George F Koob

George F Koob

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George F Koob

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Addiction and stress: An allostatic view.

Neurosci Biobehav Rev 2019 Nov 15;106:245-262. Epub 2018 Sep 15.

Department of Neuroscience, Georgetown University, United States.

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http://dx.doi.org/10.1016/j.neubiorev.2018.09.008DOI Listing
November 2019

Neurofunctional Domains Derived From Deep Behavioral Phenotyping in Alcohol Use Disorder.

Am J Psychiatry 2019 Sep 4;176(9):744-753. Epub 2019 Jan 4.

Office of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda (Kwako, Schwandt, Diazgranados, Goldman); Section on Human Psychopharmacology, NIAAA, Bethesda (Ramchandani); Office of the Director, NIAAA, Bethesda (Koob); Office of the Director, NIDA, Bethesda (Volkow); Division of Epidemiology, Services, and Prevention, NIDA, Bethesda (Blanco); and Laboratory of Neurogenetics, NIAAA, Bethesda (Goldman).

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http://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2018.18
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http://dx.doi.org/10.1176/appi.ajp.2018.18030357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609498PMC
September 2019

The neurobiology of addiction.

Ann N Y Acad Sci 2019 Sep 15;1451(1):5-28. Epub 2019 Jan 15.

NIH/NIAAA, Bethesda, Maryland.

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http://dx.doi.org/10.1111/nyas.13989DOI Listing
September 2019

Larry Stein: pioneer neuropsychopharmacology researcher, mentor, and friend.

Authors:
George F Koob

Neuropsychopharmacology 2019 Sep 9. Epub 2019 Sep 9.

National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41386-019-0509-2DOI Listing
September 2019

Refractory dependence on opioid analgesics.

Pain 2019 Aug 10. Epub 2019 Aug 10.

National Institutes of Health, Bethesda, MD, United States.

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http://dx.doi.org/10.1097/j.pain.0000000000001680DOI Listing
August 2019

Corrigendum: Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency.

Front Behav Neurosci 2019;13:188. Epub 2019 Aug 27.

Neurobiology of Addiction Section, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, United States.

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http://dx.doi.org/10.3389/fnbeh.2019.00188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718814PMC
August 2019

Ghrelin receptor deletion reduces binge-like alcohol drinking in rats.

J Neuroendocrinol 2019 Jul 16;31(7):e12663. Epub 2019 Jan 16.

Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, and National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1111/jne.12663DOI Listing
July 2019

Male and female mice develop escalation of heroin intake and dependence following extended access.

Neuropharmacology 2019 06 14;151:189-194. Epub 2019 Mar 14.

Neurobiology of Addiction Section, Integrative Neuroscience Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, 21224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2019.03.019DOI Listing
June 2019

Alcohol use disorder and sleep disturbances: a feed-forward allostatic framework.

Neuropsychopharmacology 2019 Jun 24. Epub 2019 Jun 24.

SRI Biosciences, SRI International, Menlo Park, CA, USA.

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http://dx.doi.org/10.1038/s41386-019-0446-0DOI Listing
June 2019

Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency.

Front Behav Neurosci 2019 25;13:136. Epub 2019 Jun 25.

Neurobiology of Addiction Section, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, United States.

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http://dx.doi.org/10.3389/fnbeh.2019.00136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603097PMC
June 2019

Neurobiology of Opioid Addiction: Opponent Process, Hyperkatifeia, and Negative Reinforcement.

Authors:
George F Koob

Biol Psychiatry 2019 Jun 12. Epub 2019 Jun 12.

National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland; National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.05.023DOI Listing
June 2019

Periaqueductal Gray Sheds Light on Dark Areas of Psychopathology.

Trends Neurosci 2019 May 4;42(5):349-360. Epub 2019 Apr 4.

National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA; National Institute on Drug Abuse, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2019.03.004DOI Listing
May 2019

Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala.

