George S Baillie

George S Baillie

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George S Baillie

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PDE10A mutations help to unwrap the neurobiology of hyperkinetic disorders.

Cell Signal 2019 Apr 2;60:31-38. Epub 2019 Apr 2.

IMED Biotech Unit, R&D, AstraZeneca Neuroscience, Boston, MA 024515, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2019.04.001DOI Listing
April 2019

Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A - C-Raf.

BMC Cancer 2019 Mar 25;19(1):266. Epub 2019 Mar 25.

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5489-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434832PMC
March 2019

AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA.

Cell Chem Biol 2019 Mar 21. Epub 2019 Mar 21.

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Pharmacology, University of California, 9500 Gilman Drive, BRF-II 1120, La Jolla, CA 92093-0702, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.03.003DOI Listing
March 2019

Methods to Investigate Arrestins in Complex with Phosphodiesterases.

Methods Mol Biol 2019 ;1957:121-137

Institute of Cardiovascular and Medical Sciences, College of Veterinary, Medical and Life Sciences, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1007/978-1-4939-9158-7_8DOI Listing
January 2019

A769662 Inhibits Insulin-Stimulated Akt Activation in Human Macrovascular Endothelial Cells Independent of AMP-Activated Protein Kinase.

Int J Mol Sci 2018 Dec 5;19(12). Epub 2018 Dec 5.

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.3390/ijms19123886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321332PMC
December 2018

Modelling and mathematical analysis of the M$_{2}$ receptor-dependent joint signalling and secondary messenger network in CHO cells.

Math Med Biol 2018 09;35(3):279-297

Algorithmic Bioinformatics, Bonn-Aachen International Center for IT, Rheinische Friedrich-Wilhelms-Universität Bonn, Dahlmannstr. 2, Bonn, Germany.

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http://dx.doi.org/10.1093/imammb/dqx003DOI Listing
September 2018

RAB40C regulates RACK1 stability via the ubiquitin-proteasome system.

Future Sci OA 2018 Jul 2;4(7):FSO317. Epub 2018 Jul 2.

Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.4155/fsoa-2018-0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088270PMC
July 2018

Validation of Cyclic Adenosine Monophosphate Phosphodiesterase-4D7 for its Independent Contribution to Risk Stratification in a Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes.

Eur Urol Focus 2018 04 13;4(3):376-384. Epub 2017 Jun 13.

Philips Research Europe, High Tech Campus, Eindhoven, The Netherlands; Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, Scotland, UK. Electronic address:

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http://dx.doi.org/10.1016/j.euf.2017.05.010DOI Listing
April 2018

PDE4-Mediated cAMP Signalling.

J Cardiovasc Dev Dis 2018 Jan 31;5(1). Epub 2018 Jan 31.

University of Glasgow, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.3390/jcdd5010008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872356PMC
January 2018

PDE8 controls CD4 T cell motility through the PDE8A-Raf-1 kinase signaling complex.

Cell Signal 2017 12 26;40:62-72. Epub 2017 Aug 26.

Department of Immunology, UConn Health, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2017.08.007DOI Listing
December 2017

Peptide array-based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 -acyltransferase.

J Biol Chem 2017 10 7;292(42):17190-17202. Epub 2017 Sep 7.

From The Strathclyde Institute of Pharmacy and Biomedical Sciences, 161 Cathedral Street, University of Strathclyde, Glasgow G4 0RE and

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http://dx.doi.org/10.1074/jbc.M117.799650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655499PMC
October 2017

RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells.

Cell Signal 2017 07 4;35:290-300. Epub 2016 Sep 4.

Graduate Entry Medical School, Materials and Surface Science Institute and Health Research Institute, University of Limerick, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2016.09.001DOI Listing
July 2017

PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex.

Elife 2017 07 27;6. Epub 2017 Jul 27.

Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, United Kingdom.

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http://dx.doi.org/10.7554/eLife.24578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576923PMC
July 2017

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks.

Elife 2017 03 31;6. Epub 2017 Mar 31.

Cancer Research United Kingdom Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.7554/eLife.23172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376188PMC
March 2017

Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners.

Biochem J 2017 02 19;474(4):597-609. Epub 2016 Dec 19.

