George Kunos

George Kunos

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George Kunos

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Metabolic effects of skeletal muscle-specific deletion of beta-arrestin-1 and -2 in mice.

PLoS Genet 2019 Oct 17;15(10):e1008424. Epub 2019 Oct 17.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008424DOI Listing
October 2019

Preclinical toxicity evaluation of JD5037, a peripherally restricted CB receptor inverse agonist, in rats and dogs for treatment of nonalcoholic steatohepatitis.

Regul Toxicol Pharmacol 2019 Sep 30;109:104483. Epub 2019 Sep 30.

National Center for Advancing Translational Sciences, National Institute of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yrtph.2019.104483DOI Listing
September 2019

Bleomycin Induces Drug Efflux in Lungs: A pitfall for Pharmacological Studies of Pulmonary Fibrosis.

Am J Respir Cell Mol Biol 2019 Aug 16. Epub 2019 Aug 16.

National Institute on Alcohol Abuse and Alcoholism, 8387, Laboratory of Physiological Studies, Bethesda, Maryland, United States;

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http://dx.doi.org/10.1165/rcmb.2018-0147OCDOI Listing
August 2019

Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis.

Cell Metab 2019 Aug 20. Epub 2019 Aug 20.

Laboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.08.001DOI Listing
August 2019

Targeting Peripheral CB Receptors Reduces Ethanol Intake via a Gut-Brain Axis.

Cell Metab 2019 Jun 16;29(6):1320-1333.e8. Epub 2019 May 16.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551287PMC
June 2019

Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis.

EBioMedicine 2019 Feb 31;40:471-487. Epub 2018 Dec 31.

Science for Life Laboratory, KTH - Royal Institute of Technology, SE-171 21 Stockholm, Sweden; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden; Centre for Host-Microbiome Interactions, Dental Institute, King's College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.12.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412169PMC
February 2019

Crystal Structure of the Human Cannabinoid Receptor CB2.

Cell 2019 01 10;176(3):459-467.e13. Epub 2019 Jan 10.

iHuman Institute, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713262PMC
January 2019

Synthesis of C -labeled, dual-target inhibitor of cannabinoid-1 receptor (CB R) and inducible nitric oxide synthase (iNOS).

J Labelled Comp Radiopharm 2018 May 23. Epub 2018 May 23.

Laboratory of Physiologic Studies and National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA.

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http://dx.doi.org/10.1002/jlcr.3639DOI Listing
May 2018

Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad, and the ugly.

Nat Rev Cardiol 2018 03 14;15(3):151-166. Epub 2017 Sep 14.

Laboratory of Physiological Studies, National Institutes of Health/NIAAA, 5625 Fishers Lane, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nrcardio.2017.130DOI Listing
March 2018

Cannabinoid-1 receptor deletion in podocytes mitigates both glomerular and tubular dysfunction in a mouse model of diabetic nephropathy.

Diabetes Obes Metab 2018 03 3;20(3):698-708. Epub 2017 Dec 3.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), Bethesda, Maryland.

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http://dx.doi.org/10.1111/dom.13150DOI Listing
March 2018

Neutrophil-Hepatic Stellate Cell Interactions Promote Fibrosis in Experimental Steatohepatitis.

Cell Mol Gastroenterol Hepatol 2018 Mar 8;5(3):399-413. Epub 2018 Jan 8.

Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1016/j.jcmgh.2018.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852390PMC
March 2018

Feasibility Evaluation of Myocardial Cannabinoid Type 1 Receptor Imaging in Obesity: A Translational Approach.

JACC Cardiovasc Imaging 2018 02;11(2 Pt 2):320-332

Department of Radiology, Division of Nuclear Medicine, Nuclear Cardiovascular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.jcmg.2017.11.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178217PMC
February 2018

Decreasing CB receptor signaling in Kupffer cells improves insulin sensitivity in obese mice.

Mol Metab 2017 11 1;6(11):1517-1528. Epub 2017 Sep 1.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), Bethesda, MD 20852, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681272PMC
November 2017

Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling.

Mol Metab 2017 10 24;6(10):1113-1125. Epub 2017 Jun 24.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641628PMC
October 2017

Synthesis of S-2-((S)-3-(4-chlorophenyl)-N'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-(methyl-d )butanamide-d , octadeuterated JD5037.

J Labelled Comp Radiopharm 2017 08 2;60(10):460-465. Epub 2017 Aug 2.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA.

