Gerd A Blobel

Gerd A Blobel

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Gerd A Blobel

Publications by authors named "Gerd A Blobel"

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Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription.

Cell Rep 2019 Apr;27(2):400-415.e5

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664437PMC
April 2019

Transcriptional Burst Initiation and Polymerase Pause Release Are Key Control Points of Transcriptional Regulation.

Mol Cell 2019 02 13;73(3):519-532.e4. Epub 2018 Dec 13.

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368450PMC
February 2019

The interdependence of gene-regulatory elements and the 3D genome.

J Cell Biol 2019 01 15;218(1):12-26. Epub 2018 Nov 15.

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA

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http://dx.doi.org/10.1083/jcb.201809040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314554PMC
January 2019

Charting a noncoding gene for γ-globin activation.

Blood 2018 11;132(18):1865-1867

University of New South Wales

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http://dx.doi.org/10.1182/blood-2018-09-873620DOI Listing
November 2018

Robust erythroid differentiation system for rhesus hematopoietic progenitor cells allowing preclinical screening of genetic treatment strategies for the hemoglobinopathies.

Cytotherapy 2018 10 22;20(10):1278-1287. Epub 2018 Sep 22.

Sickle Cell Branch, National Heart Lung and Blood Institutes/National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.jcyt.2018.07.002DOI Listing
October 2018

Perturbing Chromatin Structure to Understand Mechanisms of Gene Expression.

Cold Spring Harb Symp Quant Biol 2015 14;80:207-12. Epub 2015 Sep 14.

Division of Hematology, Children's Hospital of Pennsylvania, Philadelphia, Pennsylvania 19104 Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

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http://dx.doi.org/10.1101/sqb.2015.80.027359DOI Listing
January 2018

Detecting Long-Range Enhancer-Promoter Interactions by Quantitative Chromosome Conformation Capture.

Methods Mol Biol 2017 ;1468:51-62

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/978-1-4939-4035-6_6DOI Listing
January 2018

The Role of Bromodomain and Extraterminal Motif (BET) Proteins in Chromatin Structure.

Cold Spring Harb Symp Quant Biol 2017 1;82:37-43. Epub 2017 Dec 1.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

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http://dx.doi.org/10.1101/sqb.2017.82.033829DOI Listing
December 2017

The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries.

Mol Cell 2017 Apr;66(1):102-116.e7

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393350PMC
April 2017

The type 2 diabetes presumed causal variant within TCF7L2 resides in an element that controls the expression of ACSL5.

Diabetologia 2016 11 18;59(11):2360-2368. Epub 2016 Aug 18.

Divisions of Human Genetics and Endocrinology, The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Room 1102D, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s00125-016-4077-2DOI Listing
November 2016

A new bookmark of the mitotic genome in embryonic stem cells.

Nat Cell Biol 2016 Oct;18(11):1124-1125

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1038/ncb3432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742480PMC
October 2016

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers.

Blood 2016 08 12;128(8):1139-43. Epub 2016 Jul 12.

Department of Pediatrics, Division of Hematology-Oncology, Children's Blood and Cancer Foundation Laboratories, Weill Cornell Medical College, New York, NY; Department of Pediatrics, Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA;

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http://dx.doi.org/10.1182/blood-2016-01-691089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000846PMC
August 2016

Chromatin architecture underpinning transcription elongation.

Nucleus 2016 Jul 1;7(4):1-8. Epub 2016 Jul 1.

a Division of Hematology , The Children's Hospital of Philadelphia , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/19491034.2016.1200770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039000PMC
July 2016

A hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition.

Genes Dev 2016 06;30(12):1423-39

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.280859.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926865PMC
June 2016

A dynamic intron retention program in the mammalian megakaryocyte and erythrocyte lineages.

Blood 2016 04 9;127(17):e24-e34. Epub 2016 Mar 9.

Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, United States

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http://dx.doi.org/10.1182/blood-2016-01-692764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850870PMC
April 2016

Unlinking an lncRNA from Its Associated cis Element.

