George Thanassoulis

George Thanassoulis

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George Thanassoulis

Publications by authors named "George Thanassoulis"

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The spectrum of type III hyperlipoproteinemia.

J Clin Lipidol 2018 Nov - Dec;12(6):1383-1389. Epub 2018 Sep 14.

Centre Hospitalier de l'Universite Laval, Quebec, Quebec, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S19332874183040
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http://dx.doi.org/10.1016/j.jacl.2018.09.006DOI Listing
October 2019

Mortality Benefit of Alirocumab: A Bayesian Perspective.

J Am Heart Assoc 2019 Oct 10;8(20):e013170. Epub 2019 Oct 10.

McGill University Health Center Montreal Canada.

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http://dx.doi.org/10.1161/JAHA.119.013170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818032PMC
October 2019

Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review.

JAMA Cardiol 2019 Oct 23. Epub 2019 Oct 23.

Centre for Naturally Randomized Trials, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1001/jamacardio.2019.3780DOI Listing
October 2019

Trajectories of Non-HDL Cholesterol Across Midlife: Implications for Cardiovascular Prevention.

J Am Coll Cardiol 2019 Jul;74(1):70-79

Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.jacc.2019.04.047DOI Listing
July 2019

Using Genetics to Plan Future Randomized Trials of Lipoprotein(a) Lowering-How Much Reduction, for How Long, and in Whom?

JAMA Cardiol 2019 Jun;4(6):513-514

Preventive and Genomic Cardiology, McGill University Health Center and Research Institute, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1001/jamacardio.2019.1107DOI Listing
June 2019

Biomarkers of mineral metabolism and progression of aortic valve and mitral annular calcification: The Multi-Ethnic Study of Atherosclerosis.

Atherosclerosis 2019 Jun 13;285:79-86. Epub 2019 Apr 13.

Cardiology Section, San Francisco Veterans Affairs Health Care System and Departments of Medicine, Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.04.215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536341PMC
June 2019

The 2018 ACC/AHA Lipid Guidelines: A Little More or Less Canadian?

Can J Cardiol 2019 May 19;35(5):558-563. Epub 2019 Mar 19.

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1016/j.cjca.2019.03.003DOI Listing
May 2019

ApoB.

Circ Res 2019 May;124(10):1425-1427

From the Department of Medicine, McGill University, Montreal, Quebec, Canada (A.D.S., G.T.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315019DOI Listing
May 2019

Risk factors for valvular calcification.

Curr Opin Endocrinol Diabetes Obes 2019 Apr;26(2):96-102

Division of Experimental Medicine, McGill University.

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http://dx.doi.org/10.1097/MED.0000000000000471DOI Listing
April 2019

Subsequent Event Risk in Individuals With Established Coronary Heart Disease.

Authors:
Riyaz S Patel Vinicius Tragante Amand F Schmidt Raymond O McCubrey Michael V Holmes Laurence J Howe Kenan Direk Axel Åkerblom Karin Leander Salim S Virani Karol A Kaminski Jochen D Muehlschlegel Hooman Allayee Peter Almgren Maris Alver Ekaterina V Baranova Hassan Behloui Bram Boeckx Peter S Braund Lutz P Breitling Graciela Delgado Nubia E Duarte Marie-Pierre Dubé Line Dufresne Niclas Eriksson Luisa Foco Markus Scholz Crystel M Gijsberts Charlotte Glinge Yan Gong Jaana Hartiala Mahyar Heydarpour Jaroslav A Hubacek Marcus Kleber Daniel Kofink Salma Kotti Pekka Kuukasjärvi Vei-Vei Lee Andreas Leiherer Petra A Lenzini Daniel Levin Leo-Pekka Lyytikäinen Nicola Martinelli Ute Mons Christopher P Nelson Kjell Nikus Anna P Pilbrow Rafal Ploski Yan V Sun Michael W T Tanck W H Wilson Tang Stella Trompet Sander W van der Laan Jessica Van Setten Ragnar O Vilmundarson Chiara Viviani Anselmi Efthymia Vlachopoulou Lawien Al Ali Eric Boerwinkle Carlo Briguori John F Carlquist Kathryn F Carruthers Gavino Casu John Deanfield Panos Deloukas Frank Dudbridge Thomas Engstrøm Natalie Fitzpatrick Kim Fox Bruna Gigante Stefan James Marja-Liisa Lokki Paulo A Lotufo Nicola Marziliano Ify R Mordi Joseph B Muhlestein Christopher Newton-Cheh Jan Pitha Christoph H Saely Ayman Samman-Tahhan Pratik B Sandesara Andrej Teren Adam Timmis Frans Van de Werf Els Wauters Arthur A M Wilde Ian Ford David J Stott Ale Algra Maria G Andreassi Diego Ardissino Benoit J Arsenault Christie M Ballantyne Thomas O Bergmeijer Connie R Bezzina Simon C Body Eric H Boersma Peter Bogaty Michiel L Bots Hermann Brenner Jasper J Brugts Ralph Burkhardt Clara Carpeggiani Gianluigi Condorelli Rhonda M Cooper-DeHoff Sharon Cresci Nicolas Danchin Ulf de Faire Robert N Doughty Heinz Drexel James C Engert Keith A A Fox Domenico Girelli Diederick E Grobbee Emil Hagström Stanley L Hazen Claes Held Harry Hemingway Imo E Hoefer G Kees Hovingh Reza Jabbari Julie A Johnson J Wouter Jukema Marcin P Kaczor Mika Kähönen Jiri Kettner Marek Kiliszek Olaf H Klungel Bo Lagerqvist Diether Lambrechts Jari O Laurikka Terho Lehtimäki Daniel Lindholm B K Mahmoodi Anke H Maitland-van der Zee Ruth McPherson Olle Melander Andres Metspalu Anna Niemcunowicz-Janica Oliviero Olivieri Grzegorz Opolski Colin N Palmer Gerard Pasterkamp Carl J Pepine Alexandre C Pereira Louise Pilote Arshed A Quyyumi A Mark Richards Marek Sanak Agneta Siegbahn Tabassome Simon Juha Sinisalo J Gustav Smith John A Spertus Steen Stender Alexandre F R Stewart Wojciech Szczeklik Anna Szpakowicz Jean-Claude Tardif Jurriën M Ten Berg Jacob Tfelt-Hansen George Thanassoulis Joachim Thiery Christian Torp-Pedersen Yolanda van der Graaf Frank L J Visseren Johannes Waltenberger Peter E Weeke Pim Van der Harst Chim C Lang Naveed Sattar Vicky A Cameron Jeffrey L Anderson James M Brophy Guillaume Pare Benjamin D Horne Winfried März Lars Wallentin Nilesh J Samani Aroon D Hingorani Folkert W Asselbergs

