Gerard Lambeau

Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1 associated membranous nephropathy.

Authors:

George Haddad Johan M Lorenzen Hong Ma Noortje de Haan Harald Seeger Christelle Zaghrini Simone Brandt Malte Kölling Urs Wegmann Bence Kiss Gábor Pál Péter Gál Rudolf P Wuthrich Manfred Wuhrer Laurence H Beck David J Salant Gérard Lambeau Andreas D Kistler

J Clin Invest 2020 Dec 22. Epub 2020 Dec 22.

Department of Medicine, Cantonal Hospital, Frauenfeld, Switzerland.

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December 2020

Multi-Autoantibody Signature and Clinical Outcome in Membranous Nephropathy.

Authors:

Gian Marco Ghiggeri Barbara Seitz-Polski Joana Justino Christelle Zaghrini Christine Payré Vesna Brglez Guillaume Dolla Alberto Sinico Francesco Scolari Augusto Vaglio Marco Prunotto Giovanni Candiano Antonella Radice Maurizio Bruschi Gérard Lambeau

Clin J Am Soc Nephrol 2020 Dec 30;15(12):1762-1776. Epub 2020 Nov 30.

University Côte d'Azur, National Centre for Scientific Research, Institute of Molecular and Cellular Pharmacology, Valbonne Sophia Antipolis, Nice, France

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December 2020

The STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy.

Kidney Int 2020 Nov 7. Epub 2020 Nov 7.

Instituto de Investigación Hospital Universitario 12 Octubre, Madrid; Department of Medicine, Complutense University, Madrid. Electronic address:

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November 2020

PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients.

Authors:

Julien Pothlichet Thierry Rose Florence Bugault Louise Jeammet Annalisa Meola Ahmed Haouz Frederick Saul David Geny José Alcami Ezequiel Ruiz-Mateos Luc Teyton Gérard Lambeau Jacques Thèze

J Clin Invest 2020 Jun;130(6):2872-2887

Diaccurate.

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June 2020

Generation of a conditional transgenic mouse model expressing human Phospholipase A2 Receptor 1.

Authors:

Sara Jaber Delphine Goehrig Philippe Bertolino Amélie Massemin Franck Bihl Joëlle Chabry Gérard Lambeau David Vindrieux David Bernard

Sci Rep 2020 05 18;10(1):8190. Epub 2020 May 18.

Inserm U1052, CNRS UMR 5286, Université de Lyon & Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, Lyon, France.

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May 2020

Surfactant-secreted phospholipase A interplay and respiratory outcome in preterm neonates.

Authors:

Daniele De Luca Shivani Shankar-Aguilera Chiara Autilio Roberto Raschetti Luca Vedovelli Catherine Fitting Christine Payré Louise Jeammet Jesus Perez-Gil Paola E Cogo Virgilio P Carnielli Gérard Lambeau Lhousseine Touqui

Am J Physiol Lung Cell Mol Physiol 2020 07 13;319(1):L95-L104. Epub 2020 May 13.

Cystic fibrosis and Bronchial diseases team-INSERM U938, Institut Pasteur, Paris, France.

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July 2020

Anti-PLA2R1 Antibodies Containing Sera Induce In Vitro Cytotoxicity Mediated by Complement Activation.

Authors:

Maël Lateb Hajar Ouahmi Christine Payré Vesna Brglez Kevin Zorzi Guillaume Dolla Mohamad Zaidan Sonia Boyer-Suavet Bertrand Knebelmann Thomas Crépin Cécile Courivaud Noémie Jourde-Chiche Vincent Esnault Gérard Lambeau Barbara Seitz-Polski

J Immunol Res 2019 30;2019:1324804. Epub 2019 Dec 30.

Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275, Valbonne Sophia Antipolis, France.

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June 2020

12-HETE is a regulator of PGE production via COX-2 expression induced by a snake venom group IIA phospholipase A in isolated peritoneal macrophages.

Authors:

Vanessa Moreira José María Gutiérrez Bruno Lomonte Marco Aurélio Ramirez Vinolo Rui Curi Gérard Lambeau Catarina Teixeira

Chem Biol Interact 2020 Feb 4;317:108903. Epub 2019 Dec 4.

Laboratório de Farmacologia, Instituto Butantan, São Paulo, SP, Brazil.

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February 2020

Antimalarial Activity of Human Group IIA Secreted Phospholipase A in Relation to Enzymatic Hydrolysis of Oxidized Lipoproteins.

Authors:

Mélanie Dacheux Véronique Sinou Christine Payré Louise Jeammet Daniel Parzy Philippe Grellier Christiane Deregnaucourt Gérard Lambeau

Infect Immun 2019 11 18;87(11). Epub 2019 Oct 18.

Université Côte d'Azur, CNRS, IPMC, Valbonne Sophia Antipolis, France

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November 2019

High-Dose Rituximab and Early Remission in PLA2R1-Related Membranous Nephropathy.

Authors:

Barbara Seitz-Polski Karine Dahan Hanna Debiec Alexandra Rousseau Marine Andreani Christelle Zaghrini Michel Ticchioni Alessandra Rosenthal Sylvia Benzaken Ghislaine Bernard Gérard Lambeau Pierre Ronco Vincent L M Esnault

Clin J Am Soc Nephrol 2019 08 24;14(8):1173-1182. Epub 2019 Jul 24.

Department of Nephrology-Dialysis-Transplantation, Hôpital Pasteur, CHU de Nice, Université Côte d'Azur, Nice, France.

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August 2019

Enzymatic activity of mouse group X-sPLA2 improves in vitro production of preimplantation bovine embryos.

Authors:

Guillaume Martinez Jean-Pascal Hograindleur Louise Jeammet Emilie Le Blévec Charles Coutton Pascal Mermillod Gérard Lambeau Eric Schmitt Pierre F Ray Christophe Arnoult

Theriogenology 2019 Jun 1;131:113-122. Epub 2019 Apr 1.

