Publications by authors named "Gerald Wirnsberger"

21Publications

Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection.

Authors:
Vanessa Monteil Matheus Dyczynski Volker M Lauschke Hyesoo Kwon Gerald Wirnsberger Sonia Youhanna Haibo Zhang Arthur S Slutsky Carmen Hurtado Del Pozo Moritz Horn Nuria Montserrat Josef M Penninger Ali Mirazimi

EMBO Mol Med 2020 Nov 12:e13426. Epub 2020 Nov 12.

Department of Laboratory Medicine, Unit of Clinical Microbiology, Karolinska Institute, Stockholm, Sweden.

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November 2020

A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans.

Authors:
Astrid Hagelkruys Gerald Wirnsberger Johannes Stadlmann Miriam Wöhner Marion Horrer Bojan Vilagos Gustav Jonsson Melanie Kogler Luigi Tortola Maria Novatchkova Peter Bönelt David Hoffmann Rubina Koglgruber Ulrike Steffen Georg Schett Meinrad Busslinger Andreas Bergthaler Christoph Klein Josef M Penninger

J Exp Med 2021 Jan;218(1)

Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.

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January 2021

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.

Authors:
Vanessa Monteil Hyesoo Kwon Patricia Prado Astrid Hagelkrüys Reiner A Wimmer Martin Stahl Alexandra Leopoldi Elena Garreta Carmen Hurtado Del Pozo Felipe Prosper Juan Pablo Romero Gerald Wirnsberger Haibo Zhang Arthur S Slutsky Ryan Conder Nuria Montserrat Ali Mirazimi Josef M Penninger

Cell 2020 05 24;181(4):905-913.e7. Epub 2020 Apr 24.

Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohr-Gasse 3, 1030 Vienna, Austria; Department of Medical Genetics, Life Science Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address:

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May 2020

Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.

Authors:
Shane J F Cronin Corey Seehus Adelheid Weidinger Sebastien Talbot Sonja Reissig Markus Seifert Yann Pierson Eileen McNeill Maria Serena Longhi Bruna Lenfers Turnes Taras Kreslavsky Melanie Kogler David Hoffmann Melita Ticevic Débora da Luz Scheffer Luigi Tortola Domagoj Cikes Alexander Jais Manu Rangachari Shuan Rao Magdalena Paolino Maria Novatchkova Martin Aichinger Lee Barrett Alban Latremoliere Gerald Wirnsberger Guenther Lametschwandtner Meinrad Busslinger Stephen Zicha Alexandra Latini Simon C Robson Ari Waisman Nick Andrews Michael Costigan Keith M Channon Guenter Weiss Andrey V Kozlov Mark Tebbe Kai Johnsson Clifford J Woolf Josef M Penninger

Nature 2019 Aug;572(7769):E18

IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.

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August 2019

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.

Authors:
Shane J F Cronin Corey Seehus Adelheid Weidinger Sebastien Talbot Sonja Reissig Markus Seifert Yann Pierson Eileen McNeill Maria Serena Longhi Bruna Lenfers Turnes Taras Kreslavsky Melanie Kogler David Hoffmann Melita Ticevic Débora da Luz Scheffer Luigi Tortola Domagoj Cikes Alexander Jais Manu Rangachari Shuan Rao Magdalena Paolino Maria Novatchkova Martin Aichinger Lee Barrett Alban Latremoliere Gerald Wirnsberger Guenther Lametschwandtner Meinrad Busslinger Stephen Zicha Alexandra Latini Simon C Robson Ari Waisman Nick Andrews Michael Costigan Keith M Channon Guenter Weiss Andrey V Kozlov Mark Tebbe Kai Johnsson Clifford J Woolf Josef M Penninger

Nature 2018 11 7;563(7732):564-568. Epub 2018 Nov 7.

IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.

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November 2018

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.

