Gerald I Shulman

Gerald I Shulman

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Gerald I Shulman

Publications by authors named "Gerald I Shulman"

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OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance.

Proc Natl Acad Sci U S A 2020 Jul 29;117(28):16616-16625. Epub 2020 Jun 29.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520;

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http://dx.doi.org/10.1073/pnas.1916121117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368321PMC
July 2020

Mitochondrial Dysfunction, Insulin Resistance, and Potential Genetic Implications.

Endocrinology 2020 04;161(4)

Stanford Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University, Stanford, California.

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http://dx.doi.org/10.1210/endocr/bqaa017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341556PMC
April 2020

GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH).

Expert Opin Investig Drugs 2020 Feb 19;29(2):135-141. Epub 2019 Sep 19.

Departments of Internal Medicine and Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1080/13543784.2020.1668374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063378PMC
February 2020

Regulation of adipose tissue inflammation by interleukin 6.

Proc Natl Acad Sci U S A 2020 02 24;117(6):2751-2760. Epub 2020 Jan 24.

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605;

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http://dx.doi.org/10.1073/pnas.1920004117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022151PMC
February 2020

Mechanistic Links between Obesity, Insulin, and Cancer.

Trends Cancer 2020 Feb 14;6(2):75-78. Epub 2020 Jan 14.

Departments of Internal Medicine and Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520-8020, USA.

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http://dx.doi.org/10.1016/j.trecan.2019.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214048PMC
February 2020

Considering the Links Between Nonalcoholic Fatty Liver Disease and Insulin Resistance: Revisiting the Role of Protein Kinase C ε.

Hepatology 2019 12 23;70(6):2217-2220. Epub 2019 Aug 23.

Department of Internal Medicine, Yale University, New Haven, CT.

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http://dx.doi.org/10.1002/hep.30829DOI Listing
December 2019

The integrative biology of type 2 diabetes.

Nature 2019 12 4;576(7785):51-60. Epub 2019 Dec 4.

Departments of Internal Medicine and Cellular and Molecular Physiology, Yale Diabetes Research Center, Yale School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/s41586-019-1797-8DOI Listing
December 2019

Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides.

N Engl J Med 2019 11;381(19):1866-1869

From the Departments of Internal Medicine (V.T.S., G.I.S.) and Cellular and Molecular Physiology (G.I.S.), Yale School of Medicine, New Haven, and the Veterans Affairs Medical Center, West Haven (V.T.S.) - both in Connecticut.

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http://dx.doi.org/10.1056/NEJMcibr1910023DOI Listing
November 2019

Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21.

Biochim Biophys Acta Mol Basis Dis 2019 09 26;1865(9):2125-2137. Epub 2019 Apr 26.

Metabolic Biology Laboratory, Lewis Katz School of Medicine at Temple University, Center for Translational Medicine, Department of Pharmacology, Philadelphia, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439193012
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http://dx.doi.org/10.1016/j.bbadis.2019.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614009PMC
September 2019

Leptin's hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents.

Proc Natl Acad Sci U S A 2019 07 18;116(27):13670-13679. Epub 2019 Jun 18.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520;

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http://dx.doi.org/10.1073/pnas.1901795116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613139PMC
July 2019

Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats.

Nat Commun 2019 02 1;10(1):548. Epub 2019 Feb 1.

Departments of Internal Medicine, Yale University School of Medicine, P.O. Box 208020, TAC S269, New Haven, CT, 06519, USA.

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http://dx.doi.org/10.1038/s41467-019-08466-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358621PMC
February 2019

The effects of increased acetate turnover on glucose-induced insulin secretion in lean and obese humans.

J Clin Transl Sci 2019 Feb;3(1):18-20

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1017/cts.2018.342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676497PMC
February 2019

Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes.

Annu Rev Pharmacol Toxicol 2019 01;59:65-87

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA; email: , ,

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https://www.annualreviews.org/doi/10.1146/annurev-pharmtox-0
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http://dx.doi.org/10.1146/annurev-pharmtox-010716-104727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198260PMC
January 2019

Mechanisms of Insulin Action and Insulin Resistance.