Mol Cell 2016 Apr 31;62(1):104-10. Epub 2016 Mar 31.

Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.02.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877494PMC
April 2016

Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping.

Mol Cell 2016 04 7;62(2):237-247. Epub 2016 Apr 7.

Division of Hematology, Children's Hospital of Pennsylvania, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842148PMC
April 2016

Role of microRNAs in epigenetic silencing of the CHD5 tumor suppressor gene in neuroblastomas.

Oncotarget 2016 Mar;7(13):15977-85

Division of Oncology and Hematology, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.18632/oncotarget.7434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941291PMC
March 2016

Erythropoiesis provides a BRD's eye view of BET protein function.

Drug Discov Today Technol 2016 Mar 20;19:23-28. Epub 2016 Jul 20.

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ddtec.2016.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116323PMC
March 2016

Dynamic enhancer-gene body contacts during transcription elongation.

Genes Dev 2015 Oct;29(19):1992-7

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

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http://dx.doi.org/10.1101/gad.255265.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604340PMC
October 2015

The tumour suppressor CHD5 forms a NuRD-type chromatin remodelling complex.

Biochem J 2015 Jun;468(2):345-52

*Division of Oncology, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia 19104, PA, U.S.A.

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http://dx.doi.org/10.1042/BJ20150030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487910PMC
June 2015

Keeping fetal hemoglobin in the loop.

Cell Cycle 2014 ;13(20):3153-4

a Division of Hematology; Children's Hospital of Philadelphia ; Philadelphia , PA USA.

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http://dx.doi.org/10.4161/15384101.2014.969995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614825PMC
May 2015

Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility.

Epigenetics Chromatin 2015 23;8:16. Epub 2015 Apr 23.

Center for Comparative Genomics and Bioinformatics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 304 Wartik Laboratory, University Park, PA 16802 USA.

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http://dx.doi.org/10.1186/s13072-015-0009-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432502PMC
May 2015

Characterization of BRD4 during mammalian postmeiotic sperm development.

Mol Cell Biol 2015 Apr 17;35(8):1433-48. Epub 2015 Feb 17.

Penn Epigenetics Program, Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

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http://mcb.asm.org/content/early/2015/02/11/MCB.01328-14.ful
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http://mcb.asm.org/lookup/doi/10.1128/MCB.01328-14
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http://dx.doi.org/10.1128/MCB.01328-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372693PMC
April 2015

Functions of BET proteins in erythroid gene expression.

Blood 2015 Apr 18;125(18):2825-34. Epub 2015 Feb 18.

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA; Perelman School of Medicine, University of Pennsylvania, Philadelphia PA; and.

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http://dx.doi.org/10.1182/blood-2014-10-607309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424630PMC
April 2015

Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis.

Genome Res 2014 Dec 15;24(12):1945-62. Epub 2014 Oct 15.

Center for Comparative Genomics and Bioinformatics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA;

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http://dx.doi.org/10.1101/gr.164830.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248312PMC
December 2014

A comparative encyclopedia of DNA elements in the mouse genome.

