Publications by authors named "George L Mutter"

58Publications

Computational augmentation of neoplastic endometrial glands in digital pathology displays.

J Pathol 2020 Nov 9. Epub 2020 Nov 9.

Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

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November 2020

A New Classification of Benign, Premalignant, and Malignant Endometrial Tissues Using Machine Learning Applied to 1413 Candidate Variables.

Int J Gynecol Pathol 2020 Jul;39(4):333-343

Department of Pathology, Brigham and Women's Hospital (M.J.D., D.J.P., G.L.M.) Department of Pathology, Harvard Medical School (D.J.P., G.L.M.) Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute (S.T.) Department of Biostatistics, Harvard T. H. Chan School of Public Health (S.T.), Boston, Massachusetts.

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July 2020

Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas: Recommendations from the International Society of Gynecological Pathologists.

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S25-S39

Pathology Department, University of California San Francisco, San Francisco, California (J.T.R.) Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada (C.B.G.) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M.) Department of Pathology, University Hospital Arnau de Vilanova and Department of Pathology, University Hospital de Bellvitge, University of Lleida, IRBLLEIDA, IDIBELL, CIBERONC, Spain (X.M.G.) Department of Pathology, New York University Langone Medical Center, New York, New York (K.M.) Department of Pathology, Brigham and Women's Hospital (G.L.M.) Pathology Department, Massachusetts General Hospital (E.O.), Boston, Massachusetts Pathology Department, Yale New Haven Hospital, New Haven, Connecticut (V.P.) Department of Pathology, Johns Hopkins Medical Institutions (B.M.R.) Department of Pathology, University of Maryland School of Medicine (P.S.), Baltimore, Maryland Department of Histopathology, King Edward Memorial Hospital and School for Women's and Infants' Health, University of Western Australia, Perth, Australia (C.J.R.S.) Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK (W.G.M.).

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January 2019

Computational morphogenesis - Embryogenesis, cancer research and digital pathology.

Biosystems 2018 Jul 31;169-170:40-54. Epub 2018 May 31.

Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.

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July 2018

Assessment of a Chemotherapy Response Score (CRS) System for Tubo-Ovarian High-Grade Serous Carcinoma (HGSC).

Int J Gynecol Pathol 2019 May;38(3):230-240

Department of Pathology, Women's and Perinatal Pathology Division (H.M.D., K.C.S., E.E.M., W.R.W., M.S.H., B.J.Q., K.R.L., C.P.C., G.L.M., M.R.N., B.E.H.) Division of Gynecologic Oncology and Reproductive Biology (M.G.M., J.F.L., C.F., N.H., R.S.B.), Brigham and Women's Hospital Department of Pathology, Beth Israel Deaconess Medical Center (M.G., J.L.H., D.I.L.) Medical Gynecologic Oncology Program, Dana-Farber Cancer Institute (E.S., P.A.K., U.A.M.), Harvard Medical School, Boston, Massachusetts Department of Pathology, Duke University Medical Center, Durham, North Carolina (K.C.S.) Department of Gynecology and Obstetrics, Odense University Hospital, University of Southern Denmark, Odense, Denmark (K.M.J.) Department of Pathology, Stanford University, Stanford, California (B.E.H.).

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May 2019

Adiponectin, Leptin, and Insulin-Pathway Receptors as Endometrial Cancer Subtyping Markers.

Horm Cancer 2018 02 2;9(1):33-39. Epub 2018 Jan 2.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, 3rd Floor, Boston, MA, 02115, USA.

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February 2018

Template for Reporting Results of Biomarker Testing of Specimens From Patients With Carcinoma of the Endometrium.

Arch Pathol Lab Med 2017 11 16;141(11):1508-1512. Epub 2017 Mar 16.

From the Department of Pathology, Stanford Medicine, Stanford, California (Dr Longacre); the Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston (Dr Broaddus); the Department of Obstetrics, Gynecology and Reproductive Science, Hess Center for Science and Medicine, Sinai Medical Center, New York, New York (Dr Chuang); the Department of Pathology, Huntsman Cancer Hospital, Salt Lake City, Utah (Dr Cohen); the Department of Pathology, University of Utah, Salt Lake City (Dr Jarboe); the Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (Dr Mutter); the Department of Pathology, Baystate Medical Center, Springfield, Massachusetts (Dr Otis); and the Department of Pathology, Penn State Hershey Medical Center, Hershey, Pennsylvania (Dr Zaino).

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November 2017

Endometrial Cancer Risk Factors, Hormone Receptors, and Mortality Prediction.

