Publications by authors named "George Hripcsak"

100Publications

The Prognostic Value of Electrocardiogram at Presentation to Emergency Department in Patients With COVID-19.

Mayo Clin Proc 2020 10 15;95(10):2099-2109. Epub 2020 Aug 15.

Seymour, Paul, and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY; Department of Medicine, Columbia University Irving Medical Center, New York, NY; Division of Cardiology, Department of Medicine, Weill Cornell University Medical Center, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.mayocp.2020.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428764PMC
October 2020

Principles of Large-scale Evidence Generation and Evaluation across a Network of Databases (LEGEND).

J Am Med Inform Assoc 2020 Aug;27(8):1331-1337

Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, California, USA.

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http://dx.doi.org/10.1093/jamia/ocaa103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481029PMC
August 2020

Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study.

Lancet Rheumatol 2020 Nov 21;2(11):e698-e711. Epub 2020 Aug 21.

Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/S2665-9913(20)30276-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442425PMC
November 2020

Large-scale evidence generation and evaluation across a network of databases (LEGEND): assessing validity using hypertension as a case study.

J Am Med Inform Assoc 2020 Aug;27(8):1268-1277

Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1093/jamia/ocaa124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481033PMC
August 2020

Characterizing physicians' information needs related to a gap in knowledge unmet by current evidence.

JAMIA Open 2020 Jul 7;3(2):281-289. Epub 2020 May 7.

Department of Biomedical Informatics, Columbia University Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1093/jamiaopen/ooaa012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382620PMC
July 2020

Chlorthalidone and Hydrochlorothiazide for Treatment of Patients With Hypertension-Reply.

JAMA Intern Med 2020 Aug;180(8):1133-1134

Observational Health Data Sciences and Informatics, New York, New York.

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http://dx.doi.org/10.1001/jamainternmed.2020.1736DOI Listing
August 2020

Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19.

N Engl J Med 2020 06 7;382(25):2411-2418. Epub 2020 May 7.

From the Divisions of General Medicine, Infectious Diseases, and Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine (J.G., J.Z., M.B., A.L., D.K.M., C.K., R.G.B., M.E.S., N.W.S.), the Departments of Biostatistics (Y.S.) and Epidemiology (J.P., R.G.B., N.W.S.), Mailman School of Public Health, and the Department of Biomedical Informatics (G.H.), Vagelos College of Physicians and Surgeons, Columbia University, and New York-Presbyterian Hospital-Columbia University Irving Medical Center (J.G., J.Z., M.B., A.L., D.K.M., C.K.,R.G.B., M.E.S., N.W.S.) - all in New York.

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http://dx.doi.org/10.1056/NEJMoa2012410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224609PMC
June 2020

Deep phenotyping: Embracing complexity and temporality-Towards scalability, portability, and interoperability.

J Biomed Inform 2020 May 23;105:103433. Epub 2020 Apr 23.

Department of Biomedical Informatics, Columbia University, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbi.2020.103433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179504PMC
May 2020

Adapting electronic health records-derived phenotypes to claims data: Lessons learned in using limited clinical data for phenotyping.

J Biomed Inform 2020 02 19;102:103363. Epub 2019 Dec 19.

Columbia University Medical Center, New York, NY, USA; Observational Health Data Sciences and Informatics (OHDSI), New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbi.2019.103363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390483PMC
February 2020

Neurological Dashboards and Consultation Turnaround Time at an Academic Medical Center.

Appl Clin Inform 2019 10 6;10(5):849-858. Epub 2019 Nov 6.

Department of Biomedical Informatics, Columbia University, New York, New York, United States.

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http://dx.doi.org/10.1055/s-0039-1698465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834453PMC
October 2019

Comprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis.

Lancet 2019 11 24;394(10211):1816-1826. Epub 2019 Oct 24.

Epidemiology Analytics, Janssen Research & Development, Titusville, NJ, USA; Department of Biomedical Informatics, Columbia University Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1016/S0140-6736(19)32317-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924620PMC
November 2019

Comparison of First-Line Dual Combination Treatments in Hypertension: Real-World Evidence from Multinational Heterogeneous Cohorts.

Korean Circ J 2020 Jan 28;50(1):52-68. Epub 2019 Aug 28.

Division of Cardiology, Severance Cardiovascular Hospital and Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.4070/kcj.2019.0173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923236PMC
January 2020

The parameter Houlihan: A solution to high-throughput identifiability indeterminacy for brutally ill-posed problems.

Math Biosci 2019 10 24;316:108242. Epub 2019 Aug 24.