Université Grenoble Alpes, Grenoble, F-38000, France; Institute for Advanced Biosciences INSERM U1209, CNRS UMR5309, Grenoble, F-38000, France. Electronic address:

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June 2019

Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides.

Authors:

Rebecca J Edgar Vincent P van Hensbergen Alessandro Ruda Andrew G Turner Pan Deng Yoann Le Breton Najib M El-Sayed Ashton T Belew Kevin S McIver Alastair G McEwan Andrew J Morris Gérard Lambeau Mark J Walker Jeffrey S Rush Konstantin V Korotkov Göran Widmalm Nina M van Sorge Natalia Korotkova

Nat Chem Biol 2019 05 1;15(5):463-471. Epub 2019 Apr 1.

Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA.

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May 2019

Novel ELISA for thrombospondin type 1 domain-containing 7A autoantibodies in membranous nephropathy.

Authors:

Christelle Zaghrini Barbara Seitz-Polski Joana Justino Guillaume Dolla Christine Payré Noémie Jourde-Chiche Anne-Els Van de Logt Caroline Booth Emma Rigby Jennie Lonnbro-Widgren Jenny Nystrom Christophe Mariat Zhao Cui Jack F M Wetzels GianMarco Ghiggeri Laurence H Beck Pierre Ronco Hanna Debiec Gérard Lambeau

Kidney Int 2019 03;95(3):666-679

Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275 Valbonne Sophia Antipolis, France. Electronic address:

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March 2019

Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects.

Authors:

Vincent P van Hensbergen Elin Movert Vincent de Maat Christian Lüchtenborg Yoann Le Breton Gérard Lambeau Christine Payré Anna Henningham Victor Nizet Jos A G van Strijp Britta Brügger Fredric Carlsson Kevin S McIver Nina M van Sorge

PLoS Pathog 2018 10 15;14(10):e1007348. Epub 2018 Oct 15.

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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October 2018

Secreted Phospholipases A in Hereditary Angioedema With C1-Inhibitor Deficiency.

Authors:

Stefania Loffredo Anne Lise Ferrara Maria Bova Francesco Borriello Chiara Suffritti Nóra Veszeli Angelica Petraroli Maria Rosaria Galdiero Gilda Varricchi Francescopaolo Granata Andrea Zanichelli Henriette Farkas Marco Cicardi Gérard Lambeau Gianni Marone

Front Immunol 2018 23;9:1721. Epub 2018 Jul 23.

Department of Translational Medical Sciences, Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, WAO Center of Excellence, Naples, Italy.

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July 2018

Group IIA-Secreted Phospholipase A in Human Serum Kills Commensal but Not Clinical Enterococcus faecium Isolates.

Authors:

Fernanda L Paganelli Helen L Leavis Samantha He Nina M van Sorge Christine Payré Gérard Lambeau Rob J L Willems Suzan H M Rooijakkers

Infect Immun 2018 08 23;86(8). Epub 2018 Jul 23.

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

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August 2018

Phospholipase A2 Receptor 1 Epitope Spreading at Baseline Predicts Reduced Likelihood of Remission of Membranous Nephropathy.

Authors:

Barbara Seitz-Polski Hanna Debiec Alexandra Rousseau Karine Dahan Christelle Zaghrini Christine Payré Vincent L M Esnault Gérard Lambeau Pierre Ronco

J Am Soc Nephrol 2018 02 7;29(2):401-408. Epub 2017 Nov 7.

Université Pierre et Marie Curie, Sorbonne Universités, Paris, France;

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February 2018

[Membranous nephropathy: Pathophysiology and natural history].

Authors:

Barbara Seitz-Polski Gérard Lambeau Vincent Esnault

Nephrol Ther 2017 Apr;13 Suppl 1:S75-S81

Service de néphrologie, hôpital Pasteur, université de Nice-Sophia Antipolis, CHU de Nice, 30, voie romaine, CS 51069, 06001 Nice cedex 1, France.

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April 2017

Group V Secreted Phospholipase A Induces the Release of Proangiogenic and Antiangiogenic Factors by Human Neutrophils.

Authors:

Stefania Loffredo Francesco Borriello Raffaella Iannone Anne L Ferrara Maria R Galdiero Vincenzo Gigantino Pasquale Esposito Gilda Varricchi Gerard Lambeau Marco A Cassatella Francescopaolo Granata Gianni Marone

Front Immunol 2017 19;8:443. Epub 2017 Apr 19.

Division of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy.

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April 2017

Anti-phospholipase A2 receptor antibody levels at diagnosis predicts spontaneous remission of idiopathic membranous nephropathy.

Authors:

Perrine Jullien Barbara Seitz Polski Nicolas Maillard Damien Thibaudin Blandine Laurent Edouard Ollier Eric Alamartine Gérard Lambeau Christophe Mariat

Clin Kidney J 2017 Apr 20;10(2):209-214. Epub 2017 Feb 20.

Service de Néphrologie, Dialyse, Transplantation Rénale, Hôpital Nord, CHU de Saint-Etienne, GIMAP, EA 3065, Université Jean Monnet, Saint-Etienne, Comue Université de Lyon, Lyon, France.

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April 2017

Novel Role for Matrix Metalloproteinase 9 in Modulation of Cholesterol Metabolism.

Authors:

Samuel Hernandez-Anzaldo Vesna Brglez Bianca Hemmeryckx Dickson Leung Janos G Filep Jean E Vance Dennis E Vance Zamaneh Kassiri Roger H Lijnen Gérard Lambeau Carlos Fernandez-Patron

J Am Heart Assoc 2016 09 30;5(10). Epub 2016 Sep 30.

Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

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September 2016

Identification of Epithelial Phospholipase A Receptor 1 as a Potential Target in Asthma.

Authors:

James D Nolin H Luke Ogden Ying Lai William A Altemeier Charles W Frevert James G Bollinger Gajendra S Naika Anthony Kicic Stephen M Stick Gerard Lambeau William R Henderson Michael H Gelb Teal S Hallstrand

Am J Respir Cell Mol Biol 2016 12;55(6):825-836

From the 1 Division of Pulmonary and Critical Care and.

