Gerd Kullak-Ublick

Gerd Kullak-Ublick

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Gerd Kullak-Ublick

Gerd Kullak-Ublick

Publications by authors named "Gerd Kullak-Ublick"

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Renal Reabsorption of Folates: Pharmacological and Toxicological Snapshots.

Nutrients 2019 Oct 2;11(10). Epub 2019 Oct 2.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, 8006 Zurich, Switzerland.

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http://dx.doi.org/10.3390/nu11102353DOI Listing
October 2019

Renal glycosuria as a novel early sign of colistin-induced kidney damage in mice.

Antimicrob Agents Chemother 2019 Oct 7. Epub 2019 Oct 7.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, 8006 Zurich, Switzerland.

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http://dx.doi.org/10.1128/AAC.01650-19DOI Listing
October 2019

microRNA-206 modulates the hepatic expression of the organic anion-transporting polypeptide 1B1.

Liver Int 2019 Aug 13. Epub 2019 Aug 13.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.

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http://dx.doi.org/10.1111/liv.14212DOI Listing
August 2019

Drug-induced liver injury.

Nat Rev Dis Primers 2019 Aug 22;5(1):58. Epub 2019 Aug 22.

National Institute for Health Research (NIHR) Nottingham Digestive Diseases Biomedical Research Centre, Nottingham University Hospital NHS Trust and University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1038/s41572-019-0105-0DOI Listing
August 2019

Severe reduction in tacrolimus concentrations with concomitant metamizole (dipyrone) therapy in transplant patients.

Eur J Clin Pharmacol 2019 Jun 29;75(6):869-872. Epub 2019 Jan 29.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich-University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.

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http://dx.doi.org/10.1007/s00228-019-02635-yDOI Listing
June 2019

Pharmacovigilance in ophthalmology in Switzerland: an analysis of the most frequently reported ocular adverse drug reactions within the last 25 years.

Swiss Med Wkly 2019 Jun 30;149:w20085. Epub 2019 Jun 30.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Switzerland / National Poisons Information Centre, Tox Info Suisse, Associated Institute of the University of Zurich, Switzerland / Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH, Zurich, Switzerland.

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http://dx.doi.org/10.4414/smw.2019.20085DOI Listing
June 2019

Drugs and hepatic transporters: A review.

Pharmacol Res 2019 Apr 17:104234. Epub 2019 Apr 17.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Rämistrasse 100, CH-8091 Zürich, Switzerland.

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https://linkinghub.elsevier.com/retrieve/pii/S10436618193003
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http://dx.doi.org/10.1016/j.phrs.2019.04.018DOI Listing
April 2019

Statin-associated immune-mediated necrotizing myopathy: a retrospective analysis of individual case safety reports from VigiBase.

Eur J Clin Pharmacol 2019 Mar 15;75(3):409-416. Epub 2018 Nov 15.

Department of Clinical Pharmacology and Toxicology and Regional Pharmacovigilance Centre, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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http://link.springer.com/10.1007/s00228-018-2589-z
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http://dx.doi.org/10.1007/s00228-018-2589-zDOI Listing
March 2019

Do clinical and laboratory parameters predict thiopurine metabolism and clinical outcome in patients with inflammatory bowel diseases?

Eur J Clin Pharmacol 2019 Mar 4;75(3):335-342. Epub 2019 Jan 4.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Rämistrasse 100, CH-8091, Zürich, Switzerland.

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http://dx.doi.org/10.1007/s00228-018-02616-7DOI Listing
March 2019

Lipid Accumulation and Chronic Kidney Disease.

Nutrients 2019 Mar 28;11(4). Epub 2019 Mar 28.

Institute for Literature and Culture of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.

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http://dx.doi.org/10.3390/nu11040722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520701PMC
March 2019

Molecular Mechanisms of Colistin-Induced Nephrotoxicity.

Molecules 2019 Feb 12;24(3). Epub 2019 Feb 12.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, 8006 Zurich, Switzerland.

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http://dx.doi.org/10.3390/molecules24030653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384669PMC
February 2019

Safety differentiation: emerging competitive edge in drug development.

Drug Discov Today 2019 01 19;24(1):285-292. Epub 2018 Sep 19.

Novartis Institutes for Biomedical Research, Translational Medicine, Pre-Clinical Safety, Basel, Switzerland.