Circ Genom Precis Med 2019 Apr 21;12(4):e002470. Epub 2019 Mar 21.

Institute of Health Informatics (N.F., A. Timmis, H.H., F.W.A.), Faculty of Population Health Science, University College London, United Kingdom.

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http://dx.doi.org/10.1161/CIRCGEN.119.002470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629546PMC
April 2019

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events.

Authors:
Riyaz S Patel Amand F Schmidt Vinicius Tragante Raymond O McCubrey Michael V Holmes Laurence J Howe Kenan Direk Axel Åkerblom Karin Leander Salim S Virani Karol A Kaminski Jochen D Muehlschlegel Marie-Pierre Dubé Hooman Allayee Peter Almgren Maris Alver Ekaterina V Baranova Hassan Behlouli Bram Boeckx Peter S Braund Lutz P Breitling Graciela Delgado Nubia E Duarte Line Dufresne Niclas Eriksson Luisa Foco Crystel M Gijsberts Yan Gong Jaana Hartiala Mahyar Heydarpour Jaroslav A Hubacek Marcus Kleber Daniel Kofink Pekka Kuukasjärvi Vei-Vei Lee Andreas Leiherer Petra A Lenzini Daniel Levin Leo-Pekka Lyytikäinen Nicola Martinelli Ute Mons Christopher P Nelson Kjell Nikus Anna P Pilbrow Rafal Ploski Yan V Sun Michael W T Tanck W H Wilson Tang Stella Trompet Sander W van der Laan Jessica van Setten Ragnar O Vilmundarson Chiara Viviani Anselmi Efthymia Vlachopoulou Eric Boerwinkle Carlo Briguori John F Carlquist Kathryn F Carruthers Gavino Casu John Deanfield Panos Deloukas Frank Dudbridge Natalie Fitzpatrick Bruna Gigante Stefan James Marja-Liisa Lokki Paulo A Lotufo Nicola Marziliano Ify R Mordi Joseph B Muhlestein Chris Newton Cheh Jan Pitha Christoph H Saely Ayman Samman-Tahhan Pratik B Sandesara Andrej Teren Adam Timmis Frans Van de Werf Els Wauters Arthur A M Wilde Ian Ford David J Stott Ale Algra Maria G Andreassi Diego Ardissino Benoit J Arsenault Christie M Ballantyne Thomas O Bergmeijer Connie R Bezzina Simon C Body Peter Bogaty Gert J de Borst Hermann Brenner Ralph Burkhardt Clara Carpeggiani Gianluigi Condorelli Rhonda M Cooper-DeHoff Sharon Cresci Ulf de Faire Robert N Doughty Heinz Drexel James C Engert Keith A A Fox Domenico Girelli Emil Hagström Stanley L Hazen Claes Held Harry Hemingway Imo E Hoefer G Kees Hovingh Julie A Johnson Pim A de Jong J Wouter Jukema Marcin P Kaczor Mika Kähönen Jiri Kettner Marek Kiliszek Olaf H Klungel Bo Lagerqvist Diether Lambrechts Jari O Laurikka Terho Lehtimäki Daniel Lindholm Bakhtawar K Mahmoodi Anke H Maitland-van der Zee Ruth McPherson Olle Melander Andres Metspalu Witold Pepinski Oliviero Olivieri Grzegorz Opolski Colin N Palmer Gerard Pasterkamp Carl J Pepine Alexandre C Pereira Louise Pilote Arshed A Quyyumi A Mark Richards Marek Sanak Markus Scholz Agneta Siegbahn Juha Sinisalo J Gustav Smith John A Spertus Alexandre F R Stewart Wojciech Szczeklik Anna Szpakowicz Jurriën M Ten Berg George Thanassoulis Joachim Thiery Yolanda van der Graaf Frank L J Visseren Johannes Waltenberger Pim Van der Harst Jean-Claude Tardif Naveed Sattar Chim C Lang Guillaume Pare James M Brophy Jeffrey L Anderson Winfried März Lars Wallentin Vicky A Cameron Benjamin D Horne Nilesh J Samani Aroon D Hingorani Folkert W Asselbergs