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December 2016

Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer.

Authors:

Matthias Schewe Patrick F Franken Andrea Sacchetti Mark Schmitt Rosalie Joosten René Böttcher Martin E van Royen Louise Jeammet Christine Payré Patricia M Scott Nancy R Webb Michael Gelb Robert T Cormier Gérard Lambeau Riccardo Fodde

Cell Stem Cell 2016 07 9;19(1):38-51. Epub 2016 Jun 9.

Department of Pathology, Erasmus MC Cancer Institute, Rotterdam 3000CA, The Netherlands. Electronic address:

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July 2016

Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy.

Authors:

Nicola M Tomas Elion Hoxha Anna T Reinicke Lars Fester Udo Helmchen Jens Gerth Friederike Bachmann Klemens Budde Friedrich Koch-Nolte Gunther Zahner Gabriele Rune Gerard Lambeau Catherine Meyer-Schwesinger Rolf A K Stahl

J Clin Invest 2016 07 23;126(7):2519-32. Epub 2016 May 23.

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July 2016

Fluorometric High-Throughput Screening Assay for Secreted Phospholipases A2 Using Phospholipid Vesicles.

Authors:

Heather Ewing Virneliz Fernández-Vega Timothy P Spicer Peter Chase Steven Brown Louis Scampavia William R Roush Sean Riley Hugh Rosen Peter Hodder Gerard Lambeau Michael H Gelb

J Biomol Screen 2016 Aug 4;21(7):713-21. Epub 2016 May 4.

Department of Chemistry, University of Washington, Seattle, WA, USA

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August 2016

Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2β (iPLA2β) and Group X Secreted Phospholipase A2 (sPLA2).

Authors:

Roland Abi Nahed Guillaume Martinez Jessica Escoffier Sandra Yassine Thomas Karaouzène Jean-Pascal Hograindleur John Turk George Kokotos Pierre F Ray Serge Bottari Gérard Lambeau Sylviane Hennebicq Christophe Arnoult

J Biol Chem 2016 Feb 11;291(6):3076-89. Epub 2015 Dec 11.

From the Université Grenoble Alpes, F-38000 Grenoble, France, the Institut Albert Bonniot, INSERM U823, La Tronche F-38700, France,

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February 2016

Identification of a Novel Heart-Liver Axis: Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and Inflammation in the Liver.

Authors:

Samuel Hernandez-Anzaldo Evan Berry Vesna Brglez Dickson Leung Tae Jin Yun Jun Seong Lee Janos G Filep Zamaneh Kassiri Cheolho Cheong Gérard Lambeau Richard Lehner Carlos Fernandez-Patron

J Am Heart Assoc 2015 Nov 13;4(11). Epub 2015 Nov 13.

Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (S.H.A., E.B., D.L., C.F.P.) Cardiovascular Research Group, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (Z.K., C.F.P.) Mazankowski Alberta Heart Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (Z.K., C.F.P.).

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November 2015

Epitope Spreading of Autoantibody Response to PLA2R Associates with Poor Prognosis in Membranous Nephropathy.

Authors:

Barbara Seitz-Polski Guillaume Dolla Christine Payré Christophe A Girard Joel Polidori Kevin Zorzi Eléonore Birgy-Barelli Perrine Jullien Cécile Courivaud Thierry Krummel Sylvia Benzaken Ghislaine Bernard Stéphane Burtey Christophe Mariat Vincent L M Esnault Gérard Lambeau

J Am Soc Nephrol 2016 05 13;27(5):1517-33. Epub 2015 Nov 13.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275 CNRS and Université de Nice-Sophia Antipolis, Valbonne Sophia-Antipolis, France;

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May 2016

The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia.

Authors:

Kei Yamamoto Yoshimi Miki Mariko Sato Yoshitaka Taketomi Yasumasa Nishito Choji Taya Kazuaki Muramatsu Kazutaka Ikeda Hiroki Nakanishi Ryo Taguchi Naotomo Kambe Kenji Kabashima Gérard Lambeau Michael H Gelb Makoto Murakami

J Exp Med 2015 Oct 5;212(11):1901-19. Epub 2015 Oct 5.

Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan CREST, Japan Agency for Medical Research and Development (AMED) and Japan Science and Technology Agency (JST), Tokyo 100-0004, Japan

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October 2015

Cross-reactivity of anti-PLA2R1 autoantibodies to rabbit and mouse PLA2R1 antigens and development of two novel ELISAs with different diagnostic performances in idiopathic membranous nephropathy.

Authors:

Barbara Seitz-Polski Guillaume Dolla Christine Payré Nicola M Tomas Marine Lochouarn Louise Jeammet Christophe Mariat Thierry Krummel Stéphane Burtey Cécile Courivaud Wolfgang Schlumberger Kévin Zorzi Sylvia Benzaken Ghislaine Bernard Vincent L M Esnault Gérard Lambeau

Biochimie 2015 Nov 19;118:104-15. Epub 2015 Aug 19.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275 CNRS and Université de Nice-Sophia Antipolis, Valbonne Sophia-Antipolis, France. Electronic address:

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November 2015

Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA.

Proc Natl Acad Sci U S A 2015 Jul 23;112(27):E3564-73. Epub 2015 Jun 23.

Centre de Recherche du Centre Hospitalier Universitaire de Québec, Département de Microbiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, QC, G1V 4G2 Canada;

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July 2015

In vitro anti-Plasmodium falciparum properties of the full set of human secreted phospholipases A2.

Authors:

Carole Guillaume Christine Payré Ikram Jemel Louise Jeammet Sofiane Bezzine Gajendra S Naika James Bollinger Philippe Grellier Michael H Gelb Joseph Schrével Gérard Lambeau Christiane Deregnaucourt

Infect Immun 2015 Jun 30;83(6):2453-65. Epub 2015 Mar 30.

Muséum National d'Histoire Naturelle, UMR 7245 CNRS/MNHN, MCAM équipe BAMEE, Paris, France

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June 2015

Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.

