Gerald Hoefler

Gerald Hoefler

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Gerald Hoefler

Gerald Hoefler

Publications by authors named "Gerald Hoefler"

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Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice.

Authors:
Stephanie Kolleritsch Benedikt Kien Gabriele Schoiswohl Clemens Diwoky Renate Schreiber Christoph Heier Lisa Katharina Maresch Martina Schweiger Thomas O Eichmann Sarah Stryeck Petra Krenn Tamara Tomin Matthias Schittmayer Dagmar Kolb Thomas Rülicke Gerald Hoefler Heimo Wolinski Tobias Madl Ruth Birner-Gruenberger Guenter Haemmerle

Cardiovasc Res 2020 Feb;116(2):339-352

Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, 8010 Graz, Austria.

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http://dx.doi.org/10.1093/cvr/cvz119DOI Listing
February 2020

Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin.

Authors:
Simon R Lord Jennifer M Collins Wei-Chen Cheng Syed Haider Simon Wigfield Edoardo Gaude Barbara A Fielding Katherine E Pinnick Ulrike Harjes Ashvina Segaran Pooja Jha Gerald Hoefler Michael N Pollak Alastair M Thompson Pankaj G Roy Ruth English Rosie F Adams Christian Frezza Francesca M Buffa Fredrik Karpe Adrian L Harris

Br J Cancer 2020 Jan 10;122(2):258-265. Epub 2019 Dec 10.

Department of Oncology, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.

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http://dx.doi.org/10.1038/s41416-019-0665-5DOI Listing
January 2020

-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health.

Authors:
Dina C Hofer Gabriel Zirkovits Helmut J Pelzmann Katharina Huber Ariane R Pessentheiner Wenmin Xia Kyosuke Uno Toh Miyazaki Kanta Kon Hiroshi Tsuneki Tobias Pendl Wael Al Zoughbi Corina T Madreiter-Sokolowski Gert Trausinger Mahmoud Abdellatif Gabriele Schoiswohl Renate Schreiber Tobias Eisenberg Christoph Magnes Simon Sedej Matthias Eckhardt Masakiyo Sasahara Toshiyasu Sasaoka Atsumi Nitta Gerald Hoefler Wolfgang F Graier Dagmar Kratky Johan Auwerx Juliane G Bogner-Strauss

FASEB J 2019 Dec 1;33(12):13808-13824. Epub 2019 Nov 1.

Institute of Biochemistry, Graz University of Technology, Graz, Austria.

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http://dx.doi.org/10.1096/fj.201801323RDOI Listing
December 2019

Neoplastic cell percentage estimation in tissue samples for molecular oncology: recommendations from a modified Delphi study.

Authors:
Kelly Dufraing J Henricus van Krieken Gert De Hertogh Gerald Hoefler Anca Oniscu Tine P Kuhlmann Wilko Weichert Caterina Marchiò Ari Ristimäki Aleš Ryška Jean-Yves Scoazec Elisabeth Dequeker

Histopathology 2019 Sep 18;75(3):312-319. Epub 2019 Jul 18.

Biomedical Quality Assurance Research Unit, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/his.13891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851675PMC
September 2019

Tumor Macroenvironment: An Update.

Authors:
Wael Al-Zoughbi Gerald Hoefler

Pathobiology 2019 Sep 4:1-3. Epub 2019 Sep 4.

Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria,

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http://dx.doi.org/10.1159/000502097DOI Listing
September 2019

The role of germline mutation profiling in the selection of related donors for haematopoietic stem cell transplantation.

Authors:
Armin Zebisch Gerlinde Winter Karl Kashofer Stefan Hatzl Barbara Uhl Sonja Wurm Albert Wölfler Hildegard T Greinix Gerald Hoefler Heinz Sill

Bone Marrow Transplant 2019 Sep 25. Epub 2019 Sep 25.

Division of Haematology, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1038/s41409-019-0691-1DOI Listing
September 2019

Hedgehog pathway proteins SMO and GLI expression as prognostic markers in head and neck squamous cell carcinoma.

Authors:
Georg Richtig Alena M Aigelsreiter Martin Asslaber Thomas Weiland Martin Pichler Katharina Eberhard Stephan Sygulla Silvia Schauer Gerald Hoefler Ariane Aigelsreiter

Histopathology 2019 Jul 28;75(1):118-127. Epub 2019 May 28.

Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1111/his.13860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851882PMC
July 2019

Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation.

Authors:
Laura Pajed Carina Wagner Ulrike Taschler Renate Schreiber Stephanie Kolleritsch Nermeen Fawzy Isabella Pototschnig Gabriele Schoiswohl Lisa-Maria Pusch Beatrix I Wieser Paul Vesely Gerald Hoefler Thomas O Eichmann Robert Zimmermann Achim Lass

J Biol Chem 2019 Jun 25;294(23):9118-9133. Epub 2019 Apr 25.

From the Institute of Molecular Biosciences, NAWI Graz, University of Graz, Heinrichstrasse 31/II,

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http://dx.doi.org/10.1074/jbc.RA118.007201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556574PMC
June 2019

Dietary glycine decreases both tumor volume and vascularization in a combined colorectal liver metastasis and chemotherapy model.

Authors:
Juste Maneikyte Augustinas Bausys Bettina Leber Angela Horvath Nicole Feldbacher Gerald Hoefler Kestutis Strupas Philipp Stiegler Peter Schemmer

Int J Biol Sci 2019 4;15(8):1582-1590. Epub 2019 Jun 4.

General, Visceral and Transplant Surgery, Dept. of Surgery, Medical University of Graz, Austria.

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http://www.ijbs.com/v15p1582.htm
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http://dx.doi.org/10.7150/ijbs.35513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643216PMC
June 2019

Oxidation of human plasma fibronectin by inflammatory oxidants perturbs endothelial cell function.

Authors:
Siriluck Vanichkitrungruang Christine Y Chuang Clare L Hawkins Astrid Hammer Gerald Hoefler Ernst Malle Michael J Davies

Free Radic Biol Med 2019 May 5;136:118-134. Epub 2019 Apr 5.

The Heart Research Institute, Newtown, NSW, Australia; Faculty of Medicine, The University of Sydney, NSW, Australia; Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.003DOI Listing
May 2019

Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis.

Authors:
Veronica Caraffini Olivia Geiger Angelika Rosenberger Stefan Hatzl Bianca Perfler Johannes L Berg Clarice Lim Herbert Strobl Karl Kashofer Silvia Schauer Christine Beham-Schmid Gerald Hoefler Klaus Geissler Franz Quehenberger Walter Kolch Dimitris Athineos Karen Blyth Albert Wölfler Heinz Sill Armin Zebisch

Haematologica 2019 May 16. Epub 2019 May 16.

Division of Hematology, Medical University of Graz, Graz, Austria;

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http://dx.doi.org/10.3324/haematol.2018.209650DOI Listing
May 2019

Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation.

Authors:
Christina Leopold Madalina Duta-Mare Vinay Sachdev Madeleine Goeritzer Lisa Katharina Maresch Dagmar Kolb Helga Reicher Bettina Wagner Tatjana Stojakovic Thomas Ruelicke Guenter Haemmerle Gerald Hoefler Wolfgang Sattler Dagmar Kratky

Biochim Biophys Acta Mol Cell Biol Lipids 2019 04 9;1864(4):500-511. Epub 2019 Jan 9.

Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13881981193000
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http://dx.doi.org/10.1016/j.bbalip.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372077PMC
April 2019

Next-Generation Sequencing in Diagnostics and Clinical Research.

Authors:
Gerald Hoefler

Pathobiology 2017 12;84(6):289-291. Epub 2017 Dec 12.

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http://dx.doi.org/10.1159/000485366DOI Listing
February 2019

MiR-1287-5p inhibits triple negative breast cancer growth by interaction with phosphoinositide 3-kinase CB, thereby sensitizing cells for PI3Kinase inhibitors.

Authors:
Daniela Schwarzenbacher Christiane Klec Barbara Pasculli Stefanie Cerk Beate Rinner Michael Karbiener Cristina Ivan Raffaela Barbano Hui Ling Annika Wulf-Goldenberg Stefanie Stanzer Gabriel Rinnerthaler Herbert Stoeger Thomas Bauernhofer Johannes Haybaeck Gerald Hoefler Stephan Wenzel Jahn Paola Parrella George Adrian Calin Martin Pichler

Breast Cancer Res 2019 02 1;21(1):20. Epub 2019 Feb 1.

Division of Oncology, Department of Internal Medicine, Medical University of Graz (MUG), Graz, Austria.

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http://dx.doi.org/10.1186/s13058-019-1104-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359814PMC
February 2019

Intestine-Specific Overexpression of Carboxylesterase 2c Protects Mice From Diet-Induced Liver Steatosis and Obesity.

Authors:
Lisa Katharina Maresch Pia Benedikt Ursula Feiler Sandra Eder Kathrin A Zierler Ulrike Taschler Stephanie Kolleritsch Thomas O Eichmann Gabriele Schoiswohl Christina Leopold Beatrix I Wieser Caroline Lackner Thomas Rülicke Jan van Klinken Dagmar Kratky Tarek Moustafa Gerald Hoefler Guenter Haemmerle

Hepatol Commun 2019 Feb 17;3(2):227-245. Epub 2018 Dec 17.

Institute of Molecular Biosciences University of Graz Graz Austria.

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http://dx.doi.org/10.1002/hep4.1292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357831PMC
February 2019

Chlorination and oxidation of the extracellular matrix protein laminin and basement membrane extracts by hypochlorous acid and myeloperoxidase.

Authors:
Tina Nybo Simon Dieterich Luke F Gamon Christine Y Chuang Astrid Hammer Gerald Hoefler Ernst Malle Adelina Rogowska-Wrzesinska Michael J Davies

Redox Biol 2019 01 3;20:496-513. Epub 2018 Nov 3.

Dept. of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2018.10.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260226PMC
January 2019

Atypical "hairy cell-like" presentation of leukemic mantle cell lymphoma.

Authors:
Christoph Robier Gerald Hoefler Margot Egger Eva Hubmann

Clin Chem Lab Med 2018 12;57(2):e34-e36

Department of Internal Medicine 1, Hospital of the Brothers of St. John of God, Graz, Austria.

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http://dx.doi.org/10.1515/cclm-2018-0633DOI Listing
December 2018

Early Loss of Forkhead Transcription Factor, O Subgroup, Member 1 Protein in the Development of Pancreatic Ductal Adenocarcinoma.

Authors:
Wael Al-Zoughbi Silvia Schauer Martin Pichler Gerald Hoefler

Pathobiology 2018 18;85(5-6):342-347. Epub 2018 Sep 18.

Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz,

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http://dx.doi.org/10.1159/000492433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390459PMC
December 2018

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting.

Authors:
H Furkan Alkan Katharina E Walter Alba Luengo Corina T Madreiter-Sokolowski Sarah Stryeck Allison N Lau Wael Al-Zoughbi Caroline A Lewis Craig J Thomas Gerald Hoefler Wolfgang F Graier Tobias Madl Matthew G Vander Heiden Juliane G Bogner-Strauss

Cell Metab 2018 11 16;28(5):706-720.e6. Epub 2018 Aug 16.

Institute of Biochemistry, Graz University of Technology, Humboldtstrasse 46/III, 8010 Graz, Austria; BioTechMed-Graz, Graz, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390946PMC
November 2018

The TP53 Pro72Arg SNP in de novo acute myeloid leukaemia - results of two cohort studies involving 215 patients and 3759 controls.

Authors:
Eduard Schulz Karin Lind Wilfried Renner Britt-Sabina Petersen Franz Quehenberger Claudia Dill Sybille Hofer Ridhima Lal Gerald Hoefler Peter Schlenke Gerhard Ehninger Johannes Schetelig Jan M Middeke Friedrich Stölzel Heinz Sill

Br J Haematol 2018 04 20;181(1):148-151. Epub 2017 Jan 20.

Division of Haematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1111/bjh.14527DOI Listing
April 2018

Detection of prognostically relevant mutations and translocations in myeloid sarcoma by next generation sequencing.

Authors:
Karl Kashofer Max Gornicec Karin Lind Veronica Caraffini Silvia Schauer Christine Beham-Schmid Albert Wölfler Gerald Hoefler Heinz Sill Armin Zebisch

Leuk Lymphoma 2018 02 20;59(2):501-504. Epub 2017 Jun 20.

b Division of Hematology , Medical University of Graz , Graz , Austria.

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http://dx.doi.org/10.1080/10428194.2017.1339879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743000PMC
February 2018

Exposure of tropoelastin to peroxynitrous acid gives high yields of nitrated tyrosine residues, di-tyrosine cross-links and altered protein structure and function.

Authors:
Georg Degendorfer Christine Y Chuang Michele Mariotti Astrid Hammer Gerald Hoefler Per Hägglund Ernst Malle Steven G Wise Michael J Davies

Free Radic Biol Med 2018 02 27;115:219-231. Epub 2017 Nov 27.

The Heart Research Institute, Sydney, Australia; Dept. of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark; Faculty of Medicine, University of Sydney, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.11.019DOI Listing
February 2018

Loss of RKIP is a frequent event in myeloid sarcoma and promotes leukemic tissue infiltration.

Authors:
Veronica Caraffini Bianca Perfler Johannes Lorenz Berg Barbara Uhl Silvia Schauer Karl Kashofer Nassim Ghaffari-Tabrizi-Wizsy Herbert Strobl Albert Wölfler Gerald Hoefler Heinz Sill Armin Zebisch

Blood 2018 02 2;131(7):826-830. Epub 2018 Jan 2.

Division of Hematology.

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http://dx.doi.org/10.1182/blood-2017-09-804906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824335PMC
February 2018

Residual disease detection using targeted parallel sequencing predicts relapse in cytogenetically normal acute myeloid leukemia.

Authors:
Lukas Gaksch Karl Kashofer Ellen Heitzer Franz Quehenberger Shruti Daga Sybille Hofer Iris Halbwedl Ricarda Graf Nina Krisper Gerald Hoefler Armin Zebisch Heinz Sill Albert Wölfler

Am J Hematol 2018 01 19;93(1):23-30. Epub 2017 Oct 19.

Division of Hematology, Medical University of Graz, Auenbruggerplatz 38, Graz, 8036, Austria.

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http://dx.doi.org/10.1002/ajh.24922DOI Listing
January 2018

SOX9 is a proliferation and stem cell factor in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types.

Authors:
Georg Richtig Ariane Aigelsreiter Daniela Schwarzenbacher Anna Lena Ress Jan Basri Adiprasito Verena Stiegelbauer Gerald Hoefler Silvia Schauer Tobias Kiesslich Peter Kornprat Thomas Winder Florian Eisner Armin Gerger Herbert Stoeger Rudolf Stauber Carolin Lackner Martin Pichler

PLoS One 2017 9;12(11):e0187814. Epub 2017 Nov 9.

