George Simos

George Simos

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George Simos

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ERK1/2 phosphorylates HIF-2α and regulates its activity by controlling its CRM1-dependent nuclear shuttling.

J Cell Sci 2019 Apr 8;132(7). Epub 2019 Apr 8.

Laboratory of Biochemistry, Faculty of Medicine, University of Thessaly, 41500, Biopolis, Larissa, Greece

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http://dx.doi.org/10.1242/jcs.225698DOI Listing
April 2019

Protein phosphatase PPP3CA (calcineurin A) down-regulates hypoxia-inducible factor transcriptional activity.

Arch Biochem Biophys 2019 Mar 15;664:174-182. Epub 2019 Feb 15.

Laboratory of Biochemistry, Faculty of Medicine, University of Thessaly, Larissa, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2019.02.007DOI Listing
March 2019

Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism.

Cells 2019 Mar 3;8(3). Epub 2019 Mar 3.

Laboratory of Physiology, Faculty of Medicine, University of Thessaly, BIOPOLIS, 41500 Larissa, Greece.

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http://dx.doi.org/10.3390/cells8030214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468845PMC
March 2019

Hypoxia-induced changes in SUMO conjugation affect transcriptional regulation under low oxygen.

Mol Cell Proteomics 2019 Mar 29. Epub 2019 Mar 29.

Laboratory of Biochemistry, Faculty of Medicine, University of Thessaly Gerald Bronfman Department of Oncology, Faculty of Medicine, McGill University, Montreal, Canada, Greece.

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http://dx.doi.org/10.1074/mcp.RA119.001401DOI Listing
March 2019

HIF-1α-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia.

Cell Mol Life Sci 2019 Feb 10;76(4):809-825. Epub 2018 Dec 10.

Laboratory of Biochemistry, Faculty of Medicine, University of Thessaly, Biopolis, 41500, Larissa, Greece.

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http://dx.doi.org/10.1007/s00018-018-2985-7DOI Listing
February 2019

Expression of AGPAT2, an enzyme involved in the glycerophospholipid/triacylglycerol biosynthesis pathway, is directly regulated by HIF-1 and promotes survival and etoposide resistance of cancer cells under hypoxia.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 09 15;1863(9):1142-1152. Epub 2018 Jun 15.

Laboratory of Physiology, Faculty of Medicine, University of Thessaly, Larissa, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2018.06.015DOI Listing
September 2018

Mortalin-mediated and ERK-controlled targeting of HIF-1α to mitochondria confers resistance to apoptosis under hypoxia.

J Cell Sci 2017 01 1;130(2):466-479. Epub 2016 Dec 1.

Laboratory of Biochemistry, Faculty of Medicine, University of Thessaly, Panepistimiou 3, BIOPOLIS, 41500 Larissa, Greece

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http://dx.doi.org/10.1242/jcs.195339DOI Listing
January 2017

HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia.

J Cell Sci 2016 11 29;129(22):4213-4226. Epub 2016 Sep 29.

Laboratory of Biochemistry, Faculty of Medicine, University of Thessaly, Biopolis, Larissa 41500, Greece

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http://dx.doi.org/10.1242/jcs.191395DOI Listing
November 2016

Low Serum Hepcidin in Patients with Autoimmune Liver Diseases.

PLoS One 2015 13;10(8):e0135486. Epub 2015 Aug 13.

Laboratory of Biochemistry, Faculty of Medicine, University of Thessaly, Larissa, Greece; Institute for Research & Technology-Thessaly (IRETETH), Larissa, Greece.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135486PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535884PMC
May 2016

HIF-1α in colorectal carcinoma: review of the literature.

J BUON 2015 May-Jun;20(3):680-9

Department of Pathology, Faculty of Medicine, University of Thessaly, Larissa, Greece.

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August 2015

A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression.

Cell Mol Life Sci 2014 Nov 10;71(21):4243-58. Epub 2014 Apr 10.

Laboratory of Molecular Biology and Immunobiotechnology, Department of Biochemistry, Hellenic Pasteur Institute, Athens, Greece.

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http://dx.doi.org/10.1007/s00018-014-1621-4DOI Listing
November 2014

An association study between hypoxia inducible factor-1alpha (HIF-1α) polymorphisms and osteonecrosis.

PLoS One 2013 18;8(11):e79647. Epub 2013 Nov 18.

Laboratory of Biochemistry, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Larissa, Greece ; Institute of Biomedical Research and Technology (BIOMED/CERETETH), Larissa, Greece.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079647PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832621PMC
July 2014

Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells.

Int J Biochem Cell Biol 2013 Nov 16;45(11):2359-68. Epub 2013 Aug 16.

Laboratory of Biochemistry, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Larissa 41110, Greece.

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http://dx.doi.org/10.1016/j.biocel.2013.07.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855297PMC
November 2013

Oxygen-dependent secretion of a bioactive hepcidin-GFP chimera.

Biochem Biophys Res Commun 2013 Jun 8;435(4):540-5. Epub 2013 May 8.

