George Tellides

George Tellides

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George Tellides

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Complement activated interferon-γ-primed human endothelium transpresents interleukin-15 to CD8+ T cells.

J Clin Invest 2020 Mar 19. Epub 2020 Mar 19.

Department of Immunobiology, Yale University School of Medicine, New Haven, United States of America.

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http://dx.doi.org/10.1172/JCI135060DOI Listing
March 2020

Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human iPSCs.

Cell Stem Cell 2020 Feb 16;26(2):251-261.e8. Epub 2020 Jan 16.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06511, USA; Yale Stem Cell Center, New Haven, CT 06520, USA; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021512PMC
February 2020

Fas ligand and nitric oxide combination to control smooth muscle growth while sparing endothelium.

Biomaterials 2019 Aug 7;212:28-38. Epub 2019 May 7.

Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Anesthesiology, Yale University, New Haven, CT 06519, USA; Department of Biomedical Engineering, Yale University, New Haven, CT 06519, USA; Yale Stem Cell Center, New Haven, CT 06520, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01429612193027
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http://dx.doi.org/10.1016/j.biomaterials.2019.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567994PMC
August 2019

Complement Membrane Attack Complexes Assemble NLRP3 Inflammasomes Triggering IL-1 Activation of IFN-γ-Primed Human Endothelium.

Circ Res 2019 06 22;124(12):1747-1759. Epub 2019 Apr 22.

Division of Cardiovascular Medicine (C.F., D.J.-w), Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557295PMC
June 2019

Combining in vivo and in vitro biomechanical data reveals key roles of perivascular tethering in central artery function.

PLoS One 2018 7;13(9):e0201379. Epub 2018 Sep 7.

Department of Biomedical Engineering, Yale University, New Haven, CT, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201379PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128471PMC
February 2019

Multimodality Imaging Involving Magnetic Resonance Facilitates Giant Symptomatic Myxoma Resection.

Ann Thorac Surg 2019 01 2;107(1):e15-e17. Epub 2018 Jul 2.

Division of Cardiothoracic Surgery, Department of Surgery, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut; Department of Surgery, Section of Cardiac Surgery, Yale School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1016/j.athoracsur.2018.05.083DOI Listing
January 2019

Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells.

Nat Commun 2018 05 25;9(1):2073. Epub 2018 May 25.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06511, USA.

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http://dx.doi.org/10.1038/s41467-018-04447-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970166PMC
May 2018

Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering.

Biomaterials 2017 Dec 19;147:116-132. Epub 2017 Sep 19.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine Yale School of Medicine, New Haven, CT 06511, USA; Yale Stem Cell Center, New Haven, CT 06520, USA; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638652PMC
December 2017

Further Evidence Supporting a Protective Role of Transforming Growth Factor-β (TGFβ) in Aortic Aneurysm and Dissection.

Authors:
George Tellides

Arterioscler Thromb Vasc Biol 2017 11;37(11):1983-1986

From the Department of Surgery and Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT; and Veterans Affairs Connecticut Healthcare System, West Haven.

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http://dx.doi.org/10.1161/ATVBAHA.117.310031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824991PMC
November 2017

Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix.

Biomaterials 2017 Oct 22;141:63-73. Epub 2017 Jun 22.

Department of Biomedical Engineering, Yale University, United States; Department of Pathology, Yale University School of Medicine, United States. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.06.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918415PMC
October 2017

mTOR (Mechanistic Target of Rapamycin) Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice.

Arterioscler Thromb Vasc Biol 2017 09 27;37(9):1657-1666. Epub 2017 Jul 27.

From the Department of Surgery (Y.J., G.L., Q.L., R.A., L.Q., W.L., A.G., G.T.), Department of Internal Medicine (Y.Q., D.M.G.), and Vascular Biology and Therapeutics Program (Y.Q., D.M.G., A.G., J.D.H., G.T.), Yale University School of Medicine, New Haven, CT; Department of Vascular Surgery, Peking University People's Hospital, Beijing, P. R. China (Y.J., Q.L., W.L.); Department of Biomedical Engineering, Yale University, New Haven, CT (J.D.H.); and Veterans Affairs Connecticut Healthcare System, West Haven (G.T.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574180PMC
September 2017

The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis.

