Publications by authors named "Gerald M Cohen"

49Publications

Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck.

Authors:
Rachel J Carter Mateus Milani Michael Butterworth Ahoud Alotibi Nicholas Harper Govindaraju Yedida Georgia Greaves Aoula Al-Zebeeby Andrea L Jorgensen Andrew G Schache Janet M Risk Richard J Shaw Terry M Jones Joseph J Sacco Adam Hurlstone Gerald M Cohen Shankar Varadarajan

Cell Death Dis 2019 12 4;10(12):912. Epub 2019 Dec 4.

Liverpool Head and Neck Centre, Liverpool, L69 3GE, UK.

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December 2019

DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis.

Authors:
Mateus Milani Alison J Beckett Aoula Al-Zebeeby Xu Luo Ian A Prior Gerald M Cohen Shankar Varadarajan

Cell Death Discov 2019 17;5:117. Epub 2019 Jul 17.

1Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, Ashton Street, Liverpool, L69 3GE UK.

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July 2019

Apogossypol-mediated reorganisation of the endoplasmic reticulum antagonises mitochondrial fission and apoptosis.

Authors:
Govindaraju Yedida Mateus Milani Gerald M Cohen Shankar Varadarajan

Cell Death Dis 2019 07 8;10(7):521. Epub 2019 Jul 8.

Departments of Molecular and Clinical Cancer Medicine, University of Liverpool, Ashton Street, Liverpool, L69 3GE, UK.

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July 2019

Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in hematologic malignancies.

Authors:
Aoula Al-Zebeeby Meike Vogler Mateus Milani Caitlin Richards Ahoud Alotibi Georgia Greaves Martin J S Dyer Gerald M Cohen Shankar Varadarajan

Haematologica 2019 05 22;104(5):1016-1025. Epub 2018 Nov 22.

Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, UK

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May 2019

BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-X.

Authors:
Georgia Greaves Mateus Milani Michael Butterworth Rachel J Carter Dominic P Byrne Patrick A Eyers Xu Luo Gerald M Cohen Shankar Varadarajan

Cell Death Differ 2019 06 5;26(6):1037-1047. Epub 2018 Sep 5.

Departments of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, Ashton Street, Liverpool, L69 3GE, UK.

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June 2019

Selective BH3-mimetics targeting BCL-2, BCL-XL or MCL-1 induce severe mitochondrial perturbations.

Authors:
Kristina Henz Aoula Al-Zebeeby Marion Basoglu Simone Fulda Gerald M Cohen Shankar Varadarajan Meike Vogler

Biol Chem 2019 01;400(2):181-185

Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Komturstr. 3a, D-60528 Frankfurt/Main, Germany.

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January 2019

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth.

Authors:
Patrick Casara James Davidson Audrey Claperon Gaëtane Le Toumelin-Braizat Meike Vogler Alain Bruno Maïa Chanrion Gaëlle Lysiak-Auvity Thierry Le Diguarher Jérôme-Benoît Starck Ijen Chen Neil Whitehead Christopher Graham Natalia Matassova Pawel Dokurno Christopher Pedder Youzhen Wang Shumei Qiu Anne-Marie Girard Emilie Schneider Fabienne Gravé Aurélie Studeny Ghislaine Guasconi Francesca Rocchetti Sophie Maïga Jean-Michel Henlin Frédéric Colland Laurence Kraus-Berthier Steven Le Gouill Martin J S Dyer Roderick Hubbard Mike Wood Martine Amiot Gerald M Cohen John A Hickman Erick Morris James Murray Olivier Geneste

Oncotarget 2018 Apr 13;9(28):20075-20088. Epub 2018 Apr 13.

Institut de Recherches Servier Oncology R&D Unit, Croissy Sur Seine, France.

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April 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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March 2018

DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis.

Authors:
Mateus Milani Dominic P Byrne Georgia Greaves Michael Butterworth Gerald M Cohen Patrick A Eyers Shankar Varadarajan

Cell Death Dis 2017 01 12;8(1):e2552. Epub 2017 Jan 12.

Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Ashton Street, Liverpool L69 3GE, UK.

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January 2017

BH3 profiling and a toolkit of BH3-mimetic drugs predict anti-apoptotic dependence of cancer cells.

Authors:
Michael Butterworth Andrew Pettitt Shankar Varadarajan Gerald M Cohen

Br J Cancer 2016 Mar 8;114(6):638-41. Epub 2016 Mar 8.

Departments of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3GE, UK.

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March 2016

Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner.

Authors:
Shankar Varadarajan Paramasivan Poornima Mateus Milani Krishne Gowda Shantu Amin Hong-Gang Wang Gerald M Cohen

Oncotarget 2015 May;6(14):12668-81

Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.

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May 2015

BIM-mediated membrane insertion of the BAK pore domain is an essential requirement for apoptosis.

Authors:
Kathrin Weber Nicholas Harper John Schwabe Gerald M Cohen

Cell Rep 2013 Oct 10;5(2):409-20. Epub 2013 Oct 10.

MRC Toxicology Unit, University of Leicester, Hodgkin Building, Leicester LE1 9HN, UK.

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October 2013

ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets.

Authors:
Meike Vogler David Dinsdale Martin J S Dyer Gerald M Cohen

Br J Haematol 2013 Oct 4;163(1):139-42. Epub 2013 Jul 4.

Department of Biochemistry, University of Leicester, Leicester, UK.

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October 2013

Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis.

Authors:
Shankar Varadarajan Michael Butterworth Jun Wei Maurizio Pellecchia David Dinsdale Gerald M Cohen

Neoplasia 2013 May;15(5):568-78

MRC Toxicology Unit, University of Leicester, Leicester, UK.

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May 2013

Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.

Authors:
Shankar Varadarajan Kayoko Tanaka Joshua L Smalley Edward T W Bampton Maurizio Pellecchia David Dinsdale Gary B Willars Gerald M Cohen

PLoS One 2013 15;8(2):e56603. Epub 2013 Feb 15.

MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom.

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August 2013

BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.

Authors:
Meike Vogler Hassan A Hamali Xiao-Ming Sun Edward T W Bampton David Dinsdale Roger T Snowden Martin J S Dyer Alison H Goodall Gerald M Cohen

Blood 2011 Jun 11;117(26):7145-54. Epub 2011 May 11.

Medical Research Council Toxicology Unit, University of Leicester, Leicester, United Kingdom.

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June 2011

The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein.

Authors:
Meike Vogler David Dickens Martin J S Dyer Andrew Owen Munir Pirmohamed Gerald M Cohen

Biochem Biophys Res Commun 2011 May 13;408(2):344-9. Epub 2011 Apr 13.

MRC Toxicology Unit, University of Leicester, LE1 9HN Leicester, United Kingdom.

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May 2011

The in vitro cleavage of the hAtg proteins by cell death proteases.

Authors:
Joanna M Norman Gerald M Cohen Edward T W Bampton

Autophagy 2010 Nov;6(8):1042-56

MRC Toxicology Unit, The University of Leicester, Leicester, England, UK.

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November 2010

Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood.

Authors:
Meike Vogler Silviya D Furdas Manfred Jung Tomomi Kuwana Martin J S Dyer Gerald M Cohen

Clin Cancer Res 2010 Aug 2;16(16):4217-25. Epub 2010 Jul 2.

University of Leicester, Leicester, UK.

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August 2010

Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells.

Authors:
Maria Baou Susan L Kohlhaas Michael Butterworth Meike Vogler David Dinsdale Renata Walewska Aneela Majid Eric Eldering Martin J S Dyer Gerald M Cohen

Haematologica 2010 Sep 7;95(9):1510-8. Epub 2010 Apr 7.

MRC Toxicology Unit, PO Box 138, Leicester, LE1 9HN.

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September 2010