Laboratory of Biochemistry, Faculty of Medicine, University of Thessaly, Biopolis, Larissa 41500, Greece.

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http://dx.doi.org/10.1016/j.bbrc.2013.04.085DOI Listing
June 2013

High serum levels of HIF-1α in psoriatic patients correlate with an over-expression of IL-6.

Cytokine 2013 Apr 19;62(1):38-9. Epub 2013 Mar 19.

Department of Biochemistry and Biotechnology, University of Thessaly, Greece.

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http://dx.doi.org/10.1016/j.cyto.2013.02.029DOI Listing
April 2013

Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression.

J Cell Sci 2012 Jul 30;125(Pt 14):3485-93. Epub 2012 Mar 30.

Laboratory of Biochemistry, Medical School, University of Thessaly, BIOPOLIS, Larissa 41110, Greece.

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http://dx.doi.org/10.1242/jcs.106682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516382PMC
July 2012

Bortezomib represses HIF-1α protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells.

J Mol Med (Berl) 2012 Jan 10;90(1):45-54. Epub 2011 Sep 10.

Laboratory of Biochemistry, Faculty of Medicine, University of Thessaly, Biopolis, 41110 Larissa, Greece.

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http://dx.doi.org/10.1007/s00109-011-0805-8DOI Listing
January 2012

Isolation of hypoxia-inducible factor 1 (HIF-1) inhibitors from frankincense using a molecularly imprinted polymer.

Invest New Drugs 2011 Oct 1;29(5):1081-9. Epub 2010 May 1.

Department of Biochemistry, School of Medicine, Faculty of Life Sciences, University of Thessaly, 41110 Biopolis, Larissa, Greece.

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http://dx.doi.org/10.1007/s10637-010-9440-4DOI Listing
October 2011

eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}.

Cancer Res 2010 Oct 5;70(20):7820-9. Epub 2010 Oct 5.

Lady Davis Institute for Medical Research, McGill University, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0215DOI Listing
October 2010

Casein kinase 1 regulates human hypoxia-inducible factor HIF-1.

J Cell Sci 2010 Sep 10;123(Pt 17):2976-86. Epub 2010 Aug 10.

Laboratory of Biochemistry, School of Medicine, University of Thessaly, Mezourlo 41110, Larissa, Greece.

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http://dx.doi.org/10.1242/jcs.068122DOI Listing
September 2010

Building arks for tRNA: structure and function of the Arc1p family of non-catalytic tRNA-binding proteins.

FEBS Lett 2010 Sep 20;584(18):3842-9. Epub 2010 Aug 20.

Laboratory of Biochemistry, School of Medicine, University of Thessaly, BIOPOLIS, Larissa, Greece.

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http://dx.doi.org/10.1016/j.febslet.2010.08.023DOI Listing
September 2010

Validated analysis of HIF-1alpha expression in cancer cells using a controlled and comparative immunoassay.

Oncol Rep 2010 Jul;24(1):161-9

Department of Pathology, Medical School, University of Thessaly, 41110 Larissa, Greece.

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July 2010

The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions.

Biochem Biophys Res Commun 2010 Jul 15;398(1):74-8. Epub 2010 Jun 15.

Laboratory of Biochemistry, School of Medicine, University of Thessaly, BIOPOLIS, 41110 Larissa, Greece.

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http://dx.doi.org/10.1016/j.bbrc.2010.06.038DOI Listing
July 2010

Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7.

Biochem Biophys Res Commun 2009 Dec 27;390(2):235-40. Epub 2009 Sep 27.

Laboratory of Biochemistry, School of Medicine, University of Thessaly, Mezourlo, 41110 Larissa, Greece.

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http://dx.doi.org/10.1016/j.bbrc.2009.09.093DOI Listing
December 2009

Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1alpha by MAPK.

J Biol Chem 2008 Oct 7;283(41):27620-7. Epub 2008 Aug 7.

Laboratory of Biochemistry, Department of Medicine, University of Thessaly, Mezourlo, 41110 Larissa, Greece.

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http://dx.doi.org/10.1074/jbc.M803081200DOI Listing
October 2008

Incorporation of the Arc1p tRNA-binding domain to the catalytic core of MetRS can functionally replace the yeast Arc1p-MetRS complex.

J Mol Biol 2008 Sep 21;381(3):763-71. Epub 2008 Jun 21.

Laboratory of Biochemistry, Department of Medicine, University of Thessaly, P.O. Box 1400, Mezourlo, 41110 Larissa, Greece.

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http://dx.doi.org/10.1016/j.jmb.2008.06.044DOI Listing
September 2008

2-Oxoglutarate-dependent oxygenases control hepcidin gene expression.

J Hepatol 2008 May 13;48(5):801-10. Epub 2008 Feb 13.

Laboratory of Biochemistry, Department of Medicine, University of Thessaly, 22 Papakyriazi Street, Larissa, Greece.

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http://dx.doi.org/10.1016/j.jhep.2007.12.021DOI Listing
May 2008

Flavonoids induce HIF-1alpha but impair its nuclear accumulation and activity.

