George Somlo

George Somlo

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George Somlo

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Radiation-Related Toxicities Using Organ Sparing Total Marrow Irradiation Transplant Conditioning Regimens.

Int J Radiat Oncol Biol Phys 2019 Dec 14;105(5):1025-1033. Epub 2019 Aug 14.

Department of Radiation Oncology, City of Hope National Medical Center, Duarte, California. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2019.08.010DOI Listing
December 2019

Synergistic anti-cancer activity of CDK4/6 inhibitor palbociclib and dual mTOR kinase inhibitor MLN0128 in pRb-expressing ER-negative breast cancer.

Breast Cancer Res Treat 2019 Apr 3;174(3):615-625. Epub 2019 Jan 3.

Department of Cancer Biology, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA.

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http://link.springer.com/10.1007/s10549-018-05104-9
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http://dx.doi.org/10.1007/s10549-018-05104-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452902PMC
April 2019

Operative and Therapeutic Advancements in Breast Cancer Metastases to the Brain.

Clin Breast Cancer 2018 08 7;18(4):e455-e467. Epub 2017 Oct 7.

Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA.

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http://dx.doi.org/10.1016/j.clbc.2017.10.002DOI Listing
August 2018

Use of dual mTOR inhibitor MLN0128 against everolimus-resistant breast cancer.

Breast Cancer Res Treat 2018 Aug 5;170(3):499-506. Epub 2018 Apr 5.

Department of Cancer Biology, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, Kaplan CRB, Room 2002C, Duarte, CA, USA.

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http://link.springer.com/10.1007/s10549-018-4779-x
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http://dx.doi.org/10.1007/s10549-018-4779-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026053PMC
August 2018

Chemotherapy Induces Breast Cancer Stemness in Association with Dysregulated Monocytosis.

Clin Cancer Res 2018 05 2;24(10):2370-2382. Epub 2018 Mar 2.

Department of Immunology and Biotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955855PMC
May 2018

Phase IB trial of ixabepilone and vorinostat in metastatic breast cancer.

Breast Cancer Res Treat 2018 01 27;167(2):469-478. Epub 2017 Sep 27.

Cancer Research and Drug Discovery Medical Technology College, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1007/s10549-017-4516-xDOI Listing
January 2018

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer.

Nat Commun 2017 04 5;8:14802. Epub 2017 Apr 5.

Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/ncomms14802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382276PMC
April 2017

Predictors of Antiestrogen Recommendation in Women With Estrogen Receptor-Positive Ductal Carcinoma In Situ.

J Natl Compr Canc Netw 2016 09;14(9):1081-90

From the Departments of Oncologic Surgery, Biostatistics and Population Sciences, and Medical Oncology, City of Hope National Medical Center, Duarte, California.

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http://dx.doi.org/10.6004/jnccn.2016.0118DOI Listing
September 2016

Cross-kingdom inhibition of breast cancer growth by plant miR159.

Cell Res 2016 Feb 22;26(2):217-28. Epub 2016 Jan 22.

Department of Cancer Biology, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1038/cr.2016.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746606PMC
February 2016

NCCN Guidelines Insights Breast Cancer, Version 1.2016.

J Natl Compr Canc Netw 2015 Dec;13(12):1475-85

From Robert H. Lurie Comprehensive Cancer Center of Northwestern University; University of Washington/Seattle Cancer Care Alliance; UCSF Helen Diller Family Comprehensive Cancer Center; UC San Diego Moores Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; University of Colorado Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; University of Alabama at Birmingham Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Mayo Clinic Cancer Center; Fox Chase Cancer Center; Memorial Sloan Kettering Cancer Center; Massachusetts General Hospital Cancer Center; Duke Cancer Institute; Vanderbilt-Ingram Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Comprehensive Cancer Center; Fred & Pamela Buffett Cancer Center; Roswell Park Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Research Advocacy Network; Moffitt Cancer Center; City of Hope Comprehensive Cancer Center; Stanford Cancer Institute; Huntsman Cancer Institute at the University of Utah; and National Comprehensive Cancer Network.

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http://dx.doi.org/10.6004/jnccn.2015.0176DOI Listing
December 2015

Biosimilars: Extrapolating the evidence. A roundtable discussion.

EJC Suppl 2015 Dec 21;13(2):1-2. Epub 2016 Jan 21.

City of Hope Comprehensive Cancer Center, Duarte, CA, USA.

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http://dx.doi.org/10.1016/j.ejcsup.2015.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724664PMC
December 2015

Exploring Glycan Markers for Immunotyping and Precision-targeting of Breast Circulating Tumor Cells.

