Gerd Mikus

Gerd Mikus

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Gerd Mikus

Gerd Mikus

Publications by authors named "Gerd Mikus"

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Oral Yohimbine as a New Probe Drug to Predict CYP2D6 Activity: Results of a Fixed-Sequence Phase I Trial.

Clin Pharmacokinet 2020 Feb 15. Epub 2020 Feb 15.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s40262-020-00862-6DOI Listing
February 2020

Prophylactic Use of Enoxaparin in Adolescents During Bariatric Surgery-a Prospective Clinical Study.

Obes Surg 2020 Jan;30(1):63-68

Division of Pediatric Clinical Pharmacology, Children's National Health System/The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

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http://dx.doi.org/10.1007/s11695-019-04135-5DOI Listing
January 2020

A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug-Drug Interactions.

Clin Pharmacokinet 2019 Dec 19. Epub 2019 Dec 19.

Department I of Pharmacology, Center for Pharmacology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Gleueler Straße 24, 50931, Cologne, Germany.

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http://dx.doi.org/10.1007/s40262-019-00856-zDOI Listing
December 2019

Midazolam Pharmacokinetics in Obese and Non-obese Children and Adolescents.

Clin Pharmacokinet 2019 Nov 19. Epub 2019 Nov 19.

Department of Clinical Pharmacology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Bispebjerg Bakke, Entrance 20C, 2nd floor, 2400, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s40262-019-00838-1DOI Listing
November 2019

Simultaneous phenotyping of CYP2E1 and CYP3A using oral chlorzoxazone and midazolam microdoses.

Br J Clin Pharmacol 2019 Oct 9;85(10):2310-2320. Epub 2019 Aug 9.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Germany.

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http://dx.doi.org/10.1111/bcp.14040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783597PMC
October 2019

Minor contribution of cytochrome P450 3A activity on fentanyl exposure in palliative care cancer patients.

Sci Rep 2019 Oct 10;9(1):14635. Epub 2019 Oct 10.

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41598-019-51279-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786992PMC
October 2019

Microdosed Cocktail of Three Oral Factor Xa Inhibitors to Evaluate Drug-Drug Interactions with Potential Perpetrator Drugs.

Clin Pharmacokinet 2019 Sep;58(9):1155-1163

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s40262-019-00749-1DOI Listing
September 2019

Decreased Cytochrome P450 3A activity in palliative patients with haematological diseases: Potential impact on supportive drug therapies.

Basic Clin Pharmacol Toxicol 2019 Aug 15;125(2):117-122. Epub 2019 Apr 15.

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1111/bcpt.13232DOI Listing
August 2019

Novel insights into the complex pharmacokinetics of voriconazole: a review of its metabolism.

Drug Metab Rev 2019 08 16;51(3):247-265. Epub 2019 Aug 16.

Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin , Berlin , Germany.

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http://dx.doi.org/10.1080/03602532.2019.1632888DOI Listing
August 2019

Quantification of microdosed oral yohimbine and its major metabolite in human plasma in the picogram range.

Bioanalysis 2019 Aug 14;11(16):1459-1467. Epub 2019 Aug 14.

Department of Clinical Pharmacology & Pharmacoepidemiology, Im Neuenheimer Feld 410, Heidelberg University Hospital, Heidelberg 69120, Germany.

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http://dx.doi.org/10.4155/bio-2019-0129DOI Listing
August 2019

Alteration of drug-metabolizing enzyme activity in palliative care patients: Microdosed assessment of cytochrome P450 3A.

Palliat Med 2019 07 26;33(7):850-855. Epub 2019 Apr 26.

2 Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1177/0269216319843629DOI Listing
July 2019

Microdosed midazolam for the determination of cytochrome P450 3A activity: Development and clinical evaluation of a buccal film.

Eur J Pharm Sci 2019 Jul 16;135:77-82. Epub 2019 May 16.

Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2019.05.010DOI Listing
July 2019

Probes and Cocktails for Drug-Drug Interaction Evaluation: The Future Is Microdosing?

Authors:
Gerd Mikus

Clin Pharmacol Ther 2019 Jun 12;105(6):1335-1337. Epub 2019 Feb 12.

Department of Clinical Pharmacology & Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1002/cpt.1350DOI Listing
June 2019

Methodological Considerations on CYP2D6 Phenoconversion Due to Drug-Drug Interaction.

