Publications by authors named "George Hindy"

34Publications

Genome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease.

Arterioscler Thromb Vasc Biol 2020 11 22;40(11):2738-2746. Epub 2020 Sep 22.

Department of Population Medicine, Qatar University College of Medicine, QU Health, Doha (G.H.). Program of Medical and Population Genetics, Broad Institute, Cambridge, MA (K.G.A., M.C., S.K., A.V.K.). Center for Genomic Medicine (K.G.A., A.V.K.) and Division of Cardiology, Department of Medicine (S.K., A.V.K.), Massachusetts General Hospital, Boston. Department of Medicine, Harvard Medical School, Boston, MA (K.G.A., S.K., A.V.K.). Center for Computational Health, IBM Research, Cambridge, MA (K.N.). Regeneron Genetics Center, Tarrytown, NY (L.A.L., A.B.). Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden (I.D., M.O.-M., O.M.).

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http://dx.doi.org/10.1161/ATVBAHA.120.314856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577949PMC
November 2020

Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease.

J Am Coll Cardiol 2020 Jun;75(22):2769-2780

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2020.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346975PMC
June 2020

Genetic Link Between Arterial Stiffness and Atrial Fibrillation.

Circ Genom Precis Med 2019 06 18;12(6):e002453. Epub 2019 Jun 18.

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA (S.M.Z., C.R., G.H., S.A.L., P.T.E., P.N.).

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http://dx.doi.org/10.1161/CIRCGEN.118.002453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582989PMC
June 2019

Polygenic Risk Score for Coronary Heart Disease Modifies the Elevated Risk by Cigarette Smoking for Disease Incidence.

Circ Genom Precis Med 2018 01 12;11(1):e001856. Epub 2018 Jan 12.

From the Department of Clinical Sciences in Malmö, Lund University, Sweden (G.H., F.W., P.A., O.M., M.O.-M.); and Program in Medical and Population Genetics, The Broad Institute, Cambridge, MA (G.H.).

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http://dx.doi.org/10.1161/CIRCGEN.117.001856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319562PMC
January 2018

Dietary and genetic risk scores and incidence of type 2 diabetes.

Genes Nutr 2018 16;13:13. Epub 2018 May 16.

1Diabetes and Cardiovascular Disease, Genetic Epidemiology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.

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https://genesandnutrition.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12263-018-0599-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956794PMC
May 2018

Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes: A Mendelian Randomization Study.

Stroke 2018 04 13;49(4):820-827. Epub 2018 Mar 13.

From the Department of Clinical Sciences, Lund University, Malmö, Sweden (G.H., G.E., O.M., M.O.-M.); Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (G.H.); Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (S.C.L.); and Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, United Kingdom (M.T., H.S.M.).

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http://dx.doi.org/10.1161/STROKEAHA.117.019653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895121PMC
April 2018

Blood lipid genetic scores, the HMGCR gene and cancer risk: a Mendelian randomization study.

Int J Epidemiol 2018 04;47(2):495-505

Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1093/ije/dyx237DOI Listing
April 2018

A prospective study of dietary and supplemental zinc intake and risk of type 2 diabetes depending on genetic variation in .

Genes Nutr 2017 30;12:30. Epub 2017 Oct 30.

Diabetes and Cardiovascular Disease - Genetic Epidemiology, Lund University Diabetes Centre, Department of Clinical Sciences in Malmö, Lund University, Clinical Research Center 60:13, Jan Waldenströms gata 35, SE-205 02 Malmö, Sweden.

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http://dx.doi.org/10.1186/s12263-017-0586-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661924PMC
October 2017

Type 2 diabetes, glucose, insulin, BMI, and ischemic stroke subtypes: Mendelian randomization study.

Neurology 2017 Aug 30;89(5):454-460. Epub 2017 Jun 30.

From the Stroke Research Group (S.L.C., M.T., H.S.M.), Department of Clinical Neurosciences, and MRC Epidemiology Unit (R.A.S., C.C.L., N.J.W.), University of Cambridge, UK; Unit of Nutritional Epidemiology (S.C.L.), Institute of Environmental Medicine, Karolinska Institutet, Stockholm; Department of Clinical Sciences (G.H., O.M., M.O.-M.), Lund University, Malmö, Sweden; and Boston University School of Medicine (S.S.), MA.

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http://dx.doi.org/10.1212/WNL.0000000000004173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539736PMC
August 2017

Several type 2 diabetes-associated variants in genes annotated to WNT signaling interact with dietary fiber in relation to incidence of type 2 diabetes.

