Publications by authors named "George M Church"

100Publications

Pluripotent stem cell-derived CAR-macrophage cells with antigen-dependent anti-cancer cell functions.

J Hematol Oncol 2020 Nov 11;13(1):153. Epub 2020 Nov 11.

Center for Stem Cell and Regenerative Medicine, Department of Basic Medical Sciences, and The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.

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http://dx.doi.org/10.1186/s13045-020-00983-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656711PMC
November 2020

Photon-directed multiplexed enzymatic DNA synthesis for molecular digital data storage.

Nat Commun 2020 10 16;11(1):5246. Epub 2020 Oct 16.

Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41467-020-18681-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567835PMC
October 2020

TBDB: a database of structurally annotated T-box riboswitch:tRNA pairs.

Nucleic Acids Res 2020 Sep 3. Epub 2020 Sep 3.

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/nar/gkaa721DOI Listing
September 2020

Release Factor Inhibiting Antimicrobial Peptides Improve Nonstandard Amino Acid Incorporation in Wild-type Bacterial Cells.

ACS Chem Biol 2020 07 30;15(7):1852-1861. Epub 2020 Jun 30.

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acschembio.0c00055DOI Listing
July 2020

Spatial Sequencing: A Perspective.

J Biomol Tech 2020 07;31(2):44-46

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA; and.

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http://dx.doi.org/10.7171/jbt.20-3102-003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192195PMC
July 2020

Porcine genome engineering for xenotransplantation.

Adv Drug Deliv Rev 2020 Apr 7. Epub 2020 Apr 7.

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2020.04.001DOI Listing
April 2020

A Deep Learning Approach to Antibiotic Discovery.

Cell 2020 02;180(4):688-702.e13

Department of Biological Engineering, Synthetic Biology Center, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA; Abdul Latif Jameel Clinic for Machine Learning in Health, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.01.021DOI Listing
February 2020

Single-Cell CRISPR-Based Lineage Tracing in Mice.

Biochemistry 2019 12 15;58(48):4775-4776. Epub 2019 Nov 15.

Department of Genetics and Wyss Institute for Biologically Inspired Engineering , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acs.biochem.9b00688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138465PMC
December 2019

Rapid in vitro production of single-stranded DNA.

Nucleic Acids Res 2019 12;47(22):11956-11962

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/nar/gkz998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145709PMC
December 2019

A single combination gene therapy treats multiple age-related diseases.

Proc Natl Acad Sci U S A 2019 11 4;116(47):23505-23511. Epub 2019 Nov 4.

Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1910073116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876218PMC
November 2019

Characterization of porcine endogenous retrovirus particles released by the CRISPR/Cas9 inactivated cell line PK15 clone 15.

Xenotransplantation 2020 03 31;27(2):e12563. Epub 2019 Oct 31.

Division of Medical Biotechnology, Paul-Ehrlich-Institut, Langen, Germany.

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http://dx.doi.org/10.1111/xen.12563DOI Listing
March 2020

Unified rational protein engineering with sequence-based deep representation learning.

Nat Methods 2019 12 21;16(12):1315-1322. Epub 2019 Oct 21.

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41592-019-0598-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067682PMC
December 2019

Author Correction: Data privacy in the age of personal genomics.

Nat Biotechnol 2019 Nov;37(11):1380

Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41587-019-0304-yDOI Listing
November 2019

Data privacy in the age of personal genomics.

Nat Biotechnol 2019 10;37(10):1115-1117

Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41587-019-0271-3DOI Listing
October 2019

Terminator-free template-independent enzymatic DNA synthesis for digital information storage.

Nat Commun 2019 06 3;10(1):2383. Epub 2019 Jun 3.

Department of Genetics, Harvard Medical School, Boston, 02115, MA, USA.

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http://dx.doi.org/10.1038/s41467-019-10258-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546792PMC
June 2019

Functional genomics of the rapidly replicating bacterium Vibrio natriegens by CRISPRi.

Nat Microbiol 2019 07 8;4(7):1105-1113. Epub 2019 Apr 8.

Department of Genetics, Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41564-019-0423-8
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http://dx.doi.org/10.1038/s41564-019-0423-8DOI Listing
July 2019

Publisher Correction: DNA sequencing at 40: past, present and future.

Nature 2019 Apr;568(7752):E11

Department of Genome Sciences, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/s41586-019-1120-8DOI Listing
April 2019

Daisy-chain gene drives for the alteration of local populations.

Proc Natl Acad Sci U S A 2019 04 2;116(17):8275-8282. Epub 2019 Apr 2.

Media Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1716358116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486765PMC
April 2019

Cell-free Protein Expression Using the Rapidly Growing Bacterium Vibrio natriegens.

J Vis Exp 2019 03 14(145). Epub 2019 Mar 14.

Department of Genetics, Harvard Medical School; Wyss Institute for Biologically Inspired Engineering;

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https://www.jove.com/video/59495/cell-free-protein-expressio
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http://dx.doi.org/10.3791/59495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512795PMC
March 2019

Significant abundance of cis configurations of coding variants in diploid human genomes.