Circ Genom Precis Med 2019 Apr 21;12(4):e002471. Epub 2019 Mar 21.

Institute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.).

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http://dx.doi.org/10.1161/CIRCGEN.119.002471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625876PMC
April 2019

LPA genotype is associated with premature cardiovascular disease in familial hypercholesterolemia.

J Clin Lipidol 2019 Jul - Aug;13(4):627-633.e1. Epub 2019 Apr 23.

Lipids, Nutrition and Cardiovascular Prevention Clinic of the Montreal Clinical Research Institute, Québec, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, Québec, Canada; Division of Medical Biochemistry, Department of Medicine, McGill University, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2019.04.006DOI Listing
April 2019

Race-Based Differences in Lipoprotein(a)-Associated Risk of Carotid Atherosclerosis.

Arterioscler Thromb Vasc Biol 2019 Mar;39(3):523-529

From the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (B.T.S., A.B.K., M.Y.T.).

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http://dx.doi.org/10.1161/ATVBAHA.118.312267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393189PMC
March 2019

Screening for High Lipoprotein(a).

Circulation 2019 Mar;139(12):1493-1496

Preventive and Genomic Cardiology, McGill University Health Center and Research Institute, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.038989DOI Listing
March 2019

Sick Individuals and Sick Populations by Geoffrey Rose: Cardiovascular Prevention Updated.

J Am Heart Assoc 2018 10;7(19):e010049

4 Duke Clinical Research Institute Duke University School of Medicine Durham NC.

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http://dx.doi.org/10.1161/JAHA.118.010049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404899PMC
October 2018

Precision Medicine for Prosthetic Valve Deterioration: A Glimpse Into the Future?

J Am Coll Cardiol 2018 07 9;72(3):252-254. Epub 2018 Jul 9.

Preventive and Genomic Cardiology, McGill University Health Center, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.04.065DOI Listing
July 2018

Selection Bias in Cardiology Research: Another Thing to Worry About (and How to Correct for It).

Can J Cardiol 2018 06 23;34(6):705-708. Epub 2018 Mar 23.

Preventive and Genomic Cardiology, Division of Cardiology, McGill University Health Centre and Research Institute, Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2018.03.010DOI Listing
June 2018

Pathological significance of lipoprotein(a) in aortic valve stenosis.

Atherosclerosis 2018 05 15;272:168-174. Epub 2018 Mar 15.

Divisions of Cardiology and Cardiac Surgery, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, Quebec, H4A 3J1, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00219150183015
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http://dx.doi.org/10.1016/j.atherosclerosis.2018.03.025DOI Listing
May 2018

Observational and Genetic Associations of Resting Heart Rate With Aortic Valve Calcium.

Am J Cardiol 2018 05 13;121(10):1246-1252. Epub 2018 Feb 13.

Division of Intramural Research, National Heart Lung and Blood Institute (NHLBI) and NHLBI Framingham Heart Study, Framingham Massachusetts; Cardiology Section, Boston Veterans Administration Healthcare System, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2018.01.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788291PMC
May 2018

Assessment and Management of the Left Atrial Appendage Thrombus in Patients With Nonvalvular Atrial Fibrillation.

Can J Cardiol 2018 03 15;34(3):252-261. Epub 2017 Dec 15.

McGill University Health Centre, Montreal, Quebec, Canada; Research Institute of McGill University Health Centre, Montreal, Quebec, Canada; Hôpital Sacré-Coeur de Montréal, Montreal, Quebec, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X173121
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http://dx.doi.org/10.1016/j.cjca.2017.12.008DOI Listing
March 2018

Genetic Risk Prediction for Primary and Secondary Prevention of Atherosclerotic Cardiovascular Disease: an Update.

Curr Cardiol Rep 2018 03 24;20(5):36. Epub 2018 Mar 24.

