Publications by authors named "George Le"

11 Publications

  • Page 1 of 1

Managing Fractures and Sprains.

Prim Care 2022 Mar 5;49(1):145-161. Epub 2022 Jan 5.

Department of Family Medicine, Offutt AFB/UNMC Family Medicine Residency Program, University of Nebraska Medical Center College of Medicine, 983075 Nebraska Medical Center, Omaha, NE 68198-3075, USA.

Primary care physicians are often the first to evaluate patients with extremity injuries. Identification of fractures and sprains and their proper management is paramount. After appropriate imaging is obtained, immobilization and determination of definitive management, either nonoperative or operative, is critical. Appropriate immobilization is imperative to injury healing. Nonsurgical management of upper extremity fractures often uses slings, short-term splinting, gutter splints, and/or short or long arm casts. Initial fracture stabilization of the lower extremity is usually accomplished with a posterior splint. Definitive management usually uses controlled ankle movement walker boots, hard-sole shoes, or casting.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pop.2021.10.007DOI Listing
March 2022

Consumption of energy beverage is associated with attenuation of arterial endothelial flow-mediated dilatation.

World J Cardiol 2017 Feb;9(2):162-166

John P Higgins, Nikki E Herrin, Santi Yarlagadda, Brandon L Ortiz, Asif Ali, Department of Internal Medicine, McGovern Medical School, the University of Texas Health Science Center at Houston, Houston, TX 77030, United States.

Aim: To investigate whether consumption of an energy drink will acutely impair endothelial function in young healthy adults.

Methods: Energy drinks are being consumed more and more worldwide, and have been associated with some deaths in adolescents and young adults, especially when consumed while exercising. After fasting and not smoking for at least 8 h prior, eleven medical students (9 males) received an electrocardiogram, blood pressure and pulse check, and underwent baseline testing (BL) of endothelial function using the technique of endothelium-dependent flow mediated dilatation (FMD) with high-resolution ultrasound (according to recommended guidelines of the University of Wisconsin Atherosclerosis Imaging Research Program Core Laboratory). The subjects then drank an energy beverage (EB), a 24-oz can of Monster Energy, and the above was repeated at 90 min after consumption. The relative FMD (%) was calculated as the ratio between the average post-cuff release and the baseline diameter. Each image was checked for quality control, and each artery diameter was measured from the media to media points by two experts, 3 measurements at the QRS complex, repeated on 3 separate beats, and then all were averaged.

Results: Subjects characteristics averages (given with standard deviations) include: Age 24.5 ± 1.5 years, sex 9 male and 2 female, weight 71.0 ± 9.1 kg, height 176.4 ± 6.0 cm, BMI 22.8 ± 2.7 kg/m. The hemodynamics were as follows, BL EB group respectively (mean ± SD): Heart rate 65.2 ± 11.3 68.2 ± 11.8 beats per minute, systolic blood pressure 114.0 ± 10.4 mmHg 114.1 ± 10.4 mmHg, diastolic blood pressure 68.8 ± 9.3 mmHg 70.6 ± 7.1 mmHg; all were not significantly different. However after drinking the EB, a significantly attenuated peak FMD response was measured (mean ± SD): BL group 5.9% ± 4.6% EB group 1.9% ± 2.1%; = 0.03). Given the increased consumption of energy beverages associated with exercise in young adults, more research is needed.

Conclusion: Energy beverage consumption has a negative impact on arterial endothelial function in young healthy adults.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4330/wjc.v9.i2.162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329743PMC
February 2017

Effect of the dedicated education unit on nursing student self-efficacy: A quasi-experimental research study.

Nurse Educ Pract 2017 Mar 16;23:48-53. Epub 2017 Feb 16.

Alex G. McKenna School, Saint Vincent College, Latrobe, PA 15650, United States.

Although the Dedicated Education Unit (DEU) has shown initial promise related to satisfaction with the teaching/learning environment, few studies have examined student outcomes related to the use of the DEU as a clinical education model beyond student satisfaction. The purpose of this quantitative, quasi-experimental study was to compare student outcomes from the traditional clinical education (TCE) model with those from the DEU model. Participants were students enrolled in a four-year baccalaureate program in nursing (n = 193) who had clinical education activities in one of three clinical agencies. Participants were assigned to either the DEU or a TCE model. Pre-clinical and post-clinical self-efficacy scores were measured for each group using an adapted Generalized Self-Efficacy Scale (Schwarzer and Jerusalem, 1995). Both groups experienced a significant increase in self-efficacy scores post clinical education. The increase in self-efficacy for the DEU students was significantly greater than the increase in self-efficacy for the traditional students. Self-efficacy is considered an important outcome of nursing education because high self-efficacy has been linked to making an easier transition from student to nursing professional. This study supports the quality of the DEU as a clinical education model by examining student self-efficacy outcomes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nepr.2017.02.007DOI Listing
March 2017

A novel method for immobilization of proteins via entrapment of magnetic nanoparticles through epoxy cross-linking.