Physiol Rev 2018 10;98(4):2133-2223

Departments of Internal Medicine and Cellular & Molecular Physiology, Howard Hughes Medical Institute, Yale University School of Medicine , New Haven, Connecticut.

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https://www.physiology.org/doi/10.1152/physrev.00063.2017
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http://dx.doi.org/10.1152/physrev.00063.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170977PMC
October 2018

Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity.

Cell Rep 2018 07;24(5):1085-1092.e6

Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA; Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223120PMC
July 2018

Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia.

JCI Insight 2018 05 17;3(10). Epub 2018 May 17.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1172/jci.insight.120304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6012507PMC
May 2018

studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia.

Biochem J 2018 03 20;475(6):1063-1074. Epub 2018 Mar 20.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, U.S.A.

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http://dx.doi.org/10.1042/BCJ20180063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884121PMC
March 2018

The Role of Leptin in Maintaining Plasma Glucose During Starvation.

Postdoc J 2018 Mar;6(3):3-19

Department of Internal Medicine, Yale University School of Medicine.

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http://dx.doi.org/10.14304/surya.jpr.v6n3.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909716PMC
March 2018

Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance.

Cell Rep 2018 02;22(8):2133-2145

Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.01.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860817PMC
February 2018

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases.

Cell Metab 2018 01 31;27(1):22-41. Epub 2017 Aug 31.

Department of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762395PMC
January 2018

Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes.

Cell Metab 2018 01 9;27(1):210-217.e3. Epub 2017 Nov 9.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762419PMC
January 2018

Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation.

Cell 2018 01 4;172(1-2):234-248.e17. Epub 2018 Jan 4.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766366PMC
January 2018

Mechanism by which arylamine -acetyltransferase 1 ablation causes insulin resistance in mice.

Proc Natl Acad Sci U S A 2017 12 13;114(52):E11285-E11292. Epub 2017 Dec 13.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520;

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http://dx.doi.org/10.1073/pnas.1716990115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748223PMC
December 2017

Retinol saturase modulates lipid metabolism and the production of reactive oxygen species.

Arch Biochem Biophys 2017 11 18;633:93-102. Epub 2017 Sep 18.

Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2017.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659944PMC
November 2017

Regulation of hepatic glucose metabolism in health and disease.

Nat Rev Endocrinol 2017 Oct 21;13(10):572-587. Epub 2017 Jul 21.

Department of Internal Medicine, Yale School of Medicine.

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http://www.nature.com/doifinder/10.1038/nrendo.2017.80
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http://dx.doi.org/10.1038/nrendo.2017.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777172PMC
October 2017

Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms.

Proc Natl Acad Sci U S A 2017 10 10;114(43):E9172-E9180. Epub 2017 Oct 10.

Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06510;

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http://dx.doi.org/10.1073/pnas.1707797114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664516PMC
October 2017

Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance.

Trends Pharmacol Sci 2017 07 24;38(7):649-665. Epub 2017 May 24.

Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499157PMC
July 2017

A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo.

Cell Metab 2017 03 19;25(3):749-756. Epub 2017 Jan 19.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA; Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342911PMC
March 2017

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism.

Proc Natl Acad Sci U S A 2017 01 17;114(5):1189-1194. Epub 2017 Jan 17.

Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1620506114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293102PMC
January 2017

Resolution of non-alcoholic steatohepatitis after growth hormone replacement in a pediatric liver transplant patient with panhypopituitarism.

Pediatr Transplant 2016 Dec 20;20(8):1157-1163. Epub 2016 Oct 20.

Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1111/petr.12819DOI Listing
December 2016

Hypophosphatemia promotes lower rates of muscle ATP synthesis.

FASEB J 2016 10 23;30(10):3378-3387. Epub 2016 Jun 23.

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark

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http://dx.doi.org/10.1096/fj.201600473RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024687PMC
October 2016

CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha.

Immunity 2016 09 23;45(3):583-596. Epub 2016 Aug 23.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033704PMC
September 2016

XBP1s Is an Anti-lipogenic Protein.

