Publications by authors named "Georgios Skiniotis"

92Publications

Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6.

Authors:
Yang Gao Gözde Eskici Sekar Ramachandran Frédéric Poitevin Alpay Burak Seven Ouliana Panova Georgios Skiniotis Richard A Cerione

Mol Cell 2020 10 1;80(2):237-245.e4. Epub 2020 Oct 1.

Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA; Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA. Electronic address:

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October 2020

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT Serotonin Receptor.

Authors:
Kuglae Kim Tao Che Ouliana Panova Jeffrey F DiBerto Jiankun Lyu Brian E Krumm Daniel Wacker Michael J Robertson Alpay B Seven David E Nichols Brian K Shoichet Georgios Skiniotis Bryan L Roth

Cell 2020 Sep;182(6):1574-1588.e19

Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7365, USA; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7365, USA. Electronic address:

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September 2020

Structural insights into differences in G protein activation by family A and family B GPCRs.

Authors:
Daniel Hilger Kaavya Krishna Kumar Hongli Hu Mie Fabricius Pedersen Evan S O'Brien Lise Giehm Christine Jennings Gözde Eskici Asuka Inoue Michael Lerch Jesper Mosolff Mathiesen Georgios Skiniotis Brian K Kobilka

Science 2020 07;369(6503)

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA.

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July 2020

Structures of metabotropic GABA receptor.

Authors:
Makaía M Papasergi-Scott Michael J Robertson Alpay B Seven Ouliana Panova Jesper M Mathiesen Georgios Skiniotis

Nature 2020 08 24;584(7820):310-314. Epub 2020 Jun 24.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

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August 2020

GemSpot: A Pipeline for Robust Modeling of Ligands into Cryo-EM Maps.

Authors:
Michael J Robertson Gydo C P van Zundert Kenneth Borrelli Georgios Skiniotis

Structure 2020 06 14;28(6):707-716.e3. Epub 2020 May 14.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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June 2020

Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction.

Authors:
Wei Kan Michael D Enos Elgin Korkmazhan Stefan Muennich Dong-Hua Chen Melissa V Gammons Mansi Vasishtha Mariann Bienz Alexander R Dunn Georgios Skiniotis William I Weis

Elife 2020 Apr 16;9. Epub 2020 Apr 16.

Department of Structural Biology and Stanford University School of Medicine, Stanford, United States.

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April 2020

Assessment of Biased Agonism among Distinct Synthetic Cannabinoid Receptor Agonist Scaffolds.

Authors:
Elise Wouters Jolien Walraed Michael Joseph Robertson Max Meyrath Martyna Szpakowska Andy Chevigné Georgios Skiniotis Christophe Stove

ACS Pharmacol Transl Sci 2020 Apr 4;3(2):285-295. Epub 2019 Nov 4.

Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.

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April 2020

Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms.

Authors:
Alpay Burak Seven Daniel Hilger Makaía M Papasergi-Scott Li Zhang Qianhui Qu Brian K Kobilka Gregory G Tall Georgios Skiniotis

Cell Rep 2020 03 2;30(11):3699-3709.e6. Epub 2020 Mar 2.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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March 2020

Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc.

Authors:
Dean P Staus Hongli Hu Michael J Robertson Alissa L W Kleinhenz Laura M Wingler William D Capel Naomi R Latorraca Robert J Lefkowitz Georgios Skiniotis

Nature 2020 03 16;579(7798):297-302. Epub 2020 Jan 16.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

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March 2020

Structure of the neurotensin receptor 1 in complex with β-arrestin 1.

Authors:
Weijiao Huang Matthieu Masureel Qianhui Qu John Janetzko Asuka Inoue Hideaki E Kato Michael J Robertson Khanh C Nguyen Jeffrey S Glenn Georgios Skiniotis Brian K Kobilka

Nature 2020 03 16;579(7798):303-308. Epub 2020 Jan 16.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

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March 2020

A non-canonical monovalent zinc finger stabilizes the integration of Cfp1 into the H3K4 methyltransferase complex COMPASS.

Authors:
Yidai Yang Monika Joshi Yoh-Hei Takahashi Zhibin Ning Qianhui Qu Joseph S Brunzelle Georgios Skiniotis Daniel Figeys Ali Shilatifard Jean-François Couture

Nucleic Acids Res 2020 01;48(1):421-431

Shanghai Institute of Materia Medica-University of Ottawa Joint Research Centre on Systems and Personalized Pharmacology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.