Authors:

Catherine Meyer-Schwesinger Gérard Lambeau Rolf A K Stahl

N Engl J Med 2015 03;372(11):1074-5

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March 2015

Special issue: from membranes to pathologies.

Authors:

Isabelle Mus-Veteau Gérard Lambeau

Biochimie 2014 Dec;107 Pt A:1-2

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December 2014

Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.

Authors:

Nicola M Tomas Laurence H Beck Catherine Meyer-Schwesinger Barbara Seitz-Polski Hong Ma Gunther Zahner Guillaume Dolla Elion Hoxha Udo Helmchen Anne-Sophie Dabert-Gay Delphine Debayle Michael Merchant Jon Klein David J Salant Rolf A K Stahl Gérard Lambeau

N Engl J Med 2014 Dec 13;371(24):2277-2287. Epub 2014 Nov 13.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275, Centre National de la Recherche Scientifique and Université de Nice Sophia Antipolis, Valbonne, France (N.M.T., B.S.-P., G.D., A.-S.D.-G., D.D., G.L.); University Medical Center Hamburg-Eppendorf, Hamburg, Germany (N.M.T., C.M.-S., G.Z., E.H., U.H., R.A.K.S.); Boston University School of Medicine, Boston (L.H.B., H.M., D.J.S.); and the University of Louisville (M.M., J.K.) and Robley Rex Veterans Affairs Medical Center (J.K.) - both in Louisville, KY.

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December 2014

Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity.

Authors:

Erwan Pernet Laurent Guillemot Pierre-Régis Burgel Clémence Martin Gérard Lambeau Isabelle Sermet-Gaudelus Dorota Sands Dominique Leduc Philippe C Morand Louise Jeammet Michel Chignard Yongzheng Wu Lhousseine Touqui

Nat Commun 2014 Oct 7;5:5105. Epub 2014 Oct 7.

1] Unité de défense innée et inflammation, Institut Pasteur, 75015 Paris, France [2] INSERM U874, 75015 Paris, France.

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October 2014

Secreted phospholipases A2 in cancer: diverse mechanisms of action.

Authors:

Vesna Brglez Gérard Lambeau Toni Petan

Biochimie 2014 Dec 5;107 Pt A:114-23. Epub 2014 Oct 5.

Department of Molecular and Biomedical Sciences, Jožef Stefan Institute, Ljubljana, Slovenia. Electronic address:

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December 2014

Emerging roles of secreted phospholipase A2 enzymes: the 3rd edition.

Authors:

Makoto Murakami Yoshitaka Taketomi Yoshimi Miki Hiroyasu Sato Kei Yamamoto Gérard Lambeau

Biochimie 2014 Dec 16;107 Pt A:105-13. Epub 2014 Sep 16.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, Centre National de la Recherche Scientifique - Université Nice Sophia Antipolis, Valbonne 06560, France.

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December 2014

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation.

Blood 2014 Oct 31;124(14):2173-83. Epub 2014 Jul 31.

Centre de Recherche du Centre Hospitalier Universitaire de Québec, Faculté de Médecine de l'Université Laval, Département de Microbiologie et Immunologie, Quebec, QC, Canada;

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October 2014

Prediction of membranous nephropathy recurrence after transplantation by monitoring of anti-PLA2R1 (M-type phospholipase A2 receptor) autoantibodies: a case series of 15 patients.

Authors:

Barbara Seitz-Polski Christine Payré Damien Ambrosetti Laetitia Albano Elisabeth Cassuto-Viguier Marine Berguignat Ahmed Jeribi Marie-Christine Thouret Ghislaine Bernard Sylvia Benzaken Gérard Lambeau Vincent L M Esnault

Nephrol Dial Transplant 2014 Dec 25;29(12):2334-42. Epub 2014 Jul 25.

Service de Néphrologie, Hôpital Pasteur, Université de Nice-Sophia Antipolis, Nice, France.

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December 2014

[New physiopathological roles for the PLA2R1 receptor in cancer and membranous nephropathy].

Authors:

Christophe A Girard Barbara Seitz-Polski Guillaume Dolla Arnaud Augert David Vindrieux David Bernard Gérard Lambeau

Med Sci (Paris) 2014 May 13;30(5):519-25. Epub 2014 Jun 13.

Institut de pharmacologie moléculaire et cellulaire, CNRS et université de Nice-Sophia Antipolis UMR 7275, 660 route des lucioles, Sophia Antipolis, 06560 Valbonne, France.

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May 2014

Lack of group X secreted phospholipase A₂ increases survival following pandemic H1N1 influenza infection.

Authors:

Alyson A Kelvin Norbert Degousee David Banner Eva Stefanski Alberto J Leόn Denis Angoulvant Stéphane G Paquette Stephen S H Huang Ali Danesh Clinton S Robbins Hossein Noyan Mansoor Husain Gerard Lambeau Michael Gelb David J Kelvin Barry B Rubin

Virology 2014 Apr 25;454-455:78-92. Epub 2014 Feb 25.

Division of Vascular Surgery, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network and the University of Toronto, Toronto, Ontario, Canada.

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April 2014

Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth.

Authors:

David Vindrieux Guillaume Devailly Arnaud Augert Benjamin Le Calvé Mylène Ferrand Pascal Pigny Léa Payen Gérard Lambeau Michael Perrais Sébastien Aubert Hélène Simonnet Robert Dante David Bernard

Oncotarget 2014 Feb;5(4):1004-13

Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.

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February 2014

Secreted phospholipases A₂are differentially expressed and epigenetically silenced in human breast cancer cells.

Authors:

Vesna Brglez Anja Pucer Jože Pungerčar Gérard Lambeau Toni Petan

Biochem Biophys Res Commun 2014 Feb 6;445(1):230-5. Epub 2014 Feb 6.

Department of Molecular and Biomedical Sciences, Jožef Stefan Institute, Ljubljana, Slovenia. Electronic address:

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February 2014

The effect of group X secreted phospholipase A2 on fertilization outcome is specific and not mimicked by other secreted phospholipases A2 or progesterone.

