George Stamatoyannopoulos

George Stamatoyannopoulos

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George Stamatoyannopoulos

George Stamatoyannopoulos

Publications by authors named "George Stamatoyannopoulos"

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76Publications

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The Simons Genome Diversity Project: 300 genomes from 142 diverse populations.

Nature 2016 Oct 21;538(7624):201-206. Epub 2016 Sep 21.

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature18964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161557PMC
October 2016

Functional validation of a constitutive autonomous silencer element.

PLoS One 2015 24;10(4):e0124588. Epub 2015 Apr 24.

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124588PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409358PMC
January 2016

Genomic discovery of potent chromatin insulators for human gene therapy.

Nat Biotechnol 2015 Feb 12;33(2):198-203. Epub 2015 Jan 12.

1] Division of Medical Genetics, University of Washington, Seattle, Washington, USA. [2] Department of Genome Sciences, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/nbt.3062DOI Listing
February 2015

Gammaretroviral vector integration occurs overwhelmingly within and near DNase hypersensitive sites.

Hum Gene Ther 2012 Feb 14;23(2):231-7. Epub 2011 Dec 14.

Department of Medicine, Division of Medical Genetics, University of Washington , Seattle, WA 98195, USA.

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http://dx.doi.org/10.1089/hum.2010.177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277727PMC
February 2012

Thalassaemia.

Lancet 2012 Jan 9;379(9813):373-83. Epub 2011 Sep 9.

Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1016/S0140-6736(11)60283-3DOI Listing
January 2012

A search for β thalassemia mutations in 4000 year old ancient DNAs of Minoan Cretans.

Blood Cells Mol Dis 2012 Jan 14;48(1):7-10. Epub 2011 Oct 14.

University of Washington, Department of Medicine, 1705 NE Pacific St., K-240 Health Sciences Building, Box 357720, Seattle, WA 98195-7720, USA.

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http://dx.doi.org/10.1016/j.bcmd.2011.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249513PMC
January 2012

Gene therapy for β-thalassaemia: the continuing challenge.

Expert Rev Mol Med 2010 Oct 1;12:e31. Epub 2010 Oct 1.

Gene and Cell Therapy Center, Hematology Department-BMT Unit, George Papanicolaou Hospital, Thessaloniki, Greece.

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http://www.journals.cambridge.org/abstract_S1462399410001626
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http://dx.doi.org/10.1017/S1462399410001626DOI Listing
October 2010

Hematopoietic stem cell mobilization strategies for gene therapy of beta thalassemia and sickle cell disease.

Ann N Y Acad Sci 2010 Aug;1202:59-63

Gene and Cell Therapy Center, Hematology-BMT Unit, George Papanicolaou Hospital, Thessaloniki, Greece.

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http://dx.doi.org/10.1111/j.1749-6632.2010.05576.xDOI Listing
August 2010

The birth of the American Society of Gene Therapy.

Mol Ther 2010 Mar;18(3):462-5

Department of Medicine and Markey Molecular Medicine Center, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1038/mt.2010.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839436PMC
March 2010

The higher structure of chromatin in the LCR of the beta-globin locus changes during development.

J Mol Biol 2009 Nov 23;394(2):197-208. Epub 2009 Sep 23.

Division of Medical Genetics, Department of Medicine, Box 357720, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.jmb.2009.09.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849742PMC
November 2009

Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator.

Mol Ther 2009 Apr 24;17(4):716-24. Epub 2009 Feb 24.

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195-7720, USA.

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http://dx.doi.org/10.1038/mt.2009.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835102PMC
April 2009

Role of chromatin structure in integration of helper-dependent adenoviral vectors containing the beta-globin locus control region.

Hum Gene Ther 2008 Feb;19(2):153-66

Department of Pathology, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1089/hum.2007.091DOI Listing
February 2008

Histone acetylation at the human beta-globin locus changes with developmental age.

Blood 2007 Dec 19;110(12):4101-7. Epub 2007 Sep 19.