Department of Biomedical Informatics, Columbia University, 622 West 168th Street, PH-20, New York, NY, USA.

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http://dx.doi.org/10.1016/j.mbs.2019.108242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759390PMC
October 2019

Network Analysis of Citation in Hypertension Clinical Guidelines.

Stud Health Technol Inform 2019 Aug;264:1017-1020

Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Korea.

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http://dx.doi.org/10.3233/SHTI190378DOI Listing
August 2019

A plea to stop using the case-control design in retrospective database studies.

Stat Med 2019 09 22;38(22):4199-4208. Epub 2019 Aug 22.

Observational Health Data Sciences and Informatics, New York, New York.

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http://dx.doi.org/10.1002/sim.8215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771795PMC
September 2019

PheValuator: Development and evaluation of a phenotype algorithm evaluator.

J Biomed Inform 2019 09 29;97:103258. Epub 2019 Jul 29.

Janssen Research & Development, 920 Route 202, Raritan, NJ 08869, USA; OHDSI Collaborators, Observational Health Data Sciences and Informatics (OHDSI), 622 West 168th Street, PH-20, New York, NY 10032, USA; Columbia University, 622 West 168th Street, PH20, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.jbi.2019.103258DOI Listing
September 2019

Comment on "How pharmacoepidemiology networks can manage distributed analyses to improve replicability and transparency and minimize bias".

Pharmacoepidemiol Drug Saf 2019 07 8;28(7):1032-1033. Epub 2019 May 8.

Observational Health Data Sciences and Informatics, New York, NY.

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http://dx.doi.org/10.1002/pds.4798DOI Listing
July 2019

Low Screening Rates for Diabetes Mellitus Among Family Members of Affected Relatives.

AMIA Annu Symp Proc 2018 5;2018:1471-1477. Epub 2018 Dec 5.

Value Institute, NewYork-Presbyterian Hospital, New York, NY.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371358PMC
January 2020

Temporal biomedical data analytics.

J Biomed Inform 2019 02 14;90:103092. Epub 2019 Jan 14.

Department of Biomedical Informatics, Columbia University, New York, NY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15320464193000
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http://dx.doi.org/10.1016/j.jbi.2018.12.006DOI Listing
February 2019

Columbia Open Health Data, clinical concept prevalence and co-occurrence from electronic health records.

Sci Data 2018 11 27;5:180273. Epub 2018 Nov 27.

Department of Biomedical Informatics, Columbia University, NY, USA.

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http://dx.doi.org/10.1038/sdata.2018.273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257042PMC
November 2018

A method for harmonization of clinical abbreviation and acronym sense inventories.

J Biomed Inform 2018 12 7;88:62-69. Epub 2018 Nov 7.

Department of Biomedical Informatics, Columbia University, New York, NY, USA; Value Institute, NewYork-Presbyterian Hospital, New York, NY, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15320464183021
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http://dx.doi.org/10.1016/j.jbi.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474250PMC
December 2018

Effect of vocabulary mapping for conditions on phenotype cohorts.

J Am Med Inform Assoc 2018 12;25(12):1618-1625

Department of Biomedical Informatics, Columbia University, New York, New York, USA.

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https://academic.oup.com/jamia/advance-article/doi/10.1093/j
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http://dx.doi.org/10.1093/jamia/ocy124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289550PMC
December 2018

Call for papers: Deep phenotyping for Precision Medicine.

J Biomed Inform 2018 11 29;87:66-67. Epub 2018 Sep 29.

Department of Biomedical Informatics, Columbia University, New York, NY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15320464183019
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http://dx.doi.org/10.1016/j.jbi.2018.09.017DOI Listing
November 2018

Methodological variations in lagged regression for detecting physiologic drug effects in EHR data.

J Biomed Inform 2018 10 30;86:149-159. Epub 2018 Aug 30.

Department of Biomedical Informatics, Columbia University Medical Center, 622 W. 168th Street, Presbyterian Building 20th Floor, New York, NY 10032, United States; Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States; NewYork-Presbyterian Hospital, 622 W. 168th Street, New York, NY 10032, United States.

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http://dx.doi.org/10.1016/j.jbi.2018.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207533PMC
October 2018

Improving reproducibility by using high-throughput observational studies with empirical calibration.

Philos Trans A Math Phys Eng Sci 2018 Sep;376(2128)

Observational Health Data Sciences and Informatics (OHDSI), New York, NY 10032, USA.

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http://rsta.royalsocietypublishing.org/lookup/doi/10.1098/rs
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http://dx.doi.org/10.1098/rsta.2017.0356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107542PMC
September 2018

Deep Phenotyping on Electronic Health Records Facilitates Genetic Diagnosis by Clinical Exomes.