Division of Cardiology, Preventive and Genomic Cardiology, McGill University Health Center, 1001 Boulevard Decarie, Montreal, QC, H4A 3J1, Canada.

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http://dx.doi.org/10.1007/s11886-018-0980-0DOI Listing
March 2018

Evaluation of the Pleiotropic Effects of Statins: A Reanalysis of the Randomized Trial Evidence Using Egger Regression-Brief Report.

Arterioscler Thromb Vasc Biol 2018 01 9;38(1):262-265. Epub 2017 Nov 9.

From the Preventive and Genomic Cardiology, Division of Cardiology, McGill University Health Centre and Research Institute, Montreal, QC, Canada (C.L., J.M.B., A.D.S., G.T.); Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada (J.M.B.); and MRC Integrative Epidemiology Unit, University of Bristol, United Kingdom (G.D.S.).

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http://dx.doi.org/10.1161/ATVBAHA.117.310052DOI Listing
January 2018

The Benefit Model for Prevention of Cardiovascular Disease: An Opportunity to Harmonize Guidelines.

JAMA Cardiol 2017 11;2(11):1175-1176

Royal Victoria Hospital-McGill University Health Centre, McGill University, Montreal, Québec, Canada.

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http://cardiology.jamanetwork.com/article.aspx?doi=10.1001/j
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http://dx.doi.org/10.1001/jamacardio.2017.2543DOI Listing
November 2017

Impact of Heart Outcomes Prevention Evaluation Trial on Statin Eligibility for the Primary Prevention of Cardiovascular Disease: Insights from the National Health and Nutrition Examination Survey.

Circulation 2017 11;136(19):1860-1862

From McGill University, Montreal, Canada (B.B.); KenAnCo Biostatistics, San Antonio, TX (K.K.A., K.W.); Baim Institute for Clinical Research, Boston, MA (C.P.C.); Duke Clinical Research Institute, Durham, NC (M.J.P.); and Preventive and Genomic Cardiology, Department of Medicine, McGill University Health Centre and Research Institute, Montreal, Canada (A.D.S., G.T.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.029102DOI Listing
November 2017

An evidence-based analysis of the National Lipid Association recommendations concerning non-HDL-C and apoB.

J Clin Lipidol 2016 Sep-Oct;10(5):1248-58. Epub 2016 Aug 2.

Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1016/j.jacl.2016.07.008DOI Listing
October 2017

Case of Reversible Complete Heart Block.

Am J Med 2017 Aug 24;130(8):e335-e336. Epub 2017 Mar 24.

Department of Cardiology, McGill University Health Centre, Montreal, Quebec, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00029343173024
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http://dx.doi.org/10.1016/j.amjmed.2017.02.022DOI Listing
August 2017

Lipoprotein(a) Induces Human Aortic Valve Interstitial Cell Calcification.

JACC Basic Transl Sci 2017 Aug 28;2(4):358-371. Epub 2017 Aug 28.

Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.jacbts.2017.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034440PMC
August 2017

Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study.

Authors:
Stephen Zewinger Marcus E Kleber Vinicius Tragante Raymond O McCubrey Amand F Schmidt Kenan Direk Ulrich Laufs Christian Werner Wolfgang Koenig Dietrich Rothenbacher Ute Mons Lutz P Breitling Herrmann Brenner Richard T Jennings Ioannis Petrakis Sarah Triem Mira Klug Alexandra Filips Stefan Blankenberg Christoph Waldeyer Christoph Sinning Renate B Schnabel Karl J Lackner Efthymia Vlachopoulou Ottar Nygård Gard Frodahl Tveitevåg Svingen Eva Ringdal Pedersen Grethe S Tell Juha Sinisalo Markku S Nieminen Reijo Laaksonen Stella Trompet Roelof A J Smit Naveed Sattar J Wouter Jukema Heinrich V Groesdonk Graciela Delgado Tatjana Stojakovic Anna P Pilbrow Vicky A Cameron A Mark Richards Robert N Doughty Yan Gong Rhonda Cooper-DeHoff Julie Johnson Markus Scholz Frank Beutner Joachim Thiery J Gustav Smith Ragnar O Vilmundarson Ruth McPherson Alexandre F R Stewart Sharon Cresci Petra A Lenzini John A Spertus Oliviero Olivieri Domenico Girelli Nicola I Martinelli Andreas Leiherer Christoph H Saely Heinz Drexel Axel Mündlein Peter S Braund Christopher P Nelson Nilesh J Samani Daniel Kofink Imo E Hoefer Gerard Pasterkamp Arshed A Quyyumi Yi-An Ko Jaana A Hartiala Hooman Allayee W H Wilson Tang Stanley L Hazen Niclas Eriksson Claes Held Emil Hagström Lars Wallentin Axel Åkerblom Agneta Siegbahn Igor Karp Christopher Labos Louise Pilote James C Engert James M Brophy George Thanassoulis Peter Bogaty Wojciech Szczeklik Marcin Kaczor Marek Sanak Salim S Virani Christie M Ballantyne Vei-Vei Lee Eric Boerwinkle Michael V Holmes Benjamin D Horne Aroon Hingorani Folkert W Asselbergs Riyaz S Patel Bernhard K Krämer Hubert Scharnagl Danilo Fliser Winfried März Thimoteus Speer

Lancet Diabetes Endocrinol 2017 07 26;5(7):534-543. Epub 2017 May 26.