Institute of Cardiovascular and Medical Science, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K.

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http://biochemj.org/lookup/doi/10.1042/BCJ20160849
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http://dx.doi.org/10.1042/BCJ20160849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290487PMC
February 2017

Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle.

J Gen Virol 2017 02;98(2):251-265

2​INSERM, U1111, Lyon 69364, France 5​Université Lyon 1, Centre International de Recherche en Infectiologie, Lyon 69364, France 1​CIRI, International Center for Infectiology Research, Oncogenic Herpesviruses Team, Université de Lyon, Lyon 69364, France 4​Ecole Normale Supérieure de Lyon, Lyon 69364, France 3​CNRS, UMR5308, Lyon 69364, France.

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http://dx.doi.org/10.1099/jgv.0.000681DOI Listing
February 2017

Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42-mediated cytotoxicity.

FEBS Open Bio 2017 Jan 5;7(1):64-73. Epub 2016 Dec 5.

Institute of Cardiovascular and Medical Sciences College of Veterinary Medical and Life Sciences University of Glasgow UK.

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http://dx.doi.org/10.1002/2211-5463.12156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221464PMC
January 2017

Location, location, location: PDE4D5 function is directed by its unique N-terminal region.

Cell Signal 2016 Jul 22;28(7):701-5. Epub 2016 Jan 22.

College of Veterinary Medical and Life Sciences, Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK.

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http://dx.doi.org/10.1016/j.cellsig.2016.01.008DOI Listing
July 2016

Editorial.

Authors:
George S Baillie

Cell Signal 2016 Jul 3;28(7):699-700. Epub 2016 Feb 3.

College of Veterinary Medical and Life Sciences, Institute of Cardiovascular and Medical Sciences, University of Glasgow, G128QQ, UK.

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http://dx.doi.org/10.1016/j.cellsig.2016.02.001DOI Listing
July 2016

Non-genetic therapeutic approaches to Canavan disease.

J Neurol Sci 2016 Jul 10;366:116-124. Epub 2016 May 10.

Gardiner Laboratory, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, UK.

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http://dx.doi.org/10.1016/j.jns.2016.05.012DOI Listing
July 2016

Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling.

Proc Natl Acad Sci U S A 2016 07 28;113(28):7786-91. Epub 2016 Jun 28.

Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, 6020 Innsbruck, Austria;

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http://dx.doi.org/10.1073/pnas.1608061113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948347PMC
July 2016

Editorial: Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels.

Front Pharmacol 2016 29;7. Epub 2016 Jan 29.

Gardiner Laboratory (535), Institute of Cardiovascular and Medical Sciences, University of Glasgow Glasgow, UK.

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http://dx.doi.org/10.3389/fphar.2016.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731503PMC
February 2016

p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.

Cell Rep 2016 Jan 31;14(2):255-68. Epub 2015 Dec 31.

Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.12.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831919PMC
January 2016

The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease.

Future Sci OA 2015 Nov 1;1(3):FSO11. Epub 2015 Nov 1.

Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.4155/fso.15.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137966PMC
November 2015

George Baillie on peptide array, a technique that transformed research on phosphodiesterases.

Authors:
George S Baillie

Future Sci OA 2015 Nov 1;1(3):FSO27. Epub 2015 Nov 1.

Institute of Cardiovascular and Medical Sciences, CMVLS, Glasgow University, Glasgow, UK.

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http://dx.doi.org/10.4155/fso.15.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137849PMC
November 2015

Heat shock protein 20 (HSP20) is a novel substrate for protein kinase D1 (PKD1).

Cell Biochem Funct 2015 Oct 6;33(7):421-6. Epub 2015 Oct 6.

Institute of Cardiovascular and Medical Sciences, CMVLS, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1002/cbf.3147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973849PMC
October 2015

Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2.

Circ Res 2015 Sep 4;117(8):707-19. Epub 2015 Aug 4.

