Gerald I Shulman

Gerald I Shulman

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Gerald I Shulman

Publications by authors named "Gerald I Shulman"

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Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21.

Biochim Biophys Acta Mol Basis Dis 2019 Sep 26;1865(9):2125-2137. Epub 2019 Apr 26.

Metabolic Biology Laboratory, Lewis Katz School of Medicine at Temple University, Center for Translational Medicine, Department of Pharmacology, Philadelphia, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439193012
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http://dx.doi.org/10.1016/j.bbadis.2019.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614009PMC
September 2019

GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH).

Expert Opin Investig Drugs 2019 Sep 19:1-7. Epub 2019 Sep 19.

Departments of Internal Medicine and Cellular & Molecular Physiology, Yale School of Medicine , New Haven , CT , USA.

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http://dx.doi.org/10.1080/13543784.2020.1668374DOI Listing
September 2019

Regulation of hepatic mitochondrial oxidation by glucose-alanine cycling during starvation in humans.

J Clin Invest 2019 Sep 23. Epub 2019 Sep 23.

Department of Medicine.

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http://dx.doi.org/10.1172/JCI129913DOI Listing
September 2019

Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance.

J Physiol 2019 Aug 4;597(15):3885-3903. Epub 2019 Jul 4.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.

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http://dx.doi.org/10.1113/JP277270DOI Listing
August 2019

Leptin's hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents.

Proc Natl Acad Sci U S A 2019 Jul 18;116(27):13670-13679. Epub 2019 Jun 18.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520;

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http://dx.doi.org/10.1073/pnas.1901795116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613139PMC
July 2019

Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats.

Nat Commun 2019 02 1;10(1):548. Epub 2019 Feb 1.

Departments of Internal Medicine, Yale University School of Medicine, P.O. Box 208020, TAC S269, New Haven, CT, 06519, USA.

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http://dx.doi.org/10.1038/s41467-019-08466-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358621PMC
February 2019

The effects of increased acetate turnover on glucose-induced insulin secretion in lean and obese humans.

J Clin Transl Sci 2019 Feb;3(1):18-20

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1017/cts.2018.342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676497PMC
February 2019

Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes.

Annu Rev Pharmacol Toxicol 2019 Jan;59:65-87

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA; email: , ,

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https://www.annualreviews.org/doi/10.1146/annurev-pharmtox-0
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http://dx.doi.org/10.1146/annurev-pharmtox-010716-104727DOI Listing
January 2019

Mechanisms of Insulin Action and Insulin Resistance.

Physiol Rev 2018 10;98(4):2133-2223

Departments of Internal Medicine and Cellular & Molecular Physiology, Howard Hughes Medical Institute, Yale University School of Medicine , New Haven, Connecticut.

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https://www.physiology.org/doi/10.1152/physrev.00063.2017
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http://dx.doi.org/10.1152/physrev.00063.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170977PMC
October 2018

Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity.

Cell Rep 2018 07;24(5):1085-1092.e6

Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA; Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223120PMC
July 2018

Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia.

JCI Insight 2018 05 17;3(10). Epub 2018 May 17.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1172/jci.insight.120304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6012507PMC
May 2018

studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia.

Biochem J 2018 03 20;475(6):1063-1074. Epub 2018 Mar 20.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, U.S.A.

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http://dx.doi.org/10.1042/BCJ20180063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884121PMC
March 2018

The Role of Leptin in Maintaining Plasma Glucose During Starvation.

Postdoc J 2018 Mar;6(3):3-19

Department of Internal Medicine, Yale University School of Medicine.

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http://dx.doi.org/10.14304/surya.jpr.v6n3.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909716PMC
March 2018

Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance.

Cell Rep 2018 02;22(8):2133-2145

Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.01.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860817PMC
February 2018

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases.

Cell Metab 2018 01 31;27(1):22-41. Epub 2017 Aug 31.

Department of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762395PMC
January 2018

Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes.