Department of Internal Medicine IV, Saarland University Hospital, Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/S2213-8587(17)30096-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651679PMC
July 2017

Fractional Flow Reserve–Guided Multivessel Angioplasty in Myocardial Infarction.

N Engl J Med 2017 07;377(4):396-7

McGill University Health Centre, Montreal, QC, Canada

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http://dx.doi.org/10.1056/NEJMc1706275DOI Listing
July 2017

Recovery in Patients With Dilated Cardiomyopathy With Loss-of-Function Mutations in the Titin Gene.

JAMA Cardiol 2017 06;2(6):700-702

Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada3Division of Cardiology, Department of Medicine, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada6Department of Human Genetics, McGill University, Montreal, Quebec, Canada7Preventive and Genomic Cardiology, McGill University Health Center, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1001/jamacardio.2017.0763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815020PMC
June 2017

Association of Triglyceride-Related Genetic Variants With Mitral Annular Calcification.

J Am Coll Cardiol 2017 Jun;69(24):2941-2948

Department of Medicine, McGill University, Montreal, Quebec, Canada; Preventive and Genomic Cardiology, McGill University Health Center and Research Institute, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.04.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538134PMC
June 2017

Statins, PCSK9 inhibitors and cholesterol homeostasis: a view from within the hepatocyte.

Clin Sci (Lond) 2017 May;131(9):791-797

Lipid Disorders Clinic, Department of Cardiology, Royal Perth Hospital, School of Medicine, University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1042/CS20160872DOI Listing
May 2017

Lipoprotein(a): new insights from modern genomics.

Curr Opin Lipidol 2017 Apr;28(2):170-176

aDepartment of Medicine, McGill University bPreventive and Genomic Cardiology, McGill University Health Center and Research Institute cDepartment of Clinical Epidemiology, McGill University Health Center, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1097/MOL.0000000000000392DOI Listing
April 2017

A Replicated, Genome-Wide Significant Association of Aortic Stenosis With a Genetic Variant for Lipoprotein(a): Meta-Analysis of Published and Novel Data.

Circulation 2017 03;135(12):1181-1183

From Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (B.J.C., R.C.T., J.G.); British Heart Foundation Centre of Research Excellence, University of Oxford, United Kingdom (B.J.C.); Kolling Institute, University of Sydney, Australia (S.C.); Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (S.C.); Guy's and St Thomas' Hospitals, London, United Kingdom (B.P.); Department of Medicine, McGill University, Montreal, QC, Canada (J.C.E., G.T.); McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada (M.L.); Preventive and Genomic Cardiology, McGill University Health Centre and Research Institute, Montreal, QC, Canada (G.T.); and Clinical Trial Service Unit and Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom (R.C.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.026103DOI Listing
March 2017

Sex Differences in Clinical Outcomes After Premature Acute Coronary Syndrome.

Can J Cardiol 2016 12 26;32(12):1447-1453. Epub 2016 Sep 26.

Divisions of Clinical Epidemiology and General Internal Medicine, The Research Institute of the McGill University Health Centre, Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2016.05.018DOI Listing
December 2016

Estimating the Population Impact of Lp(a) Lowering on the Incidence of Myocardial Infarction and Aortic Stenosis-Brief Report.

Arterioscler Thromb Vasc Biol 2016 Dec 20;36(12):2421-2423. Epub 2016 Oct 20.

From the Department of Medicine, McGill University, Montreal, Québec, Canada (M.A., A.D.S., G.T.); Preventive and Genomic Cardiology, McGill University Health Center and Research Institute, Montreal, Québec, Canada (M.A., A.D.S., G.T.); Department of Clinical Biochemistry and The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark (P.R.K., B.G.N.); KenAnCo Biostatistics, San Antonio, TX (K.W.); Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (B.G.N.); The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Denmark (B.G.N.); and Department of Clinical Epidemiology, McGill University Health Center, Montreal, Québec, Canada (G.T.).

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http://dx.doi.org/10.1161/ATVBAHA.116.308271DOI Listing
December 2016

Variants in ANGPTL4 and the Risk of Coronary Artery Disease.

N Engl J Med 2016 12;375(23):2304

McGill University Health Centre, Montreal, QC, Canada

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http://dx.doi.org/10.1056/NEJMc1607380DOI Listing
December 2016

Potential factors associated with fruit and vegetable intake after premature acute coronary syndrome: a prospective cohort study.