Authors:

Roland Abi Nahed Jessica Escoffier Charlaine Revel Louise Jeammet Christine Payré Pierre F Ray Sylviane Hennebicq Gerard Lambeau Christophe Arnoult

Biochimie 2014 Apr 25;99:88-95. Epub 2013 Nov 25.

Université Joseph Fourier, Grenoble F-38000, France; Laboratoire AGIM, Equipe AGC, CNRS FRE3405, La Tronche F-38700, France. Electronic address:

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April 2014

Group X secreted phospholipase A(2) induces lipid droplet formation and prolongs breast cancer cell survival.

Authors:

Anja Pucer Vesna Brglez Christine Payré Jože Pungerčar Gérard Lambeau Toni Petan

Mol Cancer 2013 Sep 27;12(1):111. Epub 2013 Sep 27.

Department of Molecular and Biomedical Sciences, JoŽef Stefan Institute, Ljubljana, Slovenia.

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September 2013

PLA2R1 mediates tumor suppression by activating JAK2.

Authors:

David Vindrieux Arnaud Augert Christophe A Girard Delphine Gitenay Helene Lallet-Daher Clotilde Wiel Benjamin Le Calvé Baptiste Gras Mylène Ferrand Stéphanie Verbeke Yvan de Launoit Xavier Leroy Alain Puisieux Sébastien Aubert Michael Perrais Michael Gelb Hélène Simonnet Gérard Lambeau David Bernard

Cancer Res 2013 Oct 5;73(20):6334-45. Epub 2013 Sep 5.

Authors' Affiliations: Inserm U1052, Centre de Recherche en Cancérologie de Lyon; CNRS UMR5286; Centre Léon Bérard; Université de Lyon, Lyon; UMR8161, CNRS/Universités de Lille 1 et 2; Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275, CNRS and Université de Nice-Sophia Antipolis, Valbonne; INSERM U916, Bergonié Cancer Institute, Université Bordeaux, Bordeaux; and Institut de Pathologie, CHRU, Faculté de Médecine, Université de Lille; INSERM U837, Jean-Pierre Aubert Research Center, Team 5, Lille; Department of Medicine, University of Washington, Seattle, Washington.

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October 2013

PLA2R1 kills cancer cells by inducing mitochondrial stress.

Authors:

Arnaud Augert David Vindrieux Christophe A Girard Benjamin Le Calvé Baptiste Gras Mylène Ferrand Benjamin P Bouchet Alain Puisieux Yvan de Launoit Hélène Simonnet Gérard Lambeau David Bernard

Free Radic Biol Med 2013 Dec 29;65:969-977. Epub 2013 Aug 29.

INSERM U1052, Centre de Recherche en Cancérologie de Lyon, Lyon F-69373, France; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon F-69373, France; Centre Léon Bérard, Lyon F-69373, France; Université de Lyon, Lyon F-69373, France. Electronic address:

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December 2013

Secreted group IIA phospholipase A2 protects humans against the group B streptococcus: experimental and clinical evidence.

Authors:

Elin Movert Yongzheng Wu Gérard Lambeau Fredrik Kahn Lhousseine Touqui Thomas Areschoug

J Infect Dis 2013 Dec 30;208(12):2025-35. Epub 2013 Jul 30.

Department of Laboratory Medicine, Division of Medical Microbiology, Lund University, Sweden.

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December 2013

Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators.

Authors:

Yoshimi Miki Kei Yamamoto Yoshitaka Taketomi Hiroyasu Sato Kanako Shimo Tetsuyuki Kobayashi Yukio Ishikawa Toshiharu Ishii Hiroki Nakanishi Kazutaka Ikeda Ryo Taguchi Kenji Kabashima Makoto Arita Hiroyuki Arai Gérard Lambeau James M Bollinger Shuntaro Hara Michael H Gelb Makoto Murakami

J Exp Med 2013 Jun 20;210(6):1217-34. Epub 2013 May 20.

Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.

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June 2013

Development of a standardized ELISA for the determination of autoantibodies against human M-type phospholipase A2 receptor in primary membranous nephropathy.

Authors:

Cornelia Dähnrich Lars Komorowski Christian Probst Barbara Seitz-Polski Vincent Esnault Jack F Wetzels Julia M Hofstra Elion Hoxha Rolf A Stahl Gérard Lambeau Winfried Stöcker Wolfgang Schlumberger

Clin Chim Acta 2013 Jun 27;421:213-8. Epub 2013 Mar 27.

EUROIMMUN AG, Lübeck, Germany.

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June 2013

Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice.

Authors:

Hafid Ait-Oufella Olivier Herbin Charlotte Lahoute Christelle Coatrieux Xavier Loyer Jeremie Joffre Ludivine Laurans Bhama Ramkhelawon Olivier Blanc-Brude Sonia Karabina Christophe A Girard Christine Payré Kei Yamamoto Christoph J Binder Makoto Murakami Alain Tedgui Gérard Lambeau Ziad Mallat

Arterioscler Thromb Vasc Biol 2013 Mar 24;33(3):466-73. Epub 2013 Jan 24.

Inserm U970, Paris Cardiovascular Research Center, Université René Descartes, Paris, France.

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March 2013

Absence of inflammatory conditions in human varicose saphenous veins.

Authors:

Ingrid Gomez Chabha Benyahia Julien Le Dall Christine Payré Liliane Louedec Guy Leséche Gérard Lambeau Dan Longrois Xavier Norel

Inflamm Res 2013 Mar 13;62(3):299-308. Epub 2012 Dec 13.

INSERM U698, CHU X. Bichat, 46 Rue Huchard, 75018 Paris, France.

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March 2013

Emerging roles of secreted phospholipase A(2) enzymes: an update.

Authors:

Makoto Murakami Gérard Lambeau

Biochimie 2013 Jan 25;95(1):43-50. Epub 2012 Sep 25.

Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Kamikitazawa, Setagaya-ku, Tokyo, Japan.