Authors:
Feng Yue Yong Cheng Alessandra Breschi Jeff Vierstra Weisheng Wu Tyrone Ryba Richard Sandstrom Zhihai Ma Carrie Davis Benjamin D Pope Yin Shen Dmitri D Pervouchine Sarah Djebali Robert E Thurman Rajinder Kaul Eric Rynes Anthony Kirilusha Georgi K Marinov Brian A Williams Diane Trout Henry Amrhein Katherine Fisher-Aylor Igor Antoshechkin Gilberto DeSalvo Lei-Hoon See Meagan Fastuca Jorg Drenkow Chris Zaleski Alex Dobin Pablo Prieto Julien Lagarde Giovanni Bussotti Andrea Tanzer Olgert Denas Kanwei Li M A Bender Miaohua Zhang Rachel Byron Mark T Groudine David McCleary Long Pham Zhen Ye Samantha Kuan Lee Edsall Yi-Chieh Wu Matthew D Rasmussen Mukul S Bansal Manolis Kellis Cheryl A Keller Christapher S Morrissey Tejaswini Mishra Deepti Jain Nergiz Dogan Robert S Harris Philip Cayting Trupti Kawli Alan P Boyle Ghia Euskirchen Anshul Kundaje Shin Lin Yiing Lin Camden Jansen Venkat S Malladi Melissa S Cline Drew T Erickson Vanessa M Kirkup Katrina Learned Cricket A Sloan Kate R Rosenbloom Beatriz Lacerda de Sousa Kathryn Beal Miguel Pignatelli Paul Flicek Jin Lian Tamer Kahveci Dongwon Lee W James Kent Miguel Ramalho Santos Javier Herrero Cedric Notredame Audra Johnson Shinny Vong Kristen Lee Daniel Bates Fidencio Neri Morgan Diegel Theresa Canfield Peter J Sabo Matthew S Wilken Thomas A Reh Erika Giste Anthony Shafer Tanya Kutyavin Eric Haugen Douglas Dunn Alex P Reynolds Shane Neph Richard Humbert R Scott Hansen Marella De Bruijn Licia Selleri Alexander Rudensky Steven Josefowicz Robert Samstein Evan E Eichler Stuart H Orkin Dana Levasseur Thalia Papayannopoulou Kai-Hsin Chang Arthur Skoultchi Srikanta Gosh Christine Disteche Piper Treuting Yanli Wang Mitchell J Weiss Gerd A Blobel Xiaoyi Cao Sheng Zhong Ting Wang Peter J Good Rebecca F Lowdon Leslie B Adams Xiao-Qiao Zhou Michael J Pazin Elise A Feingold Barbara Wold James Taylor Ali Mortazavi Sherman M Weissman John A Stamatoyannopoulos Michael P Snyder Roderic Guigo Thomas R Gingeras David M Gilbert Ross C Hardison Michael A Beer Bing Ren

Nature 2014 Nov;515(7527):355-64

Ludwig Institute for Cancer Research and University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nature13992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266106PMC
November 2014

Function of GATA factors in the adult mouse liver.

PLoS One 2013 18;8(12):e83723. Epub 2013 Dec 18.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America ; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083723PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867416PMC
October 2014

Comparative analysis of mitosis-specific antibodies for bulk purification of mitotic populations by fluorescence-activated cell sorting.

Biotechniques 2014 1;56(2):90-94. Epub 2014 Feb 1.

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.

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http://dx.doi.org/10.2144/000114137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090248PMC
September 2014

Reactivation of developmentally silenced globin genes by forced chromatin looping.

Cell 2014 Aug;158(4):849-860

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.05.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134511PMC
August 2014

Manipulating nuclear architecture.

Curr Opin Genet Dev 2014 Apr 12;25:1-7. Epub 2013 Dec 12.

Division of Hematology, The Children's Hospital of Philadelphia, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2013.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035372PMC
April 2014

Genetics. GWAS to therapy by genome edits?

Science 2013 Oct;342(6155):206-7

Department of Biochemistry and Molecular Biology, Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, PA 16802, USA.

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http://dx.doi.org/10.1126/science.1245813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500047PMC
October 2013

A cluster to remember.

Cell 2013 Aug;154(4):718-20

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.cell.2013.07.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878159PMC
August 2013

Analysis of disease-causing GATA1 mutations in murine gene complementation systems.

Blood 2013 Jun 23;121(26):5218-27. Epub 2013 May 23.

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1182/blood-2013-03-488080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695365PMC
June 2013

Mitotic bookmarking by transcription factors.

Epigenetics Chromatin 2013 Apr 2;6(1). Epub 2013 Apr 2.

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1186/1756-8935-6-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621617PMC
April 2013

Activating RNAs associate with Mediator to enhance chromatin architecture and transcription.

