Gerard Manning

Gerard Manning

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Gerard Manning

Publications by authors named "Gerard Manning"

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Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3.

Cell Rep 2019 Sep;28(13):3309-3319.e5

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.055DOI Listing
September 2019

HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors.

Breast Cancer Res 2018 01 30;20(1). Epub 2018 Jan 30.

Bioinformatics & Computational Biology, Genentech, Inc, 1 DNA Way, MS444a, South San Francisco, CA, 94080, USA.

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http://dx.doi.org/10.1186/s13058-018-0933-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791377PMC
January 2018

Genomics and evolution of protein phosphatases.

Sci Signal 2017 Apr 11;10(474). Epub 2017 Apr 11.

Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1126/scisignal.aag1796DOI Listing
April 2017

Necroptosis and Inflammation.

Annu Rev Biochem 2016 Jun 8;85:743-63. Epub 2016 Feb 8.

Bioinformatics and Computational Biology Department, Genentech, Inc., South San Francisco, California 94080; email:

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http://dx.doi.org/10.1146/annurev-biochem-060815-014830DOI Listing
June 2016

The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima.

Authors:
Ariel D Chipman David E K Ferrier Carlo Brena Jiaxin Qu Daniel S T Hughes Reinhard Schröder Montserrat Torres-Oliva Nadia Znassi Huaiyang Jiang Francisca C Almeida Claudio R Alonso Zivkos Apostolou Peshtewani Aqrawi Wallace Arthur Jennifer C J Barna Kerstin P Blankenburg Daniela Brites Salvador Capella-Gutiérrez Marcus Coyle Peter K Dearden Louis Du Pasquier Elizabeth J Duncan Dieter Ebert Cornelius Eibner Galina Erikson Peter D Evans Cassandra G Extavour Liezl Francisco Toni Gabaldón William J Gillis Elizabeth A Goodwin-Horn Jack E Green Sam Griffiths-Jones Cornelis J P Grimmelikhuijzen Sai Gubbala Roderic Guigó Yi Han Frank Hauser Paul Havlak Luke Hayden Sophie Helbing Michael Holder Jerome H L Hui Julia P Hunn Vera S Hunnekuhl LaRonda Jackson Mehwish Javaid Shalini N Jhangiani Francis M Jiggins Tamsin E Jones Tobias S Kaiser Divya Kalra Nathan J Kenny Viktoriya Korchina Christie L Kovar F Bernhard Kraus François Lapraz Sandra L Lee Jie Lv Christigale Mandapat Gerard Manning Marco Mariotti Robert Mata Tittu Mathew Tobias Neumann Irene Newsham Dinh N Ngo Maria Ninova Geoffrey Okwuonu Fiona Ongeri William J Palmer Shobha Patil Pedro Patraquim Christopher Pham Ling-Ling Pu Nicholas H Putman Catherine Rabouille Olivia Mendivil Ramos Adelaide C Rhodes Helen E Robertson Hugh M Robertson Matthew Ronshaugen Julio Rozas Nehad Saada Alejandro Sánchez-Gracia Steven E Scherer Andrew M Schurko Kenneth W Siggens DeNard Simmons Anna Stief Eckart Stolle Maximilian J Telford Kristin Tessmar-Raible Rebecca Thornton Maurijn van der Zee Arndt von Haeseler James M Williams Judith H Willis Yuanqing Wu Xiaoyan Zou Daniel Lawson Donna M Muzny Kim C Worley Richard A Gibbs Michael Akam Stephen Richards

PLoS Biol 2014 Nov 25;12(11):e1002005. Epub 2014 Nov 25.

Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1002005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244043PMC
November 2014

Discovery of a metabolic alternative to the classical mevalonate pathway.

Elife 2013 Dec 10;2:e00672. Epub 2013 Dec 10.

Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, United States.

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http://dx.doi.org/10.7554/eLife.00672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857490PMC
December 2013

Assessment of computational methods for predicting the effects of missense mutations in human cancers.

BMC Genomics 2013 28;14 Suppl 3:S7. Epub 2013 May 28.

Department of Bioinformatics and Computational Biology, Genentech Inc, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1186/1471-2164-14-S3-S7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665581PMC
October 2013

Insulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool release.

Cell Rep 2013 Sep 5;4(5):921-30. Epub 2013 Sep 5.

Department of Cell and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.07.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839581PMC
September 2013

RPN-6 determines C. elegans longevity under proteotoxic stress conditions.