Nat Commun 2017 06 1;8:15426. Epub 2017 Jun 1.

College of Life Sciences, Institute of Genetics and Regenerative Biology, Zhejiang University, Hangzhou, Zhejiang 310058, China.

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http://dx.doi.org/10.1038/ncomms15426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461500PMC
June 2017

Deficient Circumferential Growth Is the Primary Determinant of Aortic Obstruction Attributable to Partial Elastin Deficiency.

Arterioscler Thromb Vasc Biol 2017 05 2;37(5):930-941. Epub 2017 Mar 2.

From the Department of Surgery, Yale University School of Medicine, New Haven, CT (Y.J., G.L., L.Q., Q.L., W.L., G.T.); Department of Vascular Surgery, Peking University People's Hospital, Beijing, People's Republic of China (Y.J., Q.L., W.L.); Department of Vascular Surgery, The First Hospital of China Medical University, Shenyang, People's Republic of China (G.L.); Department of Biomedical Engineering, Yale University, New Haven, CT (A.K., A.W.C., M.R.B., J.D.H.); Department of Cell Biology, Washington University School of Medicine, St Louis, MO (R.P.M.); Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine (J.D.H., G.T.); and Veterans Affairs Connecticut Healthcare System, West Haven (G.T.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501334PMC
May 2017

Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production.

Arterioscler Thromb Vasc Biol 2017 Feb 10;37(2):328-340. Epub 2016 Nov 10.

From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of Internal Medicine (Section of Cardiovascular Medicine), Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (N.C., L.Z., B.D.Y., A.H., S.C., H.V., T.O.Y., K.I., L.Q., L.Q., G.T., K.H., J.M., R.S., H.J.C., M.M.S., J.R.B, A.R.M.); Department of Internal Medicine (Section of Cardiovascular Medicine), Alpert Medical School at Brown University, Providence, RI (A.H., A.R.M.); and Department of Molecular Pathology, Universita Vita Salute School of Medicine, San Raffaele Scientific Institute, Milan, Italy (R.P.).

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http://dx.doi.org/10.1161/ATVBAHA.116.308507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269510PMC
February 2017

Implantable tissue-engineered blood vessels from human induced pluripotent stem cells.

Biomaterials 2016 09 14;102:120-9. Epub 2016 Jun 14.

Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine Yale School of Medicine, New Haven, CT 06520, USA; Yale Stem Cell Center, New Haven, CT 06520, USA; Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939127PMC
September 2016

Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice.

Blood 2016 09 28;128(12):1642-50. Epub 2016 Jul 28.

Department of Biomedical Engineering, School of Engineering and Applied Science, Department of Pathology, and.

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http://dx.doi.org/10.1182/blood-2016-03-702845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034742PMC
September 2016

Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGFβ)-dependent smooth muscle cell phenotype modulation.

Sci Rep 2016 09 16;6:33407. Epub 2016 Sep 16.

Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/srep33407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025753PMC
September 2016

Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression.

EMBO Mol Med 2016 07 1;8(7):712-28. Epub 2016 Jul 1.

Department of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT, USA Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA

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http://dx.doi.org/10.15252/emmm.201506181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931287PMC
July 2016

Pharmacologically Improved Contractility Protects Against Aortic Dissection in Mice With Disrupted Transforming Growth Factor-β Signaling Despite Compromised Extracellular Matrix Properties.

Arterioscler Thromb Vasc Biol 2016 05 17;36(5):919-27. Epub 2016 Mar 17.

