George S Vassiliou

George S Vassiliou

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George S Vassiliou

George S Vassiliou

Publications by authors named "George S Vassiliou"

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54Publications

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NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia.

Blood 2019 Jul 11;134(4):383-388. Epub 2019 Jun 11.

Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1182/blood.2018883140DOI Listing
July 2019

Triple-mutant AML: too clever by HLF?

Blood 2019 Jul;134(3):222-224

University of Cambridge.

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http://dx.doi.org/10.1182/blood.2019001533DOI Listing
July 2019

Genome-scale drop-out screens to identify cancer cell vulnerabilities in AML.

Curr Opin Genet Dev 2019 May 4;54:83-87. Epub 2019 May 4.

Wellcome-MRC Cambridge Stem Cell Institute, Department of Haematology, University of Cambridge, Hills Road, Cambridge, CB2 0AW, United Kingdom; Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2019.04.004DOI Listing
May 2019

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells.

Genome Res 2019 04 22;29(4):564-575. Epub 2019 Feb 22.

Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1101/gr.239277.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442383PMC
April 2019

Recurrent histone mutations in T-cell acute lymphoblastic leukaemia.

Br J Haematol 2019 Feb 30;184(4):676-679. Epub 2018 Mar 30.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1111/bjh.15155DOI Listing
February 2019

Targeting MEK in vemurafenib-resistant hairy cell leukemia.

Leukemia 2019 02 19;33(2):541-545. Epub 2018 Oct 19.

Department of Haematology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/s41375-018-0270-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365378PMC
February 2019

Prediction of acute myeloid leukaemia risk in healthy individuals.

Nature 2018 07 9;559(7714):400-404. Epub 2018 Jul 9.

Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41586-018-0317-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485381PMC
July 2018

Preventing chemotherapy-induced myelosuppression by repurposing the FLT3 inhibitor quizartinib.

Sci Transl Med 2017 Aug;9(402)

School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia 6009, Australia.

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http://dx.doi.org/10.1126/scitranslmed.aam8060DOI Listing
August 2017

Therapeutics: Click and discover.

Nature 2017 08;548(7666):162-164

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK, and in the Cancer Research UK Cambridge Institute.

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http://dx.doi.org/10.1038/548162aDOI Listing
August 2017

Rapid parallel acquisition of somatic mutations after NPM1 in acute myeloid leukaemia evolution.

Br J Haematol 2017 03 7;176(5):825-829. Epub 2016 Apr 7.

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1111/bjh.13999DOI Listing
March 2017

Dynamic variation of CD5 surface expression levels within individual chronic lymphocytic leukemia clones.

Exp Hematol 2017 Feb 28;46:31-37.e10. Epub 2016 Sep 28.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK; Research Department of Infection, Division of Infection and Immunity, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261558PMC
February 2017

Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.

Cancer Discov 2016 10 17;6(10):1166-1181. Epub 2016 Aug 17.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584808PMC
October 2016

Identification of a germline F692L drug resistance variant in cis with Flt3-internal tandem duplication in knock-in mice.

Haematologica 2016 08 12;101(8):e328-31. Epub 2016 May 12.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK Department of Haematology, Cambridge University Hospitals NHS Trust, UK

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http://dx.doi.org/10.3324/haematol.2016.146159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967582PMC
August 2016

JAK2 V617F clonal disorders: fate or chance?

Blood 2016 08;128(8):1032-3

WELLCOME TRUST SANGER INSTITUTE.

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http://dx.doi.org/10.1182/blood-2016-07-726448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305049PMC
August 2016

Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies.

Blood 2016 07 27;128(1):e1-9. Epub 2016 Apr 27.

Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom; Department of Haematology, Haemato-oncology Diagnostic Service, Cambridge University Hospitals National Health Service Trust, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, Cambridge, United Kingdom;

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http://dx.doi.org/10.1182/blood-2015-11-683334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937362PMC
July 2016

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.

J Exp Med 2015 Sep 24;212(10):1551-69. Epub 2015 Aug 24.