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, 98195, USA.

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http://dx.doi.org/10.1182/blood-2007-05-091256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190615PMC
December 2007

MicroRNA expression dynamics during murine and human erythroid differentiation.

Exp Hematol 2007 Jul;35(7):1015-25

Division of Medical Genetics, Department of Medicine University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.exphem.2007.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1955220PMC
July 2007

The transcription factor KLF11 can induce gamma-globin gene expression in the setting of in vivo adult erythropoiesis.

J Cell Biochem 2007 Mar;100(4):1045-55

University of Washington Department of Medicine, Division of Medical Genetics, Seattle, WA 98195-7720, USA.

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http://doi.wiley.com/10.1002/jcb.21093
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http://dx.doi.org/10.1002/jcb.21093DOI Listing
March 2007

Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation.

J Mol Biol 2007 Mar 22;366(4):1064-73. Epub 2006 Dec 22.

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, 1705 NE Pacific Street, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.12.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1907364PMC
March 2007

Cooperativeness of the higher chromatin structure of the beta-globin locus revealed by the deletion mutations of DNase I hypersensitive site 3 of the LCR.

J Mol Biol 2007 Jan 3;365(1):31-7. Epub 2006 Oct 3.

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.09.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826273PMC
January 2007

Purification and identification of proteins that bind to the hereditary persistence of fetal hemoglobin -198 mutation in the gamma-globin gene promoter.

J Biol Chem 2007 Jan 17;282(2):853-62. Epub 2006 Nov 17.

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle 98195, USA.

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http://dx.doi.org/10.1074/jbc.M610404200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819221PMC
January 2007

Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin.

Am J Hematol 2006 Dec;81(12):981-3

Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1002/ajh.20676DOI Listing
December 2006

Transcriptional potential of the gamma-globin gene is dependent on the CACCC box in a developmental stage-specific manner.

Nucleic Acids Res 2006 12;34(14):3909-16. Epub 2006 Aug 12.

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1093/nar/gkl474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557803PMC
September 2006

Integration bias of gammaretrovirus vectors following transduction and growth of primary mouse hematopoietic progenitor cells with and without selection.

Mol Ther 2006 Aug 2;14(2):226-35. Epub 2006 May 2.

Department of Medicine, Division of Medical Genetics, University of Washington, Box 357720, Seattle, 98195, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S152500160600094
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http://dx.doi.org/10.1016/j.ymthe.2006.02.016DOI Listing
August 2006

Autonomous silencing as well as competition controls gamma-globin gene expression during development.

Mol Cell Biol 2006 Jul;26(13):4775-81

Medical Genetics, Box 357720, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1128/MCB.00406-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489144PMC
July 2006

Effects of human gamma-globin in murine beta-thalassaemia.

Br J Haematol 2006 Jul;134(1):100-8

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, 98195-7720, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2006.06102.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811697PMC
July 2006

Investigations of the induction of the goat beta(C) globin gene by erythropoietin: studies in transgenic mice.

Blood Cells Mol Dis 2005 Nov-Dec;35(3):332-8. Epub 2005 Oct 10.

Division of Medical Genetics, University of Washington, Box 357720, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.bcmd.2005.08.007DOI Listing
April 2006

Investigations of a human embryonic globin gene silencing element using YAC transgenic mice.

Exp Biol Med (Maywood) 2006 Mar;231(3):328-34

Division of Medical Genetics, University of Washington, Seattle, 98195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812921PMC
http://dx.doi.org/10.1177/153537020623100314DOI Listing
March 2006

Functional study of transcription factor KLF11 by targeted gene inactivation.

Blood Cells Mol Dis 2005 Jan-Feb;34(1):53-9

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.bcmd.2004.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808415PMC
December 2005

Hydroxamide derivatives of short-chain fatty acid have erythropoietic activity and induce gamma gene expression in vivo.

Exp Hematol 2005 Dec;33(12):1443-9

Division of Medical Genetics, University of Washington, Seattle, 98195, USA.