From the Department of Biomedical Engineering, Yale University, New Haven, CT (J.F., S.-I.M., S.U., M.Y.L.T., J.D.H.); and Department of Surgery (G.L., Y.J., G.T.) and Vascular Biology & Therapeutics Program (G.T., J.D.H.), Yale School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1161/ATVBAHA.116.307436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850095PMC
May 2016

Ephrin type-B receptor 4 activation reduces neointimal hyperplasia in human saphenous vein in vitro.

J Vasc Surg 2016 Mar 24;63(3):795-804. Epub 2014 Oct 24.

Vascular Biology and Therapeutics (VBT) Program and the Department of Surgery, Yale University School of Medicine, New Haven, Conn; Department of Surgery, VA Connecticut Healthcare System, West Haven, Conn. Electronic address:

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http://dx.doi.org/10.1016/j.jvs.2014.09.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409444PMC
March 2016

Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis.

J Exp Med 2016 Mar 8;213(3):451-63. Epub 2016 Feb 8.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT 06511

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http://jem.rupress.org/content/213/3/451.full.pdf
Web Search
http://www.jem.org/lookup/doi/10.1084/jem.20150688
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http://dx.doi.org/10.1084/jem.20150688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813675PMC
March 2016

Blocking MHC class II on human endothelium mitigates acute rejection.

JCI Insight 2016;1(1). Epub 2016 Jan 21.

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1172/jci.insight.85293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756651PMC
January 2016

Interferon-γ-mediated allograft rejection exacerbates cardiovascular disease of hyperlipidemic murine transplant recipients.

Circ Res 2015 Nov 23;117(11):943-55. Epub 2015 Sep 23.

From the Departments of Surgery (J.Z., L.Q., R.A., Q.L., Y.J., G.L., J.J.Y., G.T.) and Immunobiology (T.Y., Z.T., J.S.P.) and Medicine (Y.H., J.Z., M.M.S., F.J.G.) and the Interdepartmental Program in Vascular Biology and Therapeutics (J.J.Y., M.M.S., F.J.G., J.S.P., G.T.), Yale University School of Medicine, New Haven, CT; Veterans Affairs Connecticut Healthcare System, West Haven (J.J.Y., M.M.S., F.J.G., G.T.); Research Institute, Nationwide Children's Hospital, Columbus, OH (T.Y.); and Department of Vascular Surgery, Peking University People's Hospital, Beijing, P.R. China (Q.L., Y.J.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.306932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636943PMC
November 2015

Extravascular Lung Water and Tissue Perfusion Biomarkers After Lung Resection Surgery Under a Normovolemic Fluid Protocol.

J Cardiothorac Vasc Anesth 2015 Aug 18;29(4):977-83. Epub 2014 Dec 18.

Cardiothoracic Anesthesia Service.

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http://dx.doi.org/10.1053/j.jvca.2014.12.020DOI Listing
August 2015

Complement membrane attack complexes activate noncanonical NF-κB by forming an Akt+ NIK+ signalosome on Rab5+ endosomes.

Proc Natl Acad Sci U S A 2015 Aug 20;112(31):9686-91. Epub 2015 Jul 20.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520; Department of Pathology, Yale University School of Medicine, New Haven, CT 06520

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http://dx.doi.org/10.1073/pnas.1503535112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534258PMC
August 2015

Efficient gene disruption in cultured primary human endothelial cells by CRISPR/Cas9.

Circ Res 2015 Jul 4;117(2):121-8. Epub 2015 May 4.

From the Department of Immunobiology (P.A., M.S.K., J.S.P.), Department of Internal Medicine (W.G.C., Y.Q.), Department of Surgery (G.T.), and Department of Biomedical Engineering (W.M.S.), Yale University, New Haven, CT.

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http://dx.doi.org/10.1161/CIRCRESAHA.117.306290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490936PMC
July 2015

The Nogo-B-PirB axis controls macrophage-mediated vascular remodeling.

PLoS One 2013 20;8(11):e81019. Epub 2013 Nov 20.

The Vascular Biology and Therapeutics Program and the Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, United States of America ; Mie University Graduate School of Medicine, Department of Thoracic and Cardiovascular Surgery, Tsu, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081019PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835671PMC
May 2015

Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections.