Department of Haematology, Cambridge Institute for Medical Research and Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0XY, England, UK Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1TN, England, UK

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http://jem.rupress.org/content/212/10/1551.full.pdf
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http://www.jem.org/lookup/doi/10.1084/jem.20141661
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http://dx.doi.org/10.1084/jem.20141661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577832PMC
September 2015

Aging as a driver of leukemogenesis.

Sci Transl Med 2015 Sep 23;7(306):306fs38. Epub 2015 Sep 23.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK. Department of Haematology, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1126/scitranslmed.aac4428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916992PMC
September 2015

Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis.

Cell Rep 2015 Mar 26;10(8):1239-45. Epub 2015 Feb 26.

Haematological Cancer Genetics, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK; Department of Haematology, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0XY, UK; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542313PMC
March 2015

Effect of mutation order on myeloproliferative neoplasms.

N Engl J Med 2015 Feb;372(7):601-612

Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Stem Cell Institute (C.A.O., D.G.K., J.N., Y.S., J.G., E.J.B., C.E.M., A.L.G., D.D., A.R.G.) and Department of Hematology (C.A.O., D.G.K., J.N., Y.S., J.G., E.J.B., C.E.M., A.L.G., D.D., G.S.V., P.J.C., A.R.G.), University of Cambridge, Department of Haematology, Addenbrooke's Hospital (C.A.O., J.N., J.G., E.J.B., A.L.G., G.S.V., P.J.C., A.R.G.), Wellcome Trust Sanger Institute (D.C.W., E.P., G.S.V., P.J.C.), and Cancer Research U.K. Cambridge Institute, Li Ka Shing Centre (S.M.), Cambridge, and Guy's and St. Thomas' National Health Service Foundation Trust, Guy's Hospital, London (C.N.H.) - all in the United Kingdom; Dipartimento di Medicina Sperimentale e Clinica, University of Florence, Florence, Italy (P.G., A.V.); Departments of Pathology (B.B.) and Hematology (C.B.), Hospital del Mar, Barcelona; and the Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany (K.D.).

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http://dx.doi.org/10.1056/NEJMoa1412098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660033PMC
February 2015

Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer?

Dis Model Mech 2014 Aug;7(8):941-51

Haematological Cancer Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1242/dmm.015974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107323PMC
August 2014

Network properties derived from deep sequencing of human B-cell receptor repertoires delineate B-cell populations.

Genome Res 2013 Nov 6;23(11):1874-84. Epub 2013 Jun 6.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom;

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http://dx.doi.org/10.1101/gr.154815.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814887PMC
November 2013

The role of high-throughput technologies in clinical cancer genomics.

Expert Rev Mol Diagn 2013 Mar;13(2):167-81

Department of Hematology/Oncology, Cambridge University NHS Hospitals Foundation Trust, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1586/erm.13.1DOI Listing
March 2013

In situ thrombolysis for cerebral venous thrombosis complicating anti-leukemic therapy.

Leuk Res 2011 Aug 27;35(8):1127-9. Epub 2011 Mar 27.

Department of Haematology, Addenbrooke's Hospital, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge, UK.

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http://dx.doi.org/10.1016/j.leukres.2011.02.014DOI Listing
August 2011

Stella-Cre mice are highly efficient Cre deleters.

Genesis 2011 Aug 22;49(8):689-95. Epub 2011 Jul 22.

College of Animal Science and Technology, Huazhong Agriculture University, Wuhan, China.

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http://doi.wiley.com/10.1002/dvg.20741
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http://dx.doi.org/10.1002/dvg.20741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674523PMC
August 2011

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.

Lancet 2005 Mar 19-25;365(9464):1054-61

Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/S0140-6736(05)71142-9DOI Listing
April 2005

Management of the myeloproliferative disorders : distinguishing data from dogma.

Hematol J 2004 ;5 Suppl 3:S126-32

University Department of Haematology, Cambridge, UK.

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http://dx.doi.org/10.1038/sj.thj.6200438DOI Listing
November 2004

Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies.

Proc Natl Acad Sci U S A 2004 May 30;101(19):7341-6. Epub 2004 Apr 30.

Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 2XY, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0308195101
Publisher Site
http://dx.doi.org/10.1073/pnas.0308195101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC409920PMC
May 2004