Cell Metab 2018 01 9;27(1):210-217.e3. Epub 2017 Nov 9.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762419PMC
January 2018

Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation.

Cell 2018 01 4;172(1-2):234-248.e17. Epub 2018 Jan 4.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766366PMC
January 2018

Mechanism by which arylamine -acetyltransferase 1 ablation causes insulin resistance in mice.

Proc Natl Acad Sci U S A 2017 12 13;114(52):E11285-E11292. Epub 2017 Dec 13.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520;

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http://dx.doi.org/10.1073/pnas.1716990115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748223PMC
December 2017

Retinol saturase modulates lipid metabolism and the production of reactive oxygen species.

Arch Biochem Biophys 2017 11 18;633:93-102. Epub 2017 Sep 18.

Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2017.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659944PMC
November 2017

Regulation of hepatic glucose metabolism in health and disease.

Nat Rev Endocrinol 2017 Oct 21;13(10):572-587. Epub 2017 Jul 21.

Department of Internal Medicine, Yale School of Medicine.

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http://www.nature.com/doifinder/10.1038/nrendo.2017.80
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http://dx.doi.org/10.1038/nrendo.2017.80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777172PMC
October 2017

Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms.

Proc Natl Acad Sci U S A 2017 10 10;114(43):E9172-E9180. Epub 2017 Oct 10.

Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06510;

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http://dx.doi.org/10.1073/pnas.1707797114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664516PMC
October 2017

Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance.

Trends Pharmacol Sci 2017 07 24;38(7):649-665. Epub 2017 May 24.

Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499157PMC
July 2017

A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo.

Cell Metab 2017 03 19;25(3):749-756. Epub 2017 Jan 19.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA; Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342911PMC
March 2017

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism.

Proc Natl Acad Sci U S A 2017 01 17;114(5):1189-1194. Epub 2017 Jan 17.

Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1620506114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293102PMC
January 2017

Resolution of non-alcoholic steatohepatitis after growth hormone replacement in a pediatric liver transplant patient with panhypopituitarism.

Pediatr Transplant 2016 Dec 20;20(8):1157-1163. Epub 2016 Oct 20.

Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1111/petr.12819DOI Listing
December 2016

Hypophosphatemia promotes lower rates of muscle ATP synthesis.

FASEB J 2016 10 23;30(10):3378-3387. Epub 2016 Jun 23.

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark

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http://dx.doi.org/10.1096/fj.201600473RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024687PMC
October 2016

CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha.

Immunity 2016 09 23;45(3):583-596. Epub 2016 Aug 23.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033704PMC
September 2016

XBP1s Is an Anti-lipogenic Protein.

J Biol Chem 2016 08 20;291(33):17394-404. Epub 2016 Jun 20.

From the Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115,

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http://dx.doi.org/10.1074/jbc.M116.728949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016136PMC
August 2016

Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice.

Am J Physiol Endocrinol Metab 2016 Jul 10;311(1):E105-16. Epub 2016 May 10.

Department of Endocrinology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Center for Metabolic and Mitochondrial Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

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http://dx.doi.org/10.1152/ajpendo.00042.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967148PMC
July 2016

Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by (13)C Magnetic Resonance Spectroscopy.

Cell Metab 2016 07;24(1):167-71

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen DK-2200, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946568PMC
July 2016

Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism.

J Biol Chem 2016 Jun 21;291(23):12161-70. Epub 2016 Mar 21.

From the Departments of Internal Medicine, The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen DK 1017, Denmark Cellular and Molecular Physiology, and the Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06519,

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http://dx.doi.org/10.1074/jbc.M116.720631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933266PMC
June 2016

Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism.

Proc Natl Acad Sci U S A 2016 06 31;113(24):E3423-30. Epub 2016 May 31.

Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510;

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http://dx.doi.org/10.1073/pnas.1606022113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914193PMC
June 2016

Pleotropic effects of leptin to reverse insulin resistance and diabetic ketoacidosis.