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http://dx.doi.org/10.1002/jlcr.3521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568925PMC
August 2017

Hepatic β-arrestin 2 is essential for maintaining euglycemia.

J Clin Invest 2017 Aug 26;127(8):2941-2945. Epub 2017 Jun 26.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, Maryland, USA.

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https://www.jci.org/articles/view/92913
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http://dx.doi.org/10.1172/JCI92913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531395PMC
August 2017

Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes.

Diabetes 2017 04 12;66(4):994-1007. Epub 2017 Jan 12.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD

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http://dx.doi.org/10.2337/db16-1199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360301PMC
April 2017

Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CBR Inverse Agonist/Inducible Nitric Oxide Synthase (iNOS) Inhibitors for the Treatment of Liver Fibrosis.

J Med Chem 2017 02 27;60(3):1126-1141. Epub 2017 Jan 27.

Laboratory of Physiologic Studies, and ‡Laboratory of Cardiovascular Physiology and Tissue Injury, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health , 5625 Fishers Lane, Rockville, Maryland 20852, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01504DOI Listing
February 2017

Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids.

Neuropsychopharmacology 2016 May 30;41(6):1598-609. Epub 2015 Oct 30.

Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), Bethesda, MD, USA.

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http://dx.doi.org/10.1038/npp.2015.318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832021PMC
May 2016

Cannabinoid receptor signaling regulates liver development and metabolism.

Development 2016 Feb;143(4):609-22

Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA Harvard Stem Cell Institute, Cambridge, MA 02138, USA Gastroenterology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA Dana-Farber Cancer Institute, Boston, MA 02215, USA Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

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http://dx.doi.org/10.1242/dev.121731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760316PMC
February 2016

Stratification of Hepatocellular Carcinoma Patients Based on Acetate Utilization.

Cell Rep 2015 Dec 19;13(9):2014-26. Epub 2015 Nov 19.

Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden; Science for Life Laboratory, KTH-Royal Institute of Technology, 171 21 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.10.045DOI Listing
December 2015

Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue.

Sci Rep 2015 Oct 12;5:14953. Epub 2015 Oct 12.

Laboratory of Physiologic Studies , National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health, 5625 Fishers Lane, RM 2S-18, MSC-9413, Bethesda, Maryland 20892-9413, U.S.A.

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http://dx.doi.org/10.1038/srep14953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601089PMC
October 2015

Structural Basis of Species-Dependent Differential Affinity of 6-Alkoxy-5-Aryl-3-Pyridinecarboxamide Cannabinoid-1 Receptor Antagonists.

Mol Pharmacol 2015 Aug 26;88(2):238-44. Epub 2015 May 26.

Laboratory of Physiologic Studies (M.R.I., R.C., J.L., G.G., G.S., G.K.) and Laboratory of Molecular Physiology (H.P., S.R.I.), National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland; Naval Research Laboratory, Washington, D.C. (J.D.); and Center for Molecular Modeling, Center for Information Technology, National Institutes of Health, Bethesda, Maryland (Y.-S.L., P.J.S.)

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.115.09
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http://dx.doi.org/10.1124/mol.115.098541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518088PMC
August 2015

Blunted cardiac response to hemorrhage in cirrhotic rats is mediated by local macrophage-released endocannabinoids.

J Hepatol 2015 Jun 29;62(6):1272-7. Epub 2015 Jan 29.

Liver Unit, University of Calgary, Calgary, Canada. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045259PMC
http://dx.doi.org/10.1016/j.jhep.2015.01.021DOI Listing
June 2015

Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms.

Hepatology 2015 May 17;61(5):1615-26. Epub 2015 Feb 17.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1002/hep.27686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406817PMC
May 2015

A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome.

Proc Natl Acad Sci U S A 2015 Jan 22;112(1):285-90. Epub 2014 Dec 22.

Laboratories of Neuroendocrinology and Departments of Cell Biology and Anatomy and Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada T2N 4N1

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http://dx.doi.org/10.1073/pnas.1421420112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291642PMC
January 2015

Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy.

Proc Natl Acad Sci U S A 2014 Dec 24;111(50):E5420-8. Epub 2014 Nov 24.

Laboratory of Physiologic Studies, Section on Neuroendocrinology, and

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http://dx.doi.org/10.1073/pnas.1419901111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273328PMC
December 2014

Role of adiponectin in the metabolic effects of cannabinoid type 1 receptor blockade in mice with diet-induced obesity.

