George F Gao

George F Gao

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George F Gao

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Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.

Nat Microbiol 2019 Jul 1;4(7):1231-1241. Epub 2019 Apr 1.

CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

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http://www.nature.com/articles/s41564-019-0411-z
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http://dx.doi.org/10.1038/s41564-019-0411-zDOI Listing
July 2019

Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein.

Cell 2019 Jun 9;177(7):1714-1724.e12. Epub 2019 May 9.

Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China; School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China; CAS Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.04.008DOI Listing
June 2019

Structural insight into RNA synthesis by influenza D polymerase.

Nat Microbiol 2019 Jun 17. Epub 2019 Jun 17.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1038/s41564-019-0487-5DOI Listing
June 2019

Salt bridge-forming residues positioned over viral peptides presented by MHC class I impacts T-cell recognition in a binding-dependent manner.

Mol Immunol 2019 Jun 18;112:274-282. Epub 2019 Jun 18.

NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China; School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2019.06.005DOI Listing
June 2019

"Breathing" Hemagglutinin Reveals Cryptic Epitopes for Universal Influenza Vaccine Design.

Authors:
Yan Wu George F Gao

Cell 2019 May;177(5):1086-1088

Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences (CAS), 100101 Beijing, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 100101 Beijing, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193045
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http://dx.doi.org/10.1016/j.cell.2019.04.034DOI Listing
May 2019

Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B.

Cell 2019 May 16;177(6):1553-1565.e16. Epub 2019 May 16.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 100101 Beijing, China; CAS Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, 100101 Beijing, China; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, 100101 Beijing, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), 102206 Beijing, China; Savaid Medical School, University of Chinese Academy of Sciences, 100049 Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.04.035DOI Listing
May 2019

Molecular Basis of a Protective/Neutralizing Monoclonal Antibody Targeting Envelope Proteins of both Tick-Borne Encephalitis Virus and Louping Ill Virus.

J Virol 2019 Apr 3;93(8). Epub 2019 Apr 3.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China

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http://dx.doi.org/10.1128/JVI.02132-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450107PMC
April 2019

Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy.

MAbs 2019 May/Jun;11(4):681-690. Epub 2019 Apr 19.

b Institute of Physical Science and Information Technology , Anhui University , Hefei , China.

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http://dx.doi.org/10.1080/19420862.2019.1596513DOI Listing
April 2019

The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy.

iScience 2019 Apr 21;14:113-124. Epub 2019 Mar 21.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S25890042193008
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http://dx.doi.org/10.1016/j.isci.2019.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447726PMC
April 2019

Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells.

Cell Rep 2019 Apr;27(4):1205-1220.e4

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193042
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http://dx.doi.org/10.1016/j.celrep.2019.03.083DOI Listing
April 2019

Clinical and Immunological Characteristics of Human Infections With H5N6 Avian Influenza Virus.

Clin Infect Dis 2019 Mar;68(7):1100-1109

Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People's Hospital, Shenzhen.

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciy681DOI Listing
March 2019

Emergence and adaptation of H3N2 canine influenza virus from avian influenza virus: An overlooked role of dogs in interspecies transmission.

Transbound Emerg Dis 2019 Mar 5;66(2):842-851. Epub 2019 Jan 5.

MOE Joint International Research Laboratory of Animal Health and Food Safety, Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.

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http://dx.doi.org/10.1111/tbed.13093DOI Listing
March 2019

Comparison between human infections caused by highly and low pathogenic H7N9 avian influenza viruses in Wave Five: Clinical and virological findings.

J Infect 2019 Mar 18;78(3):241-248. Epub 2019 Jan 18.

Shenzhen Key Laboratory of Pathogen and Immunity, Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People's Hospital, Shenzhen 518112, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China; University of Chinese Academy of Sciences Medical School, Chinese Academy of Sciences, Beijing 101408, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01634453193002
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http://dx.doi.org/10.1016/j.jinf.2019.01.005DOI Listing
March 2019

HIV prevalence in suspected Ebola cases during the 2014-2016 Ebola epidemic in Sierra Leone.

Infect Dis Poverty 2019 Mar 4;8(1):15. Epub 2019 Mar 4.

NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention(China CDC), Beijing, 102206, China.

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https://idpjournal.biomedcentral.com/articles/10.1186/s40249
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http://dx.doi.org/10.1186/s40249-019-0525-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398227PMC
March 2019

Continued reassortment of avian H6 influenza viruses from Southern China, 2014-2016.

Transbound Emerg Dis 2019 Jan 26;66(1):592-598. Epub 2018 Oct 26.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing, China.

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http://doi.wiley.com/10.1111/tbed.13037
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http://dx.doi.org/10.1111/tbed.13037DOI Listing
January 2019

Isolation and Identification of a Highly Divergent Kaeng Khoi Virus from Bat Flies (Eucampsipoda sundaica) in China.

Vector Borne Zoonotic Dis 2019 01 11;19(1):73-80. Epub 2018 Dec 11.

1 State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

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http://dx.doi.org/10.1089/vbz.2018.2350DOI Listing
January 2019

Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.

