié Melanie R Hassler Tahereh Javaheri Osman Aksoy Jaine K Blayney Nicole Prutsch Anna Skucha Merima Herac Oliver H Krämer Peter Mazal Florian Grebien Gerda Egger Valeria Poli Wolfgang Mikulits Robert Eferl Harald Esterbauer Richard Kennedy Falko Fend Marcus Scharpf Martin Braun Sven Perner David E Levy Tim Malcolm Suzanne D Turner Andrea Haitel Martin Susani Ali Moazzami Stefan Rose-John Fritz Aberger Olaf Merkel Richard Moriggl Zoran Culig Helmut Dolznig Lukas Kenner

Nat Commun 2015 Oct 26;6:8802. Epub 2015 Oct 26.

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October 2015

Potential of DNA methylation in rectal cancer as diagnostic and prognostic biomarkers.

Authors:
Ruth Exner Walter Pulverer Martina Diem Lisa Spaller Laura Woltering Martin Schreiber Brigitte Wolf Markus Sonntagbauer Fabian Schröder Judith Stift Fritz Wrba Michael Bergmann Andreas Weinhäusel Gerda Egger

Br J Cancer 2015 Sep 3;113(7):1035-45. Epub 2015 Sep 3.

Clinical Institute of Pathology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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September 2015

STAT3 regulated ARF expression suppresses prostate cancer metastasis.

Authors:
Jan Pencik Michaela Schlederer Wolfgang Gruber Christine Unger Steven M Walker Athena Chalaris Isabelle J Marié Melanie R Hassler Tahereh Javaheri Osman Aksoy Jaine K Blayney Nicole Prutsch Anna Skucha Merima Herac Oliver H Krämer Peter Mazal Florian Grebien Gerda Egger Valeria Poli Wolfgang Mikulits Robert Eferl Harald Esterbauer Richard Kennedy Falko Fend Marcus Scharpf Martin Braun Sven Perner David E Levy Tim Malcolm Suzanne D Turner Andrea Haitel Martin Susani Ali Moazzami Stefan Rose-John Fritz Aberger Olaf Merkel Richard Moriggl Zoran Culig Helmut Dolznig Lukas Kenner

Nat Commun 2015 Jul 22;6:7736. Epub 2015 Jul 22.

1] Ludwig Boltzmann Institute for Cancer Research, Waehringerstrasse 13A, 1090 Vienna, Austria [2] Clinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria [3] Unit of Pathology of Laboratory Animals (UPLA), University of Veterinary Medicine Vienna, 1210 Vienna, Austria.

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July 2015

The role of AP-1 and epigenetics in ALCL.

Authors:
Ana-Iris Schiefer Paul Vesely Melanie R Hassler Gerda Egger Lukas Kenner

Front Biosci (Schol Ed) 2015 Jun 1;7:226-35. Epub 2015 Jun 1.

Clinical Institute of Pathology, Medical University of Vienna, Wahringer Gürtel 18-20, A-1090 Vienna, Austria,

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June 2015

Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2;5) translocation.

Authors:
Olaf Merkel Frank Hamacher Robert Griessl Lisa Grabner Ana-Iris Schiefer Nicole Prutsch Constance Baer Gerda Egger Michaela Schlederer Peter William Krenn Tanja Nicole Hartmann Ingrid Simonitsch-Klupp Christoph Plass Philipp Bernhard Staber Richard Moriggl Suzanne D Turner Richard Greil Lukas Kenner

J Pathol 2015 Aug 27;236(4):445-56. Epub 2015 Apr 27.

Department of Clinical Pathology, Medical University Vienna, Austria.

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August 2015

Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis.

Authors:
Beatrice Grabner Daniel Schramek Kristina M Mueller Herwig P Moll Jasmin Svinka Thomas Hoffmann Eva Bauer Leander Blaas Natascha Hruschka Katalin Zboray Patricia Stiedl Harini Nivarthi Edith Bogner Wolfgang Gruber Thomas Mohr Ralf Harun Zwick Lukas Kenner Valeria Poli Fritz Aberger Dagmar Stoiber Gerda Egger Harald Esterbauer Johannes Zuber Richard Moriggl Robert Eferl Balázs Győrffy Josef M Penninger Helmut Popper Emilio Casanova

Nat Commun 2015 Mar 3;6:6285. Epub 2015 Mar 3.