J Biol Chem 2016 08 20;291(33):17394-404. Epub 2016 Jun 20.

From the Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115,

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http://dx.doi.org/10.1074/jbc.M116.728949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016136PMC
August 2016

Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice.

Am J Physiol Endocrinol Metab 2016 Jul 10;311(1):E105-16. Epub 2016 May 10.

Department of Endocrinology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Center for Metabolic and Mitochondrial Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

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http://dx.doi.org/10.1152/ajpendo.00042.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967148PMC
July 2016

Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by (13)C Magnetic Resonance Spectroscopy.

Cell Metab 2016 07;24(1):167-71

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen DK-2200, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946568PMC
July 2016

Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism.

J Biol Chem 2016 Jun 21;291(23):12161-70. Epub 2016 Mar 21.

From the Departments of Internal Medicine, The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen DK 1017, Denmark Cellular and Molecular Physiology, and the Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06519,

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http://dx.doi.org/10.1074/jbc.M116.720631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933266PMC
June 2016

Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism.

Proc Natl Acad Sci U S A 2016 06 31;113(24):E3423-30. Epub 2016 May 31.

Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510;

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http://dx.doi.org/10.1073/pnas.1606022113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914193PMC
June 2016

Pleotropic effects of leptin to reverse insulin resistance and diabetic ketoacidosis.

Diabetologia 2016 May 10;59(5):933-7. Epub 2016 Mar 10.

Department of Internal Medicine, Yale University School of Medicine, TAC, Room S269, PO Box 208020, New Haven, CT, 06519, USA.

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http://dx.doi.org/10.1007/s00125-016-3909-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826798PMC
May 2016

Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance.

FASEB J 2016 Mar 7;30(3):1207-17. Epub 2015 Dec 7.

*Department of Internal Medicine, Department of Cellular and Molecular Physiology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA; West Haven Veterans Affairs Medical Center, West Haven, Connecticut, USA; and ISIS Pharmaceuticals, Carlsbad, California, USA

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http://dx.doi.org/10.1096/fj.15-271999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750414PMC
March 2016

AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia.

J Mol Cell Cardiol 2016 Feb 30;91:104-13. Epub 2015 Dec 30.

Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Department of Molecular and Cellular Physiology, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.12.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839186PMC
February 2016

Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice.

Proc Natl Acad Sci U S A 2016 Feb 8;113(8):2212-7. Epub 2016 Feb 8.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520

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http://dx.doi.org/10.1073/pnas.1525795113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776508PMC
February 2016

Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults.

Diabetes 2016 Jan 31;65(1):74-84. Epub 2015 Aug 31.

Division of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, MN

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http://dx.doi.org/10.2337/db15-0675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686951PMC
January 2016

Effect of aging on muscle mitochondrial substrate utilization in humans.

Proc Natl Acad Sci U S A 2015 Sep 24;112(36):11330-4. Epub 2015 Aug 24.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520

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http://dx.doi.org/10.1073/pnas.1514844112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568690PMC
September 2015

Short-term food restriction followed by controlled refeeding promotes gorging behavior, enhances fat deposition, and diminishes insulin sensitivity in mice.

J Nutr Biochem 2015 Jul 13;26(7):721-8. Epub 2015 Mar 13.

Department of Human Sciences, College of Education and Human Ecology, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2015.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461460PMC
July 2015

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis.

Nat Commun 2015 Apr 28;6:6980. Epub 2015 Apr 28.

1] Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536-8012, USA [2] Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06536-8012, USA [3] Department of Cellular &Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06536-8012, USA.

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http://dx.doi.org/10.1038/ncomms7980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413509PMC
April 2015

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats.

Science 2015 Mar 26;347(6227):1253-6. Epub 2015 Feb 26.

Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1126/science.aaa0672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495920PMC
March 2015

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.

Cell 2015 Feb 5;160(4):745-758. Epub 2015 Feb 5.

Howard Hughes Medical Institute, Yale University, New Haven, CT 06519, USA; Department of Internal Medicine, Yale University, New Haven, CT 06520, USA; Department of Cellular and Molecular Physiology, Yale University, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498261PMC
February 2015