Circ Res 2015 Apr;116(8):1448-61

From the Departments of Biomedical Engineering (J.D.H., M.A.S.), Medicine (Cardiology) (M.A.S.), Cell Biology (M.A.S.), and Surgery (G.T.), Yale University, New Haven, CT; and Department of Internal Medicine, University of Texas Health Science Center, Houston (D.M.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.114.304936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420625PMC
April 2015

Thioredoxin-2 inhibits mitochondrial reactive oxygen species generation and apoptosis stress kinase-1 activity to maintain cardiac function.

Circulation 2015 Mar 27;131(12):1082-97. Epub 2015 Jan 27.

From Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, University School of Medicine, New Haven, CT (Q.H., H.J.Z., H.Z., Y.H., F.J.G., W.M.); Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (H.J.Z., W.M.); Gilead Sciences Inc, Foster City, CA (F.H.-K., P.F., L.Y., L.B., G.R.B.); and Department of Surgery, Yale University School of Medicine, New Haven, CT (G.T.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.114.0
Publisher Site
http://dx.doi.org/10.1161/CIRCULATIONAHA.114.012725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374031PMC
March 2015

Inflammatory and immune responses in the arterial media.

Circ Res 2015 Jan;116(2):312-22

From the Departments of Surgery (G.T.) and Immunobiology (J.S.P.), Yale University School of Medicine, New Haven, CT; and Veterans Affairs Connecticut Healthcare System, West Haven, CT (G.T.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.301312DOI Listing
January 2015

Disruption of TGF-β signaling in smooth muscle cell prevents elastase-induced abdominal aortic aneurysm.

Biochem Biophys Res Commun 2014 Nov 18;454(1):137-43. Epub 2014 Oct 18.

Department of Vascular Surgery, Peking University People's Hospital, Beijing, People's Republic of China.

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http://dx.doi.org/10.1016/j.bbrc.2014.10.053DOI Listing
November 2014

Disruption of TGF-β signaling in smooth muscle cell prevents flow-induced vascular remodeling.

Biochem Biophys Res Commun 2014 Nov 24;454(1):245-50. Epub 2014 Oct 24.

Department of Vascular Surgery, Peking University People's Hospital, Beijing, People's Republic of China.

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http://dx.doi.org/10.1016/j.bbrc.2014.10.092DOI Listing
November 2014

Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium.

Sci Signal 2014 Sep 23;7(344):ra90. Epub 2014 Sep 23.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1126/scisignal.2005504DOI Listing
September 2014

Interacting mechanisms in the pathogenesis of cardiac allograft vasculopathy.

Arterioscler Thromb Vasc Biol 2014 Aug 5;34(8):1609-14. Epub 2014 Jun 5.

From the Departments of Immunobiology (J.S.P.), Internal Medicine (D.J.-w.), and Surgery (L.Q. and G.T.), Yale University School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1161/ATVBAHA.114.302818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324618PMC
August 2014

Response to letter regarding article, "ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity".

Circulation 2014 Aug;130(8):e72

Department of Internal Medicine, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, and Department of Pharmacology, Yale University, New Haven, Connecticut.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.010272DOI Listing
August 2014

Cell biology. Dysfunctional mechanosensing in aneurysms.

Science 2014 May;344(6183):477-9

Department of Biomedical Engineering, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.1126/science.1253026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360903PMC
May 2014

The docking protein FRS2α is a critical regulator of VEGF receptors signaling.

Proc Natl Acad Sci U S A 2014 Apr 2;111(15):5514-9. Epub 2014 Apr 2.

Yale Cardiovascular Research Center, Department of Internal Medicine, and Departments of Surgery, Pharmacology, and Cell Biology, Yale University School of Medicine, New Haven, CT 06520.

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http://dx.doi.org/10.1073/pnas.1404545111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992672PMC
April 2014

SOCS1 prevents graft arteriosclerosis by preserving endothelial cell function.