Am J Hum Genet 2018 07 28;103(1):58-73. Epub 2018 Jun 28.

Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA; Institute for Genomic Medicine, Columbia University, New York, NY 10032, USA; Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035281PMC
July 2018

A Data Quality Assessment Guideline for Electronic Health Record Data Reuse.

EGEMS (Wash DC) 2017 Sep 4;5(1):14. Epub 2017 Sep 4.

Department of Biomedical Informatics, Columbia University.

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http://dx.doi.org/10.5334/egems.218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983018PMC
September 2017

Disease Heritability Inferred from Familial Relationships Reported in Medical Records.

Cell 2018 06 17;173(7):1692-1704.e11. Epub 2018 May 17.

Department of Biomedical Informatics, Columbia University, New York, NY, USA; Institute for Genomic Medicine, Columbia University, New York, NY, USA; Observational Health Data Sciences and Informatics (OHDSI), New York, NY, USA; Department of Medicine, Columbia University, New York, NY, USA; Department of Systems Biology, Columbia University, New York, NY, USA; Data Science Institute, Columbia University, New York, NY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183052
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http://dx.doi.org/10.1016/j.cell.2018.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015747PMC
June 2018

Beyond discrimination: A comparison of calibration methods and clinical usefulness of predictive models of readmission risk.

J Biomed Inform 2017 Dec 24;76:9-18. Epub 2017 Oct 24.

Department of Biomedical Informatics, Columbia University, United States.

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http://dx.doi.org/10.1016/j.jbi.2017.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716927PMC
December 2017

High-fidelity phenotyping: richness and freedom from bias.

J Am Med Inform Assoc 2018 Mar;25(3):289-294

Department of Biomedical Informatics, Columbia University Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1093/jamia/ocx110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282504PMC
March 2018

A conceptual framework for evaluating data suitability for observational studies.

J Am Med Inform Assoc 2018 Mar;25(3):248-258

Department of Biomedical Informatics, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1093/jamia/ocx095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378879PMC
March 2018

Inter-labeler and intra-labeler variability of condition severity classification models using active and passive learning methods.

Artif Intell Med 2017 Sep 27;81:12-32. Epub 2017 Apr 27.

Department of Software and Information Systems Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Department of Biomedical Informatics, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1016/j.artmed.2017.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937023PMC
September 2017

Personalized glucose forecasting for type 2 diabetes using data assimilation.

PLoS Comput Biol 2017 04 27;13(4):e1005232. Epub 2017 Apr 27.

Department of Biomedical Informatics, Columbia University, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409456PMC
April 2017

EHR-based phenotyping: Bulk learning and evaluation.

J Biomed Inform 2017 06 12;70:35-51. Epub 2017 Apr 12.

Department of Biomedical Informatics, Columbia University, 622 W. 168th Street, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbi.2017.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934756PMC
June 2017

Detection of drug-drug interactions through data mining studies using clinical sources, scientific literature and social media.

Brief Bioinform 2018 09;19(5):863-877

Department of Biomedical Informatics, Columbia University, New York, USA.

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http://dx.doi.org/10.1093/bib/bbx010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454455PMC
September 2018

Comparing lagged linear correlation, lagged regression, Granger causality, and vector autoregression for uncovering associations in EHR data.

AMIA Annu Symp Proc 2016 10;2016:779-788. Epub 2017 Feb 10.

Department of Biomedical Informatics, Columbia University, New York, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333294PMC
August 2017

Computational Drug Target Screening through Protein Interaction Profiles.

Sci Rep 2016 11 15;6:36969. Epub 2016 Nov 15.

Department of Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1038/srep36969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109486PMC
November 2016

Pharmacogenetic polymorphism as an independent risk factor for frequent hospitalizations in older adults with polypharmacy: a pilot study.

Pharmgenomics Pers Med 2016 14;9:107-116. Epub 2016 Oct 14.

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.

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http://dx.doi.org/10.2147/PGPM.S117014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072537PMC
October 2016

Robust empirical calibration of p-values using observational data.

Stat Med 2016 09;35(22):3883-8

Department of Biomathematics and Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, U.S.A.

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http://dx.doi.org/10.1002/sim.6977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108459PMC
September 2016

In Reply to Corbridge and to Schattner.

Acad Med 2016 09;91(9):1192

Assistant professor, Department of Biomedical Informatics, Columbia University, New York, New York; Assistant professor, Department of Biomedical Informatics, Columbia University, and vice president, Value Institute of NewYork-Presbyterian Hospital, New York, New York. Chair and Vivian Beaumont Allen Professor of Biomedical Informatics, and director, Medical Informatics Services, NewYork-Presbyterian Hospital, New York, New York.