Nucleic Acids Res 2019 04;47(6):2981-2995

Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.

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http://dx.doi.org/10.1093/nar/gkz031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451136PMC
April 2019

CRISPR Guide RNA Cloning for Mammalian Systems.

J Vis Exp 2018 10 2(140). Epub 2018 Oct 2.

Wyss Institute for Biologically Inspired Engineering, Harvard University; Department of Genetics, Harvard Medical School;

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https://www.jove.com/video/57998/crispr-guide-rna-cloning-fo
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http://dx.doi.org/10.3791/57998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235376PMC
October 2018

Establishing a Cell-Free Vibrio natriegens Expression System.

ACS Synth Biol 2018 10 12;7(10):2475-2479. Epub 2018 Sep 12.

Department of Genetics , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acssynbio.8b00222DOI Listing
October 2018

Inter-homologue repair in fertilized human eggs?

Nature 2018 08 8;560(7717):E5-E7. Epub 2018 Aug 8.

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://www.nature.com/articles/s41586-018-0379-5
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http://dx.doi.org/10.1038/s41586-018-0379-5DOI Listing
August 2018

Biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators.

Nat Commun 2018 08 6;9(1):3101. Epub 2018 Aug 6.

Department of Genetics, Harvard Medical School, 77 Av. Louis Pasteur, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41467-018-05525-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079105PMC
August 2018

Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks.

Mol Cell 2018 07;71(1):42-55.e8

Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA; Genome Editing Core, University of Illinois at Chicago, Chicago, IL 60607, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765183044
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http://dx.doi.org/10.1016/j.molcel.2018.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063522PMC
July 2018

Characterizing Protein Kinase Substrate Specificity Using the Proteomic Peptide Library (ProPeL) Approach.

Curr Protoc Chem Biol 2018 06;10(2):e38

University of Connecticut, Department of Physiology and Neurobiology, Storrs, Connecticut.

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http://dx.doi.org/10.1002/cpch.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014603PMC
June 2018

Current CRISPR gene drive systems are likely to be highly invasive in wild populations.

Elife 2018 06 19;7. Epub 2018 Jun 19.

Program for Evolutionary Dynamics, Harvard University, Cambridge, United States.

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http://dx.doi.org/10.7554/eLife.33423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014726PMC
June 2018

Codon usage of highly expressed genes affects proteome-wide translation efficiency.

Proc Natl Acad Sci U S A 2018 05 7;115(21):E4940-E4949. Epub 2018 May 7.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel;

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http://dx.doi.org/10.1073/pnas.1719375115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003480PMC
May 2018

Simultaneous Discovery of Cell-Free DNA and the Nucleosome Ladder.

Genetics 2018 May;209(1):27-29

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1534/genetics.118.300775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937182PMC
May 2018

An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance.

Cell 2018 04;173(3):649-664.e20

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.03.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061940PMC
April 2018

Enabling multiplexed testing of pooled donor cells through whole-genome sequencing.

Genome Med 2018 04 19;10(1):31. Epub 2018 Apr 19.

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.

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https://genomemedicine.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13073-018-0541-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909281PMC
April 2018

Precise Cas9 targeting enables genomic mutation prevention.

Proc Natl Acad Sci U S A 2018 04 19;115(14):3669-3673. Epub 2018 Mar 19.

Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02115;

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http://dx.doi.org/10.1073/pnas.1718148115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889643PMC
April 2018

Adaptive evolution of genomically recoded .

Proc Natl Acad Sci U S A 2018 03 13;115(12):3090-3095. Epub 2018 Feb 13.

Department of Genetics, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1715530115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866557PMC
March 2018

Spontaneous CRISPR loci generation in vivo by non-canonical spacer integration.

Nat Microbiol 2018 03 29;3(3):310-318. Epub 2018 Jan 29.

Department of Genetics, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41564-017-0097-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832444PMC
March 2018

From Designing the Molecules of Life to Designing Life: Future Applications Derived from Advances in DNA Technologies.

Angew Chem Int Ed Engl 2018 04 23;57(16):4313-4328. Epub 2018 Feb 23.

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://doi.wiley.com/10.1002/anie.201707976
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http://dx.doi.org/10.1002/anie.201707976DOI Listing
April 2018

Engineering posttranslational proofreading to discriminate nonstandard amino acids.

Proc Natl Acad Sci U S A 2018 01 4;115(3):619-624. Epub 2018 Jan 4.

Department of Genetics, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1715137115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776986PMC
January 2018

The Future of Multiplexed Eukaryotic Genome Engineering.

ACS Chem Biol 2018 02 28;13(2):313-325. Epub 2017 Dec 28.

Department of Genetics, Harvard Medical School , Boston, Massachusetts, United States.

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http://pubs.acs.org/doi/10.1021/acschembio.7b00842
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http://dx.doi.org/10.1021/acschembio.7b00842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880278PMC
February 2018

Efficient in situ barcode sequencing using padlock probe-based BaristaSeq.