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https://linkinghub.elsevier.com/retrieve/pii/S13596446183019
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http://dx.doi.org/10.1016/j.drudis.2018.09.009DOI Listing
January 2019

Corrigendum to 'Sirtuin 5 as a novel target to blunt blood-brain barrier damage induced by cerebral ischemia/reperfusion injury' [Int. J. Cardiol. 260 (2018) 148-155].

Int J Cardiol 2018 11 13;271:405. Epub 2018 Jul 13.

Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland; Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland; Zurich Neuroscience Center (ZNZ), Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.07.004DOI Listing
November 2018

Analysis of Drug-Drug Interactions in Swiss Claims Data Using Tizanidine and Ciprofloxacin as a Prototypical Contraindicated Combination.

Ann Pharmacother 2018 10 11;52(10):983-991. Epub 2018 May 11.

1 Department of Clinical Pharmacology and Toxicology, University Hospital Zurich and University of Zurich, Switzerland.

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http://dx.doi.org/10.1177/1060028018775914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136070PMC
October 2018

Effects of Farnesoid X Receptor Activation on Arachidonic Acid Metabolism, NF-kB Signaling, and Hepatic Inflammation.

Mol Pharmacol 2018 08 9;94(2):802-811. Epub 2018 May 9.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland (Z.G., M.V., S.H., C.H., G.A.K.-U.); Experiment Center, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China (T.G.); Department of Endocrinology, Chinese PLA 309 Hospital, Peking, China (L.Z.); Department of General and Visceral Surgery, Rotkreuzklinikum Munich, Munich, Germany (W.E.T.); Department of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, Zurich, Switzerland (I.H., A.C.); and Mechanistic Safety, Novartis Global Drug Development, Basel, Switzerland (G.A.K.-U.)

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http://dx.doi.org/10.1124/mol.117.111047DOI Listing
August 2018

Fluorocholine Transport Mediated by the Organic Cation Transporter 2 (OCT2, SLC22A2): Implication for Imaging of Kidney Tumors.

Drug Metab Dispos 2018 08 24;46(8):1129-1136. Epub 2018 May 24.

Departments of Clinical Pharmacology and Toxicology (M.V., A.T., Z.G., S.H., C.L., C.H., G.A.K.-U.) and Pathology and Molecular Pathology (P.H.S., H.M.), University Hospital Zurich, University of Zurich, Zurich, Switzerland; and Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China (C.L.).

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http://dx.doi.org/10.1124/dmd.118.081091DOI Listing
August 2018

TNF-α Deficiency Prevents Renal Inflammation and Oxidative Stress in Obese Mice.

Kidney Blood Press Res 2017 7;42(3):416-427. Epub 2017 Jul 7.

Department of Nephrology, Liaocheng, China.

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http://dx.doi.org/10.1159/000478869DOI Listing
June 2018

Sirtuin 5 as a novel target to blunt blood-brain barrier damage induced by cerebral ischemia/reperfusion injury.

Int J Cardiol 2018 06;260:148-155

Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland,; Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland; Zurich Neuroscience Center (ZNZ), Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2017.12.060DOI Listing
June 2018

Severe injection site reactions after subcutaneous administration of Sayana©.

Swiss Med Wkly 2017 10;147:w14432. Epub 2017 May 10.

Regional Pharmacovigilance Centre Zurich, Department of Clinical Pharmacology and Toxicology, University Hospital Zurich and University of Zurich, Switzerland.

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http://dx.doi.org/10.4414/smw.2017.14432DOI Listing
May 2018

Drug-induced bile duct injury.

Biochim Biophys Acta Mol Basis Dis 2018 04 4;1864(4 Pt B):1498-1506. Epub 2017 Sep 4.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Switzerland; Patient Safety, Novartis Pharma, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.08.033DOI Listing
April 2018

Colistin is substrate of the carnitine/organic cation transporter 2 (OCTN2, SLC22A5).

Drug Metab Dispos 2017 12 6;45(12):1240-1244. Epub 2017 Oct 6.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1124/dmd.117.077248DOI Listing
December 2017

A MIR4646 associated methylation locus is hypomethylated in adolescent depression.

J Affect Disord 2017 10 17;220:117-128. Epub 2017 May 17.

Division of Pharmacology, Department of Neuroscience, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.jad.2017.05.017DOI Listing
October 2017

Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage.

Sci Rep 2017 08 29;7(1):9815. Epub 2017 Aug 29.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1038/s41598-017-10168-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575310PMC
August 2017

Drug-induced liver injury: recent advances in diagnosis and risk assessment.

Gut 2017 06 23;66(6):1154-1164. Epub 2017 Mar 23.