Proc Natl Acad Sci U S A 2019 01 27;116(3):988-996. Epub 2018 Dec 27.

Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences (CAS), 100101 Beijing, China;

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http://dx.doi.org/10.1073/pnas.1815716116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338850PMC
January 2019

Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope.

Cell Rep 2019 Jan;26(2):438-446.e5

Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183201
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http://dx.doi.org/10.1016/j.celrep.2018.12.065DOI Listing
January 2019

Diverse biological characteristics and varied virulence of H7N9 from Wave 5.

Emerg Microbes Infect 2019 ;8(1):94-102

a Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical Collage (PUMC); Key Laboratory of Human Disease Comparative Medicine, Ministry of Health , Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious , Beijing , People's Republic of China.

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https://www.tandfonline.com/doi/full/10.1080/22221751.2018.1
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http://dx.doi.org/10.1080/22221751.2018.1560234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456849PMC
January 2019

On the Centenary of the Spanish Flu: Being Prepared for the Next Pandemic.

Virol Sin 2018 Dec 20;33(6):463-466. Epub 2018 Dec 20.

Chinese National Influenza Center (CNIC), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, 102206, China.

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http://dx.doi.org/10.1007/s12250-018-0079-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335225PMC
December 2018

Structures of Zika Virus E & NS1: Relations with Virus Infection and Host Immune Responses.

Adv Exp Med Biol 2018;1062:77-87

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1007/978-981-10-8727-1_6DOI Listing
November 2018

An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I.

J Immunol 2018 Nov 19;201(10):3084-3095. Epub 2018 Oct 19.

School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China;

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http://dx.doi.org/10.4049/jimmunol.1800611DOI Listing
November 2018

Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.

Cell Rep 2018 Oct;25(4):909-920.e4

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen 518112, China; Shanxi Academy of Advanced Research and Innovation, Taiyuan 030032, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183153
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http://dx.doi.org/10.1016/j.celrep.2018.09.073DOI Listing
October 2018

Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice.

J Vis Exp 2018 10 17(140). Epub 2018 Oct 17.

School of Laboratory Medicine and Life Sciences, Wenzhou Medical University; NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention;

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https://www.jove.com/video/58110/evaluation-zika-virus-speci
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http://dx.doi.org/10.3791/58110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235543PMC
October 2018

Bunyavirales ribonucleoproteins: the viral replication and transcription machinery.

Crit Rev Microbiol 2018 Sep 8;44(5):522-540. Epub 2018 Mar 8.

a CAS Key Laboratory of Pathogenic Microbiology and Immunology , Institute of Microbiology, Chinese Academy of Sciences , Beijing , China.

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http://dx.doi.org/10.1080/1040841X.2018.1446901DOI Listing
September 2018

CD8 T-Cell Response-Associated Evolution of Hepatitis B Virus Core Protein and Disease Progress.

J Virol 2018 09 16;92(17). Epub 2018 Aug 16.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China

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http://dx.doi.org/10.1128/JVI.02120-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096822PMC
September 2018

Genomic characterizations of H4 subtype avian influenza viruses from live poultry markets in Sichuan province of China, 2014-2015.

Sci China Life Sci 2018 Sep 9;61(9):1123-1126. Epub 2018 Jul 9.

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

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http://dx.doi.org/10.1007/s11427-018-9327-4DOI Listing
September 2018

Origin, Genetic Diversity, and Evolutionary Dynamics of Novel Porcine Circovirus 3.

Adv Sci (Weinh) 2018 Sep 4;5(9):1800275. Epub 2018 Jul 4.

MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety Jiangsu Engineering Laboratory of Animal Immunology Institute of Immunology College of Veterinary Medicine Nanjing Agricultural University Tongwei Road, Xuanwu District Nanjing 210095 China.

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http://dx.doi.org/10.1002/advs.201800275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145280PMC
September 2018

A new threat to human reproduction system posed by Zika virus (ZIKV): From clinical investigations to experimental studies.

Virus Res 2018 08 8;254:10-14. Epub 2017 Sep 8.

CAS Key Laboratory of Pathogenic Microbiology & Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; Chinese Center for Disease Control and Prevention (China CDC), Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.virusres.2017.09.005DOI Listing
August 2018

Serological Investigation of Laboratory-Confirmed and Suspected Ebola Virus Disease Patients During the Late Phase of the Ebola Outbreak in Sierra Leone.

Virol Sin 2018 Aug 31;33(4):323-334. Epub 2018 Jul 31.

Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health, National Institute for Viral Disease Control and Prevention (IVDC), Chinese Center for Disease Control and Prevention (China CDC), Beijing, 102206, China.

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http://dx.doi.org/10.1007/s12250-018-0044-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178096PMC
August 2018

Development of a quadruple qRT-PCR assay for simultaneous identification of highly and low pathogenic H7N9 avian influenza viruses and characterization against oseltamivir resistance.

BMC Infect Dis 2018 08 15;18(1):406. Epub 2018 Aug 15.

Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People's Hospital, Shenzhen, 518112, China.