Free Radic Biol Med 2008 Feb 7;44(4):657-70. Epub 2007 Nov 7.

Department of Medicine, School of Health Sciences, University of Thessaly, 22 Papakyriazi Street, 41222 Larissa, Greece.

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http://dx.doi.org/10.1016/j.freeradbiomed.2007.10.050DOI Listing
February 2008

Molecular determinants of the yeast Arc1p-aminoacyl-tRNA synthetase complex assembly.

J Mol Biol 2007 Dec 11;374(4):1077-90. Epub 2007 Oct 11.

Laboratory of Biochemistry, Department of Medicine, University of Thessaly, 22 Papakyriazi Street, Larissa 41222, Greece.

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http://dx.doi.org/10.1016/j.jmb.2007.10.010DOI Listing
December 2007

MgcRacGAP interacts with HIF-1alpha and regulates its transcriptional activity.

Cell Physiol Biochem 2007 ;20(6):995-1006

Laboratory of Biochemistry, Department of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.

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http://dx.doi.org/10.1159/000110460DOI Listing
December 2007

Exposure of differentiated airway smooth muscle cells to serum stimulates both induction of hypoxia-inducible factor-1{alpha} and airway responsiveness to ACh.

Am J Physiol Lung Cell Mol Physiol 2007 Oct 27;293(4):L913-22. Epub 2007 Jul 27.

Department of Physiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Thessaly, Greece.

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http://dx.doi.org/10.1152/ajplung.00459.2006DOI Listing
October 2007

Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha.

J Biol Chem 2006 Nov 5;281(44):33095-106. Epub 2006 Sep 5.

Laboratory of Biochemistry, Department of Medicine, University of Thessaly, Larissa 41222, Greece.

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http://dx.doi.org/10.1074/jbc.M605058200DOI Listing
November 2006

Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes.

Nucleic Acids Res 2006 12;34(14):3968-79. Epub 2006 Aug 12.

Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

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http://dx.doi.org/10.1093/nar/gkl560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557820PMC
September 2006

Reconstitution of human hypoxia inducible factor HIF-1 in yeast: a simple in vivo system to identify and characterize HIF-1alpha effectors.

Biochem Biophys Res Commun 2006 Aug 16;346(4):1289-96. Epub 2006 Jun 16.

Laboratory of Biochemistry, School of Medicine, University of Thessaly, 41222 Larissa, Greece.

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http://dx.doi.org/10.1016/j.bbrc.2006.06.043DOI Listing
August 2006

Cobalt induces hypoxia-inducible factor-1alpha (HIF-1alpha) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism.

Free Radic Res 2006 Aug;40(8):847-56

Laboratory of Biochemistry, School of Medicine, University of Thessaly, 22 Papakyriazi Street, 41222, Larissa, Greece.

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http://dx.doi.org/10.1080/10715760600730810DOI Listing
August 2006

Bacterially produced human HIF-1alpha is competent for heterodimerization and specific DNA-binding.

Biochem Biophys Res Commun 2005 Jun;331(2):464-70

Laboratory of Biochemistry, School of Medicine, University of Thessaly, Papakyriazi 22, 41222 Larissa, Greece.

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http://dx.doi.org/10.1016/j.bbrc.2005.03.193DOI Listing
June 2005

Role of Arc1p in the modulation of yeast glutamyl-tRNA synthetase activity.

Biochemistry 2005 Feb;44(4):1344-52

UPR no. 9002 du CNRS, Institut de Biologie Moleculaire et Cellulaire du CNRS, 15 rue Rene Descartes, 67084 Strasbourg Cedex, France.

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http://dx.doi.org/10.1021/bi049024zDOI Listing
February 2005

The tRNA aminoacylation co-factor Arc1p is excluded from the nucleus by an Xpo1p-dependent mechanism.

FEBS Lett 2005 Feb 18;579(5):969-75. Epub 2005 Jan 18.

Biochemie-Zentrum Heidelberg, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.febslet.2004.11.112DOI Listing
February 2005

Cobalt induces hypoxia-inducible factor-1alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism.

Am J Respir Cell Mol Biol 2004 Nov 15;31(5):544-51. Epub 2004 Jul 15.

Laboratory of Physiology, Department of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.

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http://dx.doi.org/10.1165/rcmb.2003-0426OCDOI Listing
November 2004

Nuclear export of tRNA.

Results Probl Cell Differ 2002 ;35:115-31

Biochemie-Zentrum Heidelberg (BZH), Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.

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October 2002

Lack of pseudouridine 38/39 in the anticodon arm of yeast cytoplasmic tRNA decreases in vivo recoding efficiency.

J Biol Chem 2002 Aug 10;277(34):30445-53. Epub 2002 Jun 10.

Laboratoire d'Enzymologie et de Biochimie Structurales, CNRS, Avenue de la Terrasse, Bat. 34, F-91198 Gif sur Yvette, France.

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http://dx.doi.org/10.1074/jbc.M203456200DOI Listing
August 2002