Cancer Epidemiol Biomarkers Prev 2017 05 4;26(5):727-735. Epub 2017 Jan 4.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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May 2017

Toxicology Study of Single-walled Carbon Nanotubes and Reduced Graphene Oxide in Human Sperm.

Sci Rep 2016 08 19;6:30270. Epub 2016 Aug 19.

Demirci BAMM Labs, Department of Radiology, Canary Center at Stanford for Cancer Early Detection, School of Medicine, Stanford University, Palo Alto 94304, CA.

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August 2016

Sperm processing for advanced reproductive technologies: Where are we today?

Biotechnol Adv 2016 Sep-Oct;34(5):578-587. Epub 2016 Feb 1.

Computer Engineering & Electrical Engineering and Computer Science Lab, Florida Atlantic University, Boca Raton, FL 33431, United States; Asghar-Lab, Micro and Nanotechnology for Medicine, College of Engineering and Computer Science, Boca Raton, FL 33431, United States; Department of Biological Sciences, Florida Atlantic University, Boca Raton, FL 33431, United States. Electronic address:

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December 2017

Dyssynchronous secretory endometrial glands often show sporadically acquired progesterone nonresponsiveness.

Int J Gynecol Pathol 2015 May;34(3):239-44

Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, Massachusetts.

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May 2015

Biomarker resolution of uterine smooth muscle tumor necrosis as benign vs malignant.

Mod Pathol 2015 Jun 20;28(6):830-5. Epub 2015 Feb 20.

Department of Pathology, Division of Women's and Perinatal Pathology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.

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June 2015

ARID1A is a useful marker of malignancy in peritoneal washings for endometrial carcinoma.

Cancer Cytopathol 2015 Apr 29;123(4):253-7. Epub 2014 Dec 29.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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April 2015

Selection of functional human sperm with higher DNA integrity and fewer reactive oxygen species.

Adv Healthc Mater 2014 Oct 17;3(10):1671-9. Epub 2014 Apr 17.

Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Division of Biomedical Engineering, Division of Infectious Diseases, Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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October 2014

Emergence, involution, and progression to carcinoma of mutant clones in normal endometrial tissues.

Cancer Res 2014 May 24;74(10):2796-802. Epub 2014 Mar 24.

Authors' Affiliations: Department of Pathology at Brigham and Women's Hospital; Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts; Departments of Pathology, McGill University and the Jewish General Hospital, Montreal, Canada; Genomic Medicine Institute and Taussig Cancer Institute, Cleveland Clinic; and Department of Genetics and Genome Sciences, and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OhioAuthors' Affiliations: Department of Pathology at Brigham and Women's Hospital; Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts; Departments of Pathology, McGill University and the Jewish General Hospital, Montreal, Canada; Genomic Medicine Institute and Taussig Cancer Institute, Cleveland Clinic; and Department of Genetics and Genome Sciences, and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.

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May 2014

Endometrial intraepithelial neoplasia with secretory differentiation: diagnostic features and underlying mechanisms.

Mod Pathol 2013 Jun 18;26(6):868-73. Epub 2013 Jan 18.

Department of Pathology, Women's and Perinatal Pathology Division, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.

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June 2013

Utility of PAX2 as a marker for diagnosis of endometrial intraepithelial neoplasia.

Am J Clin Pathol 2012 Nov;138(5):678-84

University of Arkansas for Medical Sciences, Department of Pathology, Slot 517, 4301 West Markham St, Little Rock, AR 72205, USA.

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November 2012

Endometrial intraepithelial neoplasia: clinical correlates and outcomes.

Obstet Gynecol 2011 Jul;118(1):21-28

From the Departments of Obstetrics and Gynecology and Pathology, Brigham and Women's Hospital, Boston, Massachusetts.

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July 2011

Endometrial intraepithelial neoplasia.

Semin Diagn Pathol 2010 Nov;27(4):215-25

Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.

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November 2010

Clinical outcome in diagnostically ambiguous foci of 'gland crowding' in the endometrium.

Mod Pathol 2010 Nov 30;23(11):1486-91. Epub 2010 Jul 30.

Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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November 2010

Joint loss of PAX2 and PTEN expression in endometrial precancers and cancer.

Cancer Res 2010 Aug 14;70(15):6225-32. Epub 2010 Jul 14.

Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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August 2010

Secretory cell outgrowth, PAX2 and serous carcinogenesis in the Fallopian tube.