Clin Pharmacol Ther 2019 05 10;105(5):1076. Epub 2019 Feb 10.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/cpt.1336DOI Listing
May 2019

A follow-up report on potential drug interactions with clementines: Two single case experiments show no effect on CYP3A-dependent midazolam clearance.

Eur J Pharm Sci 2019 May 21;133:54-58. Epub 2019 Mar 21.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2019.03.013DOI Listing
May 2019

No alteration of voriconazole concentration by plasmapheresis in a critically ill patient.

Eur J Clin Pharmacol 2019 Feb 22;75(2):287-288. Epub 2018 Oct 22.

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00228-018-2582-6DOI Listing
February 2019

Obesity-induced CYP2E1 activity in children.

Br J Clin Pharmacol 2019 02 9;85(2):458-459. Epub 2018 Dec 9.

Department of Clinical Pharmacology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark.

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http://dx.doi.org/10.1111/bcp.13813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339961PMC
February 2019

Impact of patient education on plasma concentrations and effectiveness of posaconazole oral suspension under clinical conditions.

Basic Clin Pharmacol Toxicol 2019 Jan 2;124(1):56-61. Epub 2018 Aug 2.

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1111/bcpt.13093DOI Listing
January 2019

Ketoconazole and Liver Injury: A Five-Year Update.

Clin Pharmacol Drug Dev 2019 01;8(1):6-8

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany.

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http://doi.wiley.com/10.1002/cpdd.652
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http://dx.doi.org/10.1002/cpdd.652DOI Listing
January 2019

Rivaroxaban and macitentan can be coadministered without dose adjustment but the combination of rivaroxaban and St John's wort should be avoided.

Br J Clin Pharmacol 2018 12 11;84(12):2903-2913. Epub 2018 Oct 11.

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1111/bcp.13757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255992PMC
December 2018

Methadone against cancer: Lost in translation.

Int J Cancer 2018 10 23;143(8):1840-1848. Epub 2018 Mar 23.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany.

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http://dx.doi.org/10.1002/ijc.31356DOI Listing
October 2018

In vitro inhibition of human UGT isoforms by ritonavir and cobicistat.

Xenobiotica 2018 Aug 11;48(8):764-769. Epub 2017 Sep 11.

a Graduate Program in Pharmacology and Drug Development, Sackler School of Graduate Biomedical Sciences , Boston , MA , USA.

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http://dx.doi.org/10.1080/00498254.2017.1370655DOI Listing
August 2018

Isotopically labelled paroxetine standard allows for definite structure elucidation of the paroxetine tandem mass spectrum.

Rapid Commun Mass Spectrom 2018 08;32(15):1311-1312

University Hospital Heidelberg, Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, Heidelberg, Germany.

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http://dx.doi.org/10.1002/rcm.8178DOI Listing
August 2018

In Vivo CYP3A Activity in Palliative Care Patients: Study Protocol for a Single Arm Prospective Trial.

J Palliat Med 2018 05 12;21(5):686-688. Epub 2018 Jan 12.

2 Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital , Heidelberg, Germany .

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http://dx.doi.org/10.1089/jpm.2017.0461DOI Listing
May 2018

Correction to: Pharmacokinetics of Fentanyl and Its Derivatives in Children: A Comprehensive Review.

Clin Pharmacokinet 2018 Mar;57(3):393-417

Division of Pediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Spitalstrasse 33, 4056, Basel, Switzerland.

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http://dx.doi.org/10.1007/s40262-017-0609-2DOI Listing
March 2018

Pharmacokinetics of Fentanyl and Its Derivatives in Children: A Comprehensive Review.

Clin Pharmacokinet 2018 02;57(2):125-149

Division of Pediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Spitalstrasse 33, 4056, Basel, Switzerland.

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http://link.springer.com/10.1007/s40262-017-0569-6
Publisher Site
http://dx.doi.org/10.1007/s40262-017-0569-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756700PMC
February 2018

Inhibition of human cytochromes P450 in vitro by ritonavir and cobicistat.

J Pharm Pharmacol 2017 Dec 29;69(12):1786-1793. Epub 2017 Sep 29.