Nature 2012 Sep;489(7415):263-8

Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nature11315DOI Listing
September 2012

Genomic survey of premetazoans shows deep conservation of cytoplasmic tyrosine kinases and multiple radiations of receptor tyrosine kinases.

Sci Signal 2012 May 1;5(222):ra35. Epub 2012 May 1.

Institut de Biologia Evolutiva (UPF-CSIC), Passeig Marítim de la Barceloneta 37-49, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1126/scisignal.2002733DOI Listing
May 2012

Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis.

Nature 2012 May 13;485(7399):530-3. Epub 2012 May 13.

Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, Iowa 50011, USA.

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http://dx.doi.org/10.1038/nature11009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880581PMC
May 2012

Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities.

J Biol Chem 2011 Sep 27;286(37):32834-42. Epub 2011 Jul 27.

Department of Pharmacology, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California 92093-0721, USA.

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http://dx.doi.org/10.1074/jbc.M111.227603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173180PMC
September 2011

From Plk1 to Plk5: functional evolution of polo-like kinases.

Cell Cycle 2011 Jul 15;10(14):2255-62. Epub 2011 Jul 15.

Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230524PMC
http://dx.doi.org/10.4161/cc.10.14.16494DOI Listing
July 2011

Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.

Proc Natl Acad Sci U S A 2011 Jul 5;108(29):11860-5. Epub 2011 Jul 5.

Department of Pharmacology, University of California, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.1109290108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142007PMC
July 2011

The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology.

Genome Biol 2011 Jul 25;12(7):R66. Epub 2011 Jul 25.

Razavi Newman Center for Bioinformatics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1186/gb-2011-12-7-r66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218828PMC
July 2011

The Selaginella genome identifies genetic changes associated with the evolution of vascular plants.

Authors:
Jo Ann Banks Tomoaki Nishiyama Mitsuyasu Hasebe John L Bowman Michael Gribskov Claude dePamphilis Victor A Albert Naoki Aono Tsuyoshi Aoyama Barbara A Ambrose Neil W Ashton Michael J Axtell Elizabeth Barker Michael S Barker Jeffrey L Bennetzen Nicholas D Bonawitz Clint Chapple Chaoyang Cheng Luiz Gustavo Guedes Correa Michael Dacre Jeremy DeBarry Ingo Dreyer Marek Elias Eric M Engstrom Mark Estelle Liang Feng Cédric Finet Sandra K Floyd Wolf B Frommer Tomomichi Fujita Lydia Gramzow Michael Gutensohn Jesper Harholt Mitsuru Hattori Alexander Heyl Tadayoshi Hirai Yuji Hiwatashi Masaki Ishikawa Mineko Iwata Kenneth G Karol Barbara Koehler Uener Kolukisaoglu Minoru Kubo Tetsuya Kurata Sylvie Lalonde Kejie Li Ying Li Amy Litt Eric Lyons Gerard Manning Takeshi Maruyama Todd P Michael Koji Mikami Saori Miyazaki Shin-ichi Morinaga Takashi Murata Bernd Mueller-Roeber David R Nelson Mari Obara Yasuko Oguri Richard G Olmstead Naoko Onodera Bent Larsen Petersen Birgit Pils Michael Prigge Stefan A Rensing Diego Mauricio Riaño-Pachón Alison W Roberts Yoshikatsu Sato Henrik Vibe Scheller Burkhard Schulz Christian Schulz Eugene V Shakirov Nakako Shibagaki Naoki Shinohara Dorothy E Shippen Iben Sørensen Ryo Sotooka Nagisa Sugimoto Mamoru Sugita Naomi Sumikawa Milos Tanurdzic Günter Theissen Peter Ulvskov Sachiko Wakazuki Jing-Ke Weng William W G T Willats Daniel Wipf Paul G Wolf Lixing Yang Andreas D Zimmer Qihui Zhu Therese Mitros Uffe Hellsten Dominique Loqué Robert Otillar Asaf Salamov Jeremy Schmutz Harris Shapiro Erika Lindquist Susan Lucas Daniel Rokhsar Igor V Grigoriev

Science 2011 May 5;332(6032):960-3. Epub 2011 May 5.

Department of Botany and Plant Pathology, Purdue University, West Lafayette, IN 47907, USA.

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http://sites.psu.edu/axtell/wp-content/uploads/sites/21458/2
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http://www.sciencemag.org/cgi/doi/10.1126/science.1203810
Publisher Site
http://dx.doi.org/10.1126/science.1203810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166216PMC
May 2011

How the vertebrates were made: selective pruning of a double-duplicated genome.