Arch Med Res 2015 Nov 1;46(8):642-50. Epub 2015 Dec 1.

SRI International Biosciences Division, Menlo Park, California, USA.

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http://dx.doi.org/10.1016/j.arcmed.2015.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729604PMC
November 2015

Recommendations for the Use of WBC Growth Factors: American Society of Clinical Oncology Clinical Practice Guideline Update.

J Clin Oncol 2015 Oct 13;33(28):3199-212. Epub 2015 Jul 13.

Thomas J. Smith, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Kari Bohlke, American Society of Clinical Oncology, Alexandria; Scott J. Cross, Virginia Oncology Associates, Norfolk; James L. Khatcheressian, Virginia Cancer Institute, Richmond, VA; Gary H. Lyman, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA; Kenneth R. Carson, Washington University, St Louis, MO; Jeffrey Crawford, Duke Medicine, Durham, NC; John M. Goldberg, University of Miami Miller School of Medicine, Miami, FL; Natasha B. Leighl, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Cheryl L. Perkins, patient representative, Dallas, TX; George Somlo, City of Hope National Medical Center, Duarte, CA; James L. Wade, Cancer Care Specialists of Central Illinois, Decatur, IL; Antoinette J. Wozniak, Karmanos Cancer Institute, Detroit, MI; and James O. Armitage, University of Nebraska Medical Center, Omaha, NE.

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http://dx.doi.org/10.1200/JCO.2015.62.3488DOI Listing
October 2015

Impact of neoadjuvant chemotherapy in stage II-III triple negative breast cancer on eligibility for breast-conserving surgery and breast conservation rates: surgical results from CALGB 40603 (Alliance).

Ann Surg 2015 Sep;262(3):434-9; discussion 438-9

*Department of Surgery, Brigham and Women's Hospital, Boston, MA †Alliance Statistics and Data Center, Duke University Medical Center, Durham, NC ‡Department of Medical Oncology Women and Infants Hospital and Alpert Medical School of Brown University, Providence, RI §Alliance Statistics and Data Center, MD Anderson Cancer Center, Houston, TX ¶Department of Medical Oncology, Maine Center for Cancer Medicine, Scarborough, ME ∥Department of Medical Oncology, City of Hope Medical Center, Los Angeles, CA **Department of Medical Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY ††Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; and ‡‡Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.

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http://dx.doi.org/10.1097/SLA.0000000000001417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710511PMC
September 2015

Inflammatory Biomarkers, Comorbidity, and Neurocognition in Women With Newly Diagnosed Breast Cancer.

J Natl Cancer Inst 2015 Aug 22;107(8). Epub 2015 Jun 22.

Department of Population Sciences (SKP, ALW, FLW, MS, CK, MRP), Department of Supportive Care Medicine (SKP), Department of Medical Oncology (AH, IBP, LK, GS, JM, MRP), Department of Surgery (IBP, LK), City of Hope Medical Center and Beckman Research Institute, Duarte, California; Institute of Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL (SB); Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA (ECB, MRI).

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http://dx.doi.org/10.1093/jnci/djv131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609551PMC
August 2015

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis.

Nat Cell Biol 2015 Feb 26;17(2):183-94. Epub 2015 Jan 26.

1] Department of Cancer Biology, City of Hope Beckman Research Institute, Duarte, California 91010, USA [2] Department of Biotherapy and Key Laboratory of Cancer Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.

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http://dx.doi.org/10.1038/ncb3094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380143PMC
February 2015

Impact of the addition of carboplatin and/or bevacizumab to neoadjuvant once-per-week paclitaxel followed by dose-dense doxorubicin and cyclophosphamide on pathologic complete response rates in stage II to III triple-negative breast cancer: CALGB 40603 (Alliance).

J Clin Oncol 2015 Jan 4;33(1):13-21. Epub 2014 Aug 4.

William M. Sikov, Miriam Hospital and Alpert Medical School of Brown University, Providence, RI; Donald A. Berry, University of Texas MD Anderson Cancer Center, Houston, TX; Charles M. Perou and Lisa A. Carey, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill; Constance T. Cirrincione, Alliance Statistical Center, Durham; Charles S. Kuzma, Southeast Cancer Control Consortium, Winston-Salem, NC; Baljit Singh, New York University Medical Center; Elisa R. Port, Mount Sinai Medical Center; Clifford A. Hudis, Memorial Sloan Kettering Cancer Center, New York, NY; Sara M. Tolaney, Mehra Golshan, Jennifer R. Bellon, and Eric P. Winer, Dana-Farber Cancer Institute, Boston, MA; Timothy J. Pluard, Washington University-St Louis Medical Center, St Louis, MO; George Somlo, City of Hope Comprehensive Cancer Center, Duarte; Deborah Collyar, Patient Advocates in Research, Danville, CA; and Olwen M. Hahn, University of Chicago Medical Center, Chicago, IL.

