Publications by authors named "Gerald W Dorn"

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Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts.
Circ Res 2015 Jul 2;117(4):346-51. Epub 2015 Jun 2.
From the Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO (M.S., G.G., S.J.M., G.W.D.); Department of Biomedical Sciences, University of Montreal, Quebec, Canada (Y.B.); Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA (A.B.G.); and Departments of Medicine (Cardiology) and Cell Biology, and Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY (R.N.K.).

Mitochondrial reprogramming induced by CaMKIIδ mediates hypertrophy decompensation.
Circ Res 2015 Feb 20;116(5):e28-39. Epub 2015 Jan 20.
From the Department of Pharmacology (B.D.W., H.L., A.S.D., C.B.B.G., A.C.Z., A.N.M., J.H.B.), Department of Medicine (N.D.D., K.L.P., Y.G.), and Biomedical Sciences Graduate Program (C.B.B.G.), University of California San Diego; School of Internal Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St. Louis, MO (S.J.M., G.W.D.); Department of Cardiology, University Medical Center Groningen, Unversity of Groningen, Groningen, The Netherlands (B.D.W.)

The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble.
Circ Res 2015 Jan 16;116(1):167-82. Epub 2014 Oct 16.
From the Department of Internal Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St. Louis, MO (G.W.D.); and Departments of Medicine (Cardiology) and Cell Biology and Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY (R.N.K.).

Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling.
Proc Natl Acad Sci U S A 2014 Dec 8;111(51):E5537-44. Epub 2014 Dec 8.
Department of Physiology and Pathophysiology, Department of Pharmacology and Therapeutics, Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre, University of Manitoba, Winnipeg, MB, Canada R2H 2H6; and

Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy.
Circ Res 2014 Jul 29;115(3):348-53. Epub 2014 May 29.
From the Department of Internal Medicine, Center for Pharmacogenomics, Washington University School of Medicine, St. Louis, MO (M.S., G.G., G.W.D.); National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (E.M.); and Department of Pathology, University of Washington, Seattle (P.S.R.).

Supercomputing for the parallelization of whole genome analysis.
Bioinformatics 2014 Jun 12;30(11):1508-13. Epub 2014 Feb 12.
Department of Medicine, Computation Institute and Argonne National Laboratory, 9700 S. Cass Ave. Argonne, IL 60439, USA, Department of Human Genetics, The University of Chicago, 5841 S. Maryland Ave Chicago, IL 60637, USA, Department of Internal Medicine, The University of Michigan, 1150 W Medical Center Dr. Ann Arbor, MI 48109, USA, Perelman School of Medicine, Penn Cardiovascular Institute and Department of Medicine, University of Pennsylvania, 3400 Civic Center Blvd. Philadelphia, PA 19104, USA and Washington University School of Medicine, 660 S. Euclid Ave. St. Louis, MO 63110, USADepartment of Medicine, Computation Institute and Argonne National Laboratory, 9700 S. Cass Ave. Argonne, IL 60439, USA, Department of Human Genetics, The University of Chicago, 5841 S. Maryland Ave Chicago, IL 60637, USA, Department of Internal Medicine, The University of Michigan, 1150 W Medical Center Dr. Ann Arbor, MI 48109, USA, Perelman School of Medicine, Penn Cardiovascular Institute and Department of Medicine, University of Pennsylvania, 3400 Civic Center Blvd. Philadelphia, PA 19104, USA and Washington University School of Medicine, 660 S. Euclid Ave. St. Louis, MO 63110, USA.

Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin.
Circ Res 2014 Jan 5;114(2):257-65. Epub 2013 Nov 5.
From the Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO (P.B., M.S., Y.C., G.W.D.); and Department of Biomedical Sciences, University of Montreal, Quebec, Canada (Y.B.).

MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways.
J Immunol 2013 Dec 13;191(12):5904-13. Epub 2013 Nov 13.
Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110;

Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species.
Arterioscler Thromb Vasc Biol 2013 Oct 15;33(10):2415-24. Epub 2013 Aug 15.
From the Department of Medicine and Surgery, University of Salerno, Salerno, Italy (M.C., E.C., G.l.); Department of Pharmacology, Center for Translational Medicine, Temple University, Philadelphia, PA (M.C.); Department of Biomedical Sciences, University of Naples Federico II, Naples, Italy (D.S., A.F., C.D.G., R.A., M.G.M., B.T.); Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO (G.W.D.); and IRCCS Multimedica, Milan, Italy (G.I.).


Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalk.
Circ Res 2012 Sep 9;111(7):863-75. Epub 2012 Jul 9.
Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

Characterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytes.
J Biol Chem 2012 Jul 10;287(28):24043-52. Epub 2012 May 10.
Department of Applied Chemistry, College of Applied Sciences, Kyung Hee University, Yongin 446-701, Korea.


Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
Am J Hum Genet 2012 Mar 9;90(3):410-25. Epub 2012 Feb 9.
Center for Human Genetic Research, Massachusetts General Hospital, Boston, 02114, USA.

Gi-biased β2AR signaling links GRK2 upregulation to heart failure.
Circ Res 2012 Jan 15;110(2):265-74. Epub 2011 Dec 15.
Institute of Molecular Medicine, Peking University, Beijing 100871, China. Weizhong Zhu, MD, PhD, Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19107, USA.

Myocardial oxygen consumption change predicts left ventricular relaxation improvement in obese humans after weight loss.
Obesity (Silver Spring) 2011 Sep 7;19(9):1804-12. Epub 2011 Jul 7.
Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA.

Fatty acid synthase modulates homeostatic responses to myocardial stress.
J Biol Chem 2011 Sep 8;286(35):30949-61. Epub 2011 Jul 8.
Division of Endocrinology, Metabolism, and Lipid Research, Washington University, St. Louis, Missouri 63110, USA.

Molecular genetic and functional characterization implicate muscle-restricted coiled-coil gene (MURC) as a causal gene for familial dilated cardiomyopathy.
Circ Cardiovasc Genet 2011 Aug 3;4(4):349-58. Epub 2011 Jun 3.
Center for Cardiovascular Genetics, Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, USA.

G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.
Circulation 2011 May 25;123(18):1953-62. Epub 2011 Apr 25.
George Zallie and Family Laboratory for Cardiovascular Gene Therapy, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USA.


Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway.
PLoS One 2013 21;8(6):e66234. Epub 2013 Jun 21.
Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America ; Chaoyang Hospital, Capital Medical University, Beijing, China.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy 2016 ;12(1):1-222
kb Emory University, School of Medicine , Department of Microbiology and Immunology , Atlanta , GA , USA.

Atg5 Is Essential for the Development and Survival of Innate Lymphocytes.
Cell Rep 2016 05 19;15(9):1910-9. Epub 2016 May 19.
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:


Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether.
Proc Natl Acad Sci U S A 2016 10 19;113(40):11249-11254. Epub 2016 Sep 19.
Department of Biology, University of Padua, 35121 Padua, Italy; Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, 35129 Padua, Italy;

Correcting mitochondrial fusion by manipulating mitofusin conformations.
Nature 2016 12 24;540(7631):74-79. Epub 2016 Oct 24.
Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.



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