BMC Biol 2010 Dec 13;8:144. Epub 2010 Dec 13.

Razavi Newman Center for Bioinformatics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1186/1741-7007-8-144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001425PMC
December 2010

Genomics, evolution, and crystal structure of a new family of bacterial spore kinases.

Proteins 2010 May;78(6):1470-82

Razavi Newman Center for Bioinformatics, Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1002/prot.22663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860764PMC
May 2010

The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress.

Mol Cell 2009 Aug;35(4):442-53

Department of Pharmacology, Case Comprehensive Caner Center, School of Medicine, Case Western Reserve University, 2109 Adelbert Road, Wood Building W343A, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.molcel.2009.06.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736145PMC
August 2009

Amphioxus encodes the largest known family of green fluorescent proteins, which have diversified into distinct functional classes.

BMC Evol Biol 2009 Apr 21;9:77. Epub 2009 Apr 21.

Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1186/1471-2148-9-77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679011PMC
April 2009

TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.

Cancer Res 2009 Mar 24;69(5):1821-7. Epub 2009 Feb 24.

Molecular and Cell Biology Laboratory and Razavi Newman Center for Bioinformatics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-08-3014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652681PMC
March 2009

Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases.

Nat Chem Biol 2008 Oct 7;4(10):617-23. Epub 2008 Sep 7.

Howard Hughes Medical Institute, The Salk Institute for Biological Studies, Jack H. Skirball Center for Chemical Biology & Proteomics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nchembio.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664519PMC
October 2008

The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan.

Proc Natl Acad Sci U S A 2008 Jul 10;105(28):9674-9. Epub 2008 Jul 10.

Razavi Newman Center for Bioinformatics, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0801314105
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http://dx.doi.org/10.1073/pnas.0801314105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453073PMC
July 2008

The fold of alpha-synuclein fibrils.

Proc Natl Acad Sci U S A 2008 Jun 12;105(25):8637-42. Epub 2008 Jun 12.

The Salk Institute for Biological Studies, North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0712179105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438424PMC
June 2008

Structural and functional diversity of the microbial kinome.

PLoS Biol 2007 Mar;5(3):e17

Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.0050017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821047PMC
March 2007

The genome of the sea urchin Strongylocentrotus purpuratus.