Graduate Program in Pharmacology and Drug Development, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1111/jphp.12820DOI Listing
December 2017

Combinations of QTc-prolonging drugs: towards disentangling pharmacokinetic and pharmacodynamic effects in their potentially additive nature.

Ther Adv Psychopharmacol 2017 Dec 28;7(12):251-264. Epub 2017 Aug 28.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1177/2045125317721662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676495PMC
December 2017

Real-world complexity of atrial fibrillation treatment with oral anticoagulants: design and interpretation of pharmacoepidemiological studies.

Br J Clin Pharmacol 2017 10 21;83(10):2321-2324. Epub 2017 Jul 21.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1111/bcp.13348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595975PMC
October 2017

Autoinhibitory properties of the parent but not of the N-oxide metabolite contribute to infusion rate-dependent voriconazole pharmacokinetics.

Br J Clin Pharmacol 2017 Sep 18;83(9):1954-1965. Epub 2017 May 18.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1111/bcp.13297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555860PMC
September 2017

Ultra-sensitive and selective quantification of endothelin-1 in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry.

J Pharm Biomed Anal 2017 Aug 29;142:84-90. Epub 2017 Apr 29.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2017.04.038DOI Listing
August 2017

Intracellular vorinostat accumulation and its relationship to histone deacetylase activity in soft tissue sarcoma patients.

Cancer Chemother Pharmacol 2017 Aug 13;80(2):433-439. Epub 2017 Jun 13.

Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00280-017-3357-yDOI Listing
August 2017

Acute and painful exacerbation of RLS and PLM induced by opioid interaction - withdrawal syndrome.

Sleep Med 2017 08 27;36:186-187. Epub 2017 May 27.

Department of Internal Medicine 2, RoMed Klinikum Rosenheim, Germany.

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http://dx.doi.org/10.1016/j.sleep.2017.05.010DOI Listing
August 2017

Semisimultaneous Midazolam Administration to Evaluate the Time Course of CYP3A Activation by a Single Oral Dose of Efavirenz.

J Clin Pharmacol 2017 07 14;57(7):899-905. Epub 2017 Feb 14.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/jcph.879DOI Listing
July 2017

Clementine juice has the potential for drug interactions - In vitro comparison with grapefruit and mandarin juice.

Eur J Pharm Sci 2017 Jan 24;97:247-256. Epub 2016 Nov 24.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2016.11.021DOI Listing
January 2017

Dose-Dependent Bioavailability and CYP3A Inhibition Contribute to Non-Linear Pharmacokinetics of Voriconazole.

Clin Pharmacokinet 2016 12;55(12):1535-1545

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s40262-016-0416-1DOI Listing
December 2016

No Increased Risk of Ketoconazole Toxicity in Drug-Drug Interaction Studies.

J Clin Pharmacol 2016 10 22;56(10):1203-11. Epub 2016 Aug 22.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/jcph.795DOI Listing
October 2016

First-in-human application of the novel hepatitis B and hepatitis D virus entry inhibitor myrcludex B.

J Hepatol 2016 09 27;65(3):483-9. Epub 2016 Apr 27.

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany; German Center for Infection Research (DZIF), Heidelberg Partner Site, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jhep.2016.04.013DOI Listing
September 2016

Treatment with rilpivirine does not alter plasma concentrations of the CYP3A substrates tadalafil and midazolam in humans.

J Antimicrob Chemother 2016 08 1;71(8):2241-7. Epub 2016 May 1.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany

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http://dx.doi.org/10.1093/jac/dkw125DOI Listing
August 2016

Ultrasensitive quantification of the CYP2E1 probe chlorzoxazone and its main metabolite 6-hydroxychlorzoxazone in human plasma using ultra performance liquid chromatography coupled to tandem mass spectrometry after chlorzoxazone microdosing.

J Chromatogr B Analyt Technol Biomed Life Sci 2016 Aug 31;1027:207-13. Epub 2016 May 31.

Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, University of Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2016.05.049DOI Listing
August 2016

CYP3A activity: towards dose adaptation to the individual.

Expert Opin Drug Metab Toxicol 2016 May 26;12(5):479-97. Epub 2016 Mar 26.

a Department of Clinical Pharmacology and Pharmacoepidemiology , University Hospital Heidelberg , Heidelberg , Germany.