Genes Nutr 2016 21;11. Epub 2016 Mar 21.

Department of Clinical Sciences in Malmö, Lund University, Skåne University Hospital, Jan Waldenströms gata 35, SE-205 02 Malmö, Sweden.

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http://dx.doi.org/10.1186/s12263-016-0524-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968454PMC
August 2016

Sugar-sweetened beverage consumption and genetic predisposition to obesity in 2 Swedish cohorts.

Am J Clin Nutr 2016 09 27;104(3):809-15. Epub 2016 Jul 27.

Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden; Biobank Research, Umeå University, Umeå, Sweden; and

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http://dx.doi.org/10.3945/ajcn.115.126052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997292PMC
September 2016

High Level of Fasting Plasma Proenkephalin-A Predicts Deterioration of Kidney Function and Incidence of CKD.

J Am Soc Nephrol 2017 Jan 8;28(1):291-303. Epub 2016 Jul 8.

Department of Clinical Sciences, University Hospital Malmo Clinical Research Center, Lund University, Malmo, Sweden;

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http://dx.doi.org/10.1681/ASN.2015101177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198273PMC
January 2017

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.

Gastroenterology 2016 05 2;150(5):1219-1230.e6. Epub 2016 Feb 2.

Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden; Clinical Nutrition Unit, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy; Cardiology Department, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844071PMC
May 2016

Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium.

Int J Epidemiol 2015 Apr 6;44(2):638-50. Epub 2015 Jun 6.

Department of Public Health and Clinical Medicine, Section for Medicine, Umeå University, Umeå, Sweden, Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden, Department of Odontology, Umeå University, Umeå, Sweden, Department of Nutrition, Harvard School of Public Health, Boston, MA, USA, Department of Pediatric Dentistry, School of Dentistry, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA, Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany, Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA, Department of Periodontology, and Department of Dental Ecology, School of Dentistry, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA, Department of Prosthodontics, Gerodontology and Biomaterials, University Medicine, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany, Human Genetics Center, and Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston, Houston, TX, USA, Emeritus, Department of Periodontics, West Virginia University School of Dentistry, Morgantown, WV, USA, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Department of Biobank Research, Umeå University, Umeå, Sweden, Department of Clinical Sciences, Diabetes and Cardiovascular Disease Genetic Epidemiology, Lund University Diabetes Center, Skåne University Hosptial, Malmö, Sweden, Dental Practice and Rural Health, Morgantown, WV, USA, Department of Clinical Sciences, Hypertension and Cardiovascular Disease, Lund University Diabetes Center, Skåne University Hospital, Malmö, Sweden, Department of

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http://dx.doi.org/10.1093/ije/dyv075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817600PMC
April 2015

TCF7L2 type 2 diabetes risk variant, lifestyle factors, and incidence of prostate cancer.

Prostate 2014 Sep 24;74(12):1161-70. Epub 2014 Jun 24.

Department of Clinical Sciences in Malmö, Research Group in Nutritional Epidemiology, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1002/pros.22832DOI Listing
September 2014

Loss-of-function mutations in APOC3, triglycerides, and coronary disease.

N Engl J Med 2014 Jul 18;371(1):22-31. Epub 2014 Jun 18.

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http://dx.doi.org/10.1056/NEJMoa1307095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180269PMC
July 2014

Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.

Authors:
Gina M Peloso Paul L Auer Joshua C Bis Arend Voorman Alanna C Morrison Nathan O Stitziel Jennifer A Brody Sumeet A Khetarpal Jacy R Crosby Myriam Fornage Aaron Isaacs Johanna Jakobsdottir Mary F Feitosa Gail Davies Jennifer E Huffman Ani Manichaikul Brian Davis Kurt Lohman Aron Y Joon Albert V Smith Megan L Grove Paolo Zanoni Valeska Redon Serkalem Demissie Kim Lawson Ulrike Peters Christopher Carlson Rebecca D Jackson Kelli K Ryckman Rachel H Mackey Jennifer G Robinson David S Siscovick Pamela J Schreiner Josyf C Mychaleckyj James S Pankow Albert Hofman Andre G Uitterlinden Tamara B Harris Kent D Taylor Jeanette M Stafford Lindsay M Reynolds Riccardo E Marioni Abbas Dehghan Oscar H Franco Aniruddh P Patel Yingchang Lu George Hindy Omri Gottesman Erwin P Bottinger Olle Melander Marju Orho-Melander Ruth J F Loos Stefano Duga Piera Angelica Merlini Martin Farrall Anuj Goel Rosanna Asselta Domenico Girelli Nicola Martinelli Svati H Shah William E Kraus Mingyao Li Daniel J Rader Muredach P Reilly Ruth McPherson Hugh Watkins Diego Ardissino Qunyuan Zhang Judy Wang Michael Y Tsai Herman A Taylor Adolfo Correa Michael E Griswold Leslie A Lange John M Starr Igor Rudan Gudny Eiriksdottir Lenore J Launer Jose M Ordovas Daniel Levy Y-D Ida Chen Alexander P Reiner Caroline Hayward Ozren Polasek Ian J Deary Ingrid B Borecki Yongmei Liu Vilmundur Gudnason James G Wilson Cornelia M van Duijn Charles Kooperberg Stephen S Rich Bruce M Psaty Jerome I Rotter Christopher J O'Donnell Kenneth Rice Eric Boerwinkle Sekar Kathiresan L Adrienne Cupples