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http://dx.doi.org/10.1016/j.exphem.2005.08.007DOI Listing
December 2005

Selection with a regulated cell growth switch increases the likelihood of expression for a linked gamma-globin gene.

Blood Cells Mol Dis 2005 May-Jun;34(3):235-47

Department of Medicine, Division of Medical Genetics, University of Washington, Box 357720, HSB K236F, 1705 NE Pacific Street, Seattle, WA 98195-7720, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S107997960500026
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http://dx.doi.org/10.1016/j.bcmd.2005.01.004DOI Listing
October 2005

Juxtaposition of the HPFH2 enhancer is not sufficient to reactivate the gamma-globin gene in adult erythropoiesis.

Hum Mol Genet 2005 Oct 9;14(20):3047-56. Epub 2005 Sep 9.

Division of Medical Genetics, Department of Medicine, University of Washington, 98195, USA.

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http://dx.doi.org/10.1093/hmg/ddi337DOI Listing
October 2005

Genome architecture of the human beta-globin locus affects developmental regulation of gene expression.

Mol Cell Biol 2005 Oct;25(20):8765-78

Department of Biochemistry and Molecular Biology, MS 3030, University of Kansas Medical Center, Kansas City, 66160-7421, USA.

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http://dx.doi.org/10.1128/MCB.25.20.8765-8778.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1265765PMC
October 2005

Transcriptional potentials of the beta-like globin genes at different developmental stages in transgenic mice and hemoglobin switching.

Blood Cells Mol Dis 2004 Nov-Dec;33(3):318-25

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.bcmd.2004.06.005DOI Listing
April 2005

Differences of globin transgene expression in stably transfected cell lines and transgenic mice.

Blood 2005 Apr 30;105(8):3346-52. Epub 2004 Dec 30.

Department of Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1182/blood-2004-03-0987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808413PMC
April 2005

Control of globin gene expression during development and erythroid differentiation.

Exp Hematol 2005 Mar;33(3):259-71

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0301472X0400409
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http://dx.doi.org/10.1016/j.exphem.2004.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819985PMC
March 2005

Butyrate increases the efficiency of translation of gamma-globin mRNA.

Blood 2005 Feb 12;105(4):1807-9. Epub 2004 Oct 12.

Department of Medicine, Division of Hematology/Oncology, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1182/blood-2004-02-0454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826269PMC
February 2005

Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells.

Biochim Biophys Acta 2005 Feb;1727(2):125-33

Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

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http://dx.doi.org/10.1016/j.bbaexp.2004.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808416PMC
February 2005

Molecular cloning and characterization of ZFF29: a protein containing a unique Cys2His2 zinc-finger motif.

Biochem J 2004 Dec;384(Pt 3):647-53

Department of Hematology, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya, Japan 466-8550.

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http://dx.doi.org/10.1042/BJ20040394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1134151PMC
December 2004

Transgenic Cre expression mice for generation of erythroid-specific gene alterations.

Genesis 2004 May;39(1):1-9

Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160-7421, USA.

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http://dx.doi.org/10.1002/gene.20020DOI Listing
May 2004

The minimal promoter plays a major role in silencing of the galago gamma-globin gene in adult erythropoiesis.

Proc Natl Acad Sci U S A 2004 May 17;101(21):8096-101. Epub 2004 May 17.

Division of Medical Genetics, School of Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1073/pnas.0402594101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC419563PMC
May 2004

Developmentally specific role of the CCAAT box in regulation of human gamma-globin gene expression.

J Biol Chem 2004 Feb 26;279(7):5444-9. Epub 2003 Nov 26.

Division of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1074/jbc.M306241200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808414PMC
February 2004

Induction of human gamma globin gene expression by histone deacetylase inhibitors.

Blood 2004 Jan 14;103(2):701-9. Epub 2003 Aug 14.

Medical Genetics, Box 357720, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1182/blood-2003-02-0478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808412PMC
January 2004

Mutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes.