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January 2013

Effects of the propeptide of group X secreted phospholipase A(2) on substrate specificity and interfacial activity on phospholipid monolayers.

Authors:

Vanessa Point Anaïs Bénarouche Ikram Jemel Goetz Parsiegla Gérard Lambeau Frédéric Carrière Jean-François Cavalier

Biochimie 2013 Jan 7;95(1):51-8. Epub 2012 Aug 7.

CNRS, Aix-Marseille Université, Enzymologie Interfaciale et Physiologie de la Lipolyse, UMR 7282, Marseille Cedex, France.

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January 2013

[Do phospholipases, key enzymes in sperm physiology, represent therapeutic challenges?].

Authors:

Christophe Arnoult Jessica Escoffier Léa Munch Virginie Pierre Sylviane Hennebicq Gérard Lambeau Pierre Ray

Med Sci (Paris) 2012 May 30;28(5):512-8. Epub 2012 May 30.

Équipe génétique, infertilité et thérapeutiques, laboratoire AGIM (âge, imagerie et modélisation), CNRS FRE3405, 38700 La Tronche, France.

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May 2012

Human group X secreted phospholipase A2 induces dendritic cell maturation through lipoprotein-dependent and -independent mechanisms.

Authors:

Rajai Atout Sonia-Athina Karabina Sandra Dollet Martine Carreras Christine Payré Patrice André Gérard Lambeau Vincent Lotteau Ewa Ninio Laure Perrin-Cocon

Atherosclerosis 2012 Jun 22;222(2):367-74. Epub 2012 Mar 22.

INSERM UMRS 937, Université Pierre et Marie Curie UPMC-Paris 6, Faculté de Médecine Pierre et Marie Curie, 91 Boulevard de l'Hôpital, Paris 75634 Cedex 13, France.

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June 2012

Secreted phospholipase A(2) group IIA is a neurotoxin released by stimulated human glial cells.

Authors:

Erika B Villanueva Jonathan P Little Gérard Lambeau Andis Klegeris

Mol Cell Neurosci 2012 Apr 3;49(4):430-8. Epub 2012 Mar 3.

Laboratory of Cellular and Molecular Pharmacology, Department of Biology, University of British Columbia Okanagan, Kelowna, BC, Canada.

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April 2012

A novel bacterial resistance mechanism against human group IIA-secreted phospholipase A2: role of Streptococcus pyogenes sortase A.

Authors:

Elin Movert Yongzheng Wu Gérard Lambeau Lhousseine Touqui Thomas Areschoug

J Immunol 2011 Dec 9;187(12):6437-46. Epub 2011 Nov 9.

Division of Medical Microbiology, Department of Laboratory Medicine, Lund University, 22362 Lund, Sweden.

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December 2011

Group X secreted phospholipase A2 proenzyme is matured by a furin-like proprotein convertase and releases arachidonic acid inside of human HEK293 cells.

Authors:

Ikram Jemel Hiromi Ii Rob C Oslund Christine Payré Anne-Sophie Dabert-Gay Dominique Douguet Khaoula Chargui Sabine Scarzello Michael H Gelb Gérard Lambeau

J Biol Chem 2011 Oct 30;286(42):36509-21. Epub 2011 Aug 30.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR6097, CNRS et Université de Nice-Sophia-Antipolis, 660 Route des Lucioles, Sophia Antipolis, 06560 Valbonne, France.

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October 2011

Group V phospholipase A2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after Escherichia coli pneumonia.

Authors:

Norbert Degousee David J Kelvin Gerd Geisslinger David M Hwang Eva Stefanski Xing-Hua Wang Ali Danesh Carlo Angioni Helmut Schmidt Thomas F Lindsay Michael H Gelb James Bollinger Christine Payré Gérard Lambeau Jonathan P Arm Armand Keating Barry B Rubin

J Biol Chem 2011 Oct 17;286(41):35650-62. Epub 2011 Aug 17.

Division of Vascular Surgery, Peter Munk Cardiac Centre, University of Toronto, Toronto, Ontario M5G 2C4, Canada.

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October 2011

Group X secreted phospholipase A₂ specifically decreases sperm motility in mice.

Authors:

Jessica Escoffier Virginie J Pierre Ikram Jemel Léa Munch Zied Boudhraa Pierre F Ray Michel De Waard Gérard Lambeau Christophe Arnoult

J Cell Physiol 2011 Oct;226(10):2601-9

INSERM, U836, Grenoble, France.

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October 2011

Lipoprotein-associated and secreted phospholipases A₂ in cardiovascular disease: roles as biological effectors and biomarkers.

Authors:

Ziad Mallat Gérard Lambeau Alain Tedgui

Circulation 2010 Nov;122(21):2183-200

INSERM, Paris-Cardiovascular Research Center, Université Paris Descartes, UMR, Paris, France.

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November 2010

A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis.

Authors:

Eric Boilard Ying Lai Katherine Larabee Barbara Balestrieri Farideh Ghomashchi Daisuke Fujioka Reuben Gobezie Jonathan S Coblyn Michael E Weinblatt Elena M Massarotti Thomas S Thornhill Maziar Divangahi Heinz Remold Gérard Lambeau Michael H Gelb Jonathan P Arm David M Lee

EMBO Mol Med 2010 May;2(5):172-87

Division of Rheumatology, Immunology and Allergy and Partners Asthma Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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May 2010

Phospholipolyzed LDL induces an inflammatory response in endothelial cells through endoplasmic reticulum stress signaling.

Authors:

Sarah Gora Seraya Maouche Rajai Atout Kristell Wanherdrick Gérard Lambeau François Cambien Ewa Ninio Sonia-Athina Karabina

FASEB J 2010 Sep 29;24(9):3284-97. Epub 2010 Apr 29.

INSERM UMRS 937, Université Pierre et Marie Curie, UPMC-Paris 6, Paris, France.

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September 2010

Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice.