Department of Internal Medicine, Division of Oncology, Medical University of Graz, Graz, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187814PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679634PMC
November 2017

Expansion of BCR/ABL1 cells requires PAK2 but not PAK1.

Authors:
Leo Edlinger Angelika Berger-Becvar Ingeborg Menzl Gregor Hoermann Georg Greiner Eva Grundschober Zsuzsanna Bago-Horvath Wael Al-Zoughbi Gerald Hoefler Christine Brostjan Lars Gille Richard Moriggl Andreas Spittler Veronika Sexl Andrea Hoelbl-Kovacic

Br J Haematol 2017 10 14;179(2):229-241. Epub 2017 Jul 14.

Institute of Pharmacology and Toxicology, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/bjh.14833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655792PMC
October 2017

miR-196b-5p Regulates Colorectal Cancer Cell Migration and Metastases through Interaction with HOXB7 and GALNT5.

Authors:
Verena Stiegelbauer Petra Vychytilova-Faltejskova Michael Karbiener Anna-Maria Pehserl Andreas Reicher Margit Resel Ellen Heitzer Cristina Ivan Marc Bullock Hui Ling Alexander Deutsch Annika Wulf-Goldenberg Jan Basri Adiprasito Herbert Stoeger Johannes Haybaeck Marek Svoboda Michael Stotz Gerald Hoefler Ondrej Slaby George Adrian Calin Armin Gerger Martin Pichler

Clin Cancer Res 2017 Sep 22;23(17):5255-5266. Epub 2017 May 22.

Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0023DOI Listing
September 2017

APMAP interacts with lysyl oxidase-like proteins, and disruption of leads to beneficial visceral adipose tissue expansion.

Authors:
Ariane R Pessentheiner Katharina Huber Helmut J Pelzmann Andreas Prokesch Franz P W Radner Heimo Wolinski Josefine Lindroos-Christensen Gerald Hoefler Thomas Rülicke Ruth Birner-Gruenberger Martin Bilban Juliane G Bogner-Strauss

FASEB J 2017 09 30;31(9):4088-4103. Epub 2017 May 30.

Institute of Biochemistry, Graz University of Technology, Graz, Austria;

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http://www.fasebj.org/doi/10.1096/fj.201601337R
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http://dx.doi.org/10.1096/fj.201601337RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566180PMC
September 2017

Visualization of tumor heterogeneity by in situ padlock probe technology in colorectal cancer.

Authors:
Amin El-Heliebi Karl Kashofer Julia Fuchs Stephan W Jahn Christian Viertler Andrija Matak Peter Sedlmayr Gerald Hoefler

Histochem Cell Biol 2017 Aug 20;148(2):105-115. Epub 2017 Mar 20.

Institute of Pathology, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1007/s00418-017-1557-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508037PMC
August 2017

Somatic mutations characterize preleukemic stem cells in acute myeloid leukemia.

Authors:
Ridhima Lal Karin Lind Ellen Heitzer Peter Ulz Kristina Aubell Karl Kashofer Jan M Middeke Christian Thiede Eduard Schulz Angelika Rosenberger Sybille Hofer Birgit Feilhauer Beate Rinner Vendula Svendova Michael G Schimek Frank G Rücker Gerald Hoefler Konstanze Döhner Armin Zebisch Albert Wölfler Heinz Sill

Blood 2017 05 3;129(18):2587-2591. Epub 2017 Mar 3.

Division of Hematology.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2016-11
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http://dx.doi.org/10.1182/blood-2016-11-751008DOI Listing
May 2017

Genome-Wide miRNA Analysis Identifies miR-188-3p as a Novel Prognostic Marker and Molecular Factor Involved in Colorectal Carcinogenesis.

Authors:
Martin Pichler Verena Stiegelbauer Petra Vychytilova-Faltejskova Cristina Ivan Hui Ling Elke Winter Xinna Zhang Matthew Goblirsch Annika Wulf-Goldenberg Masahisa Ohtsuka Johannes Haybaeck Marek Svoboda Yoshinaga Okugawa Armin Gerger Gerald Hoefler Ajay Goel Ondrej Slaby George Adrian Calin

Clin Cancer Res 2017 Mar 6;23(5):1323-1333. Epub 2016 Sep 6.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544252PMC
March 2017

Skin Barrier Development Depends on CGI-58 Protein Expression during Late-Stage Keratinocyte Differentiation.

Authors:
Susanne Grond Franz P W Radner Thomas O Eichmann Dagmar Kolb Gernot F Grabner Heimo Wolinski Robert Gruber Peter Hofer Christoph Heier Silvia Schauer Thomas Rülicke Gerald Hoefler Matthias Schmuth Peter M Elias Achim Lass Rudolf Zechner Guenter Haemmerle

J Invest Dermatol 2017 02 7;137(2):403-413. Epub 2016 Oct 7.

Institute of Molecular Biosciences, University of Graz, Graz, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551682PMC
February 2017

KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients.

Authors:
Sarah Kammerer Armin Sokolowski Hubert Hackl Dieter Platzer Stephan Wenzel Jahn Amin El-Heliebi Daniela Schwarzenbacher Verena Stiegelbauer Martin Pichler Simin Rezania Heidelinde Fiegl Florentia Peintinger Peter Regitnig Gerald Hoefler Wolfgang Schreibmayer Thomas Bauernhofer

Oncotarget 2016 Dec;7(51):84705-84717

Research Unit on Ion Channels and Cancer Biology, Medical University of Graz, Austria.

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http://dx.doi.org/10.18632/oncotarget.13224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356693PMC
December 2016

Tumour heterogeneity: principles and practical consequences.

Authors:
Giorgio Stanta Stephan Wenzel Jahn Serena Bonin Gerald Hoefler

Virchows Arch 2016 Oct 13;469(4):371-84. Epub 2016 Jul 13.

Institute of Pathology, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1007/s00428-016-1987-9DOI Listing
October 2016

Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism.

Authors:
Vinay Sachdev Christina Leopold Raimund Bauer Jay V Patankar Jahangir Iqbal Sascha Obrowsky Renze Boverhof Marcela Doktorova Bernhard Scheicher Madeleine Goeritzer Dagmar Kolb Andrew V Turnbull Andreas Zimmer Gerald Hoefler M Mahmood Hussain Albert K Groen Dagmar Kratky

Biochim Biophys Acta 2016 09 23;1861(9 Pt A):1132-1141. Epub 2016 Jun 23.

Institute of Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2016.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948681PMC
September 2016

A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis.

Authors:
Karoline Kollmann Gerwin Heller Christine Schneckenleithner Wolfgang Warsch Ruth Scheicher Rene G Ott Markus Schäfer Sabine Fajmann Michaela Schlederer Ana-Iris Schiefer Ursula Reichart Matthias Mayerhofer Christoph Hoeller Sabine Zöchbauer-Müller Dontscho Kerjaschki Christoph Bock Lukas Kenner Gerald Hoefler Michael Freissmuth Anthony R Green Richard Moriggl Meinrad Busslinger Marcos Malumbres Veronika Sexl

Cancer Cell 2016 08 8;30(2):359-360. Epub 2016 Aug 8.

