Publications by authors named "George Leikauf"

68Publications

Phloretin, An Apple Polyphenol, Inhibits Pathogen-Induced Mucin Overproduction.

Mol Nutr Food Res 2020 Nov 20:e2000658. Epub 2020 Nov 20.

Department of Environmental, and Occupational Health, Graduate, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1002/mnfr.202000658DOI Listing
November 2020

Genetic Determinants of Ammonia-Induced Acute Lung Injury in Mice.

Am J Physiol Lung Cell Mol Physiol 2020 Oct 14. Epub 2020 Oct 14.

Envirionmental and Occupational Health, University of Pittsburgh, United States.

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http://dx.doi.org/10.1152/ajplung.00276.2020DOI Listing
October 2020

Albumin Protects Lung Cells against Acrolein Cytotoxicity and Acrolein-Adducted Albumin Increases Heme Oxygenase 1 Transcripts.

Chem Res Toxicol 2020 Jul 29;33(7):1969-1979. Epub 2020 Jun 29.

Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.0c00146DOI Listing
July 2020

Augmented angiogenic transcription factor, SOX18, is associated with asthma exacerbation.

J Asthma 2020 May 27:1-12. Epub 2020 May 27.

Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Gyeonggi-do, Republic of Korea.

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http://dx.doi.org/10.1080/02770903.2020.1771727DOI Listing
May 2020

Mechanisms of ultrafine particle-induced respiratory health effects.

Exp Mol Med 2020 03 17;52(3):329-337. Epub 2020 Mar 17.

Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.

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http://dx.doi.org/10.1038/s12276-020-0394-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156674PMC
March 2020

Proteomic identification of moesin upon exposure to acrolein.

Proteome Sci 2018 17;16. Epub 2018 Jan 17.

1Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon, Gyeonggi-do 420-767 South Korea.

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http://dx.doi.org/10.1186/s12953-017-0130-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773073PMC
January 2018

Alteration in Claudin-4 Contributes to Airway Inflammation and Responsiveness in Asthma.

Allergy Asthma Immunol Res 2018 Jan;10(1):25-33

Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.

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https://synapse.koreamed.org/DOIx.php?id=10.4168/aair.2018.1
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http://dx.doi.org/10.4168/aair.2018.10.1.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705480PMC
January 2018

Secreted Phosphoprotein 1 and Sex-Specific Differences in Silica-Induced Pulmonary Fibrosis in Mice.

Environ Health Perspect 2016 08 8;124(8):1199-207. Epub 2016 Mar 8.

Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1289/ehp.1510335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977050PMC
August 2016

Comment on Expression of Concern: c-Kit Is Essential for Alveolar Maintenance and Protection from Emphysema-like Disease in Mice.

Am J Respir Crit Care Med 2016 Mar;193(5):581-2

4 German Research Center for Environmental Health & Comprehensive Pneumology Center Munich (CPC-M) Munich, Germany.

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http://www.atsjournals.org/doi/10.1164/rccm.1935comment
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http://dx.doi.org/10.1164/rccm.1935commentDOI Listing
March 2016

Claudin 5 in a murine model of allergic asthma: Its implication and response to steroid treatment.

J Allergy Clin Immunol 2015 Dec 26;136(6):1694-1696.e5. Epub 2015 Sep 26.

Genome Research Center for Allergy and Respiratory Diseases, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.08.004DOI Listing
December 2015

Novel PDE4 inhibitors derived from Chinese medicine forsythia.

PLoS One 2014 30;9(12):e115937. Epub 2014 Dec 30.

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213, United States of America; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, 15213, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115937PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280171PMC
October 2015

Diesel exhaust particle-induced airway responses are augmented in obese rats.

Int J Toxicol 2014 Jan-Feb;33(1):21-8

Department of Internal Medicine, Division of Allergy and Respiratory Diseases, Soonchunhyang University Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon, Gyeonggi-Do, 420-767, Republic of Korea. Email:

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http://dx.doi.org/10.1177/1091581813518355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429286PMC
October 2014

LPS-treated macrophage cytokines repress surfactant protein-B in lung epithelial cells.

Am J Respir Cell Mol Biol 2013 Aug;49(2):306-15

Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219-3130, USA.

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http://dx.doi.org/10.1165/rcmb.2012-0283OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824031PMC
August 2013

Dysregulation of FURIN by prostaglandin-endoperoxide synthase 2 in lung epithelial NCI-H292 cells.

Mol Carcinog 2014 Mar 12;53(3):192-200. Epub 2012 Oct 12.

Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219-3130.

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http://dx.doi.org/10.1002/mc.21963DOI Listing
March 2014

WNT1-inducible signaling pathway protein 1 contributes to ventilator-induced lung injury.

Am J Respir Cell Mol Biol 2012 Oct 14;47(4):528-35. Epub 2012 Jun 14.

Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1165/rcmb.2012-0127OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488625PMC
October 2012

Acrolein - a pulmonary hazard.

Mol Nutr Food Res 2011 Sep;55(9):1342-60

Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219-3130, USA.

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http://dx.doi.org/10.1002/mnfr.201100279DOI Listing
September 2011

Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection.

J Immunol 2011 Jul 1;187(1):382-90. Epub 2011 Jun 1.

Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA.

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http://dx.doi.org/10.4049/jimmunol.1001769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119743PMC
July 2011

c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice.

Am J Respir Crit Care Med 2011 06 11;183(12):1644-52. Epub 2011 Mar 11.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.

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http://dx.doi.org/10.1164/rccm.201007-1157OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136992PMC
June 2011

Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1.

Am J Respir Crit Care Med 2011 Jun 4;183(11):1499-509. Epub 2011 Feb 4.

Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219-3130, USA.

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http://dx.doi.org/10.1164/rccm.201006-0912OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137140PMC
June 2011

JUN-CCAAT/enhancer-binding protein complexes inhibit surfactant-associated protein B promoter activity.

Am J Respir Cell Mol Biol 2011 Aug 10;45(2):436-44. Epub 2010 Dec 10.

Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15219-3130, USA.

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http://dx.doi.org/10.1165/rcmb.2010-0260OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175569PMC
August 2011

Functional genomics of chlorine-induced acute lung injury in mice.

Proc Am Thorac Soc 2010 Jul;7(4):294-6

Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219-3130, USA.

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http://dx.doi.org/10.1513/pats.201001-005SMDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136967PMC
July 2010

Endothelial dysfunction and claudin 5 regulation during acrolein-induced lung injury.

Am J Respir Cell Mol Biol 2011 Apr 4;44(4):483-90. Epub 2010 Jun 4.

Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219-3130, USA.

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http://dx.doi.org/10.1165/rcmb.2009-0391OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095921PMC
April 2011

Glutathione deficient C57BL/6J mice are not sensitized to ozone-induced lung injury.

Biochem Biophys Res Commun 2010 May 22;396(2):407-12. Epub 2010 Apr 22.

Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267-0056, USA.

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http://dx.doi.org/10.1016/j.bbrc.2010.04.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892220PMC
May 2010

The role of T cells in the regulation of acrolein-induced pulmonary inflammation and epithelial-cell pathology.

Res Rep Health Eff Inst 2009 Dec(146):5-29

Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0056, USA.

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December 2009

Specific fluorogenic probes for ozone in biological and atmospheric samples.

Nat Chem 2009 Jul;1(4):316-21

Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, USA.

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http://www.nature.com/articles/nchem.240
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http://dx.doi.org/10.1038/nchem.240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904247PMC
July 2009

Systemic inhibition of NF-kappaB activation protects from silicosis.

PLoS One 2009 May 25;4(5):e5689. Epub 2009 May 25.

Division of Occupational and Environmental Medicine, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005689PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682759PMC
May 2009

Superoxide dismutase 3, extracellular (SOD3) variants and lung function.

Physiol Genomics 2009 May 24;37(3):260-7. Epub 2009 Mar 24.

Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.

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http://dx.doi.org/10.1152/physiolgenomics.90363.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685504PMC
May 2009

Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis.

Crit Care Med 2009 Apr;37(4):1380-8

Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH, USA.

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http://pdfs.journals.lww.com/ccmjournal/2009/04000/Zinc_defi
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/CCM.0b013e31819cefe4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905048PMC
April 2009

Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells.

Am J Respir Cell Mol Biol 2009 Jul 18;41(1):69-75. Epub 2008 Dec 18.

Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1165/rcmb.2008-0409OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701961PMC
July 2009

LRpath: a logistic regression approach for identifying enriched biological groups in gene expression data.

Bioinformatics 2009 Jan 27;25(2):211-7. Epub 2008 Nov 27.

Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1093/bioinformatics/btn592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639007PMC
January 2009

Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury.

Toxicol Sci 2008 Aug 7;104(2):405-11. Epub 2008 May 7.

Department of Environmental Health and Center of Environmental Genetics, University of Cincinnati, School of Medicine, Cincinnati, OH 45267-0056, USA.

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http://dx.doi.org/10.1093/toxsci/kfn089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734296PMC
August 2008

EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis.

Am J Physiol Lung Cell Mol Physiol 2008 Jun 18;294(6):L1217-25. Epub 2008 Apr 18.

Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1152/ajplung.00020.2008DOI Listing
June 2008

Duration-dependent cytoprotective versus inflammatory effects of lung epithelial fibroblast growth factor-7 expression.

Exp Lung Res 2007 Oct-Nov;33(8-9):385-417

Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA.

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http://dx.doi.org/10.1080/01902140701703226DOI Listing
January 2008

CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure.

