Gerard Sanacora

Gerard Sanacora

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Gerard Sanacora

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Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments.

Neuron 2019 04;102(1):75-90

Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA.

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http://dx.doi.org/10.1016/j.neuron.2019.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450409PMC
April 2019

Caution Against Overinterpreting Opiate Receptor Stimulation as Mediating Antidepressant Effects of Ketamine.

Authors:
Gerard Sanacora

Am J Psychiatry 2019 03;176(3):249

Department of Psychiatry, Yale University School of Medicine, and Yale-New Haven Health System, New Haven, Conn.

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http://dx.doi.org/10.1176/appi.ajp.2018.18091061DOI Listing
March 2019

Ketamine: A Paradigm Shift for Depression Research and Treatment.

Neuron 2019 03;101(5):774-778

Departments of Psychiatry, Neuroscience, and Psychology, Yale University, New Haven, CT, USA; National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT, USA; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.neuron.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560624PMC
March 2019

A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems.

Drug Discov Today 2019 02 14;24(2):606-615. Epub 2018 Nov 14.

Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Connecticut Mental Health Center, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.drudis.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397075PMC
February 2019

ELEctroconvulsive therapy (ECT) vs. Ketamine in patients with Treatment-resistant Depression: The ELEKT-D study protocol.

Contemp Clin Trials 2019 02 17;77:19-26. Epub 2018 Dec 17.

Center for Behavioral Health, Cleveland Clinic, United States; Center for Behavioral Health, Lutheran Hospital, United States; Cleveland Clinic Lerner, College of Medicine of Case Western Reserve University, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cct.2018.12.009DOI Listing
February 2019

The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?

Pharmacol Ther 2018 10 25;190:148-158. Epub 2018 May 25.

Department of Psychiatry, Yale University School of Medicine, New Haven, USA; Clinical Neuroscience Division, Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Veterans Affairs Connecticut Healthcare System, West Haven, USA; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, USA.

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http://dx.doi.org/10.1016/j.pharmthera.2018.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165688PMC
October 2018

The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?

Pharmacol Ther 2018 10 25;190:148-158. Epub 2018 May 25.

Department of Psychiatry, Yale University School of Medicine, New Haven, USA; Clinical Neuroscience Division, Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Veterans Affairs Connecticut Healthcare System, West Haven, USA; Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, USA.

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http://dx.doi.org/10.1016/j.pharmthera.2018.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165688PMC
October 2018

Hopes and Skepticism for Unraveling the Unique Mechanisms of Ketamine's Rapid Onset Antidepressant Actions in Rodent Models.

Authors:
Gerard Sanacora

Biol Psychiatry 2018 07;84(1):7-8

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2018.05.012DOI Listing
July 2018

Acute and Longer-Term Outcomes Using Ketamine as a Clinical Treatment at the Yale Psychiatric Hospital.

J Clin Psychiatry 2018 07 24;79(4). Epub 2018 Jul 24.

Department of Psychiatry at the Yale School of Medicine and the Yale Psychiatric Hospital, New Haven, Connecticut, USA.

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http://dx.doi.org/10.4088/JCP.17m11731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296748PMC
July 2018

Hippocampal volume changes following electroconvulsive therapy: a systematic review and meta-analysis.

Biol Psychiatry Cogn Neurosci Neuroimaging 2017 May 5;2(4):327-335. Epub 2017 Feb 5.

Department of Psychiatry, Yale School of Medicine, New Haven, CT 06511.

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http://dx.doi.org/10.1016/j.bpsc.2017.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627663PMC
May 2017

Authorship Credit for Large Clinical Trials.

JAMA 2018 02;319(7):722-723

Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1001/jama.2017.20939DOI Listing
February 2018

A Randomized, Double-Blind, Placebo-Controlled, Sequential Parallel Comparison Design Trial of Adjunctive Riluzole for Treatment-Resistant Major Depressive Disorder.

Neuropsychopharmacology 2017 Dec 29;42(13):2567-2574. Epub 2017 May 29.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/npp.2017.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686483PMC
December 2017

Reply to: Ketamine and Psychosis History: Antidepressant Efficacy and Psychotomimetic Effects Postinfusion.

Biol Psychiatry 2017 09 23;82(5):e37. Epub 2017 Jan 23.

Yale University, New Haven, Connecticut.

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http://dx.doi.org/10.1016/j.biopsych.2017.01.012DOI Listing
September 2017

Co-occurring Catatonia and Posterior Reversible Encephalopathy Syndrome Responsive to Electroconvulsive Therapy.