Anal Biochem 2017 Feb 11;519:42-50. Epub 2016 Dec 11.

MagGenome Technologies Pvt. Ltd., CSEZ, Kakkanad, PIN-682037, Kochi, Kerala, India.

A method for immobilization of functional proteins by chemical cross-linking of the protein of interest and uncoated iron oxide nanoparticles in the presence of Epichlorohydrin is described. As a result of the cross-linking, the proteins form a matrix in which the particles get entrapped. The optimum concentration of Epichlorohydrin that facilitates immobilization of protein without affecting the functional properties of the protein was determined. This method was used to immobilize several functional proteins and the development and functional activity of Protein A-magnetic nanoparticles (MNPs) is described here in detail. The Protein A-MNPs possess high binding capacity due to the increased surface area of uncoated nanoparticles and robust magnetic separation due to the absence of polymeric coating materials. Protein A-MNPs were successfully used for purification of antibodies and also for immunoprecipitation. We also immobilized enzymes such as horse radish peroxidase and esterase and found that by providing the optimum incubation time, temperature and protein to nanoparticle ratio, we can retain the activity and improve the stability of the enzyme. This study is the first demonstration that Epichlorohydrin can be used to entrap nanoparticles in a cross-linked matrix of protein without impairing the activity of immobilized protein.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2016.12.007DOI Listing
February 2017

Preparing New Nurses to Address Bullying: The Effect of an Online Educational Module on Learner Self-Efficacy.

Medsurg Nurs 2016 Nov;25(6):412-6, 432

Newly licensed nurses who start their careers in supportive, nurtur- ing environments are more likely to overcome challenges and successfully transition into professional practice (Spiva et al., 2013). Introduction of content about bullying in the workplace via an online educational module can be an effective strategy for the academic preparation of pre-licensure nursing students.
View Article and Find Full Text PDF

Download full-text PDF

Source
November 2016

In-hospital mortality of intermittent vs daily antitubercular regimen in patients with meningeal tuberculosis--a retrospective study.

Indian J Tuberc 2012 Jan;59(1):6-11

Pharmacy College, Medical College, Thiruvananthapuram.

Introduction: The Revised National Tuberculosis Control Programme (RNTCP), the State-run Tuberculosis Control Initiative of the Government of India, recommends intermittent thrice a week Directly Observed Treatment Short course (DOTS) both during intensive phase and continuation phase for a total of nine months for tubercular meningitis. However, most recent guidelines recommend daily regimen.

Objective: Assessment of the in-hospital mortality in patients with meningeal tuberculosis.

Material And Methods: We retrospectively analyzed the data of patients (n = 98) admitted with a diagnosis of meningeal tuberculosis from January 1st 2006 to December 31st 2009 in a tertiary care centre in South India. Thwaites index score of four or less was used for diagnosis of meningeal tuberculosis which is a weighted diagnostic index score for dichotomised clinical variables including age, blood white cell count, duration of illness, CSF total white cell count, and CSF neutrophil percentage. We compared in-hospital treatment outcome of patients on thrice weekly intermittent DOTS regimen with daily regimen patients.

Results: The inhospital mortality was same (27%) in the two treatment regimens (p 0.944). However, there was less incidence of hepatic dysfunction in the intermittent DOTS regimen, even though it was not statistically significant (p 0.148).

Conclusions: In the short-term, both regimens have similar mortality outcomes and no statistically significant difference in hepatic dysfunction during the hospital stay.
View Article and Find Full Text PDF

Download full-text PDF

Source
January 2012

Novel role of NF-κB-p65 in antioxidant homeostasis in human kidney-2 cells.

Am J Physiol Renal Physiol 2012 Jun 7;302(11):F1440-6. Epub 2012 Mar 7.

Heart and Kidney Institute, College of Pharmacy, University of Houston, TX 77204, USA.

