Publications by authors named "Gerard Lambeau"

100Publications

Multi-Autoantibody Signature and Clinical Outcome in Membranous Nephropathy.

Clin J Am Soc Nephrol 2020 Dec 30;15(12):1762-1776. Epub 2020 Nov 30.

University Côte d'Azur, National Centre for Scientific Research, Institute of Molecular and Cellular Pharmacology, Valbonne Sophia Antipolis, Nice, France

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December 2020

Generation of a conditional transgenic mouse model expressing human Phospholipase A2 Receptor 1.

Sci Rep 2020 05 18;10(1):8190. Epub 2020 May 18.

Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.

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May 2020

Anti-PLA2R1 Antibodies Containing Sera Induce In Vitro Cytotoxicity Mediated by Complement Activation.

J Immunol Res 2019 30;2019:1324804. Epub 2019 Dec 30.

Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275, Valbonne Sophia Antipolis, France.

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June 2020

High-Dose Rituximab and Early Remission in PLA2R1-Related Membranous Nephropathy.

Clin J Am Soc Nephrol 2019 08 24;14(8):1173-1182. Epub 2019 Jul 24.

Department of Nephrology-Dialysis-Transplantation, Hôpital Pasteur, CHU de Nice, Université Côte d'Azur, Nice, France.

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August 2019

Enzymatic activity of mouse group X-sPLA2 improves in vitro production of preimplantation bovine embryos.

Theriogenology 2019 Jun 1;131:113-122. Epub 2019 Apr 1.

Université Grenoble Alpes, Grenoble, F-38000, France; Institute for Advanced Biosciences INSERM U1209, CNRS UMR5309, Grenoble, F-38000, France. Electronic address:

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June 2019

Secreted Phospholipases A in Hereditary Angioedema With C1-Inhibitor Deficiency.

Front Immunol 2018 23;9:1721. Epub 2018 Jul 23.

Department of Translational Medical Sciences, Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, WAO Center of Excellence, Naples, Italy.

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July 2018

Group IIA-Secreted Phospholipase A in Human Serum Kills Commensal but Not Clinical Enterococcus faecium Isolates.

Infect Immun 2018 08 23;86(8). Epub 2018 Jul 23.

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

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August 2018

[Membranous nephropathy: Pathophysiology and natural history].

Nephrol Ther 2017 Apr;13 Suppl 1:S75-S81

Service de néphrologie, hôpital Pasteur, université de Nice-Sophia Antipolis, CHU de Nice, 30, voie romaine, CS 51069, 06001 Nice cedex 1, France.

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April 2017

Anti-phospholipase A2 receptor antibody levels at diagnosis predicts spontaneous remission of idiopathic membranous nephropathy.

Clin Kidney J 2017 Apr 20;10(2):209-214. Epub 2017 Feb 20.

Service de Néphrologie, Dialyse, Transplantation Rénale, Hôpital Nord, CHU de Saint-Etienne, GIMAP, EA 3065, Université Jean Monnet, Saint-Etienne, Comue Université de Lyon, Lyon, France.

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April 2017

Novel Role for Matrix Metalloproteinase 9 in Modulation of Cholesterol Metabolism.

J Am Heart Assoc 2016 09 30;5(10). Epub 2016 Sep 30.

Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

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September 2016

Identification of a Novel Heart-Liver Axis: Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and Inflammation in the Liver.

J Am Heart Assoc 2015 Nov 13;4(11). Epub 2015 Nov 13.

Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (S.H.A., E.B., D.L., C.F.P.) Cardiovascular Research Group, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (Z.K., C.F.P.) Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (Z.K., C.F.P.).

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November 2015

The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia.

J Exp Med 2015 Oct 5;212(11):1901-19. Epub 2015 Oct 5.

Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan CREST, Japan Agency for Medical Research and Development (AMED) and Japan Science and Technology Agency (JST), Tokyo 100-0004, Japan

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October 2015

Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.

N Engl J Med 2014 Dec 13;371(24):2277-2287. Epub 2014 Nov 13.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275, Centre National de la Recherche Scientifique and Université de Nice Sophia Antipolis, Valbonne, France (N.M.T., B.S.-P., G.D., A.-S.D.-G., D.D., G.L.); University Medical Center Hamburg-Eppendorf, Hamburg, Germany (N.M.T., C.M.-S., G.Z., E.H., U.H., R.A.K.S.); Boston University School of Medicine, Boston (L.H.B., H.M., D.J.S.); and the University of Louisville (M.M., J.K.) and Robley Rex Veterans Affairs Medical Center (J.K.) - both in Louisville, KY.