J ECT 2017 09;33(3):e22

Department of Psychiatry, Yale University, New Haven, CT, Department of Psychiatry, Yale Depression Research Program and the Yale-New Haven Hospital Interventional, Psychiatry Program, Yale University, New Haven, CT Department of Psychiatry and Spectrum, Psychiatric Group, Yale University, New Haven, CT.

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http://dx.doi.org/10.1097/YCT.0000000000000407DOI Listing
September 2017

Ketamine for the Treatment of Depression-Reply.

Authors:
Gerard Sanacora

JAMA Psychiatry 2017 09;74(9):971-972

Yale Depression Research Program, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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http://archpsyc.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamapsychiatry.2017.1776DOI Listing
September 2017

Considerations on the Off-label Use of Ketamine as a Treatment for Mood Disorders.

JAMA 2017 Sep;318(9):793-794

Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2017.10697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248331PMC
September 2017

Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic.

Curr Psychiatry Rep 2017 Aug 26;19(10):74. Epub 2017 Aug 26.

Department of Psychiatry, Yale University School of Medicine, 300 George St., Suite #901, New Haven, CT, 06511, USA.

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http://dx.doi.org/10.1007/s11920-017-0829-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904792PMC
August 2017

A Survey of the Clinical, Off-Label Use of Ketamine as a Treatment for Psychiatric Disorders.

Am J Psychiatry 2017 07;174(7):695-696

From the Department of Psychiatry, Yale School of Medicine, New Haven, Conn.; Kaiser Permanente Northern California, San Francisco; and Ketamine Treatment Centers, Princeton, N.J.

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http://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2017.17
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http://dx.doi.org/10.1176/appi.ajp.2017.17020239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549850PMC
July 2017

Hippocampal volume changes following electroconvulsive therapy: a systematic review and meta-analysis.

Biol Psychiatry Cogn Neurosci Neuroimaging 2017 May 5;2(4):327-335. Epub 2017 Feb 5.

Department of Psychiatry, Yale School of Medicine, New Haven, CT 06511.

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http://dx.doi.org/10.1016/j.bpsc.2017.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627663PMC
May 2017

A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders.

JAMA Psychiatry 2017 Apr;74(4):399-405

Department of Psychiatry, University of Miami Miller School of Medicine, Miami, Florida.

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http://dx.doi.org/10.1001/jamapsychiatry.2017.0080DOI Listing
April 2017

Inflammation, Glutamate, and Glia: A Trio of Trouble in Mood Disorders.

Neuropsychopharmacology 2017 01 15;42(1):193-215. Epub 2016 Sep 15.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/npp.2016.199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143501PMC
January 2017

A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression.

Am J Psychiatry 2016 Aug 8;173(8):816-26. Epub 2016 Apr 8.

From Janssen Research and Development, Titusville, N.J., and Beerse, Belgium; the Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, N.Y.; the Department of Psychiatry, Yale University, New Haven, Conn.; the Department of Psychiatry and Behavioral Neurobiology, School of Medicine, University of Alabama at Birmingham; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Institute of Living, Hartford, Conn.; University of Connecticut Health Center, Farmington; the Department of Psychiatry, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1176/appi.ajp.2016.16010037DOI Listing
August 2016

KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID-ACTING ANTIDEPRESSANTS.

Depress Anxiety 2016 08 6;33(8):689-97. Epub 2016 Apr 6.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1002/da.22501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961540PMC
August 2016

What Are We Learning From Early-Phase Clinical Trials With Glutamate Targeting Medications for the Treatment of Major Depressive Disorder.

Authors:
Gerard Sanacora

JAMA Psychiatry 2016 07;73(7):651-2

Department of Psychiatry, Yale University, New Haven, Connecticut.

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http://dx.doi.org/10.1001/jamapsychiatry.2016.0780DOI Listing
July 2016

What Are We Learning From Early-Phase Clinical Trials With Glutamate Targeting Medications for the Treatment of Major Depressive Disorder.

Authors:
Gerard Sanacora

JAMA Psychiatry 2016 07;73(7):651-2

Department of Psychiatry, Yale University, New Haven, Connecticut.

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http://dx.doi.org/10.1001/jamapsychiatry.2016.0780DOI Listing
July 2016

Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.

Biol Psychiatry 2016 07;80(2):84-86

Department of Psychiatry, University Neuropsychiatric Institute, University of Utah Health Sciences Center, Salt Lake City, Utah.

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http://dx.doi.org/10.1016/j.biopsych.2016.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150945PMC
July 2016

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants.