From the Institute of Neuroscience and Psychology (A.Z., L.A.F., A.S., C.L., H.J., F.G., A.T., G.H., M.Z.) and Institute of Cardiovascular and Medical Sciences (Y.Y.S., G.S.B., S.A.N., D.G.), University of Glasgow, Glasgow, UK; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK (N.C.S., K.L., M.Z.); Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway (J.M.A., I.S.); Venetian Institute of Molecular Medicine, University of Padova, Padova, Italy (L.M., G.D., A.T., L.F., V.C.); Cardiology Section, VA Salt Lake City Health Care System and Cardiovascular Medicine Division, University of Utah School of Medicine, Salt Lake City, UT (N.S.-F., J.K., F.V., M.M.); Bjorknes College, Oslo, Norway (J.M.A.); and BHF Centre of Research Excellence, Oxford, UK (K.L., M.Z.).

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http://circres.ahajournals.org/content/early/2015/08/04/CIRC
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http://circres.ahajournals.org/lookup/doi/10.1161/CIRCRESAHA
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http://dx.doi.org/10.1161/CIRCRESAHA.114.305892DOI Listing
September 2015

Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.

Biochim Biophys Acta 2015 Jul 23;1853(7):1749-58. Epub 2015 Apr 23.

Institute of Molecular, Cellular and Systems Biology, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2015.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547084PMC
July 2015

UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy.

Cell Signal 2015 May 12;27(5):908-22. Epub 2015 Feb 12.

Department of Pharmacology, College of Medicine, University of Illinois at Chicago, E403 MSB, 835 South Wolcott Avenue, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1016/j.cellsig.2015.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361369PMC
May 2015

The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus.

FEBS Lett 2015 Mar 11;589(6):750-5. Epub 2015 Feb 11.

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK. Electronic address:

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http://doi.wiley.com/10.1016/j.febslet.2015.02.004
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http://dx.doi.org/10.1016/j.febslet.2015.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346272PMC
March 2015

Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy.

Cell Commun Signal 2015 Mar 7;13:16. Epub 2015 Mar 7.

Institute of Cardiovascular and Medical sciences, CMVLS, University of Glasgow, Glasgow, G128QQ, UK.

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http://dx.doi.org/10.1186/s12964-015-0094-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356135PMC
March 2015

Cytodynamics and endpoint selection for a reliable in vitro assessment of nanoneurotoxicity.

Nanomedicine 2015 Feb 13;11(2):407-8. Epub 2014 Nov 13.

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

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http://dx.doi.org/10.1016/j.nano.2014.08.014DOI Listing
February 2015

Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells.

J Cell Sci 2014 Dec 29;127(Pt 24):5303-16. Epub 2014 Oct 29.

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, EH4 2XR Edinburgh, UK

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http://dx.doi.org/10.1242/jcs.157560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265741PMC
December 2014

β-Adrenergic modulation of myocardial conduction velocity: Connexins vs. sodium current.

J Mol Cell Cardiol 2014 Dec 23;77:147-54. Epub 2014 Oct 23.

University of Glasgow, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.09.030DOI Listing
December 2014

PKA phosphorylation of p62/SQSTM1 regulates PB1 domain interaction partner binding.

Biochim Biophys Acta 2014 Nov 7;1843(11):2765-74. Epub 2014 Aug 7.

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2014.07.021DOI Listing
November 2014

Perihaematomal cytokine expression is a crucial component of intracerebral haemorrhage pathophysiology.

Neurol Sci 2014 Sep 12;35(9):1471-3. Epub 2014 Apr 12.

Gardiner Laboratory, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Box 318, 111 West George Str, G2-1QX, Glasgow, Scotland, UK,

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http://dx.doi.org/10.1007/s10072-014-1785-6DOI Listing
September 2014

Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression.

Cell Signal 2014 Sep 9;26(9):1958-74. Epub 2014 May 9.

Institute of Pharmaceutical Science, King's College London, 5th Floor, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2014.04.023DOI Listing
September 2014

Compartmentalisation of second messenger signalling pathways.

Curr Opin Genet Dev 2014 Aug 8;27:20-5. Epub 2014 May 8.

Institute of Cardiovascular and Medical Sciences, CMVLS, Wolfson-Link Building, University of Glasgow, Glasgow G12 8QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2014.02.001DOI Listing
August 2014

The phosphorylation of Hsp20 enhances its association with amyloid-β to increase protection against neuronal cell death.

Mol Cell Neurosci 2014 Jul 20;61:46-55. Epub 2014 May 20.