Exp Mol Pathol 2007 Dec 26;83(3):301-10. Epub 2007 Sep 26.

Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001448000700116
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http://dx.doi.org/10.1016/j.yexmp.2007.08.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140237PMC
December 2007

Reciprocal congenic lines of mice capture the aliq1 effect on acute lung injury survival time.

Am J Respir Cell Mol Biol 2008 Jan 26;38(1):68-77. Epub 2007 Jul 26.

Children's Hospital Medical Center, Division & Program in Human Genetics, 3333 Burnet Ave., MLC 7016, Building R, Room 1464, Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.1165/rcmb.2006-0162OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2176134PMC
January 2008

Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.

Am J Respir Cell Mol Biol 2007 Sep 11;37(3):309-21. Epub 2007 May 11.

Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1165/rcmb.2006-0455OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994231PMC
September 2007

Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury.

Am J Respir Cell Mol Biol 2006 Jan 15;34(1):15-27. Epub 2005 Sep 15.

Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0558, USA.

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http://dx.doi.org/10.1165/rcmb.2005-0093OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644188PMC
January 2006

The role of metallothionein in the pathogenesis of acute lung injury.

Am J Respir Cell Mol Biol 2006 Jan 15;34(1):73-82. Epub 2005 Sep 15.

Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267-0056, USA.

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http://dx.doi.org/10.1165/rcmb.2005-0248OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644192PMC
January 2006

When wheeze leads to squeeze: growth under pressure.

Am J Respir Cell Mol Biol 2005 May;32(5):366

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http://www.atsjournals.org/doi/abs/10.1165/rcmb.F297
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http://dx.doi.org/10.1165/rcmb.F297DOI Listing
May 2005

Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation.

Am J Respir Crit Care Med 2005 Feb 5;171(4):305-14. Epub 2004 Nov 5.

University of Cincinnati, P.O. Box 670056, Cincinnati, OH 45267-0056, USA.

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http://dx.doi.org/10.1164/rccm.200408-1003OCDOI Listing
February 2005

Gene expression profiling of the early pulmonary response to hyperoxia in mice.

Am J Respir Cell Mol Biol 2003 Jun;28(6):682-96

Department of Clinical Studies-Philadelphia, School of Veterinary Medicine, University of Pennsylvania, 3850 Spruce Street, Philadelphia, PA 19104-6010, USA.

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http://dx.doi.org/10.1165/rcmb.4692DOI Listing
June 2003

Genetic susceptibility to nickel-induced acute lung injury.

Chemosphere 2003 Jun;51(10):1139-48

Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267-0056, USA.

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http://dx.doi.org/10.1016/S0045-6535(02)00710-5DOI Listing
June 2003

Inhibition of nitric oxide restores surfactant gene expression following nickel-induced acute lung injury.

Am J Respir Cell Mol Biol 2003 Feb;28(2):188-98

University of Cincinnati, and Children's Hospital Medical Center, Cincinnati, OH 45267-0056, USA.

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http://dx.doi.org/10.1165/rcmb.2002-0077OCDOI Listing
February 2003

Hazardous air pollutants and asthma.

Authors:
George D Leikauf

Environ Health Perspect 2002 Aug;110 Suppl 4:505-26

Center for Environmental Genetics, Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267-0056, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241200PMC
http://dx.doi.org/10.1289/ehp.02110s4505DOI Listing
August 2002

Microarrays as cancer keys: an array of possibilities.

J Clin Oncol 2002 Jul;20(14):3165-75

Institut National de Recherche et de Sécurité, Vandoeuvre-Lès-Nancy, France.

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http://ascopubs.org/doi/10.1200/JCO.2002.12.073
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http://dx.doi.org/10.1200/JCO.2002.12.073DOI Listing
July 2002

Mucin apoprotein expression in COPD.

Chest 2002 May;121(5 Suppl):166S-182S

Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267-0056, USA.

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http://dx.doi.org/10.1378/chest.121.5_suppl.166sDOI Listing
May 2002

Genetic susceptibility to respiratory syncytial virus infection in inbred mice.

J Med Virol 2002 May;67(1):92-100

Department of Pulmonary Medicine, Allergy and Clinical Immunology, Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1002/jmv.2196DOI Listing
May 2002

Dose-related protection from nickel-induced lung injury in transgenic mice expressing human transforming growth factor-alpha.

Am J Respir Cell Mol Biol 2002 Apr;26(4):430-7

Division of Pulmonary Medicine, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.

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http://dx.doi.org/10.1165/ajrcmb.26.4.4594DOI Listing
April 2002

Acute lung injury: functional genomics and genetic susceptibility.

Chest 2002 Mar;121(3 Suppl):70S-75S

Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267-0056, USA.

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http://dx.doi.org/10.1378/chest.121.3_suppl.70sDOI Listing
March 2002