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http://www.cell.com/cancer-cell/pdf/S1535-6108(13)00321-8.pd
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http://www.cell.com/cms/attachment/2021795228/2041747319/mmc
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http://dx.doi.org/10.1016/j.ccell.2016.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637299PMC
August 2016

Serotonin signalling is crucial in the induction of PUVA-induced systemic suppression of delayed-type hypersensitivity but not local apoptosis or inflammation of the skin.

Authors:
Peter Wolf Scott N Byrne Alberto Y Limon-Flores Gerald Hoefler Stephen E Ullrich

Exp Dermatol 2016 07 18;25(7):537-43. Epub 2016 Apr 18.

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1111/exd.12990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927393PMC
July 2016

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis.

Authors:
Hui Ling Karen Pickard Cristina Ivan Claudio Isella Mariko Ikuo Richard Mitter Riccardo Spizzo Marc Bullock Cornelia Braicu Valentina Pileczki Kimberly Vincent Martin Pichler Verena Stiegelbauer Gerald Hoefler Maria I Almeida Annie Hsiao Xinna Zhang John Primrose Graham Packham Kevin Liu Krishna Bojja Roberta Gafà Lianchun Xiao Simona Rossi Jian H Song Ivan Vannini Francesca Fanini Scott Kopetz Patrick Zweidler-McKay Xuemei Wang Calin Ionescu Alexandru Irimie Muller Fabbri Giovanni Lanza Stanley R Hamilton Ioana Berindan-Neagoe Enzo Medico Alex Mirnezami George A Calin Milena S Nicoloso

Gut 2016 06 24;65(6):977-989. Epub 2015 Mar 24.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1136/gutjnl-2015-309372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581915PMC
June 2016

A synonymous EGFR polymorphism predicting responsiveness to anti-EGFR therapy in metastatic colorectal cancer patients.

Authors:
Serena Bonin Marisa Donada Gianni Bussolati Ermanno Nardon Laura Annaratone Martin Pichler Anna Maria Chiaravalli Carlo Capella Gerald Hoefler Giorgio Stanta

Tumour Biol 2016 Jun 15;37(6):7295-303. Epub 2015 Dec 15.

Department of Medical Sciences, University of Trieste, Cattinara Hospital-Surgical Pathology Building, Strada di Fiume 447, 34149, Trieste, Italy.

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June 2016

Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia.

Authors:
Wael Al-Zoughbi Martin Pichler Gregor Gorkiewicz Barbara Guertl-Lackner Johannes Haybaeck Stephan W Jahn Carolin Lackner Bernadette Liegl-Atzwanger Helmut Popper Silvia Schauer Elisa Nusshold Alida S D Kindt Zlatko Trajanoski Michael R Speicher Guenther Haemmerle Robert Zimmermann Rudolf Zechner Paul W Vesely Gerald Hoefler

Oncotarget 2016 Jun;7(23):33832-40

Institute of Pathology, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.18632/oncotarget.9418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085122PMC
June 2016

Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer.

Authors:
Peter Ulz Jelena Belic Ricarda Graf Martina Auer Ingrid Lafer Katja Fischereder Gerald Webersinke Karl Pummer Herbert Augustin Martin Pichler Gerald Hoefler Thomas Bauernhofer Jochen B Geigl Ellen Heitzer Michael R Speicher

Nat Commun 2016 06 22;7:12008. Epub 2016 Jun 22.

Institute of Human Genetics, Medical University of Graz, A-8010 Graz, Austria.

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http://dx.doi.org/10.1038/ncomms12008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917969PMC
June 2016

Tumor-Induced Hyperlipidemia Contributes to Tumor Growth.

Authors:
Jianfeng Huang Lena Li Jihong Lian Silvia Schauer Paul W Vesely Dagmar Kratky Gerald Hoefler Richard Lehner

Cell Rep 2016 Apr 31;15(2):336-48. Epub 2016 Mar 31.

Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, AB T6G 2R3, Canada; Department of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984953PMC
April 2016

Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice.

Authors:
Nemanja Vujic Stefanie Schlager Thomas O Eichmann Corina T Madreiter-Sokolowski Madeleine Goeritzer Silvia Rainer Silvia Schauer Angelika Rosenberger Albert Woelfler Prakash Doddapattar Robert Zimmermann Gerald Hoefler Achim Lass Wolfgang F Graier Branislav Radovic Dagmar Kratky

Atherosclerosis 2016 Jan 2;244:9-21. Epub 2015 Nov 2.

Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.10.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704137PMC
January 2016

MiR-96-5p influences cellular growth and is associated with poor survival in colorectal cancer patients.

Authors:
Anna Lena Ress Verena Stiegelbauer Elke Winter Daniela Schwarzenbacher Tobias Kiesslich Sigurd Lax Stefan Jahn Alexander Deutsch Thomas Bauernhofer Hui Ling Hellmut Samonigg Armin Gerger Gerald Hoefler Martin Pichler

Mol Carcinog 2015 Nov 25;54(11):1442-50. Epub 2014 Sep 25.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1002/mc.22218DOI Listing
November 2015

Deletion of SPRY4 is a frequent event in secondary acute myeloid leukemia.

Authors:
Olivia Geiger Stefan Hatzl Karl Kashofer Gerald Hoefler Albert Wölfler Heinz Sill Armin Zebisch

Ann Hematol 2015 Nov 25;94(11):1923-4. Epub 2015 Jul 25.

Division of Hematology, Medical University of Graz, Auenbruggerplatz 38, 8036, Graz, Austria.

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http://dx.doi.org/10.1007/s00277-015-2445-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024751PMC
November 2015

Mutational dichotomy in desmoplastic malignant melanoma corroborated by multigene panel analysis.

Authors:
Stephan W Jahn Karl Kashofer Iris Halbwedl Gerlinde Winter Laila El-Shabrawi-Caelen Thomas Mentzel Gerald Hoefler Bernadette Liegl-Atzwanger

Mod Pathol 2015 Jul 13;28(7):895-903. Epub 2015 Mar 13.

Institute of Pathology, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1038/modpathol.2015.39DOI Listing
July 2015

Evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients.

Authors:
Michael Stotz Joanna Szkandera Julia Seidel Tatjana Stojakovic Hellmut Samonigg Daniel Reitz Thomas Gary Peter Kornprat Renate Schaberl-Moser Gerald Hoefler Armin Gerger Martin Pichler

PLoS One 2014 18;9(8):e104730. Epub 2014 Aug 18.

Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria; Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136788PMC
May 2015

Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients.

Authors:
Julia Hoffmann Leigh M Marsh Mario Pieper Elvira Stacher Bahil Ghanim Gabor Kovacs Peter König Heinrike Wilkens Hans Michael Haitchi Gerald Hoefler Walter Klepetko Horst Olschewski Andrea Olschewski Grazyna Kwapiszewska

Am J Physiol Lung Cell Mol Physiol 2015 May 3;308(10):L1002-13. Epub 2015 Apr 3.

Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria; Department of Experimental Anesthesiology, Medical University of Graz, Graz, Austria

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http://dx.doi.org/10.1152/ajplung.00383.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437007PMC
May 2015

Low spinophilin expression enhances aggressive biological behavior of breast cancer.