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http://dx.doi.org/10.1517/17425255.2016.1163337DOI Listing
May 2016

St. John's wort treatment in women bears risks beyond pharmacokinetic drug interactions.

Arch Toxicol 2016 Apr 12;90(4):1013-5. Epub 2015 May 12.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00204-015-1532-7DOI Listing
April 2016

Use of microdose phenotyping to individualise dosing of patients.

Clin Pharmacokinet 2015 Sep;54(9):893-900

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s40262-015-0278-yDOI Listing
September 2015

Pharmacokinetic interaction of intravenous fentanyl with ketoconazole.

J Clin Pharmacol 2015 Jun 16;55(6):708-17. Epub 2015 Feb 16.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/jcph.469DOI Listing
June 2015

The effect of induction of CYP3A4 by St John's wort on ambrisentan plasma pharmacokinetics in volunteers of known CYP2C19 genotype.

Basic Clin Pharmacol Toxicol 2015 May 8;116(5):423-8. Epub 2014 Nov 8.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1111/bcpt.12332DOI Listing
May 2015

Urine drug testing for oxycodone and its metabolites as a tool for drug-drug interactions?

Authors:
Gerd Mikus

J Anal Toxicol 2015 Jan-Feb;39(1):81-2. Epub 2014 Oct 6.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany

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http://dx.doi.org/10.1093/jat/bku111DOI Listing
May 2015

Pre-systemic elimination of tilidine: localization and consequences for the formation of the active metabolite nortilidine.

Basic Clin Pharmacol Toxicol 2015 Feb 7;116(2):129-33. Epub 2014 Oct 7.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1111/bcpt.12328DOI Listing
February 2015

Midazolam microdose to determine systemic and pre-systemic metabolic CYP3A activity in humans.

Br J Clin Pharmacol 2015 Feb;79(2):278-85

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1111/bcp.12502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309633PMC
February 2015

Systemic exposure of topical erythromycin in comparison to oral administration and the effect on cytochrome P450 3A4 activity.

Br J Clin Pharmacol 2014 Dec;78(6):1433-40

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1111/bcp.12497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256632PMC
December 2014

Normal CYP3A activity during arsenic trioxide therapy.

Ann Hematol 2014 Nov 16;93(11):1941-2. Epub 2014 Apr 16.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00277-014-2076-2DOI Listing
November 2014

Deceptive argumentation against diagnostic microdosing of anticancer drugs.

Int J Cancer 2014 Oct 4;135(7):1753-4. Epub 2014 Mar 4.

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, D-69120, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.28806DOI Listing
October 2014

Aprepitant, granisetron, and dexamethasone for prevention of chemotherapy-induced nausea and vomiting after high-dose melphalan in autologous transplantation for multiple myeloma: results of a randomized, placebo-controlled phase III trial.

J Clin Oncol 2014 Oct 15;32(30):3413-20. Epub 2014 Sep 15.

Thomas Schmitt, Hartmut Goldschmidt, Anja Freiberger, Johannes Hüsing, Martina Gronkowski, Markus Thalheimer, Le Hang Pelzl, Gerd Mikus, Jürgen Burhenne, Anthony D. Ho, and Gerlinde Egerer, Heidelberg University Hospital, Heidelberg; and Kai Neben, Klinikum Mittelbaden, Baden-Baden, Germany.

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http://dx.doi.org/10.1200/JCO.2013.55.0095DOI Listing
October 2014

Understanding variability with voriconazole using a population pharmacokinetic approach: implications for optimal dosing.

J Antimicrob Chemother 2014 Jun 18;69(6):1633-41. Epub 2014 Feb 18.

Faculty of Pharmacy, University of Sydney, Camperdown, Australia Centre For Education and Research on Ageing, Concord Repatriation General Hospital, Concord, Australia

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http://dx.doi.org/10.1093/jac/dku031DOI Listing
June 2014

What, if all alerts were specific - estimating the potential impact on drug interaction alert burden.

Int J Med Inform 2014 Apr 13;83(4):285-91. Epub 2014 Jan 13.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany; Cooperation Unit Clinical Pharmacy, University of Heidelberg, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijmedinf.2013.12.006DOI Listing
April 2014

Effects and risks associated with novel psychoactive substances: mislabeling and sale as bath salts, spice, and research chemicals.