Nature 2013 Feb 17;494(7438):497-501. Epub 2013 Feb 17.

The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nature11884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109059PMC
February 2013

An encyclopedia of mouse DNA elements (Mouse ENCODE).

August 2012

Short hairpin RNA screen reveals bromodomain proteins as novel targets in acute myeloid leukemia.

Cancer Cell 2011 Sep;20(3):287-8

Division of Hematology, The Children's Hospital of Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659823PMC
September 2011

Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3.

Mol Cell Biol 2011 Jul 9;31(13):2632-40. Epub 2011 May 9.

School of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia.

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http://dx.doi.org/10.1128/MCB.05413-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133386PMC
July 2011

Insights into association of the NuRD complex with FOG-1 from the crystal structure of an RbAp48·FOG-1 complex.

J Biol Chem 2011 Jan 2;286(2):1196-203. Epub 2010 Nov 2.

Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.195842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020727PMC
January 2011

GATA Transcription Factors and Cancer.

Genes Cancer 2010 Dec;1(12):1178-88

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1177/1947601911404223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092280PMC
December 2010

Do chromatin loops provide epigenetic gene expression states?

Curr Opin Genet Dev 2010 Oct 1;20(5):548-54. Epub 2010 Jul 1.

Department of Biology, The University of Pennsylvania, Philadelphia, PA, United States.

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http://dx.doi.org/10.1016/j.gde.2010.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943049PMC
October 2010

Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes.

Mol Cell Biol 2010 Jul 3;30(14):3460-70. Epub 2010 May 3.

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1128/MCB.00001-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897567PMC
July 2010

Lnk constrains myeloproliferative diseases in mice.

J Clin Invest 2010 Jun 10;120(6):2058-69. Epub 2010 May 10.

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://www.jci.org/articles/view/42032
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http://dx.doi.org/10.1172/JCI42032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877957PMC
June 2010

Chromatin loops in gene regulation.

Biochim Biophys Acta 2009 Jan 15;1789(1):17-25. Epub 2008 Jul 15.

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.bbagrm.2008.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638769PMC
January 2009

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.

Mol Cell Biol 2008 Apr 19;28(8):2825-39. Epub 2008 Feb 19.

Division of Hematology, Abramson Research Center 315A, The Children's Hospital of Philadelphia, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.02076-07
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http://dx.doi.org/10.1128/MCB.02076-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2293113PMC
April 2008

The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex.

J Mol Cell Cardiol 2008 Feb 12;44(2):352-60. Epub 2007 Nov 12.

The Committee on Developmental Biology, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2007.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277079PMC
February 2008

Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes.

Mol Cell Biol 2007 Dec 8;27(24):8466-79. Epub 2007 Oct 8.

Children's Hospital of Philadelphia, Division of Hematology, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1128/MCB.00993-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169421PMC
December 2007

Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization.

Blood 2007 Jun 22;109(12):5199-207. Epub 2007 Feb 22.

Graduate Program in Molecular Genetics and Cell Biology, University of Chicago, IL, USA.

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http://dx.doi.org/10.1182/blood-2006-11-059378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1890844PMC
June 2007

Dissecting molecular steps in chromatin domain activation during hematopoietic differentiation.

Mol Cell Biol 2007 Jun 16;27(12):4551-65. Epub 2007 Apr 16.

University of Wisconsin School of Medicine, Department of Pharmacology, 383 Medical Sciences Center, Madison, WI 53706, USA.

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http://dx.doi.org/10.1128/MCB.00235-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900038PMC
June 2007

Acetylation of GATA-1 is required for chromatin occupancy.

Blood 2006 Dec 3;108(12):3736-8. Epub 2006 Aug 3.

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2006-07-032847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895476PMC
December 2006

Profile of histone lysine methylation across transcribed mammalian chromatin.

Mol Cell Biol 2006 Dec 9;26(24):9185-95. Epub 2006 Oct 9.