Authors:
Daniela Schwarzenbacher Verena Stiegelbauer Alexander Deutsch Anna Lena Ress Ariane Aigelsreiter Silvia Schauer Karin Wagner Tanja Langsenlehner Margit Resel Armin Gerger Hui Ling Cristina Ivan George Adrian Calin Gerald Hoefler Beate Rinner Martin Pichler

Oncotarget 2015 May;6(13):11191-202

Division of Oncology, Department of Internal Medicine, Medical University of Graz, Austria.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484449PMC
http://dx.doi.org/10.18632/oncotarget.3586DOI Listing
May 2015

Micro RNA-124a regulates lipolysis via adipose triglyceride lipase and comparative gene identification 58.

Authors:
Suman K Das Elke Stadelmeyer Silvia Schauer Anna Schwarz Heimo Strohmaier Thiery Claudel Rudolf Zechner Gerald Hoefler Paul W Vesely

Int J Mol Sci 2015 Apr 16;16(4):8555-68. Epub 2015 Apr 16.

Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria.

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http://www.mdpi.com/1422-0067/16/4/8555
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http://dx.doi.org/10.3390/ijms16048555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425096PMC
April 2015

Preexisting TP53 mutation in therapy-related acute myeloid leukemia.

Authors:
Eduard Schulz Karl Kashofer Ellen Heitzer Ketaki N Mhatre Michael R Speicher Gerald Hoefler Heinz Sill

Ann Hematol 2015 Mar 20;94(3):527-9. Epub 2014 Aug 20.

Division of Hematology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 38D, A-8036, Graz, Austria.

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http://dx.doi.org/10.1007/s00277-014-2191-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317506PMC
March 2015

The lymphocyte to monocyte ratio in peripheral blood represents a novel prognostic marker in patients with pancreatic cancer.

Authors:
Michael Stotz Joanna Szkandera Tatjana Stojakovic Julia Seidel Hellmut Samonigg Peter Kornprat Renate Schaberl-Moser Fridericke Seggewies Gerald Hoefler Armin Gerger Martin Pichler

Clin Chem Lab Med 2015 Feb;53(3):499-506

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http://dx.doi.org/10.1515/cclm-2014-0447DOI Listing
February 2015

Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X.

Authors:
Eduard Schulz Petra Klampfl Stefanie Holzapfel Andreas R Janecke Peter Ulz Wilfried Renner Karl Kashofer Satoshi Nojima Anita Leitner Armin Zebisch Albert Wölfler Sybille Hofer Armin Gerger Sigurd Lax Christine Beham-Schmid Verena Steinke Ellen Heitzer Jochen B Geigl Christian Windpassinger Gerald Hoefler Michael R Speicher C Richard Boland Atsushi Kumanogoh Heinz Sill

Nat Commun 2014 Oct 13;5:5191. Epub 2014 Oct 13.

Division of Hematology, Department of Internal Medicine, Medical University of Graz, A-8036 Graz, Austria.

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http://dx.doi.org/10.1038/ncomms6191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214414PMC
October 2014

Nephroblastomas show low expression of microR-204 and high expression of its target, the oncogenic transcription factor MEIS1.

Authors:
Karin Koller Martin Pichler Karin Koch Martina Zandl Verena Stiegelbauer Ivo Leuschner Gerald Hoefler Barbara Guertl

Pediatr Dev Pathol 2014 May-Jun;17(3):169-75. Epub 2014 Mar 11.

1  Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria.

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http://dx.doi.org/10.2350/13-01-1288-OA.1DOI Listing
September 2014

Megakaryocytic morphology and clinical parameters in essential thrombocythemia, polycythemia vera, and primary myelofibrosis with and without JAK2 V617F.

Authors:
Nataliya Vytrva Elvira Stacher Peter Regitnig Wilma Zinke-Cerwenka Sabine Hojas Eva Hubmann Anna Porwit Magnus Bjorkholm Gerald Hoefler Christine Beham-Schmid

Arch Pathol Lab Med 2014 Sep;138(9):1203-9

From the Institute of Pathology (Drs Vytrva, Stacher, Regitnig, Hoefler, and Beham-Schmid) and the Division of Hematology, Department of Medicine (Dr Zinke-Cerwenka), Medical University of Graz, Graz, Austria; the Division of Hematology, Department of Medicine, General Hospital Fürstenfeld, Fürstenfeld, Austria (Dr Hojas); the Division of Hematology, Department of Medicine, General Hospital Leoben, Leoben, Austria (Dr Hubmann); and the Department of Pathology, Radiumhemmet (Dr Porwit), and the Division of Hematology, Department of Medicine (Dr Bjorkholm), Karolinska University Hospital, Stockholm, Sweden. Dr Vytrva is now with the Department of Clinical Pathology, Ryhov Hospital, Jönköping, Sweden. Dr Porwit is now with the Department of Laboratory Hematology, General Hospital of Toronto, Toronto, Ontario, Canada. Drs Vytrva and Stacher contributed equally to the study.

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http://dx.doi.org/10.5858/arpa.2013-0018-OADOI Listing
September 2014

External validation of the derived neutrophil to lymphocyte ratio as a prognostic marker on a large cohort of pancreatic cancer patients.

Authors:
Joanna Szkandera Michael Stotz Florian Eisner Gudrun Absenger Tatjana Stojakovic Hellmut Samonigg Peter Kornprat Renate Schaberl-Moser Wael Alzoughbi Anna Lena Ress Friederike Sophia Seggewies Armin Gerger Gerald Hoefler Martin Pichler

PLoS One 2013 4;8(11):e78225. Epub 2013 Nov 4.

Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817201PMC
August 2014

Corrigendum to "Tumor Macroenvironment and Metabolism" [Seminars in Oncology, Vol 41, No 2, April 2014, pp 281-295].

Authors:
Wael Al-Zoughbi Jianfeng Huang Ganapathy S Paramasivan Holger Till Martin Pichler Barbara Guertl-Lackner Gerald Hoefler

Semin Oncol 2014 Aug 28;41(4):e31. Epub 2014 Aug 28.

Institute of Pathology, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1053/j.seminoncol.2014.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622047PMC
August 2014

Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH).

Authors:
Pooja Jha Astrid Knopf Harald Koefeler Michaela Mueller Carolin Lackner Gerald Hoefler Thierry Claudel Michael Trauner

Biochim Biophys Acta 2014 Jul 1;1842(7):959-70. Epub 2014 Mar 1.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034162PMC
July 2014

Effects of Lewis lung carcinoma and B16 melanoma on the innervation of the mouse trachea.

Authors:
Tilman Graulich Suman Kumar Das Lars Wessels Wolfgang Kummer Gerald Hoefler Christian Mühlfeld

Auton Neurosci 2014 Jul 19;183:106-10. Epub 2014 Mar 19.

Institute of Anatomy and Cell Biology, Justus-Liebig-University Giessen, Aulweg 123, 35385 Giessen, Germany; Institute of Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany. Electronic address:

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July 2014

Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing.

Authors:
Ellen Heitzer Peter Ulz Jelena Belic Stefan Gutschi Franz Quehenberger Katja Fischereder Theresa Benezeder Martina Auer Carina Pischler Sebastian Mannweiler Martin Pichler Florian Eisner Martin Haeusler Sabine Riethdorf Klaus Pantel Hellmut Samonigg Gerald Hoefler Herbert Augustin Jochen B Geigl Michael R Speicher

Genome Med 2013 5;5(4):30. Epub 2013 Apr 5.

Institute of Human Genetics, Medical University of Graz, Harrachgasse 21/8, A-8010 Graz, Austria.

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http://dx.doi.org/10.1186/gm434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707016PMC
May 2014

Tumor macroenvironment and metabolism.