Authors:
Erica Sodergren George M Weinstock Eric H Davidson R Andrew Cameron Richard A Gibbs Robert C Angerer Lynne M Angerer Maria Ina Arnone David R Burgess Robert D Burke James A Coffman Michael Dean Maurice R Elphick Charles A Ettensohn Kathy R Foltz Amro Hamdoun Richard O Hynes William H Klein William Marzluff David R McClay Robert L Morris Arcady Mushegian Jonathan P Rast L Courtney Smith Michael C Thorndyke Victor D Vacquier Gary M Wessel Greg Wray Lan Zhang Christine G Elsik Olga Ermolaeva Wratko Hlavina Gretchen Hofmann Paul Kitts Melissa J Landrum Aaron J Mackey Donna Maglott Georgia Panopoulou Albert J Poustka Kim Pruitt Victor Sapojnikov Xingzhi Song Alexandre Souvorov Victor Solovyev Zheng Wei Charles A Whittaker Kim Worley K James Durbin Yufeng Shen Olivier Fedrigo David Garfield Ralph Haygood Alexander Primus Rahul Satija Tonya Severson Manuel L Gonzalez-Garay Andrew R Jackson Aleksandar Milosavljevic Mark Tong Christopher E Killian Brian T Livingston Fred H Wilt Nikki Adams Robert Bellé Seth Carbonneau Rocky Cheung Patrick Cormier Bertrand Cosson Jenifer Croce Antonio Fernandez-Guerra Anne-Marie Genevière Manisha Goel Hemant Kelkar Julia Morales Odile Mulner-Lorillon Anthony J Robertson Jared V Goldstone Bryan Cole David Epel Bert Gold Mark E Hahn Meredith Howard-Ashby Mark Scally John J Stegeman Erin L Allgood Jonah Cool Kyle M Judkins Shawn S McCafferty Ashlan M Musante Robert A Obar Amanda P Rawson Blair J Rossetti Ian R Gibbons Matthew P Hoffman Andrew Leone Sorin Istrail Stefan C Materna Manoj P Samanta Viktor Stolc Waraporn Tongprasit Qiang Tu Karl-Frederik Bergeron Bruce P Brandhorst James Whittle Kevin Berney David J Bottjer Cristina Calestani Kevin Peterson Elly Chow Qiu Autumn Yuan Eran Elhaik Dan Graur Justin T Reese Ian Bosdet Shin Heesun Marco A Marra Jacqueline Schein Michele K Anderson Virginia Brockton Katherine M Buckley Avis H Cohen Sebastian D Fugmann Taku Hibino Mariano Loza-Coll Audrey J Majeske Cynthia Messier Sham V Nair Zeev Pancer David P Terwilliger Cavit Agca Enrique Arboleda Nansheng Chen Allison M Churcher F Hallböök Glen W Humphrey Mohammed M Idris Takae Kiyama Shuguang Liang Dan Mellott Xiuqian Mu Greg Murray Robert P Olinski Florian Raible Matthew Rowe John S Taylor Kristin Tessmar-Raible D Wang Karen H Wilson Shunsuke Yaguchi Terry Gaasterland Blanca E Galindo Herath J Gunaratne Celina Juliano Masashi Kinukawa Gary W Moy Anna T Neill Mamoru Nomura Michael Raisch Anna Reade Michelle M Roux Jia L Song Yi-Hsien Su Ian K Townley Ekaterina Voronina Julian L Wong Gabriele Amore Margherita Branno Euan R Brown Vincenzo Cavalieri Véronique Duboc Louise Duloquin Constantin Flytzanis Christian Gache François Lapraz Thierry Lepage Annamaria Locascio Pedro Martinez Giorgio Matassi Valeria Matranga Ryan Range Francesca Rizzo Eric Röttinger Wendy Beane Cynthia Bradham Christine Byrum Tom Glenn Sofia Hussain Gerard Manning Esther Miranda Rebecca Thomason Katherine Walton Athula Wikramanayke Shu-Yu Wu Ronghui Xu C Titus Brown Lili Chen Rachel F Gray Pei Yun Lee Jongmin Nam Paola Oliveri Joel Smith Donna Muzny Stephanie Bell Joseph Chacko Andrew Cree Stacey Curry Clay Davis Huyen Dinh Shannon Dugan-Rocha Jerry Fowler Rachel Gill Cerrissa Hamilton Judith Hernandez Sandra Hines Jennifer Hume Laronda Jackson Angela Jolivet Christie Kovar Sandra Lee Lora Lewis George Miner Margaret Morgan Lynne V Nazareth Geoffrey Okwuonu David Parker Ling-Ling Pu Rachel Thorn Rita Wright

Science 2006 Nov;314(5801):941-52

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http://dx.doi.org/10.1126/science.1133609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159423PMC
November 2006

Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms.

Mol Biol Cell 2006 Jun 12;17(6):2799-810. Epub 2006 Apr 12.

Department of Cellular Biology, University of Georgia, Athens, GA 30602-2607, USA.

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http://dx.doi.org/10.1091/mbc.e05-05-0450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474788PMC
June 2006

Mutational alteration of human immunodeficiency virus type 1 Vif allows for functional interaction with nonhuman primate APOBEC3G.

J Virol 2006 Jun;80(12):5984-91

Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1128/JVI.00388-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472613PMC
June 2006

The dictyostelium kinome--analysis of the protein kinases from a simple model organism.

PLoS Genet 2006 Mar 31;2(3):e38. Epub 2006 Mar 31.

Boston Biomedical Research Institute, Watertown, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.0020038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1420674PMC
March 2006

Genomic overview of protein kinases.

Authors:
Gerard Manning

WormBook 2005 Dec 13:1-19. Epub 2005 Dec 13.

Razavi-Newman Center for Bioinformatics, Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1895/wormbook.1.60.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780929PMC
December 2005

The mouse kinome: discovery and comparative genomics of all mouse protein kinases.

Proc Natl Acad Sci U S A 2004 Aug 2;101(32):11707-12. Epub 2004 Aug 2.

SUGEN, Incorporated, 230 East Grand Avenue, South San Francisco, CA 94025, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0306880101
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http://dx.doi.org/10.1073/pnas.0306880101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC511041PMC
August 2004

Evolution of protein kinase signaling from yeast to man.

Trends Biochem Sci 2002 Oct;27(10):514-20

Sugen Inc. 230 East Grand Ave, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/s0968-0004(02)02179-5DOI Listing
October 2002