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December 2014

Secreted phospholipases A2 in cancer: diverse mechanisms of action.

Biochimie 2014 Dec 5;107 Pt A:114-23. Epub 2014 Oct 5.

Department of Molecular and Biomedical Sciences, Jožef Stefan Institute, Ljubljana, Slovenia. Electronic address:

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December 2014

Emerging roles of secreted phospholipase A2 enzymes: the 3rd edition.

Biochimie 2014 Dec 16;107 Pt A:105-13. Epub 2014 Sep 16.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, Centre National de la Recherche Scientifique - Université Nice Sophia Antipolis, Valbonne 06560, France.

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December 2014

[New physiopathological roles for the PLA2R1 receptor in cancer and membranous nephropathy].

Med Sci (Paris) 2014 May 13;30(5):519-25. Epub 2014 Jun 13.

Institut de pharmacologie moléculaire et cellulaire, CNRS et université de Nice-Sophia Antipolis UMR 7275, 660 route des lucioles, Sophia Antipolis, 06560 Valbonne, France.

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May 2014

Lack of group X secreted phospholipase A₂ increases survival following pandemic H1N1 influenza infection.

Virology 2014 Apr 25;454-455:78-92. Epub 2014 Feb 25.

Division of Vascular Surgery, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network and the University of Toronto, Toronto, Ontario, Canada.

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April 2014

Secreted phospholipases A₂are differentially expressed and epigenetically silenced in human breast cancer cells.

Biochem Biophys Res Commun 2014 Feb 6;445(1):230-5. Epub 2014 Feb 6.

Department of Molecular and Biomedical Sciences, Jožef Stefan Institute, Ljubljana, Slovenia. Electronic address:

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February 2014

The effect of group X secreted phospholipase A2 on fertilization outcome is specific and not mimicked by other secreted phospholipases A2 or progesterone.

Biochimie 2014 Apr 25;99:88-95. Epub 2013 Nov 25.

Université Joseph Fourier, Grenoble F-38000, France; Laboratoire AGIM, Equipe AGC, CNRS FRE3405, La Tronche F-38700, France. Electronic address:

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April 2014

Group X secreted phospholipase A(2) induces lipid droplet formation and prolongs breast cancer cell survival.

Mol Cancer 2013 Sep 27;12(1):111. Epub 2013 Sep 27.

Department of Molecular and Biomedical Sciences, JoŽef Stefan Institute, Ljubljana, Slovenia.

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September 2013

PLA2R1 mediates tumor suppression by activating JAK2.

Cancer Res 2013 Oct 5;73(20):6334-45. Epub 2013 Sep 5.

Authors' Affiliations: Inserm U1052, Centre de Recherche en Cancérologie de Lyon; CNRS UMR5286; Centre Léon Bérard; Université de Lyon, Lyon; UMR8161, CNRS/Universités de Lille 1 et 2; Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275, CNRS and Université de Nice-Sophia Antipolis, Valbonne; INSERM U916, Bergonié Cancer Institute, Université Bordeaux, Bordeaux; and Institut de Pathologie, CHRU, Faculté de Médecine, Université de Lille; INSERM U837, Jean-Pierre Aubert Research Center, Team 5, Lille; Department of Medicine, University of Washington, Seattle, Washington.

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October 2013

PLA2R1 kills cancer cells by inducing mitochondrial stress.

Free Radic Biol Med 2013 Dec 29;65:969-977. Epub 2013 Aug 29.

INSERM U1052, Centre de Recherche en Cancérologie de Lyon, Lyon F-69373, France; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon F-69373, France; Centre Léon Bérard, Lyon F-69373, France; Université de Lyon, Lyon F-69373, France. Electronic address:

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December 2013

Secreted group IIA phospholipase A2 protects humans against the group B streptococcus: experimental and clinical evidence.

J Infect Dis 2013 Dec 30;208(12):2025-35. Epub 2013 Jul 30.

Department of Laboratory Medicine, Division of Medical Microbiology, Lund University, Sweden.

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December 2013

Absence of inflammatory conditions in human varicose saphenous veins.

Inflamm Res 2013 Mar 13;62(3):299-308. Epub 2012 Dec 13.

INSERM U698, CHU X. Bichat, 46 Rue Huchard, 75018 Paris, France.

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March 2013

Emerging roles of secreted phospholipase A(2) enzymes: an update.

Biochimie 2013 Jan 25;95(1):43-50. Epub 2012 Sep 25.

Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Kamikitazawa, Setagaya-ku, Tokyo, Japan.

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January 2013

Effects of the propeptide of group X secreted phospholipase A(2) on substrate specificity and interfacial activity on phospholipid monolayers.