National Institute for Health Research (NIHR), Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1136/gutjnl-2016-313369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532458PMC
June 2017

Impact of Organic Cation Transporters (OCT-SLC22A) on Differential Diagnosis of Intrahepatic Lesions.

Drug Metab Dispos 2017 02 30;45(2):166-173. Epub 2016 Nov 30.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Switzerland (M.V., C.H., L.H., G.A. K.-U., B.S.); Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (B.V.v.R., M.B., T.M.v.G.); Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (R.J.B.); Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (S.S.K.S.P.); Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (J.V.); Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Germany (H.K.); and Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan (I.T.)

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http://dx.doi.org/10.1124/dmd.116.072371DOI Listing
February 2017

Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor.

J Steroid Biochem Mol Biol 2016 10 20;163:77-87. Epub 2016 Apr 20.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2016.04.006DOI Listing
October 2016

Organic Cation Transporter 2 Overexpression May Confer an Increased Risk of Gentamicin-Induced Nephrotoxicity.

Antimicrob Agents Chemother 2016 09 22;60(9):5573-80. Epub 2016 Aug 22.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

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http://dx.doi.org/10.1128/AAC.00907-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997869PMC
September 2016

A Mobile App to Stabilize Daily Functional Activity of Breast Cancer Patients in Collaboration With the Physician: A Randomized Controlled Clinical Trial.

J Med Internet Res 2016 09 6;18(9):e238. Epub 2016 Sep 6.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich and University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.2196/jmir.6414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030453PMC
September 2016

No major effects of vitamin D3 (1,25 dihydroxyvitamin D3) on absorption and pharmacokinetics of folic acid and fexofenadine in healthy volunteers.

Eur J Clin Pharmacol 2016 Jul 29;72(7):797-805. Epub 2016 Mar 29.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Rämistrasse 100, CH-8091, Zürich, Switzerland.

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http://dx.doi.org/10.1007/s00228-016-2050-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909797PMC
July 2016

Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes.

Life Sci 2016 Jul 10;156:47-56. Epub 2016 May 10.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Switzerland; Division of Pharmacology, Department of Neuroscience, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.lfs.2016.04.037DOI Listing
July 2016

Bile acids in drug induced liver injury: Key players and surrogate markers.

Clin Res Hepatol Gastroenterol 2016 Jun 10;40(3):257-266. Epub 2016 Feb 10.

Drug Safety and Epidemiology, Novartis Pharma AG, Basel, Switzerland; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.clinre.2015.12.017DOI Listing
June 2016

microRNA-192 suppresses the expression of the farnesoid X receptor.

Am J Physiol Gastrointest Liver Physiol 2016 06 14;310(11):G1044-51. Epub 2016 Apr 14.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland;

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http://dx.doi.org/10.1152/ajpgi.00297.2015DOI Listing
June 2016

Concomitant administration of rifampicin and oxcarbazepine results in a significant decrease of the active MHD metabolite of oxcarbazepine.

Eur J Clin Pharmacol 2016 Mar 3;72(3):377-8. Epub 2015 Dec 3.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Raemistrasse 100, CH-8091, Zurich, Switzerland.

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http://dx.doi.org/10.1007/s00228-015-1991-zDOI Listing
March 2016

Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized Obese Mice.

J Biol Chem 2016 Jan 11;291(5):2397-411. Epub 2015 Dec 11.

From the Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, CH-8091 Zurich, Switzerland and

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http://www.jbc.org/content/291/5/2397.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.694323
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http://dx.doi.org/10.1074/jbc.M115.694323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732222PMC
January 2016

[5-0xoproline (pyroglutamic acid) acidosis and acetaminophen- a differential diagnosis in high anion gap metabolic acidosis].

Ther Umsch 2015 Dec;72(11-12):737-41

1 Klinik für Klinische Pharmakologie und Toxikologie und Regionales Pharmacovigilance Zentrum, Universitätsspital Zürich und Universität Zürich.

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http://dx.doi.org/10.1024/0040-5930/a000745DOI Listing
December 2015

Octreotide inhibits the bilirubin carriers organic anion transporting polypeptides 1B1 and 1B3 and the multidrug resistance-associated protein 2.

J Pharmacol Exp Ther 2015 Nov 1;355(2):145-51. Epub 2015 Sep 1.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Switzerland (M.V., B.S., G.A.K.-U.); and Discovery and Investigative Safety, Novartis Institutes for BioMedical Research, Basel, Switzerland (M.M., G.A.K.-U.)