Authors:
Wael Al-Zoughbi Wael Al-Zhoughbi Jianfeng Huang Ganapathy S Paramasivan Holger Till Martin Pichler Barbara Guertl-Lackner Gerald Hoefler

Semin Oncol 2014 Apr 1;41(2):281-95. Epub 2014 Mar 1.

Institute of Pathology, Medical University of Graz, Graz, Austria. Electronic address:

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http://dx.doi.org/10.1053/j.seminoncol.2014.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012137PMC
April 2014

Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia.

Authors:
Pooja Jha Thierry Claudel Anna Baghdasaryan Michaela Mueller Emina Halilbasic Suman K Das Achim Lass Robert Zimmermann Rudolf Zechner Gerald Hoefler Michael Trauner

Hepatology 2014 Mar 28;59(3):858-69. Epub 2014 Jan 28.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria; Institute of Pathology, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1002/hep.26732DOI Listing
March 2014

miR-181a is associated with poor clinical outcome in patients with colorectal cancer treated with EGFR inhibitor.

Authors:
Martin Pichler Elke Winter Anna Lena Ress Thomas Bauernhofer Armin Gerger Tobias Kiesslich Sigurd Lax Hellmut Samonigg Gerald Hoefler

J Clin Pathol 2014 Mar 4;67(3):198-203. Epub 2013 Oct 4.

Division of Oncology, Department of Internal Medicine, Medical University of Graz (MUG), , Graz, Austria.

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http://dx.doi.org/10.1136/jclinpath-2013-201904DOI Listing
March 2014

Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing.

Authors:
Sumitra Mohan Ellen Heitzer Peter Ulz Ingrid Lafer Sigurd Lax Martina Auer Martin Pichler Armin Gerger Florian Eisner Gerald Hoefler Thomas Bauernhofer Jochen B Geigl Michael R Speicher

PLoS Genet 2014 Mar 27;10(3):e1004271. Epub 2014 Mar 27.

Institute of Human Genetics, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1371/journal.pgen.1004271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967949PMC
March 2014

The PPARα agonist fenofibrate suppresses B-cell lymphoma in mice by modulating lipid metabolism.

Authors:
Jianfeng Huang Suman Kumar Das Pooja Jha Wael Al Zoughbi Silvia Schauer Thierry Claudel Veronika Sexl Paul Vesely Ruth Birner-Gruenberger Dagmar Kratky Michael Trauner Gerald Hoefler

Biochim Biophys Acta 2013 Oct 26;1831(10):1555-65. Epub 2013 Apr 26.

Institute of Pathology, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1016/j.bbalip.2013.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331670PMC
October 2013

Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.

Authors:
Prakash Doddapattar Branislav Radović Jay V Patankar Sascha Obrowsky Katharina Jandl Christoph Nusshold Dagmar Kolb Nemanja Vujić Lalit Doshi Prakash G Chandak Madeleine Goeritzer Helmut Ahammer Gerald Hoefler Wolfgang Sattler Dagmar Kratky

Mol Nutr Food Res 2013 Oct 3;57(10):1718-28. Epub 2013 May 3.

Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1002/mnfr.201200794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771820PMC
October 2013

Identification of the transcription factor HOXB4 as a novel target of miR-23a.

Authors:
Karin Koller Suman Das Ivo Leuschner Melanie Korbelius Gerald Hoefler Barbara Guertl

Genes Chromosomes Cancer 2013 Aug 30;52(8):709-15. Epub 2013 Apr 30.

Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036, Graz, Austria.

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http://dx.doi.org/10.1002/gcc.22066DOI Listing
August 2013

A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis.

Authors:
Karoline Kollmann Gerwin Heller Christine Schneckenleithner Wolfgang Warsch Ruth Scheicher Rene G Ott Markus Schäfer Sabine Fajmann Michaela Schlederer Ana-Iris Schiefer Ursula Reichart Matthias Mayerhofer Christoph Hoeller Sabine Zöchbauer-Müller Dontscho Kerjaschki Christoph Bock Lukas Kenner Gerald Hoefler Michael Freissmuth Anthony R Green Richard Moriggl Meinrad Busslinger Marcos Malumbres Veronika Sexl

Cancer Cell 2013 Aug;24(2):167-81

Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.

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http://dx.doi.org/10.1016/j.ccr.2013.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743049PMC
August 2013

Molecular cytogenetics and multiplex reverse-transcriptase polymerase chain reaction for risk stratification in acute myeloid leukemia.

Authors:
Kristina Orendi Werner Emberger Michael R Speicher Gerald Hoefler Heinz Sill

J Clin Oncol 2013 Jun 6;31(18):2360-1. Epub 2013 May 6.

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http://dx.doi.org/10.1200/JCO.2013.48.8189DOI Listing
June 2013

The role of triglyceride lipases in cancer associated cachexia.

Authors:
Suman K Das Gerald Hoefler

Trends Mol Med 2013 May 14;19(5):292-301. Epub 2013 Mar 14.

Institute of Pathology, Medical University of Graz, 8036 Graz, Austria.

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https://linkinghub.elsevier.com/retrieve/pii/S14714914130003
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http://dx.doi.org/10.1016/j.molmed.2013.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655383PMC
May 2013

The pluripotent renal stem cell regulator SIX2 is activated in renal neoplasms and influences cellular proliferation and migration.

Authors:
Upeka Senanayake Karin Koller Martin Pichler Ivo Leuschner Heimo Strohmaier Ulrike Hadler Suman Das Gerald Hoefler Barbara Guertl

Hum Pathol 2013 Mar 17;44(3):336-45. Epub 2012 Sep 17.

Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria.

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http://dx.doi.org/10.1016/j.humpath.2012.05.021DOI Listing
March 2013

Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.

Authors:
Philipp B Staber Pu Zhang Min Ye Robert S Welner César Nombela-Arrieta Christian Bach Marc Kerenyi Boris A Bartholdy Hong Zhang Meritxell Alberich-Jordà Sanghoon Lee Henry Yang Felicia Ng Junyan Zhang Mathias Leddin Leslie E Silberstein Gerald Hoefler Stuart H Orkin Berthold Göttgens Frank Rosenbauer Gang Huang Daniel G Tenen

Mol Cell 2013 Mar 8;49(5):934-46. Epub 2013 Feb 8.

Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2013.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644723PMC
March 2013

Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling.

Authors:
Sascha Obrowsky Prakash G Chandak Jay V Patankar Silvia Povoden Stefanie Schlager Erin E Kershaw Juliane G Bogner-Strauss Gerald Hoefler Sanja Levak-Frank Dagmar Kratky

J Lipid Res 2013 Feb 6;54(2):425-35. Epub 2012 Dec 6.

Institute of Molecular Biology, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1194/jlr.M031716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541705PMC
February 2013

The role of morphology in combination with ploidy analysis in characterizing early gestational abortion.

Authors:
Isabella Grinschgl Sebastian Mannweiler Margit Holzapfel-Bauer Ulrich Pferschy Gerald Hoefler Barbara Guertl

Virchows Arch 2013 Feb 21;462(2):175-82. Epub 2012 Dec 21.

Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria.

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http://dx.doi.org/10.1007/s00428-012-1350-8DOI Listing
February 2013

Histiocytic sarcoma - targeted therapy: novel therapeutic options? A series of 4 cases.

Authors:
Konstantin Schlick Ariane Aigelsreiter Martin Pichler Sonja Reitter Peter Neumeister Gerald Hoefler Christine Beham-Schmid Werner Linkesch

Onkologie 2012 12;35(7-8):447-50. Epub 2012 Jul 12.