Am J Physiol Endocrinol Metab 2014 Feb 31;306(4):E457-68. Epub 2013 Dec 31.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland.

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http://www.physiology.org/doi/10.1152/ajpendo.00489.2013
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http://dx.doi.org/10.1152/ajpendo.00489.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923090PMC
February 2014

Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides.

Hepatology 2014 Jan 18;59(1):143-53. Epub 2013 Nov 18.

Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1002/hep.26606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839256PMC
January 2014

Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase.

Proc Natl Acad Sci U S A 2013 Nov 4;110(47):18832-7. Epub 2013 Nov 4.

Laboratory of Physiologic Studies and Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1073/pnas.1309469110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839776PMC
November 2013

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

Nat Med 2013 Sep 18;19(9):1132-40. Epub 2013 Aug 18.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1038/nm.3265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050982PMC
September 2013

Chronic alcohol produces neuroadaptations to prime dorsal striatal learning.

Proc Natl Acad Sci U S A 2013 Sep 19;110(36):14783-8. Epub 2013 Aug 19.

Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, MD 20814, USA.

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http://dx.doi.org/10.1073/pnas.1308198110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767559PMC
September 2013

Metabolic effects of chronic cannabis smoking.

Diabetes Care 2013 Aug 25;36(8):2415-22. Epub 2013 Mar 25.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.

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http://dx.doi.org/10.2337/dc12-2303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714514PMC
August 2013

Modulating the endocannabinoid system in human health and disease--successes and failures.

FEBS J 2013 May 22;280(9):1918-43. Epub 2013 Apr 22.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9413, USA.

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http://doi.wiley.com/10.1111/febs.12260
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http://dx.doi.org/10.1111/febs.12260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684164PMC
May 2013

The case for peripheral CB₁ receptor blockade in the treatment of visceral obesity and its cardiometabolic complications.

Br J Pharmacol 2011 Aug;163(7):1423-31

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9413, USA.

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http://dx.doi.org/10.1111/j.1476-5381.2011.01352.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165952PMC
August 2011

Addiction research centres and the nurturing of creativity: the National Institute on Alcohol Abuse and Alcoholism.

Addiction 2011 Jun 21;106(6):1052-60. Epub 2010 Jun 21.

The National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, 10 Center Drive, Bethesda, MD 20892-1108, USA.

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http://dx.doi.org/10.1111/j.1360-0443.2010.02995.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024445PMC
June 2011

Upregulation of cannabinoid type 1 receptors in dopamine D2 receptor knockout mice is reversed by chronic forced ethanol consumption.

Alcohol Clin Exp Res 2011 Jan 19;35(1):19-27. Epub 2010 Oct 19.

Department of Health and Human Services, Laboratory of Neuroimaging, NIAAA, NIH, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1111/j.1530-0277.2010.01318.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004984PMC
January 2011

Endocannabinoids in liver disease.

Hepatology 2011 Jan;53(1):346-55

National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9413, USA.

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http://dx.doi.org/10.1002/hep.24077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073545PMC
January 2011

Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity.

J Clin Invest 2010 Aug 26;120(8):2953-66. Epub 2010 Jul 26.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1172/JCI42551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912197PMC
August 2010

Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma.

J Biol Chem 2010 Jun 21;285(25):19002-11. Epub 2010 Apr 21.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892-9413, USA.

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http://dx.doi.org/10.1074/jbc.M109.068460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885177PMC
June 2010

Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity.

Hepatology 2010 Apr;51(4):1354-62

Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1002/hep.23430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850952PMC
April 2010

Anti-inflammatory and anti-apoptotic roles of endothelial cell STAT3 in alcoholic liver injury.

Alcohol Clin Exp Res 2010 Apr 26;34(4):719-25. Epub 2010 Jan 26.

Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1111/j.1530-0277.2009.01141.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858250PMC
April 2010

Alterations in brain glucose utilization accompanying elevations in blood ethanol and acetate concentrations in the rat.

Alcohol Clin Exp Res 2010 Feb 24;34(2):375-81. Epub 2009 Nov 24.

Laboratory of Metabolic Control and Laboratory of Physiological Studies, NIH, DHHS, Bethesda, Maryland 20892-9410, USA.

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http://dx.doi.org/10.1111/j.1530-0277.2009.01099.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958045PMC
February 2010

Rimonabant (SR141716) has no effect on alcohol self-administration or endocrine measures in nontreatment-seeking heavy alcohol drinkers.