The Children's Hospital of Philadelphia, Division of Hematology, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1128/MCB.01529-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698537PMC
December 2006

In vivo dual cross-linking for identification of indirect DNA-associated proteins by chromatin immunoprecipitation.

Biotechniques 2006 Dec;41(6):694, 696, 698

The Wistar Institute, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.2144/000112297DOI Listing
December 2006

Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins.

Blood 2006 Oct 6;108(7):2198-206. Epub 2006 Jun 6.

Children's Hospital of Philadelphia, ARC 316H, 3165 Civic Center Blvd, Philadelphia, PA, USA.

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http://dx.doi.org/10.1182/blood-2006-04-019760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895561PMC
October 2006

Distinct functions of dispersed GATA factor complexes at an endogenous gene locus.

Mol Cell Biol 2006 Oct;26(19):7056-67

University of Wisconsin Medical School, Department of Pharmacology, 1300 University Avenue, Madison, WI 53706, USA.

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http://dx.doi.org/10.1128/MCB.01033-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592882PMC
October 2006

Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin.

Mol Cell 2005 Aug;19(3):381-91

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1016/j.molcel.2005.06.011DOI Listing
August 2005

FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1.

EMBO J 2005 Jul 26;24(13):2367-78. Epub 2005 May 26.

Division of Hematology, Children's Hospital of Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1038/sj.emboj.7600703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1173144PMC
July 2005

Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.

Mol Cell 2005 Feb;17(3):453-62

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.molcel.2004.12.028DOI Listing
February 2005

E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells.

J Biol Chem 2004 Dec 26;279(53):55362-71. Epub 2004 Oct 26.

Queen's University Cancer Research Institute, Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, K7L 3N6, Canada.

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http://dx.doi.org/10.1074/jbc.M408654200DOI Listing
December 2004

Global regulation of erythroid gene expression by transcription factor GATA-1.

Blood 2004 Nov 5;104(10):3136-47. Epub 2004 Aug 5.

The Children's Hospital of Philadelphia, Division of Hematology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2004-04-1603DOI Listing
November 2004

Identification of cyclin D3 as a direct target of E2A using DamID.

Mol Cell Biol 2004 Oct;24(19):8790-802

Children's Hospital of Philadelphia, 802F ARC, 3516 Civic Center Blvd., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1128/MCB.24.19.8790-8802.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC516727PMC
October 2004

Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2.

EMBO J 2004 Jul 24;23(14):2841-52. Epub 2004 Jun 24.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

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http://emboj.embopress.org/cgi/doi/10.1038/sj.emboj.7600274
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http://dx.doi.org/10.1038/sj.emboj.7600274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514941PMC
July 2004

Context-dependent regulation of GATA-1 by friend of GATA-1.

Proc Natl Acad Sci U S A 2004 Jan 26;101(2):476-81. Epub 2003 Dec 26.

University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0306315101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC327172PMC
January 2004

GATA-1-mediated proliferation arrest during erythroid maturation.

Mol Cell Biol 2003 Jul;23(14):5031-42

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC162202PMC
http://dx.doi.org/10.1128/mcb.23.14.5031-5042.2003DOI Listing
July 2003

Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1.

Mol Cell Biol 2003 Feb;23(4):1334-40

Division of Hematology, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC141148PMC
http://dx.doi.org/10.1128/mcb.23.4.1334-1340.2003DOI Listing
February 2003

Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68.

Mol Cancer Res 2002 Nov;1(1):48-55

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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November 2002

Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors.

EMBO J 2002 Oct;21(19):5225-34

University of Pennsylvania School of Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129049PMC
http://dx.doi.org/10.1093/emboj/cdf527DOI Listing
October 2002

Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain.

Proc Natl Acad Sci U S A 2002 Sep 22;99(18):11760-5. Epub 2002 Aug 22.

Department of Pharmacology, Molecular and Cellular Pharmacology Program, University of Wisconsin Medical School, 383 Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA.

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http://dx.doi.org/10.1073/pnas.192285999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129342PMC
September 2002