Am J Hum Genet 2014 Feb;94(2):223-32

Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA; National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study, Framingham, MA 01702, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928662PMC
February 2014

Smoking modifies the associated increased risk of future cardiovascular disease by genetic variation on chromosome 9p21.

PLoS One 2014 22;9(1):e85893. Epub 2014 Jan 22.

Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden ; Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085893PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899088PMC
December 2014

High intakes of protein and processed meat associate with increased incidence of type 2 diabetes.

Br J Nutr 2013 Mar 1;109(6):1143-53. Epub 2012 Aug 1.

Department of Clinical Sciences, Malmö, Diabetes and Cardiovascular Disease, Genetic Epidemiology, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1017/S0007114512003017DOI Listing
March 2013

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.

Authors:
Benjamin F Voight Gina M Peloso Marju Orho-Melander Ruth Frikke-Schmidt Maja Barbalic Majken K Jensen George Hindy Hilma Hólm Eric L Ding Toby Johnson Heribert Schunkert Nilesh J Samani Robert Clarke Jemma C Hopewell John F Thompson Mingyao Li Gudmar Thorleifsson Christopher Newton-Cheh Kiran Musunuru James P Pirruccello Danish Saleheen Li Chen Alexandre F R Stewart Arne Schillert Unnur Thorsteinsdottir Gudmundur Thorgeirsson Sonia Anand James C Engert Thomas Morgan John Spertus Monika Stoll Klaus Berger Nicola Martinelli Domenico Girelli Pascal P McKeown Christopher C Patterson Stephen E Epstein Joseph Devaney Mary-Susan Burnett Vincent Mooser Samuli Ripatti Ida Surakka Markku S Nieminen Juha Sinisalo Marja-Liisa Lokki Markus Perola Aki Havulinna Ulf de Faire Bruna Gigante Erik Ingelsson Tanja Zeller Philipp Wild Paul I W de Bakker Olaf H Klungel Anke-Hilse Maitland-van der Zee Bas J M Peters Anthonius de Boer Diederick E Grobbee Pieter W Kamphuisen Vera H M Deneer Clara C Elbers N Charlotte Onland-Moret Marten H Hofker Cisca Wijmenga W M Monique Verschuren Jolanda M A Boer Yvonne T van der Schouw Asif Rasheed Philippe Frossard Serkalem Demissie Cristen Willer Ron Do Jose M Ordovas Gonçalo R Abecasis Michael Boehnke Karen L Mohlke Mark J Daly Candace Guiducci Noël P Burtt Aarti Surti Elena Gonzalez Shaun Purcell Stacey Gabriel Jaume Marrugat John Peden Jeanette Erdmann Patrick Diemert Christina Willenborg Inke R König Marcus Fischer Christian Hengstenberg Andreas Ziegler Ian Buysschaert Diether Lambrechts Frans Van de Werf Keith A Fox Nour Eddine El Mokhtari Diana Rubin Jürgen Schrezenmeir Stefan Schreiber Arne Schäfer John Danesh Stefan Blankenberg Robert Roberts Ruth McPherson Hugh Watkins Alistair S Hall Kim Overvad Eric Rimm Eric Boerwinkle Anne Tybjaerg-Hansen L Adrienne Cupples Muredach P Reilly Olle Melander Pier M Mannucci Diego Ardissino David Siscovick Roberto Elosua Kari Stefansson Christopher J O'Donnell Veikko Salomaa Daniel J Rader Leena Peltonen Stephen M Schwartz David Altshuler Sekar Kathiresan

Lancet 2012 Aug 17;380(9841):572-80. Epub 2012 May 17.

Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S014067361260312
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http://dx.doi.org/10.1016/S0140-6736(12)60312-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419820PMC
August 2012