Hum Mol Genet 2003 Nov 23;12(22):2941-8. Epub 2003 Sep 23.

Division of Medical Genetics, University of Washington, Seattle, 98195, USA.

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http://dx.doi.org/10.1093/hmg/ddg319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808411PMC
November 2003

Induction of fetal hemoglobin by propionic and butyric acid derivatives: correlations between chemical structure and potency of Hb F induction.

Blood Cells Mol Dis 2002 Jul-Aug;29(1):48-56

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195-7720, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808417PMC
August 2003

Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro.

Cancer Res 2003 Aug;63(16):4801-4

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195, USA.

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August 2003

Functional interplay between CBP and PCAF in acetylation and regulation of transcription factor KLF13 activity.

J Mol Biol 2003 May;329(2):207-15

Division of Medical Genetics, Department of Medicine, School of Medicine, University of Washington, Seattle 98195-7720, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808423PMC
http://dx.doi.org/10.1016/s0022-2836(03)00429-7DOI Listing
May 2003

Hydroxamide derivatives of short-chain fatty acids are potent inducers of human fetal globin gene expression.

Exp Hematol 2003 Mar;31(3):197-203

Division of Medical Genetics, University of Washington, Seattle, Wash 98195, USA.

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March 2003

Locus control regions.

Blood 2002 Nov;100(9):3077-86

Division of Medical Genetics, Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1182/blood-2002-04-1104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811695PMC
November 2002

Development of virus vectors for gene therapy of beta chain hemoglobinopathies: flanking with a chromatin insulator reduces gamma-globin gene silencing in vivo.

Blood 2002 Sep;100(6):2012-9

Department of Medicine, Division of Medical Genetics, Box 357720, HSB K236F, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195-7720, USA.

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http://dx.doi.org/10.1182/blood-2002-01-0219DOI Listing
September 2002

Transcription coactivator CBP has direct DNA binding activity and stimulates transcription factor DNA binding through small domains.

Biochem Biophys Res Commun 2002 Aug;296(1):118-24

Division of Medical Genetics, Department of Medicine, University of Washington, Box 357720, 1705 NE Pacific Streets, 98195, Seattle, WA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808418PMC
http://dx.doi.org/10.1016/s0006-291x(02)00842-2DOI Listing
August 2002

Evidence that DNase I hypersensitive site 5 of the human beta-globin locus control region functions as a chromosomal insulator in transgenic mice.

Nucleic Acids Res 2002 Jun;30(11):2484-91

Division of Medical Genetics, Box 357720, Department of Medicine, University of Washington Medical School, Seattle, WA 98195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC117184PMC
http://dx.doi.org/10.1093/nar/30.11.2484DOI Listing
June 2002

Topological constraints governing the use of the chicken HS4 chromatin insulator in oncoretrovirus vectors.

Mol Ther 2002 May;5(5 Pt 1):589-98

Gene and Cell Therapy Center, Hematology Department and Bone Marrow Transplantation Unit, George Papanikolaou General Hospital, Thessaloniki, Greece.

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http://dx.doi.org/10.1006/mthe.2002.0582DOI Listing
May 2002

Developmental specificity of recruitment of TBP to the TATA box of the human gamma-globin gene.

Proc Natl Acad Sci U S A 2002 Apr;99(8):5509-14

Division of Medical Genetics, Department of Medicine, University of Washington Medical School, Box 357720, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1073/pnas.072084499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122800PMC
April 2002

Activation of the beta-like globin genes in transgenic mice is dependent on the presence of the beta-locus control region.

Hum Mol Genet 2002 Apr;11(8):893-903

Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1093/hmg/11.8.893DOI Listing
April 2002

Hematopoietic stem cell gene therapy.

Int J Hematol 2002 Apr;75(3):228-36

University of Washington Department of Medicine, Seattle 98195-7720, USA.

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April 2002

Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2.

J Biol Chem 2002 Mar 17;277(9):7029-36. Epub 2001 Dec 17.

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1074/jbc.M108826200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808425PMC
March 2002