PLoS Biol 2019 Apr 16;17(4):e2006421. Epub 2019 Apr 16.

Neurobiology of Addiction Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.2006421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467366PMC
April 2019

Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use.

Mol Psychiatry 2018 12 7;23(12):2266-2276. Epub 2018 Jun 7.

Institut de Neurosciences de la Timone, UMR 7289 CNRS & Aix-Marseille Université, 27 Bld J. Moulin, F-13000, Marseille, France.

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http://dx.doi.org/10.1038/s41380-018-0080-yDOI Listing
December 2018

Larry Parsons: Researcher, mentor, and friend.

Addict Biol 2018 11;23(6):1204-1206

Instituto IBIMA, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain.

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http://dx.doi.org/10.1111/adb.12686DOI Listing
November 2018

Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake.

Biol Psychiatry 2018 06 20;83(12):1024-1035. Epub 2017 Nov 20.

Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1016/j.biopsych.2017.10.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960600PMC
June 2018

Animal Models of Addiction and Neuropsychiatric Disorders and Their Role in Drug Discovery: Honoring the Legacy of Athina Markou.

Biol Psychiatry 2018 06 22;83(11):940-946. Epub 2018 Feb 22.

National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland.

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http://dx.doi.org/10.1016/j.biopsych.2018.02.009DOI Listing
June 2018

Age, Alcohol Use, and Brain Function: Yoda Says, "With Age and Alcohol, Confused Is the Force".

Authors:
George F Koob

JAMA Psychiatry 2018 05;75(5):422

National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland.

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http://dx.doi.org/10.1001/jamapsychiatry.2018.0009DOI Listing
May 2018

Compulsive-Like Sufentanil Vapor Self-Administration in Rats.

Neuropsychopharmacology 2018 03 16;43(4):801-809. Epub 2017 Aug 16.

Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/npp.2017.172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809787PMC
March 2018

Evaluation of Alcohol Preference and Drinking in msP Rats Bearing a Promoter Polymorphism.

Front Psychiatry 2018 15;9:28. Epub 2018 Feb 15.

Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, United States.

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http://dx.doi.org/10.3389/fpsyt.2018.00028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818434PMC
February 2018

Blockade of TRPV1 Inhibits Methamphetamine-induced Rewarding Effects.

Sci Rep 2018 01 17;8(1):882. Epub 2018 Jan 17.

Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

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http://dx.doi.org/10.1038/s41598-018-19207-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772440PMC
January 2018

Opiate dependence induces cell type-specific plasticity of intrinsic membrane properties in the rat juxtacapsular bed nucleus of stria terminalis (jcBNST).

Psychopharmacology (Berl) 2017 Dec 6;234(23-24):3485-3498. Epub 2017 Oct 6.

Department of Immunology and Microbiology and Department ofNeuroscience, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1007/s00213-017-4732-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993421PMC
December 2017

Individual differences in the neuropsychopathology of addiction.

Dialogues Clin Neurosci 2017 09;19(3):217-229

National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741105PMC
September 2017

High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats.

Neuropsychopharmacology 2017 Aug 5;42(9):1850-1859. Epub 2016 Dec 5.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/npp.2016.270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520777PMC
August 2017

Genetic studies of alcohol dependence in the context of the addiction cycle.

Neuropharmacology 2017 Aug 22;122:3-21. Epub 2017 Jan 22.

National Institutes of Health (NIH), National Institute on Alcohol Abuse and Alcoholism (NIAAA), Director NIAAA, 5635 Fishers Lane, Bethesda, MD 20852, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2017.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233301PMC
August 2017

Addictions Neuroclinical Assessment: A reverse translational approach.

Neuropharmacology 2017 Aug 7;122:254-264. Epub 2017 Mar 7.

Office of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892, USA; Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2017.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569299PMC
August 2017

A new nomenclature for classifying psychotropic drugs.

Br J Clin Pharmacol 2017 08 24;83(8):1614-1616. Epub 2017 May 24.

Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.

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http://dx.doi.org/10.1111/bcp.13302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510058PMC
August 2017

The future is now: A 2020 view of alcoholism research.

Neuropharmacology 2017 08;122:1-2

National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Rockville, MD 20852, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2017.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135244PMC
August 2017

Neuroscience of Compulsive Eating Behavior.

Front Neurosci 2017 24;11:469. Epub 2017 Aug 24.

Laboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry, Boston University School of MedicineBoston, MA, United States.

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http://dx.doi.org/10.3389/fnins.2017.00469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573809PMC
August 2017

Pathological Overeating: Emerging Evidence for a Compulsivity Construct.

Neuropsychopharmacology 2017 Jun 6;42(7):1375-1389. Epub 2016 Dec 6.

Laboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry, Boston University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1038/npp.2016.269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436113PMC
June 2017

Titrating Tipsy Targets: The Neurobiology of Low-Dose Alcohol.

Trends Pharmacol Sci 2017 06 31;38(6):556-568. Epub 2017 Mar 31.

National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2017.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597438PMC
June 2017

Antireward, compulsivity, and addiction: seminal contributions of Dr. Athina Markou to motivational dysregulation in addiction.

Authors:
George F Koob

Psychopharmacology (Berl) 2017 05 3;234(9-10):1315-1332. Epub 2017 Jan 3.

National Institute on Alcohol Abuse and Alcoholism, 5635 Fishers Lane, Room 2001, Suite 2000, Rockville, MD, 20852, USA.

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http://dx.doi.org/10.1007/s00213-016-4484-6DOI Listing
May 2017

The Dark Side of Addiction: The Horsley Gantt to Joseph Brady Connection.

Authors:
George F Koob

J Nerv Ment Dis 2017 Apr;205(4):270-272

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA.

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http://dx.doi.org/10.1097/NMD.0000000000000551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135258PMC
April 2017

Hypocretin Neurotransmission Within the Central Amygdala Mediates Escalated Cocaine Self-administration and Stress-Induced Reinstatement in Rats.

Biol Psychiatry 2017 04 16;81(7):606-615. Epub 2016 Jun 16.

Neurobiology of Addiction Section, Integrative Neuroscience Research Branch, National Institute on Drug Abuse, Baltimore, Maryland; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1016/j.biopsych.2016.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161745PMC
April 2017

Reply to: Neuroclinical Assessment of Addiction Needs to Incorporate Decision-Making Measures and Ecological Validity.

Biol Psychiatry 2017 04 30;81(7):e55. Epub 2016 Aug 30.

Office of the Clinical Director, Bethesda, Maryland; Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1016/j.biopsych.2016.08.029DOI Listing
April 2017

Dysregulation of Brain Stress Systems Mediates Compulsive Alcohol Drinking.

Curr Opin Behav Sci 2017 Feb 19;13:85-90. Epub 2016 Nov 19.

National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.cobeha.2016.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461929PMC
February 2017

Neuroclinical Framework for the Role of Stress in Addiction.

Chronic Stress (Thousand Oaks) 2017 Feb 10;1. Epub 2017 Apr 10.

National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.

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http://journals.sagepub.com/doi/10.1177/2470547017698140
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482275PMC
http://dx.doi.org/10.1177/2470547017698140DOI Listing
February 2017

Sex, strain, and estrous cycle influences on alcohol drinking in rats.

Pharmacol Biochem Behav 2017 Jan 4;152:61-67. Epub 2016 Aug 4.

Neurobiology of Addiction Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755698PMC
January 2017

Existing and Future Drugs for the Treatment of the Dark Side of Addiction.

Annu Rev Pharmacol Toxicol 2016 22;56:299-322. Epub 2015 Oct 22.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037; email: ,

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http://dx.doi.org/10.1146/annurev-pharmtox-010715-103143DOI Listing
September 2016

Corticotropin-Releasing Factor From Rodents to Primates: Translational Hope Expresses Itself, Pun Intended.

