Gerard Drewes

Gerard Drewes

UNVERIFIED PROFILE

Are you Gerard Drewes?   Register this Author

Register author
Gerard Drewes

Gerard Drewes

Publications by authors named "Gerard Drewes"

Are you Gerard Drewes?   Register this Author

66Publications

3097Reads

34Profile Views

Clinically Relevant OATP2B1 Inhibitors in Marketed Drug Space.

Mol Pharm 2020 02 2;17(2):488-498. Epub 2020 Jan 2.

Cellzome, a GlaxoSmithKline Company , 69117 Heidelberg , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.molpharmaceut.9b00897DOI Listing
February 2020

Chemoproteomics and Chemical Probes for Target Discovery.

Trends Biotechnol 2018 12 13;36(12):1275-1286. Epub 2018 Jul 13.

Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, D-60438 Frankfurt am Main, Germany; Buchmann Institute for Molecular Life Sciences, Structural Genomics Consortium, Johann Wolfgang Goethe-University, D-60438 Frankfurt am Main, Germany; German Cancer Consortium DKTK, Frankfurt/Mainz, Germany; https://www.uni-frankfurt.de/53483664/Knapp. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tibtech.2018.06.008DOI Listing
December 2018

Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome.

ACS Infect Dis 2018 10 28;4(10):1475-1486. Epub 2018 Sep 28.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences , University of Dundee , Dundee , DD1 5EH , United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsinfecdis.8b00097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199744PMC
October 2018

Screening Pools of Compounds against Multiple Endogenously Expressed Targets in a Chemoproteomics Binding Assay.

J Lab Autom 2016 Feb 13;21(1):133-42. Epub 2015 Jul 13.

Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Heidelberg, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2211068215595355DOI Listing
February 2016

Discovery of Novel Small Molecules that Activate Satellite Cell Proliferation and Enhance Repair of Damaged Muscle.

ACS Chem Biol 2016 Feb 7;11(2):518-29. Epub 2016 Jan 7.

Muscle Metabolism Discovery Performance Unit, GlaxoSmithKline , Research Triangle Park, North Carolina 27709, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.5b00772DOI Listing
February 2016

Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.

Nat Methods 2015 Dec 2;12(12):1129-31. Epub 2015 Nov 2.

Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.3652DOI Listing
December 2015

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.

Nat Chem Biol 2015 Mar 26;11(3):189-91. Epub 2015 Jan 26.

1] EpiNova DPU, Immuno-Inflammation Therapy Area, GlaxoSmithKline,Medicines Research Centre, Stevenage, Hertfordshire, UK. [2] AstraZeneca, Oncology iMed, Cambridge Science Park, Cambridge, UK (R.J.S. and D.M.W.); Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA (D.J.S.); University of Massachussetts Medical School, Worcester, Massachusetts, USA (P.R.T.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio.1735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397581PMC
March 2015

Chemoproteomics reveals time-dependent binding of histone deacetylase inhibitors to endogenous repressor complexes.

ACS Chem Biol 2014 Aug 6;9(8):1736-46. Epub 2014 Jun 6.

Cellzome GmbH, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cb500235nDOI Listing
August 2014

Drug selectivity: Running in the family.

Nat Chem Biol 2014 Aug 6;10(8):608-9. Epub 2014 Jul 6.

Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio.1585DOI Listing
August 2014

Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor.

J Med Chem 2013 Apr 29;56(7):3012-23. Epub 2013 Mar 29.

SFI CAST Biomedical Innovation Center, Unit for Cell Signaling, Oslo University Hospital, Forskningsparken, Gaustadalleén 21, 0349 Oslo, Norway.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm4000566DOI Listing
April 2013

Affinity profiling of the cellular kinome for the nucleotide cofactors ATP, ADP, and GTP.

ACS Chem Biol 2013 Mar 7;8(3):599-607. Epub 2013 Jan 7.

Cellzome GmbH, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/cb3005879
Publisher Site
http://dx.doi.org/10.1021/cb3005879DOI Listing
March 2013

Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei.

ACS Chem Biol 2012 Nov 23;7(11):1858-65. Epub 2012 Aug 23.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cb300326zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621575PMC
November 2012

Mass spectrometry approaches to monitor protein-drug interactions.

Methods 2012 Aug 8;57(4):430-40. Epub 2012 Jun 8.

Cellzome AG, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymeth.2012.05.008DOI Listing
August 2012

Chemical proteomics in drug discovery.

Authors:
Gerard Drewes

Methods Mol Biol 2012 ;803:15-21

Cellzome AG, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-1-61779-364-6_2
Publisher Site
http://dx.doi.org/10.1007/978-1-61779-364-6_2DOI Listing
March 2012

Chemoproteomic approaches to drug target identification and drug profiling.

Bioorg Med Chem 2012 Mar 9;20(6):1973-8. Epub 2011 Nov 9.

Cellzome AG, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2011.11.003DOI Listing
March 2012

Interactions of MAP/microtubule affinity regulating kinases with the adaptor complex AP-2 of clathrin-coated vesicles.

Cell Motil Cytoskeleton 2009 Aug;66(8):661-72

Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cm.20394DOI Listing
August 2009

Chemical and pathway proteomics: powerful tools for oncology drug discovery and personalized health care.

Mol Cell Proteomics 2008 Oct 1;7(10):1887-901. Epub 2008 Aug 1.