1] Ludwig Boltzmann Institute for Cancer Research (LBI-CR), Vienna 1090, Austria [2] Department of Physiology, Center of Physiology and Pharmacology, Comprehensive Cancer Center, Medical University of Vienna, Vienna 1090, Austria.

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March 2015

Strategies for validation and testing of DNA methylation biomarkers.

Authors:
Christa Noehammer Walter Pulverer Melanie R Hassler Manuela Hofner Matthias Wielscher Klemens Vierlinger Triantafillos Liloglou David McCarthy Taylor J Jensen Anders Nygren Henning Gohlke Geert Trooskens Maarten Braspenning Wim Van Criekinge Gerda Egger Andreas Weinhaeusel

Epigenomics 2014 ;6(6):603-22

Health & Environment Department, Molecular Diagnostics, AIT Austrian Institute of Technology, Vienna, Austria.

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August 2015

Brain-derived neurotrophic factor (BDNF)-epigenetic regulation in unipolar and bipolar affective disorder.

Authors:
Laura Carlberg Janine Scheibelreiter Melanie R Hassler Monika Schloegelhofer Michaela Schmoeger Birgit Ludwig Siegfried Kasper Harald Aschauer Gerda Egger Alexandra Schosser

J Affect Disord 2014 Oct 19;168:399-406. Epub 2014 Jul 19.

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria; Zentrum für Seelische Gesundheit LEOpoldau, Vienna, Austria. Electronic address:

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October 2014

Cytosine 5-Hydroxymethylation of the LZTS1 Gene Is Reduced in Breast Cancer.

Authors:
Matthias Wielscher Willy Liou Walter Pulverer Christian F Singer Christine Rappaport-Fuerhauser Daniela Kandioler Gerda Egger Andreas Weinhäusel

Transl Oncol 2013 Dec 1;6(6):715-21. Epub 2013 Dec 1.

Molecular Diagnostics Unit, Health and Environment Department, Austrian Institute of Technology, Vienna, Austria.

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December 2013

Combating the epigenome: epigenetic drugs against non-Hodgkin's lymphoma.

Authors:
Melanie R Hassler Ana-Iris Schiefer Gerda Egger

Epigenomics 2013 Aug;5(4):397-415

Clinical Institute of Pathology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

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August 2013

Increased copy-number and not DNA hypomethylation causes overexpression of the candidate proto-oncogene CYP24A1 in colorectal cancer.

Authors:
Julia Höbaus Doris M Hummel Ursula Thiem Irfete S Fetahu Abhishek Aggarwal Leonhard Müllauer Gerwin Heller Gerda Egger Ildiko Mesteri Sabina Baumgartner-Parzer Enikö Kallay

Int J Cancer 2013 Sep 5;133(6):1380-8. Epub 2013 Apr 5.

Department of Pathophysiology, Medical University of Vienna, Vienna, 1090, Austria.

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September 2013

Enhanced lymph vessel density, remodeling, and inflammation are reflected by gene expression signatures in dermal lymphatic endothelial cells in type 2 diabetes.

Authors:
Monika Haemmerle Thomas Keller Gerda Egger Helga Schachner Carl Walter Steiner Dejan Stokic Christoph Neumayer Markus K Brown Dontscho Kerjaschki Brigitte Hantusch

Diabetes 2013 Jul 19;62(7):2509-29. Epub 2013 Feb 19.

Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.

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July 2013

The dichloromethane extract of the ethnomedicinal plant Neurolaena lobata inhibits NPM/ALK expression which is causal for anaplastic large cell lymphomagenesis.

Authors:
Christine Unger Ruxandra Popescu Benedikt Giessrigl Daniela Laimer Susanne Heider Mareike Seelinger Rene Diaz Bruno Wallnöfer Gerda Egger Melanie Hassler Martin Knöfler Leila Saleh Emine Sahin Michael Grusch Monika Fritzer-Szekeres Helmut Dolznig Richard Frisch Lukas Kenner Brigitte Kopp Georg Krupitza

Int J Oncol 2013 Jan 6;42(1):338-48. Epub 2012 Nov 6.

Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.

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January 2013

PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas.