Institute of Cardiovascular and Medical Science, College of Veterinary, Medical and life sciences, University of Glasgow, Glasgow G128QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2014.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148482PMC
July 2014

A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells.

Nat Commun 2014 Jul 16;5:4431. Epub 2014 Jul 16.

1] Department of Endocrinology, Metabolism and Diabetes, Inserm, U1016, Institut Cochin, 27 rue du Faubourg St Jaques, Paris 75014, France [2] CNRS, UMR8104, Paris 75014, France [3] University Paris Descartes, Sorbonne Paris Cité, Paris 75014, France.

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http://dx.doi.org/10.1038/ncomms5431DOI Listing
July 2014

Arrestin-dependent localization of phosphodiesterases.

Handb Exp Pharmacol 2014 ;219:293-307

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G128QQ, UK.

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http://dx.doi.org/10.1007/978-3-642-41199-1_15DOI Listing
April 2014

Arrestin regulation of small GTPases.

Handb Exp Pharmacol 2014 ;219:375-85

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G128QQ, UK.

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http://dx.doi.org/10.1007/978-3-642-41199-1_19DOI Listing
April 2014

The cardioprotective role of small heat-shock protein 20.

Biochem Soc Trans 2014 Apr;42(2):270-3

*Institute of Cardiovascular and Medical Sciences, University of Glasgow, Wolfson-Link Building, Glasgow G12 8QQ, U.K.

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http://dx.doi.org/10.1042/BST20130272DOI Listing
April 2014

Real-time probing of β-amyloid self-assembly and inhibition using fluorescence self-quenching between neighbouring dyes.

Mol Biosyst 2014 Jan 29;10(1):34-44. Epub 2013 Oct 29.

SUPA School of Physics and Astronomy, University of St Andrews, North Haugh, Fife, Scotland, KY16 9SS, UK.

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http://xlink.rsc.org/?DOI=C3MB70272C
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http://dx.doi.org/10.1039/c3mb70272cDOI Listing
January 2014

The extent and the nature of the cholinergic contribution to the hepatic encephalopathy-induced cognitive impairment.

Free Radic Biol Med 2013 Dec 22;65:1516-1517. Epub 2013 Aug 22.

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G2-1QX, UK.

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http://dx.doi.org/10.1016/j.freeradbiomed.2013.08.165DOI Listing
December 2013

Lanthanum-induced neurotoxicity: solving the riddle of its involvement in cognitive impairment?

Arch Toxicol 2013 Nov 10;87(11):2031-2035. Epub 2013 Aug 10.

Gardiner Laboratory (535), Wolfson Link Building, College of Medical, Veterinary and Life Sciences, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Box 318, 111 West George Str., Glasgow, G2-1QX, Scotland, UK.

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http://dx.doi.org/10.1007/s00204-013-1112-7DOI Listing
November 2013

RACK1 to the future--a historical perspective.

Cell Commun Signal 2013 Aug 1;11:53. Epub 2013 Aug 1.

Department of Life Sciences, Materials and Surface Science Institute and Stokes Institute, University of Limerick, Limerick, Ireland.

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http://dx.doi.org/10.1186/1478-811X-11-53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750812PMC
August 2013

Can acetylcholinesterase activity be considered as a reliable biomarker for the assessment of cadmium-induced neurotoxicity?

Food Chem Toxicol 2013 Jun 5;56:406-10. Epub 2013 Mar 5.

Gardiner Laboratory, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

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http://dx.doi.org/10.1016/j.fct.2013.02.048DOI Listing
June 2013

Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4).

Biochem Pharmacol 2013 May 5;85(9):1297-305. Epub 2013 Mar 5.

Institute of Cardiovascular and Medical Sciences, CMVLS, Glasgow University, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.1016/j.bcp.2013.02.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625111PMC
May 2013

Reciprocal regulation of PKA and Rac signaling.

Proc Natl Acad Sci U S A 2013 May 8;110(21):8531-6. Epub 2013 May 8.

Institutes of Biochemistry, University of Innsbruck, A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1073/pnas.1215902110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666698PMC
May 2013

Phosphodiesterase-8A binds to and regulates Raf-1 kinase.