J Am Coll Cardiol 2014 Jan 7-14;63(1):21-9. Epub 2013 Aug 28.

Interdepartmental Program in Vascular Biology and Therapeutics, Departments of Pathology and Surgery, Yale University School of Medicine, New Haven, Connecticut; Institute of Genetics, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2013.08.694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932325PMC
March 2014

Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2.

J Exp Med 2014 Mar 10;211(3):395-404. Epub 2014 Feb 10.

Department of Immunobiology and 2 Department of Surgery, Yale University School of Medicine, New Haven, CT 06510.

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http://dx.doi.org/10.1084/jem.20131125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949571PMC
March 2014

Alloantibody and complement promote T cell-mediated cardiac allograft vasculopathy through noncanonical nuclear factor-κB signaling in endothelial cells.

Circulation 2013 Dec 17;128(23):2504-16. Epub 2013 Sep 17.

Section of Cardiovascular Medicine, Department of Internal Medicine (D.J.-w.), Department of Immunobiology (T.D.M., N.C.K.-S., P.A., J.D., J.S.P.), Department of Surgery (T.Y., L.W., S.K., G.T.), Department of Neurology (P.C.), and Department of Pathology (G.M., J.S.P.), Yale School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.002972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885874PMC
December 2013

Ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity.

Circulation 2013 Oct 27;128(18):2047-57. Epub 2013 Sep 27.

Department of Internal Medicine, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine (R.L., Y.J., W.T., X.Z., J.H., J.Y., K.A.M.), Department of Surgery (Cardiac Surgery) (L.Q., G.T.), and Department of Pharmacology (K.A.M.), Yale University, New Haven, CT.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.002887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899790PMC
October 2013

The effect of a lung cancer care coordination program on timeliness of care.

Clin Lung Cancer 2013 Sep 1;14(5):527-34. Epub 2013 Jul 1.

Frank Netter School of Medicine at Quinnipiac University and Midstate Medical Center, Meriden, CT, USA.

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http://dx.doi.org/10.1016/j.cllc.2013.04.004DOI Listing
September 2013

Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency.

Arterioscler Thromb Vasc Biol 2013 May 14;33(5):1028-35. Epub 2013 Mar 14.

Department of Surgery, Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1161/ATVBAHA.112.300407DOI Listing
May 2013

Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells.

J Clin Invest 2013 Apr 8;123(4):1677-93. Epub 2013 Mar 8.

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8089, USA.

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http://dx.doi.org/10.1172/JCI66204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613923PMC
April 2013

Claudin-5 controls intercellular barriers of human dermal microvascular but not human umbilical vein endothelial cells.

Arterioscler Thromb Vasc Biol 2013 Mar 3;33(3):489-500. Epub 2013 Jan 3.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA.

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http://dx.doi.org/10.1161/ATVBAHA.112.300893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655806PMC
March 2013

FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression.

Cell Rep 2012 Dec 29;2(6):1684-96. Epub 2012 Nov 29.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1016/j.celrep.2012.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534912PMC
December 2012

Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells.

Circulation 2012 Oct 22;126(14):1695-704. Epub 2012 Aug 22.

YCVRC Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, Yale Stem Cell Center, Ste 773A, 300 George St, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.116996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586776PMC
October 2012

Modulation of transforming growth factor-β signaling and extracellular matrix production in myxomatous mitral valves by angiotensin II receptor blockers.

Circulation 2012 Sep;126(11 Suppl 1):S189-97

Section of Cardiac Surgery, Yale University School of Medicine, 330 Cedar Street, BB204, PO Box 208039, New Haven, CT 06520-8039, USA.

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September 2012

Molecular imaging of vascular endothelial growth factor receptors in graft arteriosclerosis.

Arterioscler Thromb Vasc Biol 2012 Aug 21;32(8):1849-55. Epub 2012 Jun 21.

Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1161/ATVBAHA.112.252510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401339PMC
August 2012

miR-1 mediated suppression of Sorcin regulates myocardial contractility through modulation of Ca2+ signaling.

J Mol Cell Cardiol 2012 May 4;52(5):1027-37. Epub 2012 Feb 4.

Section of Cardiac Surgery, Department of Surgery, Yale University, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2012.01.020DOI Listing
May 2012

Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report.

Arterioscler Thromb Vasc Biol 2012 Mar 17;32(3):756-9. Epub 2011 Nov 17.

Department of Pharmacology, Yale University School of Medicine, Amistad Research Bldg, 10 Amistad St, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1161/ATVBAHA.111.238113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288647PMC
March 2012

Vascular smooth muscle cell-derived adiponectin: a paracrine regulator of contractile phenotype.

J Mol Cell Cardiol 2012 Feb 17;52(2):474-84. Epub 2011 Sep 17.

Dartmouth Medical School, Department of Surgery, Section of Vascular Surgery, Lebanon, NH 03756, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2011.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264700PMC
February 2012

Participation of blood vessel cells in human adaptive immune responses.

Trends Immunol 2012 Jan 24;33(1):49-57. Epub 2011 Oct 24.

Yale University School of Medicine, PO Box 208089, 10 Amistad Street, RM 401, New Haven, CT 06520-8089, USA.

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http://dx.doi.org/10.1016/j.it.2011.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253953PMC
January 2012

Activation of human vascular cells decreases their expression of transforming growth factor-beta.

Atherosclerosis 2011 Dec 5;219(2):417-24. Epub 2011 Aug 5.

Department of Surgery, Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT, United States.

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http://dx.doi.org/10.1016/j.atherosclerosis.2011.07.121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226933PMC
December 2011

Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161+ CD4+ regulatory T cells.

J Immunol 2011 Dec 14;187(12):6268-80. Epub 2011 Nov 14.

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.4049/jimmunol.1003774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237826PMC
December 2011

AIP1 prevents graft arteriosclerosis by inhibiting interferon-γ-dependent smooth muscle cell proliferation and intimal expansion.

Circ Res 2011 Aug 23;109(4):418-27. Epub 2011 Jun 23.

Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA.

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.111.24824
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http://dx.doi.org/10.1161/CIRCRESAHA.111.248245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227522PMC
August 2011

Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDGF-dependent vascular smooth muscle cell proliferation.

Proc Natl Acad Sci U S A 2011 Feb 18;108(5):1914-8. Epub 2011 Jan 18.

Department of Internal Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1073/pnas.1019443108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033290PMC
February 2011

Human vascular smooth muscle cells lack essential costimulatory molecules to activate allogeneic memory T cells.

Arterioscler Thromb Vasc Biol 2010 Sep 10;30(9):1795-801. Epub 2010 Jun 10.

Departments of Surgery, Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1161/ATVBAHA.109.200758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924449PMC
September 2010

CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses.

J Exp Med 2010 Aug 23;207(9):1951-66. Epub 2010 Aug 23.

Department of Surgery, Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1084/jem.20100098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931170PMC
August 2010

Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.

Circulation 2009 Mar 2;119(10):1424-32. Epub 2009 Mar 2.

Interdepartmental Program in Vascular Biology and Therapeutics and Department of Surgery, Yale University School of Medicine, New Haven, Conn., USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.108.827618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898514PMC
March 2009

Human aortic smooth muscle cells promote arteriole formation by coengrafted endothelial cells.

Tissue Eng Part A 2009 Jan;15(1):165-73

Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06520-8089, USA.

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http://dx.doi.org/10.1089/ten.tea.2008.0010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679183PMC
January 2009

CXCL12 induction of inducible nitric oxide synthase in human CD8 T cells.

J Heart Lung Transplant 2008 Dec;27(12):1333-9

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8089, USA.

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http://dx.doi.org/10.1016/j.healun.2008.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645593PMC
December 2008

MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries.