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http://dx.doi.org/10.1124/jpet.115.227546DOI Listing
November 2015

Therapeutic Drug Monitoring of Daptomycin: A Retrospective Monocentric Analysis.

Ther Drug Monit 2015 Oct;37(5):634-40

*Department of Clinical Pharmacology and Toxicology, University Hospital Zurich; †Institute of General Practice and Health Services Research, University of Zurich; and ‡Institute of Clinical Chemistry, University Hospital Zurich, Zürich, Switzerland.

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http://dx.doi.org/10.1097/FTD.0000000000000196DOI Listing
October 2015

[Nalmefene and Opioid Withdrawal Syndrome: Analysis of the Global Pharmacovigilance Database for Adverse Drug Reactions].

Praxis (Bern 1994) 2015 Oct;104(21):1129-34

1 Regionales Pharmacovigilance Zentrum, Klinik für Klinische Pharmakologie und Toxikologie, Universitätsspital Zürich und Universität Zürich.

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http://dx.doi.org/10.1024/1661-8157/a002160DOI Listing
October 2015

G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal Inflammation.

Inflamm Bowel Dis 2015 Jun;21(6):1269-81

*Division of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland; †Institute of Physiology, University of Zürich, Zürich, Switzerland; ‡Department of Clinical Pharmacology and Toxicology, University Hospital Zürich, Zürich, Switzerland; and §Novartis Institutes for Biomedical Research, Basel, Switzerland.

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http://www.zora.uzh.ch/111122/1/G%20Protein-coupled%20pH-sen
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MIB.0000000000000375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450952PMC
June 2015

The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes.

Liver Int 2015 Apr 29;35(4):1152-61. Epub 2014 Apr 29.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1111/liv.12558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407926PMC
April 2015

Opposing effects of reduced kidney mass on liver and skeletal muscle insulin sensitivity in obese mice.

Diabetes 2015 Apr 16;64(4):1131-41. Epub 2014 Oct 16.

Division of Pediatric Endocrinology and Diabetology, University Children's Hospital, Zurich, Switzerland Children's Research Center, University Children's Hospital, Zurich, Switzerland Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland

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http://dx.doi.org/10.2337/db14-0779DOI Listing
April 2015

Drug-induced liver injury: the dawn of biomarkers?

F1000Prime Rep 2015 3;7:34. Epub 2015 Mar 3.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich Raemistrasse 100, CH-8091 Zurich Switzerland ; Discovery and Investigative Safety, Novartis Institutes for BioMedical Research Klybeckstrasse 141, 4057 Basel Switzerland.

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http://dx.doi.org/10.12703/P7-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371234PMC
April 2015

Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IκB Kinase.

Cell Mol Gastroenterol Hepatol 2015 Mar 26;1(2):171-187.e1. Epub 2014 Dec 26.

Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland; Zurich Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.jcmgh.2014.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301135PMC
March 2015

Fire eater's lung: retrospective analysis of 123 cases reported to a National Poison Center.

Respiration 2014 21;87(2):98-104. Epub 2013 Jun 21.

Pulmonary Division, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1159/000350443DOI Listing
February 2015

Methodology to assess clinical liver safety data.

Drug Saf 2014 Nov;37 Suppl 1:S33-45

Discovery and Investigative Safety, Novartis Institutes for BioMedical Research, Klybeckstrasse 141, WKL-135.1.78, 4057, Basel, Switzerland,

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http://dx.doi.org/10.1007/s40264-014-0184-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212156PMC
November 2014

Liver safety assessment in special populations (hepatitis B, C, and oncology trials).

Drug Saf 2014 Nov;37 Suppl 1:S57-62

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland,

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http://link.springer.com/10.1007/s40264-014-0186-3
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http://dx.doi.org/10.1007/s40264-014-0186-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212149PMC
November 2014

Uninephrectomy augments the effects of high fat diet induced obesity on gene expression in mouse kidney.

Biochim Biophys Acta 2014 Sep 10;1842(9):1870-8. Epub 2014 Jul 10.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Switzerland; Zurich Centre for Integrative Human Physiology, University of Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.07.001DOI Listing
September 2014

Rivaroxaban postmarketing risk of liver injury.

J Hepatol 2014 Aug 28;61(2):293-300. Epub 2014 Mar 28.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland; Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.jhep.2014.03.026DOI Listing
August 2014

Urinary excretion of melatonin and association with breast cancer: meta-analysis and review of the literature.

Breast Care (Basel) 2014 Jul;9(3):182-7

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland ; Breast-Center Zürich and Onkozentrum Klinik im Park, Zurich, Switzerland.