Nat Med 2016 Mar;22(3):238-49

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/nm.4050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405628PMC
March 2016

A history of early life parental loss or separation is associated with successful cognitive-behavioral therapy in major depressive disorder.

J Affect Disord 2015 Nov 19;187:241-4. Epub 2015 Aug 19.

Yale University Department of Psychiatry/Connecticut Mental Health Center, Abraham Ribicoff Research Facilities, 34 Park St., 3rd floor, New Haven, CT 06519, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01650327153039
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http://dx.doi.org/10.1016/j.jad.2015.08.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814568PMC
November 2015

Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics.

Annu Rev Med 2015 17;66:509-23. Epub 2014 Oct 17.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511; email: , , ,

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http://dx.doi.org/10.1146/annurev-med-053013-062946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428310PMC
September 2015

Decreased occipital cortical glutamate levels in response to successful cognitive-behavioral therapy and pharmacotherapy for major depressive disorder.

Psychother Psychosom 2014 6;83(5):298-307. Epub 2014 Aug 6.

Abraham Ribicoff Research Facilities, Connecticut Mental Health Center (CMHC), Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA.

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http://dx.doi.org/10.1159/000361078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164203PMC
June 2015

In vivo ketamine-induced changes in [¹¹C]ABP688 binding to metabotropic glutamate receptor subtype 5.

Biol Psychiatry 2015 Feb 10;77(3):266-275. Epub 2014 Jul 10.

Department of Psychiatry, Columbia University, New York, New York; Departments of Biomedical Engineering, Yale University, New Haven; Child Study Center, Yale University, New Haven.

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http://dx.doi.org/10.1016/j.biopsych.2014.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277907PMC
February 2015

Ketamine: promising path or false prophecy in the development of novel therapeutics for mood disorders?

Neuropsychopharmacology 2015 Jan 26;40(2):259-67. Epub 2014 Sep 26.

Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1038/npp.2014.261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443967PMC
January 2015

Regulation of extrasynaptic glutamate levels as a pathophysiological mechanism in disorders of motivation and addiction.

Neuropsychopharmacology 2015 Jan;40(1):254-5

Clinical Neuroscience Research Unit, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/npp.2014.218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262905PMC
January 2015

Glutamate metabolism in major depressive disorder.

Am J Psychiatry 2014 Dec 31;171(12):1320-7. Epub 2014 Oct 31.

From the Department of Psychiatry, the Department of Diagnostic Imaging, and the Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Conn.; the Clinical Neuroscience Research Unit, Connecticut Mental Health Center, New Haven; and the Clinical Neuroscience Division, National Center for PTSD, West Haven, Conn.

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http://dx.doi.org/10.1176/appi.ajp.2014.14010067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472484PMC
December 2014

Delayed amnesic syndrome after riluzole use in major depressive disorder: a case report.

Psychosomatics 2013 Sep-Oct;54(5):488-92. Epub 2013 Mar 6.

Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA.

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https://linkinghub.elsevier.com/retrieve/pii/S00333182130003
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http://dx.doi.org/10.1016/j.psym.2013.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681895PMC
April 2014

Glial abnormalities in substance use disorders and depression: does shared glutamatergic dysfunction contribute to comorbidity?

World J Biol Psychiatry 2014 Jan 12;15(1):2-16. Epub 2013 Sep 12.

Yale University Department of Psychiatry/Connecticut Mental Health Center (CMHC), Clinical Neuroscience Research Unit (CNRU) , New Haven, CT , USA.

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http://dx.doi.org/10.3109/15622975.2013.829585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180366PMC
January 2014

Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses.

Biol Psychiatry 2013 Nov 14;74(10):742-9. Epub 2013 Jun 14.

Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Departments of Psychiatry, Neurobiology, and Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1016/j.biopsych.2013.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773272PMC
November 2013

Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond.

Biol Psychiatry 2013 Jun;73(12):1133-41

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1016/j.biopsych.2013.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671489PMC
June 2013

From pathophysiology to novel antidepressant drugs: glial contributions to the pathology and treatment of mood disorders.

Biol Psychiatry 2013 Jun;73(12):1172-9

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1016/j.biopsych.2013.03.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688253PMC
June 2013

Rapid antidepressant effect of ketamine in the electroconvulsive therapy setting.

J ECT 2012 Sep;28(3):157-61

Department of Psychiatry and the Ribicoff Research Facilities, Yale University School of Medicine, New Haven, CT, USA.

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https://insights.ovid.com/crossref?an=00124509-201209000-000
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http://dx.doi.org/10.1097/YCT.0b013e31824f8296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426617PMC
September 2012

¹H-[¹³C]-nuclear magnetic resonance spectroscopy measures of ketamine's effect on amino acid neurotransmitter metabolism.