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http://dx.doi.org/10.1097/ACM.0000000000001314DOI Listing
September 2016

Patient Experiences Using an Inpatient Personal Health Record.

Appl Clin Inform 2016 1;7(2):446-60. Epub 2016 Jun 1.

Department of Biomedical Informatics, Columbia University, New York, NY; NewYork-Presbyterian Hospital, New York, NY.

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http://dx.doi.org/10.4338/ACI-2015-10-RA-0130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941852PMC
November 2017

Leveraging 3D chemical similarity, target and phenotypic data in the identification of drug-protein and drug-adverse effect associations.

J Cheminform 2016 1;8:35. Epub 2016 Jul 1.

Department of Biomedical Informatics, Columbia University Medical Center, New York, NY USA.

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http://dx.doi.org/10.1186/s13321-016-0147-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930585PMC
July 2016

Characterizing treatment pathways at scale using the OHDSI network.

Proc Natl Acad Sci U S A 2016 07 6;113(27):7329-36. Epub 2016 Jun 6.

Observational Health Data Sciences and Informatics, New York, NY 10032; Department of Statistics, Columbia University, New York, NY 10027.

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http://dx.doi.org/10.1073/pnas.1510502113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941483PMC
July 2016

Potential utility of precision medicine for older adults with polypharmacy: a case series study.

Pharmgenomics Pers Med 2016 15;9:31-45. Epub 2016 Apr 15.

Department of Medicine, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.2147/PGPM.S101474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846041PMC
May 2016

Revealing structures in narratives: A mixed-methods approach to studying interdisciplinary handoff in critical care.

J Biomed Inform 2016 08 7;62:117-24. Epub 2016 Apr 7.

Biomedical Informatics, Arizona State University, United States; Mayo Clinic Arizona, United States.

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http://dx.doi.org/10.1016/j.jbi.2016.03.025DOI Listing
August 2016

How Do Residents Spend Their Shift Time? A Time and Motion Study With a Particular Focus on the Use of Computers.

Acad Med 2016 06;91(6):827-32

L. Mamykina is assistant professor of biomedical informatics, Department of Biomedical Informatics, Columbia University, New York, New York. D.K. Vawdrey is assistant professor of clinical biomedical informatics, Department of Biomedical Informatics, Columbia University, and vice president, Value Institute, NewYork-Presbyterian Hospital, New York, New York. G. Hripcsak is chair, Department of Biomedical Informatics, Vivian Beaumont Allen Professor of Biomedical Informatics, Columbia University, and director, Medical Informatics Services, NewYork-Presbyterian/Columbia University Medical Center, New York, New York.

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http://dx.doi.org/10.1097/ACM.0000000000001148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879085PMC
June 2016

Improving condition severity classification with an efficient active learning based framework.

J Biomed Inform 2016 06 22;61:44-54. Epub 2016 Mar 22.

Department of Biomedical Informatics, Columbia University, New York, NY, USA; Department of Systems Biology, Columbia University, New York, NY, USA; Department of Medicine, Columbia University, New York, NY, USA; Observational Health Data Sciences and Informatics, Columbia University, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbi.2016.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486916PMC
June 2016

Preserving temporal relations in clinical data while maintaining privacy.

J Am Med Inform Assoc 2016 11 24;23(6):1040-1045. Epub 2016 Mar 24.

Department of Biomedical Informatics, School of Medicine, Vanderbilt University, Nashville, TN 37203, USA.

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http://dx.doi.org/10.1093/jamia/ocw001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070517PMC
November 2016

Utilizing a structural meta-ontology for family-based quality assurance of the BioPortal ontologies.

J Biomed Inform 2016 06 14;61:63-76. Epub 2016 Mar 14.

Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.jbi.2016.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893909PMC
June 2016

Participatory approach to the development of a knowledge base for problem-solving in diabetes self-management.

Int J Med Inform 2016 Jan 8;85(1):96-103. Epub 2015 Aug 8.

Department of Biomedical Informatics, Columbia University, New York, NY, USA; Department of Epidemiology and Population Health, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijmedinf.2015.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699307PMC
January 2016

Origins of the Arden Syntax.

Artif Intell Med 2018 11 2;92:7-9. Epub 2015 Jul 2.

Department of Biomedical Informatics, Columbia University, 622 W 168th Street, PH20, New York, NY 10032, USA; Department of Biomedical Informatics, University of Utah, 421 Wakara Way, Ste 140, Salt Lake City, UT 84108, USA.