Authors:

Jessica Escoffier Ikram Jemel Akemi Tanemoto Yoshitaka Taketomi Christine Payre Christelle Coatrieux Hiroyasu Sato Kei Yamamoto Seiko Masuda Karin Pernet-Gallay Virginie Pierre Shuntaro Hara Makoto Murakami Michel De Waard Gérard Lambeau Christophe Arnoult

J Clin Invest 2010 May 26;120(5):1415-28. Epub 2010 Apr 26.

Grenoble Institute of Neuroscience, INSERM U836, Grenoble, France.

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May 2010

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.

Authors:

Caroline Subra David Grand Karine Laulagnier Alexandre Stella Gérard Lambeau Michael Paillasse Philippe De Medina Bernard Monsarrat Bertrand Perret Sandrine Silvente-Poirot Marc Poirot Michel Record

J Lipid Res 2010 Aug 27;51(8):2105-20. Epub 2010 Apr 27.

Metabolism, Oncogenesis and Cell Differentiation Group, INSERM Research Center 563, Pathophysiology Center of Toulouse Purpan, Hôpital Purpan, Toulouse, France.

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August 2010

Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2.

Authors:

Francescopaolo Granata Annunziata Frattini Stefania Loffredo Rosaria I Staiano Angelica Petraroli Domenico Ribatti Rob Oslund Michael H Gelb Gerard Lambeau Gianni Marone Massimo Triggiani

J Immunol 2010 May 31;184(9):5232-41. Epub 2010 Mar 31.

Division of Clinical Immunology and Allergy and Center for Basic and Clinical Immunology Research, University of Naples Federico II, Naples.

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May 2010

Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice.

Authors:

Makoto Murakami Yoshitaka Taketomi Christophe Girard Kei Yamamoto Gérard Lambeau

Biochimie 2010 Jun 27;92(6):561-82. Epub 2010 Mar 27.

Biomembrane Signaling Project, The Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.

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June 2010

Snake venoms as a source of compounds modulating sperm physiology: Secreted phospholipases A2 from Oxyuranus scutellatus scutellatus impact sperm motility, acrosome reaction and in vitro fertilization in mice.

Authors:

Jessica Escoffier Morgane Couvet Harold de Pomyers Pierre F Ray Michel Sève Gérard Lambeau Michel De Waard Christophe Arnoult

Biochimie 2010 Jul 11;92(7):826-36. Epub 2010 Mar 11.

INSERM U836, Grenoble, F-38000, France.

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July 2010

Two cutinase-like proteins secreted by Mycobacterium tuberculosis show very different lipolytic activities reflecting their physiological function.

Authors:

Mathieu Schué Damien Maurin Rabeb Dhouib Jean-Claude Bakala N'Goma Vincent Delorme Gérard Lambeau Frédéric Carrière Stéphane Canaan

FASEB J 2010 Jun 26;24(6):1893-903. Epub 2010 Jan 26.

Centre National de la Recherche Scientifique, Aix-Marseille Université, Enzymologie Interfaciale et Physiologie de la Lipolyse UPR 9025, Marseille, France.

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June 2010

Group X phospholipase A2 stimulates the proliferation of colon cancer cells by producing various lipid mediators.

Authors:

Fanny Surrel Ikram Jemel Eric Boilard James G Bollinger Christine Payré Carine M Mounier Kati A Talvinen Veli J O Laine Timo J Nevalainen Michael H Gelb Gérard Lambeau

Mol Pharmacol 2009 Oct 14;76(4):778-90. Epub 2009 Jul 14.

Institut de Pharmacologie Moléculaire et Cellulaire, Université de Nice Sophia Antipolis et Centre National de la Recherche Scientifique, 06560 Valbonne, France.

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October 2009

M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.

Authors:

Laurence H Beck Ramon G B Bonegio Gérard Lambeau David M Beck David W Powell Timothy D Cummins Jon B Klein David J Salant

N Engl J Med 2009 Jul;361(1):11-21

Boston University School of Medicine, Boston, MA, USA.

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July 2009

Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease.

Authors:

Sarah Gora Claire Perret Ikram Jemel Viviane Nicaud Gérard Lambeau François Cambien Ewa Ninio Stefan Blankenberg Laurence Tiret Sonia-Athina Karabina

J Mol Med (Berl) 2009 Jul 3;87(7):723-33. Epub 2009 Jun 3.

INSERM, UMRS937, UPMC Université Paris 06 and Faculté de Médecine Pierre et Marie Curie, 91, Boulevard de l'Hôpital, 75634, Paris, France.

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July 2009

1,3,5-Triazepan-2,6-diones as conformationally constrained dipeptide mimetics. In silico guided identification of sPLA2 inhibitors.

Authors:

Gilles Guichard Gersande Léna Joel Boeglin Pascal Muller Eric Boilard Gérard Lambeau Didier Rognan Claude Didierjean

Adv Exp Med Biol 2009 ;611:201-2

CNRS; Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.

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June 2009

The M-type receptor PLA2R regulates senescence through the p53 pathway.

Authors:

Arnaud Augert Christine Payré Yvan de Launoit Jesus Gil Gérard Lambeau David Bernard

EMBO Rep 2009 Mar 6;10(3):271-7. Epub 2009 Feb 6.

UMR 8161, Institut de Biologie de Lille, CNRS/Universités de Lille 1 et 2/Institut Pasteur de Lille, IFR 142, 59021 Lille, France.

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March 2009

Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis.

Authors:

Giorgio Giannattasio Ying Lai Francescopaolo Granata Carine M Mounier Laxman Nallan Rob Oslund Christina C Leslie Gianni Marone Gérard Lambeau Michael H Gelb Massimo Triggiani

Biochim Biophys Acta 2009 Feb 16;1791(2):92-102. Epub 2008 Dec 16.

Department of Clinical Immunology and Allergy and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.

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February 2009

Biochemistry and physiology of mammalian secreted phospholipases A2.

Authors:

Gérard Lambeau Michael H Gelb

Annu Rev Biochem 2008 ;77:495-520

Institut de Pharmacologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université de Nice-Sophia-Antipolis, 06560 Valbonne, France.