Biol Psychiatry 2012 Jun 9;71(11):1022-5. Epub 2011 Dec 9.

Department of Psychiatry and the Ribicoff Research Facilities, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1016/j.biopsych.2011.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660962PMC
June 2012

Cortical GABA levels in primary insomnia.

Sleep 2012 Jun 1;35(6):807-14. Epub 2012 Jun 1.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.5665/sleep.1880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353043PMC
June 2012

Glutamate-based depression GBD.

Med Hypotheses 2012 May 4;78(5):675-81. Epub 2012 Mar 4.

Clinical Neuroscience AstraZeneca Pharmaceuticals LP, Wilmington, DE, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S03069877120007
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http://dx.doi.org/10.1016/j.mehy.2012.02.009DOI Listing
May 2012

Antidepressant-like properties of oral riluzole and utility of incentive disengagement models of depression in mice.

Psychopharmacology (Berl) 2012 Feb 21;219(3):805-14. Epub 2011 Jul 21.

Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, CT 06511, USA.

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http://link.springer.com/10.1007/s00213-011-2403-4
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http://dx.doi.org/10.1007/s00213-011-2403-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674097PMC
February 2012

Overview of glutamatergic neurotransmission in the nervous system.

Pharmacol Biochem Behav 2012 Feb 26;100(4):656-64. Epub 2011 Aug 26.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA.

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http://dx.doi.org/10.1016/j.pbb.2011.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253893PMC
February 2012

The roles of glutamate receptors across major neurological and psychiatric disorders.

Pharmacol Biochem Behav 2012 Feb 13;100(4):653-5. Epub 2011 Nov 13.

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http://dx.doi.org/10.1016/j.pbb.2011.11.002DOI Listing
February 2012

Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders.

Neuropharmacology 2012 Jan 3;62(1):63-77. Epub 2011 Aug 3.

Department of Psychiatry, Clinical Neuroscience Research Unit, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2011.07.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205453PMC
January 2012

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission.

Nat Rev Neurosci 2011 Nov 30;13(1):22-37. Epub 2011 Nov 30.

Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133 Milan, Italy.

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http://dx.doi.org/10.1038/nrn3138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645314PMC
November 2011

Levetiracetam in the management of bipolar depression: a randomized, double-blind, placebo-controlled trial.

J Clin Psychiatry 2011 Jun 19;72(6):744-50. Epub 2010 Oct 19.

Department of Psychiatry, Yale University, New Haven, Connecticut, USA.

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http://dx.doi.org/10.4088/JCP.09m05659greDOI Listing
June 2011

Computerized ambulatory monitoring in mood disorders: feasibility, compliance, and reactivity.

Psychiatry Res 2010 Jul 21;178(2):440-2. Epub 2010 May 21.

New York State Psychiatric Institute, Columbia University, New York, NY 10019, USA.

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http://dx.doi.org/10.1016/j.psychres.2010.04.045DOI Listing
July 2010

Reduced density of calbindin immunoreactive GABAergic neurons in the occipital cortex in major depression: relevance to neuroimaging studies.

Biol Psychiatry 2010 Mar 9;67(5):465-70. Epub 2009 Dec 9.

Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.

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http://dx.doi.org/10.1016/j.biopsych.2009.10.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823848PMC
March 2010

Cortical inhibition, gamma-aminobutyric acid, and major depression: there is plenty of smoke but is there fire?

Authors:
Gerard Sanacora

Biol Psychiatry 2010 Mar;67(5):397-8

Department of Psychiatry, Clinical Neuroscience Research Unit, Yale University School of Medicine, New Haven, Connecticut 06519, USA.

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http://dx.doi.org/10.1016/j.biopsych.2010.01.003DOI Listing
March 2010

Do glutamatergic agents represent a new class of antidepressant drugs? Part 2.

Authors:
Gerard Sanacora

J Clin Psychiatry 2009 Nov;70(11):1604-5

Yale University, 34 Park St, New Haven, CT 06519, USA.

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http://dx.doi.org/10.4088/JCP.09ac05757bluDOI Listing
November 2009

Do glutamatergic agents represent a new class of antidepressant drugs? Part 1.

Authors:
Gerard Sanacora

J Clin Psychiatry 2009 Oct;70(10):1473-5

Department of Psychiatry, Yale University, New Haven, CT 06519, USA.

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http://dx.doi.org/10.4088/JCP.09ac05680bluDOI Listing
October 2009

Targeting glial physiology and glutamate cycling in the treatment of depression.