Department of Internal Medicine, Division of Hematooncology, Paracelsus Medical University of Salzburg, Austria.

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http://dx.doi.org/10.1159/000340066DOI Listing
January 2013

A TRPC3 blocker, ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (Pyr3), prevents stent-induced arterial remodeling.

Authors:
Sarah Koenig Michaela Schernthaner Heinrich Maechler C Oliver Kappe Toma N Glasnov Gerald Hoefler Marlen Braune Eric Wittchow Klaus Groschner

J Pharmacol Exp Ther 2013 Jan 25;344(1):33-40. Epub 2012 Sep 25.

Institute of Biophysics, Department of Cardiac Surgery, Medical University of Graz, Graz, Austria.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.112.19683
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http://dx.doi.org/10.1124/jpet.112.196832DOI Listing
January 2013

Comparison of the 2002 and 2010 TNM classification systems regarding outcome prediction in clear cell and papillary renal cell carcinoma.

Authors:
Martin Pichler Georg C Hutterer Thomas F Chromecki Johanna Jesche Karin Kampel-Kettner Andrea Groselj-Strele Gerald Hoefler Karl Pummer Richard Zigeuner

Histopathology 2013 Jan 28;62(2):237-46. Epub 2012 Sep 28.

Division of Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 25, Graz, Austria.

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http://doi.wiley.com/10.1111/his.12001
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http://dx.doi.org/10.1111/his.12001DOI Listing
January 2013

Mutations inDNMT3A and loss of RKIP are independent events in acute monocytic leukemia.

Authors:
Isabella Fried Albert Wölfler Franz Quehenberger Gerald Hoefler Heinz Sill Armin Zebisch

Haematologica 2012 Dec 8;97(12):1936-7. Epub 2012 Aug 8.

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http://dx.doi.org/10.3324/haematol.2012.068429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590102PMC
December 2012

Sunitinib causes dose-dependent negative functional effects on myocardium and cardiomyocytes.

Authors:
Peter P Rainer Bernhard Doleschal Jonathan A Kirk Vidhya Sivakumaran Zora Saad Klaus Groschner Heinrich Maechler Gerald Hoefler Thomas Bauernhofer Hellmut Samonigg Georg Hutterer David A Kass Burkert Pieske Dirk von Lewinski Martin Pichler

BJU Int 2012 Nov 17;110(10):1455-62. Epub 2012 Apr 17.

Division of Cardiology, Department of Internal Medicine, Medical University Graz, Austria.

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http://dx.doi.org/10.1111/j.1464-410X.2012.11134.xDOI Listing
November 2012

Intestinal GATA4 deficiency protects from diet-induced hepatic steatosis.

Authors:
Jay V Patankar Sascha Obrowsky Prakash Doddapattar Gerald Hoefler Michele Battle Sanja Levak-Frank Dagmar Kratky

J Hepatol 2012 Nov 28;57(5):1061-8. Epub 2012 Jun 28.

Institute of Molecular Biology and Biochemistry, Medical University of Graz, Austria.

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http://dx.doi.org/10.1016/j.jhep.2012.06.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477492PMC
November 2012

Cancer cachexia alters intracellular surfactant metabolism but not total alveolar surface area.

Authors:
Tilman Graulich Suman Kumar Das Gabriela Krasteva Clemens Ruppert Lars Wessels Gerald Hoefler Christian Mühlfeld

Histochem Cell Biol 2012 Nov 19;138(5):803-13. Epub 2012 Jul 19.

Institute of Anatomy and Cell Biology, Justus-Liebig-University Giessen, Aulweg 123, 35385, Giessen, Germany.

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http://dx.doi.org/10.1007/s00418-012-0995-3DOI Listing
November 2012

Implementation of formalin-fixed, paraffin-embedded cell line pellets as high-quality process controls in quality assessment programs for KRAS mutation analysis.

Authors:
Jeroen R Dijkstra Frank J M Opdam Jerry Boonyaratanakornkit E Ralf Schönbrunner Mona Shahbazian Anders Edsjö Gerald Hoefler Andreas Jung Athanassios Kotsinas Vassilis G Gorgoulis Fernando López-Ríos Karin de Stricker Etienne Rouleau Bart Biesmans J Han J M van Krieken

J Mol Diagn 2012 May-Jun;14(3):187-91. Epub 2012 Mar 10.

Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.jmoldx.2012.01.002DOI Listing
September 2012

Trends of stage, grade, histology and tumour necrosis in renal cell carcinoma in a European centre surgical series from 1984 to 2010.

Authors:
Martin Pichler Georg C Hutterer Thomas F Chromecki Johanna Jesche Karin Kampel-Kettner Katharina Eberhard Gerald Hoefler Karl Pummer Richard Zigeuner

J Clin Pathol 2012 Aug 25;65(8):721-4. Epub 2012 May 25.

Division of Oncology, Department of Internal Medicine, Medical University of Graz (MUG), Graz, Austria.

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http://dx.doi.org/10.1136/jclinpath-2012-200797DOI Listing
August 2012

miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms.

Authors:
Upeka Senanayake Suman Das Paul Vesely Wael Alzoughbi Leopold F Fröhlich Pooja Chowdhury Ivo Leuschner Gerald Hoefler Barbara Guertl

Carcinogenesis 2012 May 19;33(5):1014-21. Epub 2012 Mar 19.

Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria.

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http://dx.doi.org/10.1093/carcin/bgs126DOI Listing
May 2012

Cardiac fibrosis in human transplanted hearts is mainly driven by cells of intracardiac origin.

Authors:
Martin Pichler Peter P Rainer Silvia Schauer Gerald Hoefler

J Am Coll Cardiol 2012 Mar;59(11):1008-16

Division of Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, Graz, Austria.

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http://dx.doi.org/10.1016/j.jacc.2011.11.036DOI Listing
March 2012

Intramural and extramural vascular invasion in colorectal cancer: prognostic significance and quality of pathology reporting.

Authors:
Johannes Betge Marion J Pollheimer Richard A Lindtner Peter Kornprat Andrea Schlemmer Peter Rehak Michael Vieth Gerald Hoefler Cord Langner

Cancer 2012 Feb 12;118(3):628-38. Epub 2011 Jul 12.

Institute of Pathology, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1002/cncr.26310DOI Listing
February 2012

The times have changed: molecular pathology is here to stay. A commentary on: analytical performance of a PCR assay for the detection of KRAS mutations (codons 12/13 and 61) in formalin-fixed paraffin-embedded tissue samples of colorectal carcinoma, by Lee et al. In this issue.

Authors:
J Han van Krieken Gerald Hoefler

Virchows Arch 2012 Feb 23;460(2):129-30. Epub 2012 Feb 23.

Department of Pathology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00428-012-1197-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303056PMC
February 2012

Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice.

Authors:
Prakash G Chandak Sascha Obrowsky Branislav Radovic Prakash Doddapattar Elma Aflaki Adelheid Kratzer Lalit S Doshi Silvia Povoden Helmut Ahammer Gerald Hoefler Sanja Levak-Frank Dagmar Kratky

Biochim Biophys Acta 2011 Dec 1;1811(12):1011-20. Epub 2011 Sep 1.

Institute of Molecular Biology and Biochemistry, Medical University of Graz, Harrachgasse 21, Graz, Austria.