Authors:
Daniela Laimer Helmut Dolznig Karoline Kollmann Paul W Vesely Michaela Schlederer Olaf Merkel Ana-Iris Schiefer Melanie R Hassler Susi Heider Lena Amenitsch Christiane Thallinger Philipp B Staber Ingrid Simonitsch-Klupp Matthias Artaker Sabine Lagger Suzanne D Turner Stefano Pileri Pier Paolo Piccaluga Peter Valent Katia Messana Indira Landra Thomas Weichhart Sylvia Knapp Medhat Shehata Maria Todaro Veronika Sexl Gerald Höfler Roberto Piva Enzo Medico Bruce A Ruggeri Mangeng Cheng Robert Eferl Gerda Egger Josef M Penninger Ulrich Jaeger Richard Moriggl Giorgio Inghirami Lukas Kenner

Nat Med 2012 Nov 14;18(11):1699-704. Epub 2012 Oct 14.

Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.

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November 2012

Epigenetics.

Authors:
Paola B Arimondo Gerda Egger Jorg Tost

Biochimie 2012 Nov 11;94(11):2191-2. Epub 2012 Sep 11.

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November 2012

Antineoplastic activity of the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine in anaplastic large cell lymphoma.

Authors:
Melanie R Hassler Aleksandra Klisaroska Karoline Kollmann Irene Steiner Martin Bilban Ana-Iris Schiefer Veronika Sexl Gerda Egger

Biochimie 2012 Nov 9;94(11):2297-307. Epub 2012 Jun 9.

Clinical Institute of Pathology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

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November 2012

Epigenomics of cancer - emerging new concepts.

Authors:
Melanie R Hassler Gerda Egger

Biochimie 2012 Nov 17;94(11):2219-30. Epub 2012 May 17.

Clinical Institute of Pathology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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November 2012

DNA methylation testing and marker validation using PCR: diagnostic applications.

Authors:
Gerda Egger Matthias Wielscher Walter Pulverer Albert Kriegner Andreas Weinhäusel

Expert Rev Mol Diagn 2012 Jan;12(1):75-92

Clinical Institute of Pathology, Medical University of Vienna, Austria.

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January 2012

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.

Authors:
Kristina M Mueller Jan-Wilhelm Kornfeld Katrin Friedbichler Leander Blaas Gerda Egger Harald Esterbauer Peter Hasselblatt Michaela Schlederer Susanne Haindl Kay-Uwe Wagner David Engblom Guenter Haemmerle Dagmar Kratky Veronika Sexl Lukas Kenner Andrey V Kozlov Luigi Terracciano Rudolf Zechner Guenther Schuetz Emilio Casanova J Andrew Pospisilik Markus H Heim Richard Moriggl

Hepatology 2011 Oct;54(4):1398-409

Ludwig-Boltzmann-Institute for Cancer Research, Vienna, Austria.

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October 2011

High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia.

Authors:
Wolfgang Warsch Karoline Kollmann Eva Eckelhart Sabine Fajmann Sabine Cerny-Reiterer Andrea Hölbl Karoline V Gleixner Michael Dworzak Matthias Mayerhofer Gregor Hoermann Harald Herrmann Christian Sillaber Gerda Egger Peter Valent Richard Moriggl Veronika Sexl

Blood 2011 Mar 10;117(12):3409-20. Epub 2011 Jan 10.

Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

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March 2011

Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans.

Authors:
Sabine Lagger Dominique Meunier Mario Mikula Reinhard Brunmeir Michaela Schlederer Matthias Artaker Oliver Pusch Gerda Egger Astrid Hagelkruys Wolfgang Mikulits Georg Weitzer Ernst W Muellner Martin Susani Lukas Kenner Christian Seiser

EMBO J 2010 Dec 22;29(23):3992-4007. Epub 2010 Oct 22.

Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Vienna Biocenter, Vienna, Austria.

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December 2010

Identification of differential and functionally active miRNAs in both anaplastic lymphoma kinase (ALK)+ and ALK- anaplastic large-cell lymphoma.

Authors:
Olaf Merkel Frank Hamacher Daniela Laimer Eveline Sifft Zlatko Trajanoski Marcel Scheideler Gerda Egger Melanie R Hassler Christiane Thallinger Ana Schmatz Suzanne D Turner Richard Greil Lukas Kenner

Proc Natl Acad Sci U S A 2010 Sep 30;107(37):16228-33. Epub 2010 Aug 30.