Biochem Pharmacol 2009 Sep 17;78(5):431-9. Epub 2009 Apr 17.

Yale University, Department of Psychiatry, CNRU, 34 Park Street, New Haven, CT 06508, USA.

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http://dx.doi.org/10.1016/j.bcp.2009.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801154PMC
September 2009

Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia.

Drug Discov Today 2009 Jul 19;14(13-14):690-7. Epub 2009 May 19.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, United States.

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http://dx.doi.org/10.1016/j.drudis.2009.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898127PMC
July 2009

New understanding of mechanisms of action of bipolar medications.

Authors:
Gerard Sanacora

J Clin Psychiatry 2008 ;69 Suppl 5:22-7

Yale Depression Research Program, Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA.

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March 2009

Reviewing medications for bipolar disorder: understanding the mechanisms of action.

Authors:
Gerard Sanacora

J Clin Psychiatry 2009 Jan;70(1):e02

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.4088/jcp.7128br6c.e02DOI Listing
January 2009

Chronic riluzole treatment increases glucose metabolism in rat prefrontal cortex and hippocampus.

J Cereb Blood Flow Metab 2008 Dec 16;28(12):1892-7. Epub 2008 Jul 16.

Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/jcbfm.2008.78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739056PMC
December 2008

Riluzole in the treatment of mood and anxiety disorders.

CNS Drugs 2008 ;22(9):761-86

Clinical Neuroscience Research Unit, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.2165/00023210-200822090-00004DOI Listing
December 2008

Major depression: emerging therapeutics.

Mt Sinai J Med 2008 May-Jun;75(3):204-25

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1002/msj.20043DOI Listing
December 2008

Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications.

Biol Psychiatry 2008 Sep 24;64(6):527-32. Epub 2008 Jun 24.

Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, Connecticut 06519, USA.

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http://dx.doi.org/10.1016/j.biopsych.2008.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597158PMC
September 2008

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders.

Nat Rev Drug Discov 2008 May;7(5):426-37

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1038/nrd2462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715836PMC
May 2008

It is time to take a stand for medical research and against terrorism targeting medical scientists.

Biol Psychiatry 2008 Apr;63(8):725-7

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1016/j.biopsych.2008.03.005DOI Listing
April 2008

The NMDA receptor as a therapeutic target in major depressive disorder.

CNS Neurol Disord Drug Targets 2007 Apr;6(2):101-15

Department of Psychiatry, Yale University, USA.

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http://dx.doi.org/10.2174/187152707780363267DOI Listing
April 2007

GABAergic contributions to the pathophysiology of depression and the mechanism of antidepressant action.

CNS Neurol Disord Drug Targets 2007 Apr;6(2):127-40

Yale University School of Medicine, Department of Psychiatry, USA.

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http://dx.doi.org/10.2174/187152707780363294DOI Listing
April 2007

Antidepressant-like effects of ceftriaxone in male C57BL/6J mice.

Biol Psychiatry 2007 Jan 24;61(2):250-2. Epub 2006 Jul 24.

Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06519, USA.

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http://dx.doi.org/10.1016/j.biopsych.2006.04.037DOI Listing
January 2007

Can cognitive behavioral therapy reduce relapse rates of depression after ECT? a preliminary study.

J ECT 2006 Sep;22(3):196-8

Yale Depression Research Program, Yale University School of Medicine, New Haven, CT 06511, USA.

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http://dx.doi.org/10.1097/01.yct.0000235201.42287.b4DOI Listing
September 2006

Cortical gamma-aminobutyric acid concentrations in depressed patients receiving cognitive behavioral therapy.

Biol Psychiatry 2006 Feb 1;59(3):284-6. Epub 2005 Sep 1.

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1016/j.biopsych.2005.07.015DOI Listing
February 2006

Sex differences in diencephalon serotonin transporter availability in major depression.

Biol Psychiatry 2006 Jan 1;59(1):40-7. Epub 2005 Sep 1.

Department of Psychiatry, Yale University School of Medicine and West Haven VA Connecticut Health Care System, CT 06516, USA.

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http://dx.doi.org/10.1016/j.biopsych.2005.06.012DOI Listing
January 2006

Beyond monoamines: glutamatergic function in mood disorders.

CNS Spectr 2005 Oct;10(10):808-19

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1017/s1092852900010403DOI Listing
October 2005

Antidepressant effect of ketamine during ECT.

Am J Psychiatry 2005 Jul;162(7):1385-6

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http://dx.doi.org/10.1176/appi.ajp.162.7.1385DOI Listing
July 2005