Int J Food Sci Nutr 2015 3;66(8):943-9. Epub 2015 Nov 3.

b Division of Clinical Epidemiology , Research Institute of McGill University Health Centre , Montreal , Quebec , Canada .

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http://dx.doi.org/10.3109/09637486.2015.1102873DOI Listing
September 2016

Risk of Premature Cardiovascular Disease vs the Number of Premature Cardiovascular Events.

JAMA Cardiol 2016 07;1(4):492-4

Department of Biostatistics and Bioinformatics, Duke Clinical Research Institute, Duke University, Durham, North Carolina.

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http://dx.doi.org/10.1001/jamacardio.2016.0991DOI Listing
July 2016

Lipoprotein (a) in calcific aortic valve disease: from genomics to novel drug target for aortic stenosis.

J Lipid Res 2016 06 18;57(6):917-24. Epub 2015 Dec 18.

Preventive and Genomic Cardiology, McGill University Health Center and Research Institute and Department of Medicine, McGill University, Montreal, QC, Canada

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http://dx.doi.org/10.1194/jlr.R051870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878194PMC
June 2016

Association Between Family History, a Genetic Risk Score, and Severity of Coronary Artery Disease in Patients With Premature Acute Coronary Syndromes.

Arterioscler Thromb Vasc Biol 2016 06 21;36(6):1286-92. Epub 2016 Apr 21.

From the Department of Medicine, McGill University, Montreal, Québec, Canada (W.H., L.P., C.L., J.C.E., G.T.); Department of Medicine, University of Toronto, Toronto, Ontario, Canada (A.C., H.A.-L.); and McGill University Health Center Research Institute, Montreal, QC, Canada (L.D., J.C.E.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.115.306944
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http://dx.doi.org/10.1161/ATVBAHA.115.306944DOI Listing
June 2016

Lipoprotein(a) Levels Are Associated With Subclinical Calcific Aortic Valve Disease in White and Black Individuals: The Multi-Ethnic Study of Atherosclerosis.

Arterioscler Thromb Vasc Biol 2016 05 3;36(5):1003-9. Epub 2016 Mar 3.

From the Department of Laboratory Medicine and Pathology (J.C., B.T.S., M.Y.T.), Division of Biostatistics, School of Public Health (W.G.), University of Minnesota, Minneapolis; Department of Medicine, University of California, Los Angeles (M.B.); Department of Medicine, John Hopkins University, Baltimore, MD (W.S.P.); Department of Medicine, McGill University, Montreal, Québec, Canada (G.T.); Division of Nephrology, Kidney Research Institute, University of Washington, Seattle (B.K.); and Health Diagnostics Laboratory, Richmond, VA (J.P.M., R.W.).

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http://dx.doi.org/10.1161/ATVBAHA.115.306683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850093PMC
May 2016

Genetic loci associated with ideal cardiovascular health: A meta-analysis of genome-wide association studies.

Am Heart J 2016 May 23;175:112-20. Epub 2016 Jan 23.

Division of Intramural Research, National Heart, Lung and Blood Institute (NHLBI), Framingham, MA; NHLBI's Framingham Heart Study, Framingham, MA; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1016/j.ahj.2015.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873714PMC
May 2016

Individualized Statin Benefit for Determining Statin Eligibility in the Primary Prevention of Cardiovascular Disease.

Circulation 2016 Apr 4;133(16):1574-81. Epub 2016 Mar 4.

From Preventive and Genomic Cardiology, Department of Medicine, McGill University Health Center and Research Institute, Montreal, QC, Canada (G.T., A.D.S.); KenAnCo Biostatistics, San Antonio, TX (K.W., K.K.); Department of Medicine, University of Texas Health Science Center at San Antonio (K.W.); Duke Clinical Research Institute, Durham, NC (M.J.P.); and Harvard Clinical Research Institute and Brigham and Women's Hospital, Boston, MA (C.P.C.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.018383DOI Listing
April 2016

Lipoprotein(a) Interactions With Low-Density Lipoprotein Cholesterol and Other Cardiovascular Risk Factors in Premature Acute Coronary Syndrome (ACS).

J Am Heart Assoc 2016 04 23;5(4). Epub 2016 Apr 23.

Department of Medicine, McGill University, Montreal, Quebec, Canada Preventive and Genomic Cardiology, McGill University Health Center and Research Institute, Montreal, Quebec, Canada Department of Clinical Epidemiology, McGill University Health Center, Montreal, Quebec, Canada

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http://dx.doi.org/10.1161/JAHA.115.003012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859285PMC
April 2016

Sex Versus Gender-Related Characteristics: Which Predicts Outcome After Acute Coronary Syndrome in the Young?

J Am Coll Cardiol 2016 Jan;67(2):127-135

Divisions of General Internal Medicine and of Clinical Epidemiology, Department of Medicine, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada; Division of Internal Medicine, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2015.10.067DOI Listing
January 2016

The Risk-Benefit Paradigm vs the Causal Exposure Paradigm: LDL as a primary cause of vascular disease.