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http://dx.doi.org/10.1159/000363426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132247PMC
July 2014

Risks of inflammatory bowel disease treatment with glucocorticosteroids and aminosalicylates.

Dig Dis 2013 14;31(3-4):368-73. Epub 2013 Nov 14.

Department of Clinical Pharmacology and Toxicology, University Hospital Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1159/000354699DOI Listing
June 2014

Atypical antipsychotic poisoning in young children: a multicentre analysis of poisons centres data.

Eur J Pediatr 2014 Jun 27;173(6):743-50. Epub 2013 Dec 27.

Division of Science, Swiss Toxicological Information Centre, Associated Institute of the University of Zurich, Freiestrasse 16, Zurich, CH-8032, Switzerland.

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http://dx.doi.org/10.1007/s00431-013-2241-yDOI Listing
June 2014

Impact of variable CYP genotypes on breast cancer relapse in patients undergoing adjuvant tamoxifen therapy.

Cancer Chemother Pharmacol 2014 Jun 29;73(6):1181-8. Epub 2014 Mar 29.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland.

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http://link.springer.com/10.1007/s00280-014-2453-5
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http://dx.doi.org/10.1007/s00280-014-2453-5DOI Listing
June 2014

Effect of chronic renal failure on the hepatic, intestinal, and renal expression of bile acid transporters.

Am J Physiol Renal Physiol 2014 Jan 6;306(1):F130-7. Epub 2013 Nov 6.

Dept. of Clinical Pharmacology and Toxicology, Univ. Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland.

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http://dx.doi.org/10.1152/ajprenal.00114.2013DOI Listing
January 2014

Gastric pharmacobezoars in quetiapine extended-release overdose: a case series.

Clin Toxicol (Phila) 2013 Dec 8;51(10):937-40. Epub 2013 Nov 8.

Swiss Toxicological Information Centre, Associated Institute of the University of Zurich , Zurich , Switzerland.

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http://dx.doi.org/10.3109/15563650.2013.856442DOI Listing
December 2013

[Thrombocyte aggregation inhibitors: what are the risks?].

Praxis (Bern 1994) 2013 Oct;102(20):1243-50

Klinik für Klinische Pharmakologie und Toxikologie, Universitätsspital Zürich.

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http://dx.doi.org/10.1024/1661-8157/a001431DOI Listing
October 2013

[Living donor liver donation - primum nihil nocere?].

Praxis (Bern 1994) 2013 Oct;102(21):1277-83; quiz 1284-5

Innere Medizin, Universitätsspital Zürich.

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http://dx.doi.org/10.1024/1661-8157/a001471DOI Listing
October 2013

Low allopurinol doses are sufficient to optimize azathioprine therapy in inflammatory bowel disease patients with inadequate thiopurine metabolite concentrations.

Eur J Clin Pharmacol 2013 Aug 16;69(8):1521-31. Epub 2013 Apr 16.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1007/s00228-013-1500-1DOI Listing
August 2013

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Arch Toxicol 2013 Aug 23;87(8):1315-530. Epub 2013 Aug 23.

Leibniz Research Centre for Working Environment and Human Factors (IFADO), 44139, Dortmund, Germany.

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http://dx.doi.org/10.1007/s00204-013-1078-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753504PMC
August 2013

Comparative performance of two drug interaction screening programmes analysing a cross-sectional prescription dataset of 84,625 psychiatric inpatients.

Drug Saf 2013 Apr;36(4):247-58

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.

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http://dx.doi.org/10.1007/s40264-013-0027-9DOI Listing
April 2013

Medication wrong route administration: a poisons center-based study.

Expert Opin Drug Saf 2013 Mar;12(2):145-52

Associated Institute of the University of Zurich, Swiss Toxicological Information Centre, Zurich, Switzerland.

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http://dx.doi.org/10.1517/14740338.2013.770468DOI Listing
March 2013

Patterns of toxicity and factors influencing severity in acute adult trimipramine poisoning.

Br J Clin Pharmacol 2013 Jan;75(1):227-35

Swiss Toxicological Information Centre, Associated Institute of the University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1111/j.1365-2125.2012.04344.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555062PMC
January 2013

Roflumilast--a phosphodiesterase-4 inhibitor licensed for add-on therapy in severe COPD.

Swiss Med Wkly 2012 25;142:w13628. Epub 2012 Jul 25.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Switzerland.