Psychopharmacology (Berl) 2010 Jan 10;208(1):37-44. Epub 2009 Nov 10.

Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, 10 CRC-Hatfield Center, Rm. 1-5330, MSC 1108, Bethesda, MD 20892-1108, USA.

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http://dx.doi.org/10.1007/s00213-009-1704-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963590PMC
January 2010

Receptors for acylethanolamides-GPR55 and GPR119.

Prostaglandins Other Lipid Mediat 2009 Sep 15;89(3-4):105-11. Epub 2009 Jul 15.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.prostaglandins.2009.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751869PMC
September 2009

The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels.

J Pharmacol Exp Ther 2009 Jan 15;328(1):351-61. Epub 2008 Oct 15.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, MD 20892-9413, USA.

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http://dx.doi.org/10.1124/jpet.108.144717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605781PMC
January 2009

Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain?

Trends Pharmacol Sci 2009 Jan 29;30(1):1-7. Epub 2008 Nov 29.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.tips.2008.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748782PMC
January 2009

A tribute to Dr. Ting-Kai Li.

Authors:
George Kunos

Alcohol Clin Exp Res 2008 Dec 1;32(12):2030. Epub 2008 Nov 1.

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http://dx.doi.org/10.1111/j.1530-0277.2008.00840.xDOI Listing
December 2008

Endocannabinoids and the control of energy homeostasis.

J Biol Chem 2008 Nov 11;283(48):33021-5. Epub 2008 Aug 11.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-9413, USA.

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http://dx.doi.org/10.1074/jbc.R800012200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586261PMC
November 2008

Modulation of the endocannabinoid system in cardiovascular disease: therapeutic potential and limitations.

Hypertension 2008 Oct 8;52(4):601-7. Epub 2008 Sep 8.

Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892-9413, USA.

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.105.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.105.063651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568884PMC
October 2008

Synthesis of 2-(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenamidoethyl-d(4) Dihydrogen Phosphate, Tetra-deuterated pAEA.

J Labelled Comp Radiopharm 2008 Oct;51(12):389-390

Drug Design and Synthesis Section, Chemical Biology Research Branch, 5625 Fishers Lane, Room 4N03, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, MSC 9415, MD 20852, USA.

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http://doi.wiley.com/10.1002/jlcr.1540
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http://dx.doi.org/10.1002/jlcr.1540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600674PMC
October 2008

Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms.

Nat Med 2008 Jun 1;14(6):667-75. Epub 2008 Jun 1.

Department of Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1005, New York, New York 10029, USA.

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http://dx.doi.org/10.1038/nm1775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671848PMC
June 2008

Endocannabinoids and liver disease. IV. Endocannabinoid involvement in obesity and hepatic steatosis.

Am J Physiol Gastrointest Liver Physiol 2008 May 21;294(5):G1101-4. Epub 2008 Feb 21.

NIAAA, NIH, Bethesda, MD 20892-9413, USA.

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http://dx.doi.org/10.1152/ajpgi.00057.2008DOI Listing
May 2008

Sustained weight loss after Roux-en-Y gastric bypass is characterized by down regulation of endocannabinoids and mitochondrial function.

Ann Surg 2008 May;247(5):779-90

Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, University Hospital, SUNY Upstate Medical University, Syracuse, New York 13210, USA.

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http://dx.doi.org/10.1097/SLA.0b013e318166fd5fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671862PMC
May 2008

Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury.

Gastroenterology 2008 Apr 11;134(4):1148-58. Epub 2008 Jan 11.

Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1053/j.gastro.2008.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376046PMC
April 2008

Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver.

Cell Metab 2008 Mar;7(3):227-35

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cmet.2007.12.007DOI Listing
March 2008

Multiple pathways involved in the biosynthesis of anandamide.

Neuropharmacology 2008 Jan 6;54(1):1-7. Epub 2007 Jun 6.

Laboratory of Physiologic Studies, NIAAA/NIH, 5625 Fishers Lane, MS-9413, Bethesda, MD 20892-9413, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2007.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219543PMC
January 2008

Inhibition of human hair follicle growth by endo- and exocannabinoids.

FASEB J 2007 Nov 12;21(13):3534-41. Epub 2007 Jun 12.

Department of Physiology, University of Debrecen, Medical and Health Science Center, 4032 Debrecen, Hungary.