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http://dx.doi.org/10.1016/j.artmed.2015.05.006DOI Listing
November 2018

Improving Detection of Arrhythmia Drug-Drug Interactions in Pharmacovigilance Data through the Implementation of Similarity-Based Modeling.

PLoS One 2015 12;10(6):e0129974. Epub 2015 Jun 12.

Department of Biomedical Informatics, Columbia University, New York, NY, United States of America; Department of Systems Biology, Columbia University, New York, NY, United States of America; Observational Health Data Sciences and Informatics (OHDSI), New York, NY, United States of America; Department of Medicine, Columbia University, New York, NY, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129974PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466327PMC
April 2016

Development of novel adenosine receptor ligands based on the 3-amidocoumarin scaffold.

Bioorg Chem 2015 Aug 22;61:1-6. Epub 2015 May 22.

Institut für Pharmakologie und Toxikologie, Universität Würzburg, 97078 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.bioorg.2015.05.008DOI Listing
August 2015

Birth month affects lifetime disease risk: a phenome-wide method.

J Am Med Inform Assoc 2015 Sep 2;22(5):1042-53. Epub 2015 Jun 2.

Department of Biomedical Informatics Observational Health Data Sciences and Informatics (OHDSI) Department of Systems Biology Department of Medicine, Columbia University, New York, NY, USA

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986668PMC
September 2015

Development and validation of a classification approach for extracting severity automatically from electronic health records.

J Biomed Semantics 2015 6;6:14. Epub 2015 Apr 6.

Department of Biomedical Informatics, Columbia University, New York, NY USA ; Observational Health Data Sciences and Informatics (OHDSI), Columbia University, 622 West 168th Street, PH-20, New York, NY USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386082PMC
April 2015

3D pharmacophoric similarity improves multi adverse drug event identification in pharmacovigilance.

Sci Rep 2015 Mar 6;5:8809. Epub 2015 Mar 6.

Department of Biomedical Informatics, Columbia University Medical Center, New York, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351525PMC
March 2015

Parameterizing time in electronic health record studies.

J Am Med Inform Assoc 2015 Jul 26;22(4):794-804. Epub 2015 Feb 26.

Department of Biomedical Informatics, Columbia University Medical Center, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169471PMC
July 2015

Intercepting wrong-patient orders in a computerized provider order entry system.

Ann Emerg Med 2015 Jun 18;65(6):679-686.e1. Epub 2014 Dec 18.

Department of Biomedical Informatics, Columbia University, New York, NY; Medical Informatics Services, NewYork-Presbyterian Hospital, New York, NY.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447590PMC
June 2015

Potent and selective MAO-B inhibitory activity: amino- versus nitro-3-arylcoumarin derivatives.

Bioorg Med Chem Lett 2015 Feb 8;25(3):642-8. Epub 2014 Dec 8.

Departamento de Farmacología, CIMUS, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

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February 2015

A tribal abstraction network for SNOMED CT target hierarchies without attribute relationships.

J Am Med Inform Assoc 2015 May 20;22(3):628-39. Epub 2014 Oct 20.

Department of Biomedical Informatics, Columbia University, New York, New Jersey, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283061PMC
May 2015

Similarity-based modeling in large-scale prediction of drug-drug interactions.

Nat Protoc 2014 Sep 14;9(9):2147-63. Epub 2014 Aug 14.

1] Department of Biomedical Informatics, Columbia University Medical Center, New York, New York, USA. [2] Department of Systems Biology, Columbia University Medical Center, New York, New York, USA. [3] Department of Medicine, Columbia University Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nprot.2014.151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422192PMC
September 2014

Estimating heritability of drug-induced liver injury from common variants and implications for future study designs.

Sci Rep 2014 Jul 21;4:5762. Epub 2014 Jul 21.

1] Department of Biomedical Informatics, Columbia University, New York, NY [2] Department of Systems Biology, Columbia University, New York, NY [3] JP Sulzberger Columbia Genome Center, Columbia University, New York, NY.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104390PMC
July 2014

Dynamical phenotyping: using temporal analysis of clinically collected physiologic data to stratify populations.

PLoS One 2014 16;9(6):e96443. Epub 2014 Jun 16.

Department of Biomedical Informatics, Columbia University, New York, New York, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059642PMC
October 2015

Temporal trends of hemoglobin A1c testing.

J Am Med Inform Assoc 2014 Nov-Dec;21(6):1038-44. Epub 2014 Jun 13.

Department of Biomedical Informatics, Columbia University, New York, USA.

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May 2015