Authors:
Luigi Tortola Roberto Nitsch Mathieu J M Bertrand Melanie Kogler Younes Redouane Ivona Kozieradzki Iris Uribesalgo Lilian M Fennell Mads Daugaard Helene Klug Gerald Wirnsberger Reiner Wimmer Thomas Perlot Renu Sarao Shuan Rao Toshikatsu Hanada Nozomi Takahashi Elisabeth Kernbauer Duygu Demiröz Michaela Lang Giulio Superti-Furga Thomas Decker Andrea Pichler Fumiyo Ikeda Guido Kroemer Peter Vandenabeele Poul H Sorensen Josef M Penninger

Cell Rep 2016 09 20;16(12):3414. Epub 2016 Sep 20.

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September 2016

Inhibition of CBLB protects from lethal Candida albicans sepsis.

Authors:
Gerald Wirnsberger Florian Zwolanek Tomoko Asaoka Ivona Kozieradzki Luigi Tortola Reiner A Wimmer Anoop Kavirayani Friedrich Fresser Gottfried Baier Wallace Y Langdon Fumiyo Ikeda Karl Kuchler Josef M Penninger

Nat Med 2016 08 18;22(8):915-23. Epub 2016 Jul 18.

Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, Austria.

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August 2016

RANKL/RANK control Brca1 mutation- .

Authors:
Verena Sigl Kwadwo Owusu-Boaitey Purna A Joshi Anoop Kavirayani Gerald Wirnsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujana For Cimba Holger Heyn Enrique Vidal Jennifer Cruickshank Hal Berman Renu Sarao Melita Ticevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva Yhp Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha Laundette P Jones Josef M Penninger

Cell Res 2016 07 31;26(7):761-74. Epub 2016 May 31.

IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna 1030, Austria.

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July 2016

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.

Authors:
Luigi Tortola Roberto Nitsch Mathieu J M Bertrand Melanie Kogler Younes Redouane Ivona Kozieradzki Iris Uribesalgo Lilian M Fennell Mads Daugaard Helene Klug Gerald Wirnsberger Reiner Wimmer Thomas Perlot Renu Sarao Shuan Rao Toshikatsu Hanada Nozomi Takahashi Elisabeth Kernbauer Duygu Demiröz Michaela Lang Giulio Superti-Furga Thomas Decker Andrea Pichler Fumiyo Ikeda Guido Kroemer Peter Vandenabeele Poul H Sorensen Josef M Penninger

Cell Rep 2016 05 5;15(7):1481-1492. Epub 2016 May 5.

Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), 1030 Vienna, Austria. Electronic address:

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May 2016

Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense.

Authors:
Gerald Wirnsberger Florian Zwolanek Johannes Stadlmann Luigi Tortola Shang Wan Liu Thomas Perlot Päivi Järvinen Gerhard Dürnberger Ivona Kozieradzki Renu Sarao Alba De Martino Kaan Boztug Karl Mechtler Karl Kuchler Christoph Klein Ulrich Elling Josef M Penninger

Nat Genet 2014 Sep 17;46(9):1028-33. Epub 2014 Aug 17.

Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, Austria.

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September 2014

A dual role for autophagy in a murine model of lung cancer.

Authors:
Shuan Rao Luigi Tortola Thomas Perlot Gerald Wirnsberger Maria Novatchkova Roberto Nitsch Peter Sykacek Lukas Frank Daniel Schramek Vukoslav Komnenovic Verena Sigl Karin Aumayr Gerald Schmauss Nicole Fellner Stephan Handschuh Martin Glösmann Pawel Pasierbek Michaela Schlederer Guenter P Resch Yuting Ma Heng Yang Helmuth Popper Lukas Kenner Guido Kroemer Josef M Penninger

Nat Commun 2014 ;5:3056

IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna 1030, Austria.

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November 2015

Seventy-five genetic loci influencing the human red blood cell.