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January 2020

Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.

Authors:
Yang Gao Hongli Hu Sekar Ramachandran Jon W Erickson Richard A Cerione Georgios Skiniotis

Mol Cell 2019 08 9;75(4):781-790.e3. Epub 2019 Jul 9.

Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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August 2019

Self-Assembly Behavior and Application of Terphenyl-Cored Trimaltosides for Membrane-Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability.

Authors:
Muhammad Ehsan Yang Du Jonas S Mortensen Parameswaran Hariharan Qianhui Qu Lubna Ghani Manabendra Das Anne Grethen Bernadette Byrne Georgios Skiniotis Sandro Keller Claus J Loland Lan Guan Brian K Kobilka Pil Seok Chae

Chemistry 2019 Sep 5;25(49):11545-11554. Epub 2019 Aug 5.

Department of Bionanotechnology, Hanyang University, Ansan, 15588, Korea.

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September 2019

Conformational transitions of a neurotensin receptor 1-G complex.

Authors:
Hideaki E Kato Yan Zhang Hongli Hu Carl-Mikael Suomivuori Francois Marie Ngako Kadji Junken Aoki Kaavya Krishna Kumar Rasmus Fonseca Daniel Hilger Weijiao Huang Naomi R Latorraca Asuka Inoue Ron O Dror Brian K Kobilka Georgios Skiniotis

Nature 2019 08 26;572(7767):80-85. Epub 2019 Jun 26.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

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August 2019

Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.

Authors:
Shoji Maeda Qianhui Qu Michael J Robertson Georgios Skiniotis Brian K Kobilka

Science 2019 05;364(6440):552-557

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

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May 2019

Author Correction: Structural insights into the activation of metabotropic glutamate receptors.

Authors:
Antoine Koehl Hongli Hu Dan Feng Bingfa Sun Yan Zhang Michael J Robertson Matthew Chu Tong Sun Kobilka Toon Laeremans Jan Steyaert Jeffrey Tarrasch Somnath Dutta Rasmus Fonseca William I Weis Jesper M Mathiesen Georgios Skiniotis Brian K Kobilka

Nature 2019 Mar;567(7747):E10

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

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March 2019

Structural insights into the activation of metabotropic glutamate receptors.

Authors:
Antoine Koehl Hongli Hu Dan Feng Bingfa Sun Yan Zhang Michael J Robertson Matthew Chu Tong Sun Kobilka Toon Laeremans Jan Steyaert Jeffrey Tarrasch Somnath Dutta Rasmus Fonseca William I Weis Jesper M Mathiesen Georgios Skiniotis Brian K Kobilka

Nature 2019 02 23;566(7742):79-84. Epub 2019 Jan 23.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

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February 2019

Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.

Authors:
Kaavya Krishna Kumar Moran Shalev-Benami Michael J Robertson Hongli Hu Samuel D Banister Scott A Hollingsworth Naomi R Latorraca Hideaki E Kato Daniel Hilger Shoji Maeda William I Weis David L Farrens Ron O Dror Sanjay V Malhotra Brian K Kobilka Georgios Skiniotis

Cell 2019 01 10;176(3):448-458.e12. Epub 2019 Jan 10.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA; Department of Structural Biology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA; Department of Photon Science, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA. Electronic address:

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January 2019

De novo computational RNA modeling into cryo-EM maps of large ribonucleoprotein complexes.

Authors:
Kalli Kappel Shiheng Liu Kevin P Larsen Georgios Skiniotis Elisabetta Viani Puglisi Joseph D Puglisi Z Hong Zhou Rui Zhao Rhiju Das

Nat Methods 2018 11 30;15(11):947-954. Epub 2018 Oct 30.

Biophysics Program, Stanford University, Stanford, CA, USA.

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November 2018

Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation.

Authors:
John Faissal Haddad Yidai Yang Yoh-Hei Takahashi Monika Joshi Nidhi Chaudhary Ashley R Woodfin Aissa Benyoucef Sylvain Yeung Joseph S Brunzelle Georgios Skiniotis Marjorie Brand Ali Shilatifard Jean-François Couture

Structure 2018 12 27;26(12):1594-1603.e4. Epub 2018 Sep 27.

Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Roger Guindon Hall, Ottawa, ON K1H 8M5, Canada. Electronic address:

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December 2018