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http://dx.doi.org/10.1200/JCO.2014.57.0572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268249PMC
January 2015

A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis.

Nat Cell Biol 2014 Dec 2;16(12):1238-48. Epub 2014 Nov 2.

1] Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 265 Campus Drive Stanford, California 94305, USA [2] Department of medicine, Division of Oncology, Stanford University, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/ncb3058DOI Listing
December 2014

TGFβ induces "BRCAness" and sensitivity to PARP inhibition in breast cancer by regulating DNA-repair genes.

Mol Cancer Res 2014 Nov 7;12(11):1597-609. Epub 2014 Aug 7.

Department of Cancer Biology, City of Hope Beckman Research Institute and Medical Center, Duarte, California. Department of Biotherapy and Key Laboratory of Cancer Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233161PMC
November 2014

Distribution profiling of circulating microRNAs in serum.

Anal Chem 2014 Sep 5;86(18):9343-9. Epub 2014 Sep 5.

Department of Chemistry; ‡Program in Biomedical Sciences; §Department of Statistics, University of California, Riverside , Riverside, California 92521, United States.

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http://dx.doi.org/10.1021/ac5028929DOI Listing
September 2014

The role of transplant in multiple myeloma.

J Natl Compr Canc Netw 2014 Aug;12(8):1131-8

From the Departments of Medical Oncology & Therapeutics Research, and Hematology & Hematopoietic Cell Transplantation, City of Hope Comprehensive Cancer Center, Duarte, California.From the Departments of Medical Oncology & Therapeutics Research, and Hematology & Hematopoietic Cell Transplantation, City of Hope Comprehensive Cancer Center, Duarte, California.

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http://www.jnccn.org/content/12/8/1131.full.pdf
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http://dx.doi.org/10.6004/jnccn.2014.0110DOI Listing
August 2014

Phase I/II trial of vinorelbine and sorafenib in metastatic breast cancer.

Clin Breast Cancer 2014 Apr 26;14(2):94-100. Epub 2013 Oct 26.

Division of Medical Oncology and Therapeutics Research, City of Hope, Duarte, CA. Electronic address:

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http://dx.doi.org/10.1016/j.clbc.2013.10.013DOI Listing
April 2014

Human epidermal growth factor receptor family-targeted therapies in the treatment of HER2-overexpressing breast cancer.

Oncologist 2014 Feb 16;19(2):135-50. Epub 2014 Jan 16.

City of Hope Comprehensive Cancer Center, Duarte, California, USA; Harbor-UCLA Medical Center, Torrance, California, USA.

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http://theoncologist.alphamedpress.org/cgi/doi/10.1634/theon
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http://dx.doi.org/10.1634/theoncologist.2013-0283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926785PMC
February 2014

Role of SMC1 in overcoming drug resistance in triple negative breast cancer.

PLoS One 2013 22;8(5):e64338. Epub 2013 May 22.

Department of Diabetes, Endocrinology and Metabolic Diseases, City of Hope Comprehensive Cancer Center, Duarte, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064338PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661439PMC
January 2014

A phase II study of docetaxel and vinorelbine plus filgrastim for HER-2 negative, stage IV breast cancer: SWOG S0102.

Breast Cancer Res Treat 2014 Jan 19;143(2):351-8. Epub 2013 Dec 19.

University of Washington School of Medicine/Seattle Cancer Care Alliance, 825 Eastlake Avenue East, G3-630, Seattle, WA, 98109, USA,

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http://dx.doi.org/10.1007/s10549-013-2797-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889983PMC
January 2014

Metaplastic Breast Carcinoma in the Lungs: A Case Report.

World J Oncol 2013 Dec 16;4(6):252-254. Epub 2014 Jan 16.

City of Hope National Medical Center, 1500 East Duarte Road, Duarte CA 91010, USA.

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http://dx.doi.org/10.4021/wjon637wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649851PMC
December 2013

Barriers to treatment in patients with locally advanced breast cancer.

J Natl Compr Canc Netw 2013 Oct;11(10):1193-8

From the aDepartment of Nursing, Sage College, Troy, New York; bDepartment of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California; cDivision of Medical Oncology, Cedars Sinai-Samuel Oschin Cancer Center, Los Angeles, California; dDivision of Biostatistics, Department of Information Sciences, City of Hope Comprehensive Cancer Center, Duarte, California; and eDivision of Nursing Research and Education, Department of Population Science, City of Hope Comprehensive Cancer Center, Duarte, California.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159358PMC
http://dx.doi.org/10.6004/jnccn.2013.0141DOI Listing
October 2013

Enrollment onto breast cancer therapeutic clinical trials: a tertiary cancer center experience.