J Exp Med 2008 Dec 8;205(13):3159-71. Epub 2008 Dec 8.

Department of Surgery, Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1084/jem.20081298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605224PMC
December 2008

Endothelial nitric oxide synthase stimulates aneurysm growth in aged mice.

J Vasc Res 2008 10;45(3):251-8. Epub 2008 Jan 10.

Department of Surgery, Yale University School of Medicine, New Haven, Conn 06520-8089, USA.

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http://dx.doi.org/10.1159/000112940DOI Listing
June 2008

Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation.

J Biol Chem 2008 Mar 11;283(11):6832-42. Epub 2008 Jan 11.

Interdepartmental Program in Vascular Biology and Transplantation and the Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1074/jbc.M706021200DOI Listing
March 2008

Induction of indoleamine 2,3-dioxygenase in vascular smooth muscle cells by interferon-gamma contributes to medial immunoprivilege.

J Immunol 2007 Oct;179(8):5246-54

Interdepartmental Program in Vascular Biology and Transplantation, Department of Surgery, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.4049/jimmunol.179.8.5246DOI Listing
October 2007

Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activation.

Circ Res 2007 Sep 26;101(6):560-9. Epub 2007 Jul 26.

Interdepartmental Program in Vascular Biology and Transplantation, Department of Surgery, Yale University School of Medicine, New Haven, Conn., USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.107.151068DOI Listing
September 2007

Venous identity is lost but arterial identity is not gained during vein graft adaptation.

Arterioscler Thromb Vasc Biol 2007 Jul 26;27(7):1562-71. Epub 2007 Apr 26.

Yale University School of Medicine, Department of Surgery, New Haven, CT 06519, USA.

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http://dx.doi.org/10.1161/ATVBAHA.107.143032DOI Listing
July 2007

Low levels of Nogo-B in human carotid atherosclerotic plaques are associated with an atheromatous phenotype, restenosis, and stenosis severity.

Arterioscler Thromb Vasc Biol 2007 Jun 5;27(6):1354-60. Epub 2007 Apr 5.

Department of Cardiology, Experimental Cardiology Laboratory, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

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http://dx.doi.org/10.1161/ATVBAHA.107.140913DOI Listing
June 2007

Alloimmune-mediated vascular remodeling of human coronary artery grafts in immunodeficient mouse recipients is independent of preexisting atherosclerosis.

Transplantation 2007 Jun;83(11):1501-5

Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1097/01.tp.0000264560.51845.67DOI Listing
June 2007

Development of a mouse model for evaluation of small diameter vascular grafts.

J Surg Res 2007 May 2;139(1):1-6. Epub 2007 Mar 2.

Department of Surgery, Yale School of Medicine, New Haven, Connecticut 06513, USA.

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http://dx.doi.org/10.1016/j.jss.2006.07.040DOI Listing
May 2007

Interferon-gamma axis in graft arteriosclerosis.

Circ Res 2007 Mar;100(5):622-32

Interdepartmental Program in Vascular Biology and Transplantation, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1161/01.RES.0000258861.72279.29DOI Listing
March 2007

Periadventitial fat.

Authors:
George Tellides

Arch Pathol Lab Med 2007 Mar;131(3):346-7

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http://dx.doi.org/10.1043/1543-2165(2007)131[346:PF]2.0.CO;2DOI Listing
March 2007

Induction of inducible NO synthase in bystander human T cells increases allogeneic responses in the vasculature.

Proc Natl Acad Sci U S A 2007 Jan 16;104(4):1313-8. Epub 2007 Jan 16.

Interdepartmental Program in Vascular Biology and Transplantation, Section of Immunobiology, and Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0607731104
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http://dx.doi.org/10.1073/pnas.0607731104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783095PMC
January 2007

Direct evidence for a crucial role of the arterial wall in control of atherosclerosis susceptibility.

Circulation 2006 Nov 13;114(22):2382-9. Epub 2006 Nov 13.

Department of Radiology, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.640185DOI Listing
November 2006