Publications by authors named "Georgios Skiniotis"

92Publications

Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6.

Mol Cell 2020 10 1;80(2):237-245.e4. Epub 2020 Oct 1.

Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA; Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA. Electronic address:

View Article and Find Full Text PDF
October 2020

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT Serotonin Receptor.

Cell 2020 Sep;182(6):1574-1588.e19

Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7365, USA; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7365, USA. Electronic address:

View Article and Find Full Text PDF
September 2020

Structures of metabotropic GABA receptor.

Nature 2020 08 24;584(7820):310-314. Epub 2020 Jun 24.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

View Article and Find Full Text PDF
August 2020

GemSpot: A Pipeline for Robust Modeling of Ligands into Cryo-EM Maps.

Structure 2020 06 14;28(6):707-716.e3. Epub 2020 May 14.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

View Article and Find Full Text PDF
June 2020

Assessment of Biased Agonism among Distinct Synthetic Cannabinoid Receptor Agonist Scaffolds.

ACS Pharmacol Transl Sci 2020 Apr 4;3(2):285-295. Epub 2019 Nov 4.

Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.

View Article and Find Full Text PDF
April 2020

Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms.

Cell Rep 2020 03 2;30(11):3699-3709.e6. Epub 2020 Mar 2.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

View Article and Find Full Text PDF
March 2020

Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc.

Nature 2020 03 16;579(7798):297-302. Epub 2020 Jan 16.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

View Article and Find Full Text PDF
March 2020

Structure of the neurotensin receptor 1 in complex with β-arrestin 1.

Nature 2020 03 16;579(7798):303-308. Epub 2020 Jan 16.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

View Article and Find Full Text PDF
March 2020

A non-canonical monovalent zinc finger stabilizes the integration of Cfp1 into the H3K4 methyltransferase complex COMPASS.

Nucleic Acids Res 2020 01;48(1):421-431

Shanghai Institute of Materia Medica-University of Ottawa Joint Research Centre on Systems and Personalized Pharmacology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.

View Article and Find Full Text PDF
January 2020

Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.

Mol Cell 2019 08 9;75(4):781-790.e3. Epub 2019 Jul 9.

Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

View Article and Find Full Text PDF
August 2019

Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.

Science 2019 05;364(6440):552-557

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

View Article and Find Full Text PDF
May 2019

Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.

Cell 2019 01 10;176(3):448-458.e12. Epub 2019 Jan 10.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA; Department of Structural Biology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA; Department of Photon Science, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA. Electronic address:

View Article and Find Full Text PDF
January 2019

Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation.

Structure 2018 12 27;26(12):1594-1603.e4. Epub 2018 Sep 27.

Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Roger Guindon Hall, Ottawa, ON K1H 8M5, Canada. Electronic address:

View Article and Find Full Text PDF
December 2018