Proc Natl Acad Sci U S A 2013 Apr 18;110(16):E1533-42. Epub 2013 Mar 18.

Institute of Cardiovascular and Medical Science, Cellular and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.

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http://www.pnas.org/content/110/16/E1533.full.pdf
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http://researchrepository.ucd.ie/bitstream/handle/10197/5062
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http://www.pnas.org/cgi/doi/10.1073/pnas.1303004110
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http://dx.doi.org/10.1073/pnas.1303004110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631629PMC
April 2013

Targeting protein-protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease.

Future Med Chem 2013 Mar;5(4):451-64

Institute of Cardiovascular & Medical Science, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.

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http://dx.doi.org/10.4155/fmc.12.216DOI Listing
March 2013

The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16).

Biochem J 2012 Sep;446(3):437-43

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.1042/BJ20120570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498943PMC
September 2012

Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation.

FEBS Lett 2012 Jun 3;586(11):1631-7. Epub 2012 May 3.

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.1016/j.febslet.2012.04.033DOI Listing
June 2012

cAMP: novel concepts in compartmentalised signalling.

Semin Cell Dev Biol 2012 Apr 13;23(2):181-90. Epub 2011 Sep 13.

Institute of Neuroscience and Molecular Pharmacology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.1016/j.semcdb.2011.09.005DOI Listing
April 2012

PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects.

Biochem Soc Trans 2012 Feb;40(1):210-4

Centre for Molecular Pharmacology, College of Medical, Veterinary and Life Sciences, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.1042/BST20110673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269834PMC
February 2012

Protein kinase D in the hypertrophy pathway.

Biochem Soc Trans 2012 Feb;40(1):287-9

Molecular Pharmacology Group, Institute of Cardiovascular and Medical Science, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.1042/BST20110626DOI Listing
February 2012

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation.

Biochem J 2011 May;435(3):755-69

Molecular Pharmacology Group, Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, Wolfson Link and Davidson Buildings, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

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http://dx.doi.org/10.1042/BJ20101184DOI Listing
May 2011

The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease.

J Biol Chem 2011 Mar 22;286(12):10530-9. Epub 2010 Dec 22.

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.177394
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http://dx.doi.org/10.1074/jbc.M110.177394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060506PMC
March 2011

p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways.

Cell Signal 2010 Oct 19;22(10):1576-96. Epub 2010 Jun 19.

Neuroscience and Molecular Pharmacology, Wolfson and Davidson Buildings, Faculty of Biomedical & Life Sciences, University of Glasgow, Glasgow, G12 8QQ, Scotland, United Kingdom.

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http://dx.doi.org/10.1016/j.cellsig.2010.06.003DOI Listing
October 2010

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.

Biochem J 2010 Apr 28;428(1):55-65. Epub 2010 Apr 28.

Neuroscience and Molecular Pharmacology, Division of Integrative Biology, IBLS, Wolfson Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.

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http://dx.doi.org/10.1042/BJ20091672DOI Listing
April 2010

A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex.

FEBS Lett 2009 Oct 24;583(20):3310-6. Epub 2009 Sep 24.

Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, Wolfson Building, Glasgow University, Glasgow G12 8QQ, United Kingdom.

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http://dx.doi.org/10.1016/j.febslet.2009.09.035DOI Listing
October 2009

Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.

J Biol Chem 2009 Jul 7;284(30):20263-74. Epub 2009 May 7.

From the Cell Biology Laboratory, Department of Biochemistry, BioSciences Institute, University College Cork, Cork, Ireland.

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http://dx.doi.org/10.1074/jbc.M109.017640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740452PMC
July 2009

Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5.

J Biol Chem 2009 Jun 16;284(24):16170-82. Epub 2009 Apr 16.

Neuroscience and Molecular Pharmacology, Wolfson and Davidson Buildings, Faculty of Biomedical & Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M109.008078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713507PMC
June 2009

Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases.

Authors:
George S Baillie

FEBS J 2009 Apr 23;276(7):1790-9. Epub 2009 Feb 23.

Division of Neuroscience and Molecular Pharmacology, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1111/j.1742-4658.2009.06926.xDOI Listing
April 2009