Diabetologia 2016 May 10;59(5):933-7. Epub 2016 Mar 10.

Department of Internal Medicine, Yale University School of Medicine, TAC, Room S269, PO Box 208020, New Haven, CT, 06519, USA.

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http://dx.doi.org/10.1007/s00125-016-3909-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826798PMC
May 2016

Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance.

FASEB J 2016 Mar 7;30(3):1207-17. Epub 2015 Dec 7.

*Department of Internal Medicine, Department of Cellular and Molecular Physiology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA; West Haven Veterans Affairs Medical Center, West Haven, Connecticut, USA; and ISIS Pharmaceuticals, Carlsbad, California, USA

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http://dx.doi.org/10.1096/fj.15-271999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750414PMC
March 2016

AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia.

J Mol Cell Cardiol 2016 Feb 30;91:104-13. Epub 2015 Dec 30.

Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Department of Molecular and Cellular Physiology, Yale University School of Medicine, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.12.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839186PMC
February 2016

Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice.

Proc Natl Acad Sci U S A 2016 Feb 8;113(8):2212-7. Epub 2016 Feb 8.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520

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http://dx.doi.org/10.1073/pnas.1525795113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776508PMC
February 2016

Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults.

Diabetes 2016 Jan 31;65(1):74-84. Epub 2015 Aug 31.

Division of Endocrinology and Metabolism, Mayo Clinic College of Medicine, Rochester, MN

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http://dx.doi.org/10.2337/db15-0675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686951PMC
January 2016

Effect of aging on muscle mitochondrial substrate utilization in humans.

Proc Natl Acad Sci U S A 2015 Sep 24;112(36):11330-4. Epub 2015 Aug 24.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520

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http://dx.doi.org/10.1073/pnas.1514844112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568690PMC
September 2015

Type 2 diabetes mellitus.

Nat Rev Dis Primers 2015 07 23;1:15019. Epub 2015 Jul 23.

Department of Human Metabolism and Nutrition, Braun School of Public Health, Hebrew University, Jerusalem, Israel.

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http://dx.doi.org/10.1038/nrdp.2015.19DOI Listing
July 2015

Short-term food restriction followed by controlled refeeding promotes gorging behavior, enhances fat deposition, and diminishes insulin sensitivity in mice.

J Nutr Biochem 2015 Jul 13;26(7):721-8. Epub 2015 Mar 13.

Department of Human Sciences, College of Education and Human Ecology, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2015.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461460PMC
July 2015

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis.

Nat Commun 2015 Apr 28;6:6980. Epub 2015 Apr 28.

1] Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536-8012, USA [2] Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06536-8012, USA [3] Department of Cellular &Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06536-8012, USA.

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http://dx.doi.org/10.1038/ncomms7980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413509PMC
April 2015

ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content.

J Lipid Res 2015 Mar 29;56(3):526-36. Epub 2014 Dec 29.

Departments of Internal Medicine Yale University School of Medicine, New Haven, CT Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT.

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http://www.jlr.org/content/56/3/526.full.pdf
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http://www.jlr.org/lookup/doi/10.1194/jlr.M054080
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http://dx.doi.org/10.1194/jlr.M054080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340301PMC
March 2015

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats.

Science 2015 Mar 26;347(6227):1253-6. Epub 2015 Feb 26.

Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1126/science.aaa0672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495920PMC
March 2015

Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation.

Proc Natl Acad Sci U S A 2015 Feb 20;112(5):1607-12. Epub 2015 Jan 20.

Department of Cellular and Molecular Physiology, Program in Cellular Neuroscience, Neurodegeneration and Repair, and

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http://dx.doi.org/10.1073/pnas.1421419112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321293PMC
February 2015

Reply to Constantin-Teodosiu et al.: mice with genetic PDH activation are not protected from high-fat diet-induced muscle insulin resistance.