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September 2008

Exploration of associations between phospholipase A2 gene family polymorphisms and AIDS progression using the SNPlex method.

Authors:

Sophie Limou Cédric Coulonges Mario Foglio Simon Heath Gora Diop Sigrid Leclerc Thomas Hirtzig Jean-Louis Spadoni Amu Therwath Gérard Lambeau Ivo Gut Jean-François Zagury

Biomed Pharmacother 2008 Jan 3;62(1):31-40. Epub 2007 Dec 3.

CEA/Institut de Génomique, Centre National de Génotypage, 2 rue Gaston Crémieux, 91057 Evry, France.

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January 2008

Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors.

Authors:

Julie Pannequin Nathalie Delaunay Michael Buchert Fanny Surrel Jean-François Bourgaux Joanne Ryan Stéphanie Boireau Jessica Coelho André Pélegrin Pomila Singh Arthur Shulkes Mildred Yim Graham S Baldwin Christine Pignodel Gérard Lambeau Philippe Jay Dominique Joubert Frédéric Hollande

Gastroenterology 2007 Nov 24;133(5):1554-68. Epub 2007 Oct 24.

CNRS UMR5203, Montpellier, France.

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November 2007

Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities.

Authors:

Mohamed Touaibia Atimé Djimdé Fei Cao Eric Boilard Sofiane Bezzine Gérard Lambeau Catherine Redeuilh Aazdine Lamouri France Massicot François Chau Chang-Zhi Dong Françoise Heymans

J Med Chem 2007 Apr 3;50(7):1618-26. Epub 2007 Mar 3.

Unité de Pharmacochimie Moléculaire et Systèmes Membranaires (EA2381), Université Paris7-Denis Diderot, case 7066, 2 place Jussieu, 75251 Paris, Cedex 05, France.

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April 2007

An envelope-determined endocytic route of viral entry allows HIV-1 to escape from secreted phospholipase A2 entry blockade.

Authors:

Thomas Maurin David Fenard Gérard Lambeau Alain Doglio

J Mol Biol 2007 Mar 17;367(3):702-14. Epub 2007 Jan 17.

Inserm U526, Laboratoire de Virologie, Faculté de Médecine, Avenue de Valombrose, 06107 Nice cedex 2, France.

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March 2007

Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor.

Authors:

Morgane Rouault Catherine Le Calvez Eric Boilard Fanny Surrel Alan Singer Farideh Ghomashchi Sofiane Bezzine Sabine Scarzello James Bollinger Michael H Gelb Gérard Lambeau

Biochemistry 2007 Feb;46(6):1647-62

Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France.

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February 2007

In silico-guided target identification of a scaffold-focused library: 1,3,5-triazepan-2,6-diones as novel phospholipase A2 inhibitors.

Authors:

Pascal Muller Gersande Lena Eric Boilard Sofiane Bezzine Gérard Lambeau Gilles Guichard Didier Rognan

J Med Chem 2006 Nov;49(23):6768-78

Bioinformatics of the Drug, CNRS UMR 7175, F-67400 Illkirch, and Immunologie et Chimie Thérapeutiques, CNRS UPR 9021, Institut de Biologie Moléculaire et Cellulaire (IBMC), F-67084 Strasbourg Cedex, France.

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November 2006

Atherogenic properties of LDL particles modified by human group X secreted phospholipase A2 on human endothelial cell function.

Authors:

Sonia-Athina Karabina Isabelle Brochériou Gilles Le Naour Monique Agrapart Hervé Durand Michael Gelb Gérard Lambeau Ewa Ninio

FASEB J 2006 Dec 31;20(14):2547-9. Epub 2006 Oct 31.

INSERM UMRS 525, Faculté de Médecine Pierre et Marie Curie, 91, boulevard de l'Hôpital, 75634 Paris, France.

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December 2006

Secreted phospholipase A2 inhibitors are also potent blockers of binding to the M-type receptor.

Authors:

Eric Boilard Morgane Rouault Fanny Surrel Catherine Le Calvez Sofiane Bezzine Alan Singer Michael H Gelb Gérard Lambeau

Biochemistry 2006 Nov;45(44):13203-18

Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR 6097, 660 route des Lucioles, Sophia-Antipolis, 06560 Valbonne, France.

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November 2006

The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2.

Authors:

Sarah Gora Gerard Lambeau James G Bollinger Michael Gelb Ewa Ninio Sonia-Athina Karabina

Biochim Biophys Acta 2006 Sep 5;1761(9):1093-9. Epub 2006 Aug 5.

INSERM U525, Université Pierre et Marie Curie-Paris 6, Faculté de Médecine Pierre et Marie Curie, Paris, France.

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September 2006

Analysis of expression of secreted phospholipases A2 in mouse tissues at protein and mRNA levels.

Authors:

Leena I Eerola Fanny Surrel Timo J Nevalainen Michael H Gelb Gérard Lambeau V Jukka O Laine

Biochim Biophys Acta 2006 Jul 27;1761(7):745-56. Epub 2006 Apr 27.

Department of Pathology, University of Turku, Turku, Finland.

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July 2006

Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity.

Authors:

Morgane Rouault Lachlan D Rash Pierre Escoubas Eric Boilard James Bollinger Bruno Lomonte Thomas Maurin Carole Guillaume Stéphane Canaan Christiane Deregnaucourt Joseph Schrével Alain Doglio José María Gutiérrez Michel Lazdunski Michael H Gelb Gérard Lambeau

Biochemistry 2006 May;45(18):5800-16

Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France.

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May 2006

The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a.

Authors:

Miguel Salinas Lachlan D Rash Anne Baron Gérard Lambeau Pierre Escoubas Michel Lazdunski

J Physiol 2006 Jan 10;570(Pt 2):339-54. Epub 2005 Nov 10.

Institut de Pharmacologie Moléculaire et Cellulaire, CNRS Université de Nice Sophia-Antipolis, UMR-6097, Institut Paul Hamel, Sophia Antipolis, Valbonne, France.

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January 2006