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http://dx.doi.org/10.4414/smw.2012.13628DOI Listing
January 2013

Comparative evaluation of three clinical decision support systems: prospective screening for medication errors in 100 medical inpatients.

Eur J Clin Pharmacol 2012 Aug 29;68(8):1209-19. Epub 2012 Feb 29.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1007/s00228-012-1241-6DOI Listing
August 2012

The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course.

PPAR Res 2012 14;2012:349469. Epub 2012 Feb 14.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.

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http://www.hindawi.com/journals/ppar/2012/349469/
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http://dx.doi.org/10.1155/2012/349469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289871PMC
August 2012

Comparative evaluation of the drug interaction screening programs MediQ and ID PHARMA CHECK in neurological inpatients.

Pharmacoepidemiol Drug Saf 2012 Aug 20;21(8):872-80. Epub 2012 Apr 20.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1002/pds.3279DOI Listing
August 2012

The SLCO1A2 gene, encoding human organic anion-transporting polypeptide 1A2, is transactivated by the vitamin D receptor.

Mol Pharmacol 2012 Jul 3;82(1):37-46. Epub 2012 Apr 3.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland.

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http://molpharm.aspetjournals.org/content/82/1/37.full.pdf
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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.112.07
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http://dx.doi.org/10.1124/mol.112.077909DOI Listing
July 2012

Mushroom poisoning: a study on circumstances of exposure and patterns of toxicity.

Eur J Intern Med 2012 Jun 17;23(4):e85-91. Epub 2012 Apr 17.

Swiss Toxicological Information Centre, Associated Institute of the University of Zurich, Freiestrasse 16, 8032 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.ejim.2012.03.014DOI Listing
June 2012

Potentially inappropriate prescribing for elderly outpatients in Germany: a retrospective claims data analysis.

Int J Clin Pharmacol Ther 2012 Mar;50(3):185-94

Institute of Clinical Pharmacology, Technische Universität Dresden, Dresden, Germany.

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http://dx.doi.org/10.5414/cp201441DOI Listing
March 2012

Regulation of the gene encoding the intestinal bile acid transporter ASBT by the caudal-type homeobox proteins CDX1 and CDX2.

Am J Physiol Gastrointest Liver Physiol 2012 Jan 20;302(1):G123-33. Epub 2011 Oct 20.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1152/ajpgi.00102.2011DOI Listing
January 2012

Electronic prescribing increases uptake of clinical pharmacologists' recommendations in the hospital setting.

Br J Clin Pharmacol 2011 Dec;72(6):958-64

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1111/j.1365-2125.2011.04032.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244643PMC
December 2011

Evaluation of medication safety in the discharge medication of 509 surgical inpatients using electronic prescription support software and an extended operational interaction classification.

Eur J Clin Pharmacol 2011 Dec 14;67(12):1273-82. Epub 2011 Jun 14.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.

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http://dx.doi.org/10.1007/s00228-011-1081-9DOI Listing
December 2011

Performance of different data sources in identifying adverse drug events in hospitalized patients.

Eur J Clin Pharmacol 2011 Sep 11;67(9):909-18. Epub 2011 Mar 11.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.

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http://dx.doi.org/10.1007/s00228-011-1020-9DOI Listing
September 2011

Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease.

Pharmacogenet Genomics 2011 Sep;21(9):559-64

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Switzerland.

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http://dx.doi.org/10.1097/FPC.0b013e328348f70cDOI Listing
September 2011

Effect of ABCB1 genotype on pre- and post-cardiac transplantation plasma lipid concentrations.

J Cardiovasc Transl Res 2011 Jun 29;4(3):304-12. Epub 2011 Mar 29.

Transplant Unit, Royal Brompton and Harefield NHS Trust, Harefield Hospital, London, UK.

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http://dx.doi.org/10.1007/s12265-011-9269-zDOI Listing
June 2011

Moderate toxic effects following acute zonisamide overdose.

Epilepsy Behav 2011 May 3;21(1):91-3. Epub 2011 Apr 3.

Swiss Toxicological Information Centre, Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.yebeh.2011.02.023DOI Listing
May 2011

Transporters involved in the hepatic uptake of (99m)Tc-mebrofenin and indocyanine green.

J Hepatol 2011 Apr 1;54(4):738-45. Epub 2010 Oct 1.

Department of Experimental Surgery, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jhep.2010.07.047DOI Listing
April 2011

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

Nat Genet 2010 Dec;42(12):1118-25

Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, Germany.

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http://dx.doi.org/10.1038/ng.717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299551PMC
December 2010