Biochimie 2013 Jan 7;95(1):51-8. Epub 2012 Aug 7.

CNRS, Aix-Marseille Université, Enzymologie Interfaciale et Physiologie de la Lipolyse, UMR 7282, Marseille Cedex, France.

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January 2013

[Do phospholipases, key enzymes in sperm physiology, represent therapeutic challenges?].

Med Sci (Paris) 2012 May 30;28(5):512-8. Epub 2012 May 30.

Équipe génétique, infertilité et thérapeutiques, laboratoire AGIM (âge, imagerie et modélisation), CNRS FRE3405, 38700 La Tronche, France.

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May 2012

Human group X secreted phospholipase A2 induces dendritic cell maturation through lipoprotein-dependent and -independent mechanisms.

Atherosclerosis 2012 Jun 22;222(2):367-74. Epub 2012 Mar 22.

INSERM UMRS 937, Université Pierre et Marie Curie UPMC-Paris 6, Faculté de Médecine Pierre et Marie Curie, 91 Boulevard de l'Hôpital, Paris 75634 Cedex 13, France.

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June 2012

Secreted phospholipase A(2) group IIA is a neurotoxin released by stimulated human glial cells.

Mol Cell Neurosci 2012 Apr 3;49(4):430-8. Epub 2012 Mar 3.

Laboratory of Cellular and Molecular Pharmacology, Department of Biology, University of British Columbia Okanagan, Kelowna, BC, Canada.

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April 2012

A novel bacterial resistance mechanism against human group IIA-secreted phospholipase A2: role of Streptococcus pyogenes sortase A.

J Immunol 2011 Dec 9;187(12):6437-46. Epub 2011 Nov 9.

Division of Medical Microbiology, Department of Laboratory Medicine, Lund University, 22362 Lund, Sweden.

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December 2011

Group X secreted phospholipase A2 proenzyme is matured by a furin-like proprotein convertase and releases arachidonic acid inside of human HEK293 cells.

J Biol Chem 2011 Oct 30;286(42):36509-21. Epub 2011 Aug 30.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR6097, CNRS et Université de Nice-Sophia-Antipolis, 660 Route des Lucioles, Sophia Antipolis, 06560 Valbonne, France.

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October 2011

Lipoprotein-associated and secreted phospholipases A₂ in cardiovascular disease: roles as biological effectors and biomarkers.

Circulation 2010 Nov;122(21):2183-200

INSERM, Paris-Cardiovascular Research Center, Université Paris Descartes, UMR, Paris, France.

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November 2010

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.

J Lipid Res 2010 Aug 27;51(8):2105-20. Epub 2010 Apr 27.

Metabolism, Oncogenesis and Cell Differentiation Group, INSERM Research Center 563, Pathophysiology Center of Toulouse Purpan, Hôpital Purpan, Toulouse, France.

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August 2010

Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice.

Biochimie 2010 Jun 27;92(6):561-82. Epub 2010 Mar 27.

Biomembrane Signaling Project, The Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.

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June 2010

Two cutinase-like proteins secreted by Mycobacterium tuberculosis show very different lipolytic activities reflecting their physiological function.

FASEB J 2010 Jun 26;24(6):1893-903. Epub 2010 Jan 26.

Centre National de la Recherche Scientifique, Aix-Marseille Université, Enzymologie Interfaciale et Physiologie de la Lipolyse UPR 9025, Marseille, France.

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June 2010

Group X phospholipase A2 stimulates the proliferation of colon cancer cells by producing various lipid mediators.

Mol Pharmacol 2009 Oct 14;76(4):778-90. Epub 2009 Jul 14.

Institut de Pharmacologie Moléculaire et Cellulaire, Université de Nice Sophia Antipolis et Centre National de la Recherche Scientifique, 06560 Valbonne, France.

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October 2009

Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease.

J Mol Med (Berl) 2009 Jul 3;87(7):723-33. Epub 2009 Jun 3.

INSERM, UMRS937, UPMC Université Paris 06 and Faculté de Médecine Pierre et Marie Curie, 91, Boulevard de l'Hôpital, 75634, Paris, France.

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July 2009

The M-type receptor PLA2R regulates senescence through the p53 pathway.

EMBO Rep 2009 Mar 6;10(3):271-7. Epub 2009 Feb 6.

UMR 8161, Institut de Biologie de Lille, CNRS/Universités de Lille 1 et 2/Institut Pasteur de Lille, IFR 142, 59021 Lille, France.

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March 2009

Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis.