Nucleic Acids Res 2018 02;46(4):e22

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1093/nar/gkx1206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829746PMC
February 2018

A CRISPR-Cas9-based gene drive platform for genetic interaction analysis in Candida albicans.

Nat Microbiol 2018 Jan 23;3(1):73-82. Epub 2017 Oct 23.

Department of Biological Engineering, Institute for Medical Engineering and Science, Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s41564-017-0043-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832965PMC
January 2018

DNA sequencing at 40: past, present and future.

Nature 2017 10 11;550(7676):345-353. Epub 2017 Oct 11.

Department of Genome Sciences, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/nature24286DOI Listing
October 2017

Heterologous erythromycin production across strain and plasmid construction.

Biotechnol Prog 2018 01 13;34(1):271-276. Epub 2017 Oct 13.

Dept. of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY.

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http://dx.doi.org/10.1002/btpr.2567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821549PMC
January 2018

A systematic comparison of error correction enzymes by next-generation sequencing.

Nucleic Acids Res 2017 Sep;45(15):9206-9217

Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1093/nar/gkx691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587813PMC
September 2017

Beyond editing to writing large genomes.

Nat Rev Genet 2017 12 30;18(12):749-760. Epub 2017 Aug 30.

Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts, 02115, USA, and at the Wyss Institute for Biologically Inspired Engineering, 3 Blackfan Circle, Boston, Massachusetts, 02115, USA.

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http://dx.doi.org/10.1038/nrg.2017.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793211PMC
December 2017

Imaging of Isolated Extracellular Vesicles Using Fluorescence Microscopy.

Methods Mol Biol 2017 ;1660:233-241

Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, USA.

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http://link.springer.com/10.1007/978-1-4939-7253-1_19
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http://dx.doi.org/10.1007/978-1-4939-7253-1_19DOI Listing
May 2018

Extracellular Vesicle Isolation and Analysis by Western Blotting.

Methods Mol Biol 2017 ;1660:143-152

Department of Genetics, Harvard Medical School, Boston, MA, USA.

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http://link.springer.com/10.1007/978-1-4939-7253-1_12
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http://dx.doi.org/10.1007/978-1-4939-7253-1_12DOI Listing
May 2018

Dissecting limiting factors of the Protein synthesis Using Recombinant Elements (PURE) system.

Translation (Austin) 2017 9;5(1):e1327006. Epub 2017 May 9.

Department of Genetics, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1080/21690731.2017.1327006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501384PMC
May 2017

CRISPR-Cas encoding of a digital movie into the genomes of a population of living bacteria.

Nature 2017 07 12;547(7663):345-349. Epub 2017 Jul 12.

Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature23017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842791PMC
July 2017

Scalable Device for Automated Microbial Electroporation in a Digital Microfluidic Platform.

ACS Synth Biol 2017 09 7;6(9):1701-1709. Epub 2017 Jun 7.

Department of Electrical and Computer Engineering, Duke University , Durham, North Carolina 27708, United States.

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http://pubs.acs.org/doi/10.1021/acssynbio.7b00007
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http://dx.doi.org/10.1021/acssynbio.7b00007DOI Listing
September 2017

Addressing the ethical issues raised by synthetic human entities with embryo-like features.

Elife 2017 03 21;6. Epub 2017 Mar 21.

Department of Genetics, Harvard Medical School, Boston, United States.

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http://dx.doi.org/10.7554/eLife.20674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360441PMC
March 2017

Nucleotide-time alignment for molecular recorders.

PLoS Comput Biol 2017 05 1;13(5):e1005483. Epub 2017 May 1.

Department of Physical Medicine and Rehabilitation, Rehabilitation Institute of Chicago, Northwestern University, Chicago, Illinois, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432193PMC
May 2017

Evolutionary dynamics of CRISPR gene drives.

Sci Adv 2017 Apr 5;3(4):e1601964. Epub 2017 Apr 5.

Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1126/sciadv.1601964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381957PMC
April 2017

Cogenerating Synthetic Parts toward a Self-Replicating System.

ACS Synth Biol 2017 07 29;6(7):1327-1336. Epub 2017 Mar 29.

Department of Genetics, Harvard Medical School , 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acssynbio.6b00342DOI Listing
July 2017

sgRNA Scorer 2.0: A Species-Independent Model To Predict CRISPR/Cas9 Activity.

ACS Synth Biol 2017 05 10;6(5):902-904. Epub 2017 Feb 10.

Department of Genetics, Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acssynbio.6b00343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793212PMC
May 2017

Cushing's syndrome mutant PKA exhibits altered substrate specificity.

FEBS Lett 2017 02 3;591(3):459-467. Epub 2017 Feb 3.

Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA.

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http://dx.doi.org/10.1002/1873-3468.12562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321106PMC
February 2017

Rapidly evolving homing CRISPR barcodes.

Nat Methods 2017 02 5;14(2):195-200. Epub 2016 Dec 5.

Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.4108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322472PMC
February 2017