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http://dx.doi.org/10.1016/j.bbalip.2011.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223411PMC
December 2011

Activation of beta-catenin is a late event in the pathogenesis of nephroblastomas and rarely correlated with genetic changes of the APC gene.

Authors:
Christine Grill Sandra Sunitsch Martina Hatz Cornelia Hauser-Kronberger Ivo Leuschner Gerald Hoefler Barbara Guertl

Pathology 2011 Dec;43(7):702-6

Department of Pathology General Hospital and Paracelsus Medical University Salzburg, Salzburg.

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http://dx.doi.org/10.1097/PAT.0b013e32834bf65cDOI Listing
December 2011

Lim1, an embryonal transcription factor, is absent in multicystic renal dysplasia, but reactivated in nephroblastomas.

Authors:
Barbara Guertl Upeka Senanayake Elisa Nusshold Ivo Leuschner Sebastian Mannweiler Birgit Ebner Gerald Hoefler

Pathobiology 2011 19;78(4):210-9. Epub 2011 Jul 19.

Institute of Pathology, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1159/000326769DOI Listing
November 2011

Cancer induces cardiomyocyte remodeling and hypoinnervation in the left ventricle of the mouse heart.

Authors:
Christian Mühlfeld Suman Kumar Das Frank R Heinzel Albrecht Schmidt Heiner Post Silvia Schauer Tamara Papadakis Wolfgang Kummer Gerald Hoefler

PLoS One 2011 26;6(5):e20424. Epub 2011 May 26.

Institute of Anatomy and Cell Biology, Justus-Liebig-University Giessen, Giessen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020424PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102720PMC
September 2011

Gastric cancer and concomitant renal cancer: a systematic immunohistochemical and molecular analysis.

Authors:
Johannes Betge Marion J Pollheimer Andrea Schlemmer Gerald Hoefler Cord Langner

Oncol Rep 2011 Sep 15;26(3):567-75. Epub 2011 Jun 15.

Institute of Pathology, Medical University of Graz, 8036 Graz, Austria.

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http://dx.doi.org/10.3892/or.2011.1346DOI Listing
September 2011

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.

Authors:
Guenter Haemmerle Tarek Moustafa Gerald Woelkart Sabrina Büttner Albrecht Schmidt Tineke van de Weijer Matthijs Hesselink Doris Jaeger Petra C Kienesberger Kathrin Zierler Renate Schreiber Thomas Eichmann Dagmar Kolb Petra Kotzbeck Martina Schweiger Manju Kumari Sandra Eder Gabriele Schoiswohl Nuttaporn Wongsiriroj Nina M Pollak Franz P W Radner Karina Preiss-Landl Thomas Kolbe Thomas Rülicke Burkert Pieske Michael Trauner Achim Lass Robert Zimmermann Gerald Hoefler Saverio Cinti Erin E Kershaw Patrick Schrauwen Frank Madeo Bernd Mayer Rudolf Zechner

Nat Med 2011 Aug 21;17(9):1076-85. Epub 2011 Aug 21.

Institute of Molecular Biosciences, University of Graz, Graz, Austria.

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http://dx.doi.org/10.1038/nm.2439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244833PMC
August 2011

Multiple intratumoral KRAS mutations can clonally segregate to different lymph node metastases in colon cancer.

Authors:
Stephan W Jahn Gerlinde Winter Elvira Stacher Iris Halbwedl Stefan Gattenlöhner Richard Stockinger Stefan Spreitzer Julie Waldispuehl-Geigl Jochen B Geigl Felix Offner Gerald Hoefler

Histopathology 2011 Aug;59(2):342-5

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http://dx.doi.org/10.1111/j.1365-2559.2011.03902.xDOI Listing
August 2011

Adipose triglyceride lipase and hormone-sensitive lipase are involved in fat loss in JunB-deficient mice.

Authors:
Montserrat Pinent Andreas Prokesch Hubert Hackl Peter J Voshol Ariane Klatzer Evelyn Walenta Ute Panzenboeck Lukas Kenner Zlatko Trajanoski Gerald Hoefler Juliane G Bogner-Strauss

Endocrinology 2011 Jul 3;152(7):2678-89. Epub 2011 May 3.

Institute for Genomics and Bioinformatics, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria.

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http://dx.doi.org/10.1210/en.2010-1477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152802PMC
July 2011

Adipose triglyceride lipase contributes to cancer-associated cachexia.

Authors:
Suman K Das Sandra Eder Silvia Schauer Clemens Diwoky Hannes Temmel Barbara Guertl Gregor Gorkiewicz Kuppusamy P Tamilarasan Pooja Kumari Michael Trauner Robert Zimmermann Paul Vesely Guenter Haemmerle Rudolf Zechner Gerald Hoefler

Science 2011 Jul 16;333(6039):233-8. Epub 2011 Jun 16.

Institute of Pathology, Medical University of Graz, Graz, Austria.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1198973
Publisher Site
http://dx.doi.org/10.1126/science.1198973DOI Listing
July 2011

Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice.

Authors:
Jay V Patankar Prakash G Chandak Sascha Obrowsky Thomas Pfeifer Clemens Diwoky Andreas Uellen Wolfgang Sattler Rudolf Stollberger Gerald Hoefler Akos Heinemann Michele Battle Stephen Duncan Dagmar Kratky Sanja Levak-Frank

Am J Physiol Endocrinol Metab 2011 Mar 21;300(3):E478-88. Epub 2010 Dec 21.

Institute of Molecular Biology and Biochemistry, Medical University of Graz, Harrachgasse 21/3, Graz, Austria.

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http://dx.doi.org/10.1152/ajpendo.00457.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163292PMC
March 2011

Loss of PTEN/MMAC1 activity is a rare and late event in the pathogenesis of nephroblastomas.

Authors:
Christine Grill Christian Guelly Birgit Ebner Ivo Leuschner Cornelia Hauser-Kronberger Gerald Hoefler Barbara Guertl

Hum Pathol 2010 Aug 8;41(8):1172-7. Epub 2010 Apr 8.

Department of Pathology, General Hospital and Paracelsus Medical University Salzburg, Muellner Hauptstrasse 48, A-5020 Salzburg, Austria.

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http://dx.doi.org/10.1016/j.humpath.2009.10.024DOI Listing
August 2010

Quantitative short-tandem repeat analysis of recipient-derived cells as an additional tool for diagnosing cardiac allograft rejection.

Authors:
Martin Pichler Jan Beckendorf Elke Winter Reinhold Kleinert Daniela Kniepeiss Gerald Hoefler

Transplantation 2010 Mar;89(6):749-55

Department of Oncology, University Clinic of Internal Medicine, Medical University of Graz, Graz, Austria.

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https://insights.ovid.com/crossref?an=00007890-201003270-000
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http://dx.doi.org/10.1097/TP.0b013e3181cab05cDOI Listing
March 2010

Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58).

Authors:
Franz P W Radner Ingo E Streith Gabriele Schoiswohl Martina Schweiger Manju Kumari Thomas O Eichmann Gerald Rechberger Harald C Koefeler Sandra Eder Silvia Schauer H Christian Theussl Karina Preiss-Landl Achim Lass Robert Zimmermann Gerald Hoefler Rudolf Zechner Guenter Haemmerle

J Biol Chem 2010 Mar 18;285(10):7300-11. Epub 2009 Dec 18.

Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A-8010 Graz, Austria.

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http://dx.doi.org/10.1074/jbc.M109.081877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844178PMC
March 2010