J Clin Lipidol 2014 Nov-Dec;8(6):594-605. Epub 2014 Aug 30.

Department of Medicine, Royal Victoria Hospital, McGill University Health Centre, Montreal, QC, Canada.

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http://dx.doi.org/10.1016/j.jacl.2014.08.004DOI Listing
September 2015

Is the Guideline Process Replicable and, if Not, What Does This Mean?

Prog Cardiovasc Dis 2015 Jul-Aug;58(1):3-9. Epub 2015 May 7.

Preventive and Genomic Cardiology, Department of Medicine, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.pcad.2015.05.002DOI Listing
September 2015

Pericardial fat and atrial fibrillation: Epidemiology, mechanisms and interventions.

Int J Cardiol 2015 Sep 21;195:98-103. Epub 2015 May 21.

Department of Medicine, Division of Cardiology, McGill University Health Center, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2015.05.129DOI Listing
September 2015

Placing HPS2-THRIVE in context using Bayesian analysis.

Int J Cardiol 2015 Sep 29;195:203-4. Epub 2015 May 29.

McGill University Health Center, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.ijcard.2015.05.156DOI Listing
September 2015

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study.

PLoS Med 2015 Aug 25;12(8):e1001866. Epub 2015 Aug 25.

Centre for Clinical Epidemiology, Department of Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Department of Human Genetics, McGill University, Montreal, Quebec, Canada; Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.1001866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549308PMC
August 2015

Limitations in the conventional assessment of the incremental value of predictors of cardiovascular risk.

Curr Opin Lipidol 2015 Jun;26(3):210-4

aMike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, Quebec, Canada bDepartment of Biostatistics and Bioinformatics, Duke University, DCRI, Durham, North Carolina, USA cDepartment of Medicine, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1097/MOL.0000000000000181DOI Listing
June 2015

A Systematic Review on the Progression of Paroxysmal to Persistent Atrial Fibrillation: Shedding New Light on the Effects of Catheter Ablation.

JACC Clin Electrophysiol 2015 Jun 13;1(3):105-115. Epub 2015 May 13.

McGill University Health Center, Montreal, Quebec, Canada; Hôpital Sacré-Coeur de Montréal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.jacep.2015.04.010DOI Listing
June 2015

Screening Strategies and Primary Prevention Interventions in Relatives of People With Coronary Artery Disease: A Systematic Review and Meta-analysis.

Can J Cardiol 2015 May 20;31(5):649-57. Epub 2015 Feb 20.

Department of Medicine, Division of Cardiology, McGill University Health Centre, Montreal, Québec, Canada; Preventive and Genomic Cardiology, McGill University Health Centre, Montreal, Québec, Canada; The Research Institute of the McGill University Health Centre, McGill University Health Centre, Montreal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2015.02.019DOI Listing
May 2015

A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease.

Nat Commun 2015 May 28;6:7060. Epub 2015 May 28.

1] Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, Quebec H3A 0G4, Canada [2] Department of Medicine, McGill University, Montreal, Quebec H3A 0G4, Canada [3] Department of Human Genetics, McGill University, Montréal, Québec H3A 0G4, Canada [4] Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.

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http://dx.doi.org/10.1038/ncomms8060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458864PMC
May 2015

A systematic review and meta-analysis of the association between implantable cardioverter-defibrillator shocks and long-term mortality.

Can J Cardiol 2015 Mar 26;31(3):270-7. Epub 2014 Nov 26.

McGill University Health Center, Montréal, Québec, Canada; Hôpital Sacré-Cœur de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1016/j.cjca.2014.11.023DOI Listing
March 2015

Mendelian randomisation applied to drug development in cardiovascular disease: a review.

J Med Genet 2015 Feb 16;52(2):71-9. Epub 2014 Dec 16.

Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada Department of Medicine, McGill University, Montreal, Canada Department of Twin Research, King's College London, London, UK.

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http://dx.doi.org/10.1136/jmedgenet-2014-102438DOI Listing
February 2015

Fish consumption and acute coronary syndrome: a meta-analysis.

Am J Med 2014 Sep 4;127(9):848-57.e2. Epub 2014 May 4.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Division of Clinical Epidemiology, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada; Division of General Internal Medicine, McGill University Health Centre, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2014.04.016DOI Listing
September 2014

Taking a longer term view of cardiovascular risk: the causal exposure paradigm.

BMJ 2014 May 21;348:g3047. Epub 2014 May 21.

Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1136/bmj.g3047DOI Listing
May 2014

Relations of change in plasma levels of LDL-C, non-HDL-C and apoB with risk reduction from statin therapy: a meta-analysis of randomized trials.

J Am Heart Assoc 2014 Apr 14;3(2):e000759. Epub 2014 Apr 14.