Nuclear factor-κB (NF-κB) plays a role in inflammation. However, we recently reported an association between NF-κB and antioxidant enzymes in renal proximal tubules of exercise-trained rats, suggesting its role in antioxidant homeostasis (George L, Lokhandwala MF, Asghar M. Am J Physiol Renal Physiol 297: F1174-F1180, 2009). A direct role of NF-κB in antioxidant homeostasis in renal cells has not been elucidated and warrants investigation. Therefore, we examined whether NF-κB has a direct role in antioxidant homeostasis and redox balance in human kidney-2 cells overexpressing NF-κB-p65 and compared them with the cells overexpressing Nrf-2, a well-known transcription factor involved in antioxidant homeostasis. The ability of NF-κB-p65 to increase antioxidant enzymes, to reduce reactive oxygen species (ROS), and to rescue ROS-induced renal dopamine D1 receptor dysfunction, was studied. The transcription activity of NF-κB-p65 and Nrf-2, measured as luciferase reporter activity, increased in cells overexpressing these nuclear factors. The levels of mRNA and activity of glutathione peroxidase as well as the protein levels of superoxide dismutase-1 and glutamylcystein transferase were increased in cells overexpressing NF-κB-p65 and Nrf-2. Furthermore, the levels of ROS decreased and D1 receptor agonist SKF38393-mediated [(35)S]GTPγS binding (index of D1 receptor function) increased in the presence of hydrogen peroxide in cells overexpressing NF-κB-p65 and Nrf-2. These results suggest a direct role of NF-κB-p65 in antioxidant homeostasis, contributing to redox balance in renal cells.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajprenal.00006.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378177PMC
June 2012

Technology in nursing education: a study of PDA use by students.

J Prof Nurs 2010 Nov-Dec;26(6):371-6

School of Nursing and Health Sciences, Robert Morris University, Moon Twp, PA 15108, USA.

Personal digital assistants (PDAs) were first used by the public in the early 1990 s. Initially used as a device to manage personal information, these devices quickly evolved. Currently, PDAs are capable of storing and exchanging large amounts of information, which truly make them handheld computers. As such, they have great value for professional use. Health care professionals require access to ever-expanding knowledge, and PDAs or other handheld computer devices can serve as valuable tools for education, information storage and retrieval, and clinical practice. This article describes the use of PDAs by undergraduate and graduate nursing students during their educational process. A descriptive study was conducted at a small, private university school of nursing at which all nursing students receive PDAs prior to their first clinical experiences. Findings from the study indicated that students used their PDAs for both classroom and clinical activities and that drug reference software was the most frequently used software application. Information was also obtained about the facilitators and barriers to PDA use.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.profnurs.2010.08.001DOI Listing
March 2011

Calming the panic over hepatitis A.

Nursing 2004 Jun;34(6):45-7

School of Nursing and Allied Health, Robert Morris University, Moon Township, PA, USA.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/00152193-200406000-00041DOI Listing
June 2004

Nurses' use of the media to provide public health information during a hepatitis A outbreak.

J Prof Nurs 2004 Mar-Apr;20(2):134-6

Department of Nursing, Robert Morris University, Moon Township, PA, USA.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.profnurs.2004.02.003DOI Listing
July 2004

Serotonin stimulates adenosine 3',5'-monophosphate accumulation in parathyroid adenoma.

J Clin Endocrinol Metab 1980 Dec;51(6):1274-8

The effect of serotonin on cAMP accumulation in parathyroid adenoma tissue from patients with primary hyperparathyroidism was studied in vitro. Incubation with 10(-5) M serotonin elicited a marked increase (of 90--150%) in cAMP content in slices of parathyroid adenoma tissue. This stimulatory effect of serotonin was already apparent after 2 min of incubation; stimulation by serotonin was dose dependent, with the highest stimulation being achieved at 10(-4) M serotonin. The serotonin antagonists, methylsergide and cinanserin, in concentrations equimolar to serotonin completely blocked the stimulatory effect of serotonin on cAMP increase. The serotonin content in surgically removed parathyroid adenoma tissue, as determined by fluorometric assay, was 6.4 +/- 1.2 pmol/mg wet wt (approximately 0.8 x 10(-5) M). The present observations demonstrate that parathyroid adenoma tissue has a high content of serotonin, and serotonin stimulates cAMP accumulation in this tissue. Since cAMP acts as a mediator of parathyroid hormone (PTH) release, our results suggest that serotonin could be one of the factors regulating PTH secretion and/or contributing to PTH hypersecretion in various forms of primary hyperparathyroidism.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1210/jcem-51-6-1274DOI Listing
December 1980
-->