Authors:
George F Koob

Biol Psychiatry 2016 09;80(5):340-2

National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2016.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145175PMC
September 2016

Addictions Neuroclinical Assessment: A Neuroscience-Based Framework for Addictive Disorders.

Biol Psychiatry 2016 08 17;80(3):179-89. Epub 2015 Nov 17.

Office of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland; Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1016/j.biopsych.2015.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870153PMC
August 2016

Neurobiology of addiction: a neurocircuitry analysis.

Lancet Psychiatry 2016 Aug;3(8):760-73

National Institute on Drug Abuse, National Institutes of Health, Rockville, MD, USA.

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http://www.thelancet.com/pdfs/journals/lanpsy/PIIS2215-0366(
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http://dx.doi.org/10.1016/S2215-0366(16)00104-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135092PMC
August 2016

Neurocircuitry of alcohol addiction: synthesis from animal models.

Authors:
George F Koob

Handb Clin Neurol 2014 ;125:33-54

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-444-62619-6.00003-3DOI Listing
July 2016

5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking.

Neuropsychopharmacology 2016 Apr 1;41(5):1210-22. Epub 2015 Sep 1.

Department of Molecular Therapeutics, The Scripps Research Institute-Florida, Jupiter, FL, USA.

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http://dx.doi.org/10.1038/npp.2015.268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793105PMC
April 2016

Sex Differences in Animal Models: Focus on Addiction.

Pharmacol Rev 2016 Apr;68(2):242-63

Molecular & Behavioral Neuroscience Institute, Department of Psychiatry, Department of Psychology, University of Michigan, Ann Arbor, Michigan (J.B.B.); and Director, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland (G.F.K.)

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http://dx.doi.org/10.1124/pr.115.011163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813426PMC
April 2016

Dynorphin, Dysphoria, and Dependence: the Stress of Addiction.

Neuropsychopharmacology 2016 Jan;41(1):373-4

National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA.

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http://dx.doi.org/10.1038/npp.2015.258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677142PMC
January 2016

Alcohol use disorders: tracts, twins, and trajectories.

Authors:
George F Koob

Am J Psychiatry 2015 Jun 18;172(6):499-501. Epub 2015 May 18.

From the National Institute on Alcohol Abuse and Alcoholism, Rockville, Md.

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http://dx.doi.org/10.1176/appi.ajp.2015.15020240DOI Listing
June 2015

The darkness within: individual differences in stress.

Authors:
George F Koob

Cerebrum 2015 Mar-Apr;2015. Epub 2015 Apr 1.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445593PMC
June 2015

The dark side of emotion: the addiction perspective.

Authors:
George F Koob

Eur J Pharmacol 2015 Apr 9;753:73-87. Epub 2015 Jan 9.

National Institute on Alcohol Abuse and Alcoholism, Washington, DC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2014.11.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380644PMC
April 2015

Pharmacology, Biochemistry and Behavior: the 2015 transition.

Pharmacol Biochem Behav 2015 Apr 4;131:iii. Epub 2015 Feb 4.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, CA, USA; Sanofi, Strategy, Science Policy & External Innovation, Chilly-Mazarin, FRANCE. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2015.02.001DOI Listing
April 2015

Heterogeneity of alcohol use disorder: understanding mechanisms to advance personalized treatment.

Alcohol Clin Exp Res 2015 Apr;39(4):579-84

NIAAA's Clinical Investigations Group (NCIG), Division of Treatment and Recovery Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.

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http://dx.doi.org/10.1111/acer.12669DOI Listing
April 2015

Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia.

Addict Biol 2015 Mar 13;20(2):275-84. Epub 2013 Dec 13.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, CA, USA.

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http://dx.doi.org/10.1111/adb.12120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057367PMC
March 2015

Self-administration of ethanol, cocaine, or nicotine does not decrease the soma size of ventral tegmental area dopamine neurons.

