Publications by authors named "Gerald Hoefler"

100Publications

Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis.

Cancer Metab 2020 Nov 26;8(1):26. Epub 2020 Nov 26.

Institute of Biochemistry, Graz University of Technology, Humboldtstrasse 46/III, 8010, Graz, Austria.

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November 2020

Adipose triglyceride lipase activity regulates cancer cell proliferation via AMP-kinase and mTOR signaling.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 09 11;1865(9):158737. Epub 2020 May 11.

Institute of Molecular Biosciences, University of Graz, Graz 8010, Austria. Electronic address:

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September 2020

The leading role of pathology in assessing the somatic molecular alterations of cancer: Position Paper of the European Society of Pathology.

Virchows Arch 2020 Apr 2;476(4):491-497. Epub 2020 Mar 2.

Institute for Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

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April 2020

Tumor Macroenvironment: An Update.

Pathobiology 2020 4;87(2):58-60. Epub 2019 Sep 4.

Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria,

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September 2019

Oxidation of human plasma fibronectin by inflammatory oxidants perturbs endothelial cell function.

Free Radic Biol Med 2019 05 5;136:118-134. Epub 2019 Apr 5.

The Heart Research Institute, Newtown, NSW, Australia; Faculty of Medicine, The University of Sydney, NSW, Australia; Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Denmark. Electronic address:

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May 2019

Early Loss of Forkhead Transcription Factor, O Subgroup, Member 1 Protein in the Development of Pancreatic Ductal Adenocarcinoma.

Pathobiology 2018 18;85(5-6):342-347. Epub 2018 Sep 18.

Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz,

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December 2018

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting.

Cell Metab 2018 11 16;28(5):706-720.e6. Epub 2018 Aug 16.

Institute of Biochemistry, Graz University of Technology, Humboldtstrasse 46/III, 8010 Graz, Austria; BioTechMed-Graz, Graz, Austria. Electronic address:

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November 2018

Atypical "hairy cell-like" presentation of leukemic mantle cell lymphoma.

Clin Chem Lab Med 2018 12;57(2):e34-e36

Department of Internal Medicine 1, Hospital of the Brothers of St. John of God, Graz, Austria.

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December 2018

Exposure of tropoelastin to peroxynitrous acid gives high yields of nitrated tyrosine residues, di-tyrosine cross-links and altered protein structure and function.

Free Radic Biol Med 2018 02 27;115:219-231. Epub 2017 Nov 27.

The Heart Research Institute, Sydney, Australia; Dept. of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark; Faculty of Medicine, University of Sydney, Sydney, Australia. Electronic address:

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February 2018

Next-Generation Sequencing in Diagnostics and Clinical Research.

Authors:
Gerald Hoefler

Pathobiology 2017 12;84(6):289-291. Epub 2017 Dec 12.

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February 2019

Expansion of BCR/ABL1 cells requires PAK2 but not PAK1.

Br J Haematol 2017 10 14;179(2):229-241. Epub 2017 Jul 14.

Institute of Pharmacology and Toxicology, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Vienna, Austria.

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October 2017

Visualization of tumor heterogeneity by in situ padlock probe technology in colorectal cancer.

Histochem Cell Biol 2017 Aug 20;148(2):105-115. Epub 2017 Mar 20.

Institute of Pathology, Medical University of Graz, Graz, Austria.

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August 2017

Tumour heterogeneity: principles and practical consequences.

Virchows Arch 2016 Oct 13;469(4):371-84. Epub 2016 Jul 13.

Institute of Pathology, Medical University of Graz, Graz, Austria.

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October 2016

Tumor-Induced Hyperlipidemia Contributes to Tumor Growth.

Cell Rep 2016 Apr 31;15(2):336-48. Epub 2016 Mar 31.

Group on Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, AB T6G 2R3, Canada; Department of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada. Electronic address:

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April 2016

A synonymous EGFR polymorphism predicting responsiveness to anti-EGFR therapy in metastatic colorectal cancer patients.

Tumour Biol 2016 Jun 15;37(6):7295-303. Epub 2015 Dec 15.

Department of Medical Sciences, University of Trieste, Cattinara Hospital-Surgical Pathology Building, Strada di Fiume 447, 34149, Trieste, Italy.

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June 2016

Deletion of SPRY4 is a frequent event in secondary acute myeloid leukemia.

Ann Hematol 2015 Nov 25;94(11):1923-4. Epub 2015 Jul 25.

Division of Hematology, Medical University of Graz, Auenbruggerplatz 38, 8036, Graz, Austria.

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November 2015

Micro RNA-124a regulates lipolysis via adipose triglyceride lipase and comparative gene identification 58.

Int J Mol Sci 2015 Apr 16;16(4):8555-68. Epub 2015 Apr 16.

Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria.

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April 2015

Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients.

Am J Physiol Lung Cell Mol Physiol 2015 May 3;308(10):L1002-13. Epub 2015 Apr 3.

Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria; Department of Experimental Anesthesiology, Medical University of Graz, Graz, Austria

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May 2015

Megakaryocytic morphology and clinical parameters in essential thrombocythemia, polycythemia vera, and primary myelofibrosis with and without JAK2 V617F.

Arch Pathol Lab Med 2014 Sep;138(9):1203-9

From the Institute of Pathology (Drs Vytrva, Stacher, Regitnig, Hoefler, and Beham-Schmid) and the Division of Hematology, Department of Medicine (Dr Zinke-Cerwenka), Medical University of Graz, Graz, Austria; the Division of Hematology, Department of Medicine, General Hospital Fürstenfeld, Fürstenfeld, Austria (Dr Hojas); the Division of Hematology, Department of Medicine, General Hospital Leoben, Leoben, Austria (Dr Hubmann); and the Department of Pathology, Radiumhemmet (Dr Porwit), and the Division of Hematology, Department of Medicine (Dr Bjorkholm), Karolinska University Hospital, Stockholm, Sweden. Dr Vytrva is now with the Department of Clinical Pathology, Ryhov Hospital, Jönköping, Sweden. Dr Porwit is now with the Department of Laboratory Hematology, General Hospital of Toronto, Toronto, Ontario, Canada. Drs Vytrva and Stacher contributed equally to the study.

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September 2014

Preexisting TP53 mutation in therapy-related acute myeloid leukemia.

Ann Hematol 2015 Mar 20;94(3):527-9. Epub 2014 Aug 20.

Division of Hematology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 38D, A-8036, Graz, Austria.

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March 2015

Evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients.

PLoS One 2014 18;9(8):e104730. Epub 2014 Aug 18.

Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria; Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.

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May 2015

Tumor macroenvironment and metabolism.

Semin Oncol 2014 Apr 1;41(2):281-95. Epub 2014 Mar 1.

Institute of Pathology, Medical University of Graz, Graz, Austria. Electronic address:

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April 2014

Effects of Lewis lung carcinoma and B16 melanoma on the innervation of the mouse trachea.

Auton Neurosci 2014 Jul 19;183:106-10. Epub 2014 Mar 19.

Institute of Anatomy and Cell Biology, Justus-Liebig-University Giessen, Aulweg 123, 35385 Giessen, Germany; Institute of Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany. Electronic address:

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July 2014

Nephroblastomas show low expression of microR-204 and high expression of its target, the oncogenic transcription factor MEIS1.

Pediatr Dev Pathol 2014 May-Jun;17(3):169-75. Epub 2014 Mar 11.

1  Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria.

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September 2014

Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH).

Biochim Biophys Acta 2014 Jul 1;1842(7):959-70. Epub 2014 Mar 1.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria. Electronic address:

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July 2014

miR-181a is associated with poor clinical outcome in patients with colorectal cancer treated with EGFR inhibitor.

J Clin Pathol 2014 Mar 4;67(3):198-203. Epub 2013 Oct 4.

Division of Oncology, Department of Internal Medicine, Medical University of Graz (MUG), , Graz, Austria.

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March 2014

Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia.

Hepatology 2014 Mar 28;59(3):858-69. Epub 2014 Jan 28.

Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria; Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria; Institute of Pathology, Medical University of Graz, Graz, Austria.

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March 2014

Identification of the transcription factor HOXB4 as a novel target of miR-23a.

Genes Chromosomes Cancer 2013 Aug 30;52(8):709-15. Epub 2013 Apr 30.

Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036, Graz, Austria.

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August 2013

The role of triglyceride lipases in cancer associated cachexia.

Trends Mol Med 2013 May 14;19(5):292-301. Epub 2013 Mar 14.

Institute of Pathology, Medical University of Graz, 8036 Graz, Austria.

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May 2013

The role of morphology in combination with ploidy analysis in characterizing early gestational abortion.

Virchows Arch 2013 Feb 21;462(2):175-82. Epub 2012 Dec 21.

Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria.

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February 2013

Histiocytic sarcoma - targeted therapy: novel therapeutic options? A series of 4 cases.

Onkologie 2012 12;35(7-8):447-50. Epub 2012 Jul 12.

Department of Internal Medicine, Division of Hematooncology, Paracelsus Medical University of Salzburg, Austria.

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January 2013

Cancer cachexia alters intracellular surfactant metabolism but not total alveolar surface area.

Histochem Cell Biol 2012 Nov 19;138(5):803-13. Epub 2012 Jul 19.

Institute of Anatomy and Cell Biology, Justus-Liebig-University Giessen, Aulweg 123, 35385, Giessen, Germany.

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November 2012

Intestinal GATA4 deficiency protects from diet-induced hepatic steatosis.

J Hepatol 2012 Nov 28;57(5):1061-8. Epub 2012 Jun 28.

Institute of Molecular Biology and Biochemistry, Medical University of Graz, Austria.

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November 2012

Cardiac fibrosis in human transplanted hearts is mainly driven by cells of intracardiac origin.

J Am Coll Cardiol 2012 Mar;59(11):1008-16

Division of Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, Graz, Austria.

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March 2012