J Pathol 2010 Sep;222(1):110-6

Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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September 2010

Coexisting intraepithelial serous carcinomas of the endometrium and fallopian tube: frequency and potential significance.

Int J Gynecol Pathol 2009 Jul;28(4):308-15

Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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July 2009

Involution of latent endometrial precancers by hormonal and nonhormonal mechanisms.

Cancer 2009 May;115(10):2111-8

Department of Pathology, National Taiwan University College of Medicine, Taipei, Taiwan.

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May 2009

Squamous morules are functionally inert elements of premalignant endometrial neoplasia.

Mod Pathol 2009 Feb 19;22(2):167-74. Epub 2008 Sep 19.

Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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February 2009

Evidence for a latent precursor (p53 signature) that may precede serous endometrial intraepithelial carcinoma.

Mod Pathol 2009 Mar 16;22(3):345-50. Epub 2009 Jan 16.

Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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March 2009

Endometrial changes from short-term therapy with CDB-4124, a selective progesterone receptor modulator.

Mod Pathol 2009 Mar 9;22(3):450-9. Epub 2009 Jan 9.

Department of Pathology, University of Maryland, Baltimore, MD, USA.

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March 2009

PTEN expression in endometrial biopsies as a marker of progression to endometrial carcinoma.

Cancer Res 2008 Jul;68(14):6014-20

Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.

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July 2008

Histologic and immunohistochemical decision-making in endometrial adenocarcinoma.

Mod Pathol 2008 Aug 23;21(8):937-42. Epub 2008 May 23.

Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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August 2008

Biopsy histomorphometry predicts uterine myoinvasion by endometrial carcinoma: a Gynecologic Oncology Group study.

Hum Pathol 2008 Jun 23;39(6):866-74. Epub 2008 Apr 23.

Department of Pathology, BDivision of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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June 2008

Breast-cancer stromal cells with TP53 mutations and nodal metastases.

N Engl J Med 2007 Dec;357(25):2543-51

Genomic Medicine Institute, Cleveland Clinic Foundation, Cleveland 44195, USA.

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December 2007

Genomic instability within tumor stroma and clinicopathological characteristics of sporadic primary invasive breast carcinoma.

JAMA 2007 May;297(19):2103-11

Genomic Medicine Institute, Lerner Research Institute and Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

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May 2007

Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia.

Int J Gynecol Pathol 2007 Apr;26(2):103-14

Department of Pathology at Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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April 2007

Molecular and pathologic aspects of endometrial carcinogenesis.

J Clin Oncol 2006 Oct;24(29):4783-91

Department of Pathology, Beth-Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA.

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October 2006

Regression of latent endometrial precancers by progestin infiltrated intrauterine device.

Cancer Res 2006 Jun;66(11):5613-7

Department of Pathology, University of Tromso, Tromso, Norway.

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June 2006

Total-genome analysis of BRCA1/2-related invasive carcinomas of the breast identifies tumor stroma as potential landscaper for neoplastic initiation.

Am J Hum Genet 2006 Jun 12;78(6):961-72. Epub 2006 Apr 12.

Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA.

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June 2006

Combined total genome loss of heterozygosity scan of breast cancer stroma and epithelium reveals multiplicity of stromal targets.

Cancer Res 2004 Oct;64(20):7231-6

Clinical Cancer Genetics Program, Division of Human Cancer Genetics, Department of Molecular Virology, Immunology, and Medical Genetics, School of Public Health, The Ohio State University, Columbus, Ohio, USA.

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October 2004

Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling.

Genes Chromosomes Cancer 2004 Jun;40(2):97-108

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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June 2004

Involution of PTEN-null endometrial glands with progestin therapy.

Gynecol Oncol 2004 Mar;92(3):1008-13

Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA.

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March 2004

Hertig and beyond: a systematic and practical approach to the endometrial biopsy.

Adv Anat Pathol 2003 Nov;10(6):301-18

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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November 2003

Factors associated with disposition of cryopreserved reproductive tissue.

Fertil Steril 2003 Sep;80(3):584-9

Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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September 2003

Biomarkers in diagnostic obstetric and gynecologic pathology: a review.

Adv Anat Pathol 2003 Mar;10(2):55-68

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachussetts 02115, USA.

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March 2003

p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract.

Am J Pathol 2002 Oct;161(4):1111-7

Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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October 2002

Estradiol-induced hyperplasia in endometrial biopsies from women on hormone replacement therapy.

Am J Surg Pathol 2002 Oct;26(10):1269-75

Department of Pathology, Columbia University Presbiterian Medical Center, New York, New York 10032, USA.

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October 2002