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http://dx.doi.org/10.1096/fj.06-7689comDOI Listing
November 2007

The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species.

FASEB J 2007 Sep 17;21(11):2798-806. Epub 2007 Apr 17.

Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA.

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http://dx.doi.org/10.1096/fj.06-7717comDOI Listing
September 2007

Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats.

Am J Physiol Heart Circ Physiol 2007 Sep 8;293(3):H1689-95. Epub 2007 Jun 8.

Section on Neuroendocrinology, Laboratory of Physiological Studies, NIAAA, National Institutes of Health, MSC 9413, Rm. 2N17, 5625 Fishers Lane, Bethesda, MD 20892-9413, USA.

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http://dx.doi.org/10.1152/ajpheart.00538.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225474PMC
September 2007

Understanding metabolic homeostasis and imbalance: what is the role of the endocannabinoid system?

Authors:
George Kunos

Am J Med 2007 Sep;120(9 Suppl 1):S18-24; discussion S24

National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20817, USA.

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http://dx.doi.org/10.1016/j.amjmed.2007.06.007DOI Listing
September 2007

Cannabinoid modulation of Kaposi's sarcoma-associated herpesvirus infection and transformation.

Cancer Res 2007 Aug;67(15):7230-7

Division of Experimental Medicine and Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0960DOI Listing
August 2007

Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury.

FASEB J 2007 Jun 27;21(8):1788-800. Epub 2007 Feb 27.

Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892-9413, USA.

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http://dx.doi.org/10.1096/fj.06-7451comDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228252PMC
June 2007

Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference.

Neuropsychopharmacology 2007 Jan 8;32(1):117-26. Epub 2006 Feb 8.

Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD 20892-1108, USA.

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http://dx.doi.org/10.1038/sj.npp.1301034DOI Listing
January 2007

A biosynthetic pathway for anandamide.

Proc Natl Acad Sci U S A 2006 Sep 28;103(36):13345-50. Epub 2006 Aug 28.

Laboratories of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0601832103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557387PMC
September 2006

The endocannabinoid system as an emerging target of pharmacotherapy.

Pharmacol Rev 2006 Sep;58(3):389-462

Laboratory of Physiological Studies, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 2S-24, Bethesda, MD 20892-9413, USA.

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http://pharmrev.aspetjournals.org/cgi/doi/10.1124/pr.58.3.2
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http://dx.doi.org/10.1124/pr.58.3.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241751PMC
September 2006

N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties.

Proc Natl Acad Sci U S A 2006 Feb 7;103(7):2428-33. Epub 2006 Feb 7.

Department of Medicinal Chemistry and Natural Products, Medical Faculty, and Laboratory of Environmental Physiology, Faculty of Dental Medicine, Hebrew University, Jerusalem 91120, Israel.

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http://www.pnas.org/lookup/doi/10.1073/pnas.0510676103
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413724PMC
February 2006

Low doses of alcohol substantially decrease glucose metabolism in the human brain.

Neuroimage 2006 Jan 8;29(1):295-301. Epub 2005 Aug 8.

National Institute on Drug Abuse, 6001 Executive Blvd., Room 5274, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2005.07.004DOI Listing
January 2006

Cirrhotic cardiomyopathy: an endocannabinoid connection?

Br J Pharmacol 2005 Oct;146(3):313-4

LPS, NIAAA, NIH, Bethesda, MD 20892-9413, USA.

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http://doi.wiley.com/10.1038/sj.bjp.0706332
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576282PMC
October 2005

Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide.

Neuroendocrinology 2005 29;81(4):273-82. Epub 2005 Aug 29.

Section on Neuroendocrinology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1159/000087925DOI Listing
October 2005

Coronary vasodilator effects of endogenous cannabinoids in vasopressin-preconstricted unpaced rat isolated hearts.

J Cardiovasc Pharmacol 2005 Sep;46(3):348-55

Department of Internal Medicine I, Center of Cardiovascular Medicine, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1097/01.fjc.0000175437.87283.f2DOI Listing
September 2005

Blood pressure regulation by endocannabinoids and their receptors.

Neuropharmacology 2005 Jun 19;48(8):1130-8. Epub 2005 Feb 19.

Laboratory of Physiologic Studies, National Institute on Alcohol Abuse & Alcoholism, National Institutes of Health, Bethesda, MD 20892-8115, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2004.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225528PMC
June 2005