PLoS One 2014 22;9(4):e95962. Epub 2014 Apr 22.

Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095962PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995955PMC
January 2015

Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus.

Psychopharmacology (Berl) 2015 Jan 26;232(2):453-63. Epub 2014 Jul 26.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1007/s00213-014-3685-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297709PMC
January 2015

Compulsive-like responding for opioid analgesics in rats with extended access.

Neuropsychopharmacology 2015 Jan 25;40(2):421-8. Epub 2014 Jul 25.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/npp.2014.188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443956PMC
January 2015

Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction.

Psychopharmacology (Berl) 2014 Oct 13;231(19):3911-7. Epub 2014 Jun 13.

Committee on the Neurobiology of Addictive Disorders, Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA, 92037, USA,

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http://dx.doi.org/10.1007/s00213-014-3623-1DOI Listing
October 2014

Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats.

Behav Brain Res 2014 Sep 7;271:171-6. Epub 2014 Jun 7.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, United States.

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http://dx.doi.org/10.1016/j.bbr.2014.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216724PMC
September 2014

Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats.

Neuropsychopharmacology 2014 Jun 29;39(7):1722-31. Epub 2014 Jan 29.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/npp.2014.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023146PMC
June 2014

Anxiolytic-like effects of antisauvagine-30 in mice are not mediated by CRF2 receptors.

PLoS One 2013 28;8(8):e63942. Epub 2013 Aug 28.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, United States of America ; Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063942PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756045PMC
May 2014

Corticotropin releasing factor: a key role in the neurobiology of addiction.

Front Neuroendocrinol 2014 Apr 20;35(2):234-44. Epub 2014 Jan 20.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.yfrne.2014.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213066PMC
April 2014

Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats.

Psychopharmacology (Berl) 2014 Mar 13;231(5):929-37. Epub 2013 Nov 13.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA, 92037, USA,

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http://dx.doi.org/10.1007/s00213-013-3307-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945412PMC
March 2014

Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala.

Neuropharmacology 2014 Feb 21;77:294-302. Epub 2013 Oct 21.

Committee on the Neurobiology of Addictive Disorders & Pearson Center for Alcoholism and Addiction Research, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2013.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873141PMC
February 2014

The development and maintenance of drug addiction.

Neuropsychopharmacology 2014 Jan 11;39(2):254-62. Epub 2013 Oct 11.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/npp.2013.261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870778PMC
January 2014

BK channel β1 and β4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice.

Front Integr Neurosci 2013 30;7:105. Epub 2013 Dec 30.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute La Jolla, San Diego, CA, USA.

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http://dx.doi.org/10.3389/fnint.2013.00105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874544PMC
January 2014

Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake.

J Neurosci 2013 Dec;33(49):19384-92

Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037.

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http://dx.doi.org/10.1523/JNEUROSCI.1979-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850049PMC
December 2013

Probing the effects of hapten stability on cocaine vaccine immunogenicity.

Mol Pharm 2013 Nov 4;10(11):4176-84. Epub 2013 Oct 4.

Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, The Worm Institute of Research and Medicine, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/mp400214wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946501PMC
November 2013

Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction.

Biol Psychiatry 2013 Oct 14;74(7):520-8. Epub 2013 Jun 14.

School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy; Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California.

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http://dx.doi.org/10.1016/j.biopsych.2013.04.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773286PMC
October 2013

Escalation of drug self-administration as a hallmark of persistent addiction liability.

Behav Pharmacol 2013 Sep;24(5-6):356-62

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1097/FBP.0b013e3283644d15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866817PMC
September 2013

Addiction is a Reward Deficit and Stress Surfeit Disorder.

Authors:
George F Koob

Front Psychiatry 2013 1;4:72. Epub 2013 Aug 1.

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute , La Jolla, CA , USA.

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http://dx.doi.org/10.3389/fpsyt.2013.00072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730086PMC
August 2013