Proc Natl Acad Sci U S A 2015 Feb 23;112(8):E825. Epub 2015 Jan 23.

Departments of Internal Medicine and Cellular and Molecular Physiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510

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http://dx.doi.org/10.1073/pnas.1423574112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345552PMC
February 2015

Response to burgess.

Nat Med 2015 Feb;21(2):109-10

1] Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA. [3] Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/nm.3790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400583PMC
February 2015

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.

Cell 2015 Feb 5;160(4):745-758. Epub 2015 Feb 5.

Howard Hughes Medical Institute, Yale University, New Haven, CT 06519, USA; Department of Internal Medicine, Yale University, New Haven, CT 06520, USA; Department of Cellular and Molecular Physiology, Yale University, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498261PMC
February 2015

Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis.

Mol Cell Biol 2015 Jan 13;35(1):26-40. Epub 2014 Oct 13.

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, Connecticut, USA

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http://mcb.asm.org/content/35/1/26.full.pdf
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http://mcb.asm.org/lookup/doi/10.1128/MCB.00503-14
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http://dx.doi.org/10.1128/MCB.00503-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295383PMC
January 2015

An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ.

Nature 2015 Jan 17;517(7534):391-5. Epub 2014 Nov 17.

1] Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature13887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297557PMC
January 2015

Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.

Proc Natl Acad Sci U S A 2015 Jan 6;112(4):1143-8. Epub 2015 Jan 6.

Departments of Internal Medicine and Cellular and Molecular Physiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536; and

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http://dx.doi.org/10.1073/pnas.1423952112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313795PMC
January 2015

Mitochondrial GTP insensitivity contributes to hypoglycemia in hyperinsulinemia hyperammonemia by inhibiting glucagon release.

Diabetes 2014 Dec 14;63(12):4218-29. Epub 2014 Jul 14.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT.

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http://diabetes.diabetesjournals.org/content/63/12/4218.full
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http://diabetes.diabetesjournals.org/content/early/2014/07/1
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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db14-07
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http://dx.doi.org/10.2337/db14-0783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237996PMC
December 2014

Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II.

Am J Physiol Endocrinol Metab 2014 Dec 14;307(11):E1057-64. Epub 2014 Oct 14.

Department of Cellular and Molecular Physiology, Yale University School of Medicine New Haven, Connecticut; Department of Pharmacology, Yale University School of Medicine New Haven, Connecticut;

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http://dx.doi.org/10.1152/ajpendo.00236.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254986PMC
December 2014

The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells.

Nucleic Acids Res 2014 Dec 15;42(22):13799-811. Epub 2014 Nov 15.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06510, USA

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http://dx.doi.org/10.1093/nar/gku1160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267628PMC
December 2014

Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice.

Nat Med 2014 Nov 5;20(11):1263-9. Epub 2014 Oct 5.

Department of Pharmacology, Rutgers University-Robert Wood Johnson Medical School, Piscataway, New Jersey, USA.

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http://dx.doi.org/10.1038/nm.3699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299950PMC
November 2014

Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance.

Proc Natl Acad Sci U S A 2014 Nov 3;111(46):16508-13. Epub 2014 Nov 3.

Departments of Internal Medicine and Cellular & Molecular Physiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510

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http://dx.doi.org/10.1073/pnas.1419104111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246337PMC
November 2014

Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease.

Authors:
Gerald I Shulman

N Engl J Med 2014 Sep;371(12):1131-41

From the Howard Hughes Medical Institute and the Departments of Internal Medicine and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1056/NEJMra1011035DOI Listing
September 2014

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans.

Proc Natl Acad Sci U S A 2014 Jul 16;111(26):9597-602. Epub 2014 Jun 16.

Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany;German Center for Diabetes Research, Partner Düsseldorf, Düsseldorf, Germany;Department of Endocrinology and Diabetology, University Hospital Düsseldorf, 40225 Düsseldorf, Germany; and

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084449PMC
July 2014