Dtsch Arztebl Int 2014 Feb;111(9):139-47

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital.

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http://dx.doi.org/10.3238/arztebl.2014.0139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965957PMC
February 2014

Clarithromycin substantially increases steady-state bosentan exposure in healthy volunteers.

Br J Clin Pharmacol 2014 Jan;77(1):141-8

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1111/bcp.12177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895355PMC
January 2014

Prolonged sedation of lorazepam due to absent UGT2B4/2B7 glucuronidation.

Arch Toxicol 2014 Jan 19;88(1):179-80. Epub 2013 Dec 19.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00204-013-1173-7DOI Listing
January 2014

Steady-state pharmacokinetics and metabolism of voriconazole in patients.

J Antimicrob Chemother 2013 Nov 13;68(11):2592-9. Epub 2013 Jun 13.

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1093/jac/dkt229DOI Listing
November 2013

Reduced exposure variability of the CYP3A substrate simvastatin by dose individualization to CYP3A activity.

J Clin Pharmacol 2013 Nov 31;53(11):1199-204. Epub 2013 Aug 31.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1002/jcph.161DOI Listing
November 2013

Interaction of ambrisentan with clarithromycin and its modulation by polymorphic SLCO1B1.

Eur J Clin Pharmacol 2013 Oct 9;69(10):1785-93. Epub 2013 Jun 9.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital of Heidelberg, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00228-013-1529-1DOI Listing
October 2013

Concentration effect relationship of CYP3A inhibition by ritonavir in humans.

Eur J Clin Pharmacol 2013 Oct 9;69(10):1795-800. Epub 2013 Jun 9.

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00228-013-1530-8DOI Listing
October 2013

Fentanyl pharmacokinetics is not dependent on hepatic uptake by organic anion-transporting polypeptide 1B1 in human beings.

Basic Clin Pharmacol Toxicol 2013 Jul 6;113(1):43-8. Epub 2013 Apr 6.

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1111/bcpt.12066DOI Listing
July 2013

Pharmacological treatment of constipation in palliative care.

Curr Opin Support Palliat Care 2013 Jun;7(2):183-91

Clinic of Palliative Medicine, MediClin Robert Janker Klinik, Germany.

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http://dx.doi.org/10.1097/SPC.0b013e32835f1e17DOI Listing
June 2013

Contribution of oxycodone and its metabolites to the overall analgesic effect after oxycodone administration.

Expert Opin Drug Metab Toxicol 2013 May 14;9(5):517-28. Epub 2013 Mar 14.

University of Heidelberg, Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1517/17425255.2013.779669DOI Listing
May 2013

Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity.

Eur J Clin Pharmacol 2013 Mar 12;69(3):507-13. Epub 2012 Sep 12.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00228-012-1388-1DOI Listing
March 2013

Contribution of CYP2C19 and CYP3A4 to the formation of the active nortilidine from the prodrug tilidine.

Br J Clin Pharmacol 2012 Nov;74(5):854-63

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, Heidelberg, Germany.

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http://doi.wiley.com/10.1111/j.1365-2125.2012.04261.x
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http://dx.doi.org/10.1111/j.1365-2125.2012.04261.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495150PMC
November 2012

In vitro identification of the cytochrome P450 isozymes involved in the N-demethylation of the active opioid metabolite nortilidine to bisnortilidine.

Naunyn Schmiedebergs Arch Pharmacol 2012 Jun 15;385(6):633-9. Epub 2012 Feb 15.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany.

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http://link.springer.com/content/pdf/10.1007/s00210-012-0737
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http://link.springer.com/10.1007/s00210-012-0737-z
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http://dx.doi.org/10.1007/s00210-012-0737-zDOI Listing
June 2012

Drug interaction of efavirenz and midazolam: efavirenz activates the CYP3A-mediated midazolam 1'-hydroxylation in vitro.

Drug Metab Dispos 2012 Jun 12;40(6):1178-82. Epub 2012 Mar 12.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1124/dmd.111.043844DOI Listing
June 2012

Frequency of the SLCO1B1 388A>G and the 521T>C polymorphism in Tanzania genotyped by a new LightCycler®-based method.