Laboratory for Immunological and Molecular Cancer Research, Third Medical Department with Hematology, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.

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September 2010

Epigenetic regulation of a murine retrotransposon by a dual histone modification mark.

Authors:
Reinhard Brunmeir Sabine Lagger Elisabeth Simboeck Anna Sawicka Gerda Egger Astrid Hagelkruys Yu Zhang Patrick Matthias Wolfgang J Miller Christian Seiser

PLoS Genet 2010 Apr 29;6(4):e1000927. Epub 2010 Apr 29.

Max F. Perutz Laboratories, Medical University of Vienna, Vienna Biocenter, Vienna, Austria.

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April 2010

Disruption of the growth hormone--signal transducer and activator of transcription 5--insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis.

Authors:
Leander Blaas Jan-Wilhelm Kornfeld Daniel Schramek Monica Musteanu Gernot Zollner Judith Gumhold Franziska van Zijl Doris Schneller Harald Esterbauer Gerda Egger Markus Mair Lukas Kenner Wolfgang Mikulits Robert Eferl Richard Moriggl Josef Penninger Michael Trauner Emilio Casanova

Hepatology 2010 Apr;51(4):1319-26

Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.

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April 2010

The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation.

Authors:
Gordin Zupkovitz Reinhard Grausenburger Reinhard Brunmeir Silvia Senese Julia Tischler Jennifer Jurkin Martina Rembold Dominique Meunier Gerda Egger Sabine Lagger Susanna Chiocca Fritz Propst Georg Weitzer Christian Seiser

Mol Cell Biol 2010 Mar 22;30(5):1171-81. Epub 2009 Dec 22.

Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, Vienna Biocenter, Dr. Bohr-Gasse 9/2, A-1030 Vienna, Austria.

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March 2010

Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling.

Authors:
Pamina Pflegerl Paul Vesely Brigitte Hantusch Michaela Schlederer Rainer Zenz Elke Janig Günter Steiner Arabella Meixner Peter Petzelbauer Peter Wolf Afschin Soleiman Gerda Egger Richard Moriggl Tadamitsu Kishimoto Erwin F Wagner Lukas Kenner

Proc Natl Acad Sci U S A 2009 Dec 16;106(48):20423-8. Epub 2009 Nov 16.

Institute of Clinical Pathology, Department of Internal Medicine III, Medical University of Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria.

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December 2009

Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA.

Authors:
Shinwu Jeong Gangning Liang Shikhar Sharma Joy C Lin Si Ho Choi Han Han Christine B Yoo Gerda Egger Allen S Yang Peter A Jones

Mol Cell Biol 2009 Oct 20;29(19):5366-76. Epub 2009 Jul 20.

Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center Keck School of Medicine, University of Southern California, NOR 8302L, 9181, Los Angeles, CA 90089-9181, USA.

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October 2009

Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice.

Authors:
Christine B Yoo Jody C Chuang Hyang-Min Byun Gerda Egger Allen S Yang Louis Dubeau Tiffany Long Peter W Laird Victor E Marquez Peter A Jones

Cancer Prev Res (Phila) 2008 Sep 19;1(4):233-40. Epub 2008 Mar 19.

Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033-9181, USA.

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September 2008

Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells.

Authors:
Yoshimasa Saito Jeffrey M Friedman Yoshitomo Chihara Gerda Egger Jody C Chuang Gangning Liang

Biochem Biophys Res Commun 2009 Feb 29;379(3):726-31. Epub 2008 Dec 29.

Department of Urology, Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089-9181, USA.

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February 2009

Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line.

Authors:
Einav Nili Gal-Yam Gerda Egger Leo Iniguez Heather Holster Steingrímur Einarsson Xinmin Zhang Joy C Lin Gangning Liang Peter A Jones Amos Tanay

Proc Natl Acad Sci U S A 2008 Sep 27;105(35):12979-84. Epub 2008 Aug 27.

Department of Urology, Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9181, USA.

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September 2008

Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island.

Authors:
Joy C Lin Shinwu Jeong Gangning Liang Daiya Takai Merhnaz Fatemi Yvonne C Tsai Gerda Egger Einav Nili Gal-Yam Peter A Jones

Cancer Cell 2007 Nov;12(5):432-44

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

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November 2007

Cancer epigenetics: modifications, screening, and therapy.