Biochim Biophys Acta 2009 Feb 16;1791(2):92-102. Epub 2008 Dec 16.

Department of Clinical Immunology and Allergy and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.

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February 2009

Biochemistry and physiology of mammalian secreted phospholipases A2.

Annu Rev Biochem 2008 ;77:495-520

Institut de Pharmacologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université de Nice-Sophia-Antipolis, 06560 Valbonne, France.

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September 2008

Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities.

J Med Chem 2007 Apr 3;50(7):1618-26. Epub 2007 Mar 3.

Unité de Pharmacochimie Moléculaire et Systèmes Membranaires (EA2381), Université Paris7-Denis Diderot, case 7066, 2 place Jussieu, 75251 Paris, Cedex 05, France.

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April 2007

An envelope-determined endocytic route of viral entry allows HIV-1 to escape from secreted phospholipase A2 entry blockade.

J Mol Biol 2007 Mar 17;367(3):702-14. Epub 2007 Jan 17.

Inserm U526, Laboratoire de Virologie, Faculté de Médecine, Avenue de Valombrose, 06107 Nice cedex 2, France.

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March 2007

In silico-guided target identification of a scaffold-focused library: 1,3,5-triazepan-2,6-diones as novel phospholipase A2 inhibitors.

J Med Chem 2006 Nov;49(23):6768-78

Bioinformatics of the Drug, CNRS UMR 7175, F-67400 Illkirch, and Immunologie et Chimie Thérapeutiques, CNRS UPR 9021, Institut de Biologie Moléculaire et Cellulaire (IBMC), F-67084 Strasbourg Cedex, France.

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November 2006

Atherogenic properties of LDL particles modified by human group X secreted phospholipase A2 on human endothelial cell function.

FASEB J 2006 Dec 31;20(14):2547-9. Epub 2006 Oct 31.

INSERM UMRS 525, Faculté de Médecine Pierre et Marie Curie, 91, boulevard de l'Hôpital, 75634 Paris, France.

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December 2006

Secreted phospholipase A2 inhibitors are also potent blockers of binding to the M-type receptor.

Biochemistry 2006 Nov;45(44):13203-18

Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR 6097, 660 route des Lucioles, Sophia-Antipolis, 06560 Valbonne, France.

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November 2006

The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2.

Biochim Biophys Acta 2006 Sep 5;1761(9):1093-9. Epub 2006 Aug 5.

INSERM U525, Université Pierre et Marie Curie-Paris 6, Faculté de Médecine Pierre et Marie Curie, Paris, France.

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September 2006

Analysis of expression of secreted phospholipases A2 in mouse tissues at protein and mRNA levels.

Biochim Biophys Acta 2006 Jul 27;1761(7):745-56. Epub 2006 Apr 27.

Department of Pathology, University of Turku, Turku, Finland.

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July 2006

The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a.

J Physiol 2006 Jan 10;570(Pt 2):339-54. Epub 2005 Nov 10.

Institut de Pharmacologie Moléculaire et Cellulaire, CNRS Université de Nice Sophia-Antipolis, UMR-6097, Institut Paul Hamel, Sophia Antipolis, Valbonne, France.

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January 2006

In vivo protective role of human group IIa phospholipase A2 against experimental anthrax.

J Immunol 2005 Nov;175(10):6786-91

Unité Toxines et Pathogénie Bactérienne/Centre National de la Recherche Scientifique Unité de Recherche Associée 2172, Paris, France.

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November 2005

Time-resolved fluoroimmunoassays of the complete set of secreted phospholipases A2 in human serum.

Biochim Biophys Acta 2005 Apr 7;1733(2-3):210-23. Epub 2005 Jan 7.

Department of Pathology, University of Turku, Finland.

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April 2005

Secretory phospholipase A2 induces dendritic cell maturation.

Eur J Immunol 2004 Aug;34(8):2293-302

Institut Fédératif de Recherche 128, Institut National de la Santé et de la Recherche Médicale Unit 503, F-69365 Lyon Cedex 07, France.

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August 2004

Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity.

Biochemistry 2003 Oct;42(39):11494-503

Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France.

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October 2003

Inhibitory effects of surfactant protein A on surfactant phospholipid hydrolysis by secreted phospholipases A2.

J Immunol 2003 Jul;171(2):995-1000

Unité de Défense Innée et Inflammation, Institut Pasteur, Institut National de la Santé et de la Recherche Médicale E 336, Paris, France.

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July 2003

Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels.

Protein Sci 2003 Jul;12(7):1332-43

Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), CNRS UMR 6097, Sophia-Antipolis, 06560 Valbonne, France.

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July 2003