Authors:
Pim van der Harst Weihua Zhang Irene Mateo Leach Augusto Rendon Niek Verweij Joban Sehmi Dirk S Paul Ulrich Elling Hooman Allayee Xinzhong Li Aparna Radhakrishnan Sian-Tsung Tan Katrin Voss Christian X Weichenberger Cornelis A Albers Abtehale Al-Hussani Folkert W Asselbergs Marina Ciullo Fabrice Danjou Christian Dina Tõnu Esko David M Evans Lude Franke Martin Gögele Jaana Hartiala Micha Hersch Hilma Holm Jouke-Jan Hottenga Stavroula Kanoni Marcus E Kleber Vasiliki Lagou Claudia Langenberg Lorna M Lopez Leo-Pekka Lyytikäinen Olle Melander Federico Murgia Ilja M Nolte Paul F O'Reilly Sandosh Padmanabhan Afshin Parsa Nicola Pirastu Eleonora Porcu Laura Portas Inga Prokopenko Janina S Ried So-Youn Shin Clara S Tang Alexander Teumer Michela Traglia Sheila Ulivi Harm-Jan Westra Jian Yang Jing Hua Zhao Franco Anni Abdel Abdellaoui Antony Attwood Beverley Balkau Stefania Bandinelli François Bastardot Beben Benyamin Bernhard O Boehm William O Cookson Debashish Das Paul I W de Bakker Rudolf A de Boer Eco J C de Geus Marleen H de Moor Maria Dimitriou Francisco S Domingues Angela Döring Gunnar Engström Gudmundur Ingi Eyjolfsson Luigi Ferrucci Krista Fischer Renzo Galanello Stephen F Garner Bernd Genser Quince D Gibson Giorgia Girotto Daniel Fannar Gudbjartsson Sarah E Harris Anna-Liisa Hartikainen Claire E Hastie Bo Hedblad Thomas Illig Jennifer Jolley Mika Kähönen Ido P Kema John P Kemp Liming Liang Heather Lloyd-Jones Ruth J F Loos Stuart Meacham Sarah E Medland Christa Meisinger Yasin Memari Evelin Mihailov Kathy Miller Miriam F Moffatt Matthias Nauck Maria Novatchkova Teresa Nutile Isleifur Olafsson Pall T Onundarson Debora Parracciani Brenda W Penninx Lucia Perseu Antonio Piga Giorgio Pistis Anneli Pouta Ursula Puc Olli Raitakari Susan M Ring Antonietta Robino Daniela Ruggiero Aimo Ruokonen Aude Saint-Pierre Cinzia Sala Andres Salumets Jennifer Sambrook Hein Schepers Carsten Oliver Schmidt Herman H W Silljé Rob Sladek Johannes H Smit John M Starr Jonathan Stephens Patrick Sulem Toshiko Tanaka Unnur Thorsteinsdottir Vinicius Tragante Wiek H van Gilst L Joost van Pelt Dirk J van Veldhuisen Uwe Völker John B Whitfield Gonneke Willemsen Bernhard R Winkelmann Gerald Wirnsberger Ale Algra Francesco Cucca Adamo Pio d'Adamo John Danesh Ian J Deary Anna F Dominiczak Paul Elliott Paolo Fortina Philippe Froguel Paolo Gasparini Andreas Greinacher Stanley L Hazen Marjo-Riitta Jarvelin Kay Tee Khaw Terho Lehtimäki Winfried Maerz Nicholas G Martin Andres Metspalu Braxton D Mitchell Grant W Montgomery Carmel Moore Gerjan Navis Mario Pirastu Peter P Pramstaller Ramiro Ramirez-Solis Eric Schadt James Scott Alan R Shuldiner George Davey Smith J Gustav Smith Harold Snieder Rossella Sorice Tim D Spector Kari Stefansson Michael Stumvoll W H Wilson Tang Daniela Toniolo Anke Tönjes Peter M Visscher Peter Vollenweider Nicholas J Wareham Bruce H R Wolffenbuttel Dorret I Boomsma Jacques S Beckmann George V Dedoussis Panos Deloukas Manuel A Ferreira Serena Sanna Manuela Uda Andrew A Hicks Josef Martin Penninger Christian Gieger Jaspal S Kooner Willem H Ouwehand Nicole Soranzo John C Chambers

Nature 2012 Dec 5;492(7429):369-75. Epub 2012 Dec 5.

Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.

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December 2012

Forward and reverse genetics through derivation of haploid mouse embryonic stem cells.

Authors:
Ulrich Elling Jasmin Taubenschmid Gerald Wirnsberger Ronan O'Malley Simon-Pierre Demers Quentin Vanhaelen Andrey I Shukalyuk Gerald Schmauss Daniel Schramek Frank Schnuetgen Harald von Melchner Joseph R Ecker William L Stanford Johannes Zuber Alexander Stark Josef M Penninger

Cell Stem Cell 2011 Dec;9(6):563-74

IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria.

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December 2011

B7/CD28 in central tolerance: costimulation promotes maturation of regulatory T cell precursors and prevents their clonal deletion.

Authors:
Maria Hinterberger Gerald Wirnsberger Ludger Klein

Front Immunol 2011 25;2:30. Epub 2011 Jul 25.

Institute for Immunology, University of Munich Munich, Germany.

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August 2012

Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes.

Authors:
Gerald Wirnsberger Maria Hinterberger Ludger Klein

Immunol Cell Biol 2011 Jan 2;89(1):45-53. Epub 2010 Nov 2.

Institute for Immunology, Ludwig-Maximilians-University, Munich, Germany.

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January 2011

Antigen presentation in the thymus for positive selection and central tolerance induction.

Authors:
Ludger Klein Maria Hinterberger Gerald Wirnsberger Bruno Kyewski

Nat Rev Immunol 2009 Dec;9(12):833-44

Institute for Immunology, Ludwig-Maximilians University, Goethestrasse 31, 80336 Munich, Germany.

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December 2009

Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice.

Authors:
Katharina Lahl Christian T Mayer Tobias Bopp Jochen Huehn Christoph Loddenkemper Gérard Eberl Gerald Wirnsberger Klaus Dornmair Robert Geffers Edgar Schmitt Jan Buer Tim Sparwasser

J Immunol 2009 Nov 7;183(9):5662-72. Epub 2009 Oct 7.

Institut fuer Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universitaet Muenchen, Munich, Germany.

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November 2009

Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control.

Authors:
Gerald Wirnsberger Florian Mair Ludger Klein

Proc Natl Acad Sci U S A 2009 Jun 10;106(25):10278-83. Epub 2009 Jun 10.

Institute for Immunology, Ludwig-Maximilian-University, Munich, Germany.

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June 2009

Identification of a distal tandem STAT6 element within the CCL17 locus.

Authors:
Elisabeth Maier Gerald Wirnsberger Jutta Horejs-Hoeck Albert Duschl Daniel Hebenstreit

Hum Immunol 2007 Dec 26;68(12):986-92. Epub 2007 Nov 26.

Department of Molecular Biology, University of Salzburg, Salzburg, Austria.

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December 2007

IL-4 induces expression of TARC/CCL17 via two STAT6 binding sites.

Authors:
Gerald Wirnsberger Daniel Hebenstreit Gernot Posselt Jutta Horejs-Hoeck Albert Duschl

Eur J Immunol 2006 Jul;36(7):1882-91

Department of Molecular Biology, University of Salzburg, Salzburg, Austria.

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July 2006

Signaling mechanisms, interaction partners, and target genes of STAT6.

Authors:
Daniel Hebenstreit Gerald Wirnsberger Jutta Horejs-Hoeck Albert Duschl

Cytokine Growth Factor Rev 2006 Jun 15;17(3):173-88. Epub 2006 Mar 15.

Department of Molecular Biology, University of Salzburg, 5020 Salzburg, Austria.

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June 2006