Appl Nurs Res 2013 Aug 13;26(3):133-5. Epub 2013 Mar 13.

Clinical Research Office-Medical Oncology, Cedars Sinai-Samuel Oschin Cancer Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/j.apnr.2013.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748286PMC
August 2013

Analysis of circulating tumor cells in breast cancer.

J Natl Compr Canc Netw 2013 Aug;11(8):977-85

From Departments of aMedical Oncology and Therapeutic Research and bHematology and Hematopoietic Cell Transplantation, City of Hope Cancer Center, Duarte, California.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159355PMC
http://dx.doi.org/10.6004/jnccn.2013.0118DOI Listing
August 2013

Dasatinib : a novel therapy for breast cancer?

Expert Opin Investig Drugs 2013 Jun 18;22(6):795-801. Epub 2013 Apr 18.

City of Hope Comprehensive Cancer Center, 1500 Duarte Road, Duarte, CA 91010-3012, USA.

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http://dx.doi.org/10.1517/13543784.2013.793308DOI Listing
June 2013

Molecular subtyping of early-stage breast cancer identifies a group of patients who do not benefit from neoadjuvant chemotherapy.

Breast Cancer Res Treat 2013 Jun 12;139(3):759-67. Epub 2013 Jun 12.

Sylvester Comprehensive Cancer Center, University of Miami, 1475 NW 12th Avenue, Suite 3510, Miami, FL 33136, USA.

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http://dx.doi.org/10.1007/s10549-013-2572-4DOI Listing
June 2013

Second primary malignancies after autologous hematopoietic cell transplantation for multiple myeloma.

Biol Blood Marrow Transplant 2013 Feb 13;19(2):260-5. Epub 2012 Oct 13.

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California 91010, USA.

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http://dx.doi.org/10.1016/j.bbmt.2012.09.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553262PMC
February 2013

Diffuse large B-cell lymphoma with calf muscle localization.

Case Rep Hematol 2011 9;2011:292494. Epub 2011 Jul 9.

Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, 1500 E Duarte Road, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1155/2011/292494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420606PMC
August 2012

Bevacizumab in neoadjuvant treatment for breast cancer.

Authors:
George Somlo

N Engl J Med 2012 04;366(17):1637-8; author reply 1638-40

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http://dx.doi.org/10.1056/NEJMc1202229DOI Listing
April 2012

Combining emerging agents in advanced breast cancer.

Oncologist 2011 4;16(6):760-71. Epub 2011 May 4.

Department of Medical Oncology and Therapeutics Research, City of Hope Cancer Center, Duarte, California, USA.

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http://dx.doi.org/10.1634/theoncologist.2010-0345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228217PMC
October 2011

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors.

Nat Med 2010 Dec 21;16(12):1421-8. Epub 2010 Nov 21.

Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, California, USA.

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http://dx.doi.org/10.1038/nm.2250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088498PMC
December 2010

Papillary carcinoma of the breast: an overview.

Breast Cancer Res Treat 2010 Aug 4;122(3):637-45. Epub 2010 Jun 4.

Department of Medical Oncology & Therapeutics Research, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1007/s10549-010-0961-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244819PMC
August 2010

Novel targeted therapies in the treatment of soft-tissue sarcomas.

Expert Rev Anticancer Ther 2010 Aug;10(8):1303-11

Department of Medical Oncology, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1586/era.10.100DOI Listing
August 2010

Diagnostic and therapeutic delays among a multiethnic sample of breast and cervical cancer survivors.

Cancer 2010 Jul;116(13):3195-204

CCARE, Division of Population Sciences, City of Hope Medical Center, Duarte, California, USA.

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http://dx.doi.org/10.1002/cncr.25060DOI Listing
July 2010

Phase II clinical trial of imatinib mesylate in therapy of KIT and/or PDGFRalpha-expressing Ewing sarcoma family of tumors and desmoplastic small round cell tumors.

Anticancer Res 2010 Feb;30(2):547-52

Department of Medical Oncology, City of Hope Comprehensive Cancer Center, 1500 E. Duarte Road, Duarte, CA 91010, USA.

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February 2010

Phase I trial of fixed-dose rate gemcitabine in combination with bortezomib in advanced solid tumors.

Anticancer Res 2010 Jan;30(1):167-74

Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, 1500 E. Duarte Rd., Duarte, CA 91010, USA.

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January 2010