Preventive and Genomic Cardiology, McGill University Health Centre, Department of Medicine, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1161/JAHA.113.000759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187506PMC
April 2014

Review of published cases of adverse cardiovascular events after ingestion of energy drinks.

Am J Cardiol 2014 Jan 4;113(1):168-72. Epub 2013 Oct 4.

Center for Preventive and Genomic Cardiology, Divisions of Cardiology and Clinical Epidemiology, Department of Medicine, McGill University Health Centre, Montreal, Canada.

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http://dx.doi.org/10.1016/j.amjcard.2013.08.058DOI Listing
January 2014

Sex- and gender-related risk factor burden in patients with premature acute coronary syndrome.

Can J Cardiol 2014 Jan 13;30(1):109-17. Epub 2013 Nov 13.

Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Québec, Canada; Division of General Internal Medicine, McGill University Health Centre, Montreal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2013.07.674DOI Listing
January 2014

Depression and disease severity in patients with premature acute coronary syndrome.

Am J Med 2014 Jan 16;127(1):87-93.e1-2. Epub 2013 Oct 16.

Division of Clinical Epidemiology, The Research Institute of the McGill University Health Centre, Montréal, Québec, Canada; Division of Internal Medicine, McGill University, Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2013.09.026DOI Listing
January 2014

Counterpoint: statins do reduce fatal events.

J Clin Lipidol 2013 May-Jun;7(3):225-7; discussion 228. Epub 2013 Feb 8.

Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.jacl.2012.12.004DOI Listing
October 2013

Among statin-treated patients, LDL, non-HDL and apoB cholesterol biomarkers were associated with increased risks of cardiovascular events.

Evid Based Med 2013 Apr 14;18(2):73-4. Epub 2012 Aug 14.

Department of Medicine/Cardiology, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1136/eb-2012-100787DOI Listing
April 2013

Do statins lower testosterone and does it matter?

BMC Med 2013 Feb 28;11:58. Epub 2013 Feb 28.

Division of Cardiology, McGill University Health Centre, 687 Pine Avenue West, Montreal, QC H3A 1A1, Canada.

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http://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7
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http://dx.doi.org/10.1186/1741-7015-11-58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621773PMC
February 2013

Mendelian randomization: how genetics is pushing the boundaries of epidemiology to identify new causes of heart disease.

Can J Cardiol 2013 Jan 29;29(1):30-6. Epub 2012 Nov 29.

McGill University Health Centre and Research Institute, Montreal, Quéebec, Canada.

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http://dx.doi.org/10.1016/j.cjca.2012.09.014DOI Listing
January 2013

Comparison of coronary calcium screening versus broad statin therapy for patients at intermediate cardiovascular risk.

Am J Cardiol 2012 Aug 10;110(4):530-3. Epub 2012 May 10.

Division of Cardiology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.amjcard.2012.04.025DOI Listing
August 2012

The causal exposure model of vascular disease.

Clin Sci (Lond) 2012 Apr;122(8):369-73

Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, QC, Canada.

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http://dx.doi.org/10.1042/CS20110449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244267PMC
April 2012

A genetic risk score is associated with incident cardiovascular disease and coronary artery calcium: the Framingham Heart Study.

Circ Cardiovasc Genet 2012 Feb 10;5(1):113-21. Epub 2012 Jan 10.

Division of Cardiology and Clinical Epidemiology, McGill University Health Center and McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1161/CIRCGENETICS.111.961342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292865PMC
February 2012

Genetic cardiovascular risk prediction: will we get there?

Circulation 2010 Nov;122(22):2323-34

Framingham Heart Study, 73 Mt Wayte, #2, Framingham, MA 01702-5803, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.109.909309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075800PMC
November 2010

Prevalence, distribution, and risk factor correlates of high pericardial and intrathoracic fat depots in the Framingham heart study.

Circ Cardiovasc Imaging 2010 Sep 4;3(5):559-66. Epub 2010 Jun 4.

National Institutes of Health/National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, MA, Boston, USA.

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http://dx.doi.org/10.1161/CIRCIMAGING.110.956706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063852PMC
September 2010

Pericardial fat is associated with prevalent atrial fibrillation: the Framingham Heart Study.

Circ Arrhythm Electrophysiol 2010 Aug 17;3(4):345-50. Epub 2010 Jun 17.

Framingham Heart Study, Boston University and the National Institutes of Health/National Heart, Lung, and Blood Institute, 73 Mt. Wayte Ave. No. 2, Framingham, MA 01702, USA.

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http://dx.doi.org/10.1161/CIRCEP.109.912055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953855PMC
August 2010

Gout, allopurinol use, and heart failure outcomes.

Arch Intern Med 2010 Aug;170(15):1358-64

Department of Medicine, McGill University Health Center, 687 Pine Ave W, Room A4.23, Montreal, QC H3A 1A1, Canada.

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http://dx.doi.org/10.1001/archinternmed.2010.198DOI Listing
August 2010