Authors:
Einav Nili Gal-Yam Yoshimasa Saito Gerda Egger Peter A Jones

Annu Rev Med 2008 ;59:267-80

Department of Urology, Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles 90089, USA.

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May 2008

Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides.

Authors:
Christine B Yoo Shinwu Jeong Gerda Egger Gangning Liang Pasit Phiasivongsa Chunlin Tang Sanjeev Redkar Peter A Jones

Cancer Res 2007 Jul;67(13):6400-8

Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

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July 2007

Inhibition of histone deacetylation does not block resilencing of p16 after 5-aza-2'-deoxycytidine treatment.

Authors:
Gerda Egger Ana M Aparicio Sonia G Escobar Peter A Jones

Cancer Res 2007 Jan;67(1):346-53

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA.

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January 2007

Constitutive nucleosome depletion and ordered factor assembly at the GRP78 promoter revealed by single molecule footprinting.

Authors:
Einav Nili Gal-Yam Shinwu Jeong Amos Tanay Gerda Egger Amy S Lee Peter A Jones

PLoS Genet 2006 Sep;2(9):e160

Department of Urology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

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September 2006

Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival.

Authors:
Gerda Egger Shinwu Jeong Sonia G Escobar Connie C Cortez Tony W H Li Yoshimasa Saito Christine B Yoo Peter A Jones Gangning Liang

Proc Natl Acad Sci U S A 2006 Sep 8;103(38):14080-5. Epub 2006 Sep 8.

Norris Comprehensive Cancer Center, Departments of Urology and Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA.

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September 2006

Negative and positive regulation of gene expression by mouse histone deacetylase 1.

Authors:
Gordin Zupkovitz Julia Tischler Markus Posch Iwona Sadzak Katrin Ramsauer Gerda Egger Reinhard Grausenburger Norbert Schweifer Susanna Chiocca Thomas Decker Christian Seiser

Mol Cell Biol 2006 Nov 28;26(21):7913-28. Epub 2006 Aug 28.

Max F. Perutz Laboratories, Department of Medical Biochemistry, Medical University of Vienna, A-1030 Vienna, Austria.

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November 2006

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells.

Authors:
Yoshimasa Saito Gangning Liang Gerda Egger Jeffrey M Friedman Jody C Chuang Gerhard A Coetzee Peter A Jones

Cancer Cell 2006 Jun;9(6):435-43

Department of Urology, Biochemistry, and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA.

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June 2006

Footprinting of mammalian promoters: use of a CpG DNA methyltransferase revealing nucleosome positions at a single molecule level.

Authors:
Mehrnaz Fatemi Martha M Pao Shinwu Jeong Einav Nili Gal-Yam Gerda Egger Daniel J Weisenberger Peter A Jones

Nucleic Acids Res 2005 Nov 27;33(20):e176. Epub 2005 Nov 27.

Department of Urology, Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California Los Angeles, CA 90089-9181, USA.

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November 2005

Single inner cell masses yield embryonic stem cell lines differing in lifr expression and their developmental potential.

Authors:
Martin Lauss Martina Stary Julia Tischler Gerda Egger Sonja Puz Alice Bader-Allmer Christian Seiser Georg Weitzer

Biochem Biophys Res Commun 2005 Jun;331(4):1577-86

Max F. Perutz Laboratories, University Institutes at the Vienna Biocenter, Department of Medical Biochemistry, Division of Molecular Cell Biology, Medical University of Vienna, Dr. Bohrgasse 9, A1030 Vienna, Austria.

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June 2005

Epigenetics in human disease and prospects for epigenetic therapy.

Authors:
Gerda Egger Gangning Liang Ana Aparicio Peter A Jones

Nature 2004 May;429(6990):457-63

Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, Room 8302L, Los Angeles, California 90089-9181, USA.

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May 2004

Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome.

Authors:
Gangning Liang Joy C Y Lin Vivian Wei Christine Yoo Jonathan C Cheng Carvell T Nguyen Daniel J Weisenberger Gerda Egger Daiya Takai Felicidad A Gonzales Peter A Jones

Proc Natl Acad Sci U S A 2004 May 3;101(19):7357-62. Epub 2004 May 3.

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, MS 8302L, Los Angeles, CA 90089-9181.

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May 2004