Eur J Clin Pharmacol 2011 Nov 1;67(11):1139-45. Epub 2011 Jun 1.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital-Huddinge C-168, Karolinska Institute, SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-011-1065-9DOI Listing
November 2011

Daily honey consumption does not change CYP3A activity in humans.

J Clin Pharmacol 2011 Aug 8;51(8):1223-32. Epub 2010 Dec 8.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, D-69120 Heidelberg, Germany.

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http://doi.wiley.com/10.1177/0091270010382022
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http://dx.doi.org/10.1177/0091270010382022DOI Listing
August 2011

Pharmacogenomics of the triazole antifungal agent voriconazole.

Pharmacogenomics 2011 Jun;12(6):861-72

Department of Clinical Pharmacology & Pharmacoepidemiology, University Hospital of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.

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https://www.futuremedicine.com/doi/10.2217/pgs.11.18
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http://dx.doi.org/10.2217/pgs.11.18DOI Listing
June 2011

Modulators of very low voriconazole concentrations in routine therapeutic drug monitoring.

Ther Drug Monit 2011 Feb;33(1):86-93

Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1097/FTD.0b013e31820530cdDOI Listing
February 2011

[Introduction to adverse drug reactions and drug-drug interaction].

Authors:
Gerd Mikus

Ther Umsch 2011 Jan;68(1):3-9

Abteilung Klinische Pharmakologie und Pharmakoepidemiologie, Medizinische Klinik, Universitätsklinikum Heidelberg.

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http://dx.doi.org/10.1024/0040-5930/a000135DOI Listing
January 2011

[Adverse drug reactions and drug interactions in analgesic therapy].

Ther Umsch 2011 Jan;68(1):19-26

Abteilung Klinische Pharmakologie und Pharmakoepidemiologie, Universitätsklinikum Heidelberg und Abteilung Klinische Pharmazie, Institut für Pharmazie, Universität Leipzig.

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http://dx.doi.org/10.1024/0040-5930/a000115DOI Listing
January 2011

Proposal of a new limited sampling strategy to predict CYP3A activity using a partial AUC of midazolam.

Eur J Clin Pharmacol 2010 Nov 3;66(11):1137-41. Epub 2010 Aug 3.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00228-010-0878-2DOI Listing
November 2010

No evidence for induction of ABC transporters in peripheral blood mononuclear cells in humans after 14 days of efavirenz treatment.

Antimicrob Agents Chemother 2010 Oct 26;54(10):4185-91. Epub 2010 Jul 26.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, D-69120 Heidelberg, Germany.

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http://aac.asm.org/cgi/doi/10.1128/AAC.00283-10
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http://dx.doi.org/10.1128/AAC.00283-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944620PMC
October 2010

Combined oral prolonged-release oxycodone and naloxone in opioid-induced bowel dysfunction: review of efficacy and safety data in the treatment of patients experiencing chronic pain.

Expert Opin Pharmacother 2010 Feb;11(2):297-310

University of Bonn, Malteser Hospital Bonn/Rhein-Sieg, Centre for Palliative Medicine, Department of Science and Research, von-Hompesch-Str. 1, D-53123 Bonn, Germany.

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http://dx.doi.org/10.1517/14656560903483222DOI Listing
February 2010

Pharmacokinetics, metabolism and bioavailability of the triazole antifungal agent voriconazole in relation to CYP2C19 genotype.

Br J Clin Pharmacol 2009 Dec;68(6):906-15

Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1111/j.1365-2125.2009.03534.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810802PMC
December 2009

Inhibition of the active principle of the weak opioid tilidine by the triazole antifungal voriconazole.

Br J Clin Pharmacol 2009 Nov;68(5):712-20

Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany.

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http://doi.wiley.com/10.1111/j.1365-2125.2009.03498.x
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http://dx.doi.org/10.1111/j.1365-2125.2009.03498.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791977PMC
November 2009

Efavirenz treatment and false-positive results in benzodiazepine screening tests.

Clin Infect Dis 2009 Jun;48(12):1787-9

Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Heidelberg 69120, Germany.

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http://dx.doi.org/10.1086/599109DOI Listing
June 2009

CYP2C19 genotype is a major factor contributing to the highly variable pharmacokinetics of voriconazole.

J Clin Pharmacol 2009 Feb 25;49(2):196-204. Epub 2008 Nov 25.

Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1177/0091270008327537DOI Listing
February 2009