Deptartment of Discovery Technology, Cellzome AG, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.R800006-MCP200DOI Listing
October 2008

Human Proteinpedia enables sharing of human protein data.

Authors:
Suresh Mathivanan Mukhtar Ahmed Natalie G Ahn Hainard Alexandre Ramars Amanchy Philip C Andrews Joel S Bader Brian M Balgley Marcus Bantscheff Keiryn L Bennett Erik Björling Blagoy Blagoev Ron Bose Samir K Brahmachari Alma S Burlingame Xosé R Bustelo Gerard Cagney Greg T Cantin Helene L Cardasis Julio E Celis Raghothama Chaerkady Feixia Chu Philip A Cole Catherine E Costello Robert J Cotter David Crockett James P DeLany Angelo M De Marzo Leroi V DeSouza Eric W Deutsch Eric Dransfield Gerard Drewes Arnaud Droit Michael J Dunn Kojo Elenitoba-Johnson Rob M Ewing Jennifer Van Eyk Vitor Faca Jayson Falkner Xiangming Fang Catherine Fenselau Daniel Figeys Pierre Gagné Cecilia Gelfi Kris Gevaert Jeffrey M Gimble Florian Gnad Renu Goel Pavel Gromov Samir M Hanash William S Hancock H C Harsha Gerald Hart Faith Hays Fuchu He Prashantha Hebbar Kenny Helsens Heiko Hermeking Winston Hide Karin Hjernø Denis F Hochstrasser Oliver Hofmann David M Horn Ralph H Hruban Nieves Ibarrola Peter James Ole N Jensen Pia Hønnerup Jensen Peter Jung Kumaran Kandasamy Indu Kheterpal Reiko F Kikuno Ulrike Korf Roman Körner Bernhard Kuster Min-Seok Kwon Hyoung-Joo Lee Young-Jin Lee Michael Lefevre Minna Lehvaslaiho Pierre Lescuyer Fredrik Levander Megan S Lim Christian Löbke Joseph A Loo Matthias Mann Lennart Martens Juan Martinez-Heredia Mark McComb James McRedmond Alexander Mehrle Rajasree Menon Christine A Miller Harald Mischak S Sujatha Mohan Riaz Mohmood Henrik Molina Michael F Moran James D Morgan Robert Moritz Martine Morzel David C Muddiman Anuradha Nalli J Daniel Navarro Thomas A Neubert Osamu Ohara Rafael Oliva Gilbert S Omenn Masaaki Oyama Young-Ki Paik Kyla Pennington Rainer Pepperkok Balamurugan Periaswamy Emanuel F Petricoin Guy G Poirier T S Keshava Prasad Samuel O Purvine B Abdul Rahiman Prasanna Ramachandran Y L Ramachandra Robert H Rice Jens Rick Ragna H Ronnholm Johanna Salonen Jean-Charles Sanchez Thierry Sayd Beerelli Seshi Kripa Shankari Shi Jun Sheng Vivekananda Shetty K Shivakumar Richard J Simpson Ravi Sirdeshmukh K W Michael Siu Jeffrey C Smith Richard D Smith David J States Sumio Sugano Matthew Sullivan Giulio Superti-Furga Maarit Takatalo Visith Thongboonkerd Jonathan C Trinidad Mathias Uhlen Joël Vandekerckhove Julian Vasilescu Timothy D Veenstra José-Manuel Vidal-Taboada Mauno Vihinen Robin Wait Xiaoyue Wang Stefan Wiemann Billy Wu Tao Xu John R Yates Jun Zhong Ming Zhou Yunping Zhu Petra Zurbig Akhilesh Pandey

Nat Biotechnol 2008 Feb;26(2):164-7

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nbt0208-164DOI Listing
February 2008

Pathway proteomics and chemical proteomics team up in drug discovery.

Neurodegener Dis 2007 ;4(2-3):270-80

Cellzome AG, Department of Discovery Research, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000101851DOI Listing
October 2007

MARKing tau for tangles and toxicity.

Authors:
Gerard Drewes

Trends Biochem Sci 2004 Oct;29(10):548-55

Cellzome AG, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S096800040400202
Publisher Site
http://dx.doi.org/10.1016/j.tibs.2004.08.001DOI Listing
October 2004

Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.

J Biol Chem 2004 Mar 15;279(13):12804-11. Epub 2003 Dec 15.

Cellzome AG, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M312171200
Publisher Site
http://dx.doi.org/10.1074/jbc.M312171200DOI Listing
March 2004

MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes.

J Biol Chem 2004 Feb 1;279(7):5915-23. Epub 2003 Nov 1.

Department of Medicinal Chemistry, University of Kansas, Malott Hall, Lawrence, Kansas 66045, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M304528200
Publisher Site
http://dx.doi.org/10.1074/jbc.M304528200DOI Listing
February 2004

The protein kinase kin1, the fission yeast orthologue of mammalian MARK/PAR-1, localises to new cell ends after mitosis and is important for bipolar growth.

FEBS Lett 2003 Nov;554(1-2):45-9

Cell Cycle Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0014-5793(03)01080-9DOI Listing
November 2003

Global approaches to protein-protein interactions.

Curr Opin Cell Biol 2003 Apr;15(2):199-205

Cellzome AG, Meyerhofstrasse 1, 69117, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0955-0674(03)00005-xDOI Listing
April 2003