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http://dx.doi.org/10.1186/s12879-018-3302-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094886PMC
August 2018

[Antibiotic resistome in farm animals and their related environments: a review].

Sheng Wu Gong Cheng Xue Bao 2018 Aug;34(8):1226-1233

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

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http://doi.cnki.net/Resolution/Handler?doi=10.13345/j.cjb.18
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http://dx.doi.org/10.13345/j.cjb.180163DOI Listing
August 2018

Novel cyclo-peptides inhibit Ebola pseudotyped virus entry by targeting primed GP protein.

Antiviral Res 2018 07 27;155:1-11. Epub 2018 Apr 27.

Department of Immunology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing 100050, China. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2018.04.020DOI Listing
July 2018

Glycan Binding Specificity and Mechanism of Human and Porcine P[6]/P[19] Rotavirus VP8*s.

J Virol 2018 07 29;92(14). Epub 2018 Jun 29.

Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing, China

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http://dx.doi.org/10.1128/JVI.00538-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026740PMC
July 2018

A case of Naegleria fowleri related primary amoebic meningoencephalitis in China diagnosed by next-generation sequencing.

BMC Infect Dis 2018 07 28;18(1):349. Epub 2018 Jul 28.

Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, 29 Bulan Rd, Shenzhen, 518112, China.

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http://dx.doi.org/10.1186/s12879-018-3261-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064090PMC
July 2018

Testing Experimental Therapies in a Guinea Pig Model for Hemorrhagic Fever.

Methods Mol Biol 2018 ;1604:269-278

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.

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http://dx.doi.org/10.1007/978-1-4939-6981-4_21DOI Listing
June 2018

New Threats from H7N9 Influenza Virus: Spread and Evolution of High- and Low-Pathogenicity Variants with High Genomic Diversity in Wave Five.

J Virol 2018 06 14;92(11). Epub 2018 May 14.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China

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http://dx.doi.org/10.1128/JVI.00301-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952148PMC
June 2018

Human Group C Rotavirus VP8*s Recognize Type A Histo-Blood Group Antigens as Ligands.

J Virol 2018 06 14;92(11). Epub 2018 May 14.

Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of the People's Republic of China, Beijing, China

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http://dx.doi.org/10.1128/JVI.00442-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952154PMC
June 2018

Bat-Origin Coronaviruses Expand Their Host Range to Pigs.

Trends Microbiol 2018 06 18;26(6):466-470. Epub 2018 Apr 18.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China; Shenzhen Key Laboratory of Pathogen and Immunity, Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen 518112, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China. Electronic address:

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http://dx.doi.org/10.1016/j.tim.2018.03.001DOI Listing
June 2018

Cellular-Beacon-Mediated Counting for the Ultrasensitive Detection of Ebola Virus on an Integrated Micromagnetic Platform.

Anal Chem 2018 06 7;90(12):7310-7317. Epub 2018 Jun 7.

Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences , Wuhan University , Wuhan 430072 , China.

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http://dx.doi.org/10.1021/acs.analchem.8b00513DOI Listing
June 2018

Proteomic Analysis of Zika Virus Infected Primary Human Fetal Neural Progenitors Suggests a Role for Doublecortin in the Pathological Consequences of Infection in the Cortex.

Front Microbiol 2018 5;9:1067. Epub 2018 Jun 5.

Joint Center of Translational Precision Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center, Guangzhou, China.

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http://dx.doi.org/10.3389/fmicb.2018.01067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996093PMC
June 2018

A Sulfonozanamivir Analogue Has Potent Anti-influenza Virus Activity.

ChemMedChem 2018 04 15;13(8):785-789. Epub 2018 Mar 15.

Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland, 4222, Australia.

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http://dx.doi.org/10.1002/cmdc.201800092DOI Listing
April 2018

Crystal Structure of the Capsid Protein from Zika Virus.

J Mol Biol 2018 03 15;430(7):948-962. Epub 2018 Feb 15.

Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen 518112, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2018.02.006DOI Listing
March 2018

Endogenous Cellular MicroRNAs Mediate Antiviral Defense against Influenza A Virus.

Mol Ther Nucleic Acids 2018 Mar 30;10:361-375. Epub 2017 Dec 30.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2017.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862538PMC
March 2018

From "A"IV to "Z"IKV: Attacks from Emerging and Re-emerging Pathogens.

Authors:
George F Gao

Cell 2018 03;172(6):1157-1159

Chinese Center for Disease Control and Prevention (China CDC), China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), China. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.02.025DOI Listing
March 2018

Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT.

Nat Commun 2018 03 22;9(1):1196. Epub 2018 Mar 22.

West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, 610041, China.

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http://www.nature.com/articles/s41467-018-03625-x
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http://dx.doi.org/10.1038/s41467-018-03625-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864733PMC
March 2018

From bench to almost bedside: the long road to a licensed Ebola virus vaccine.

Expert Opin Biol Ther 2018 02 17;18(2):159-173. Epub 2017 Nov 17.

c National Microbiology Laboratory , Public Health Agency of Canada , Winnipeg , MB , Canada.

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https://www.tandfonline.com/doi/full/10.1080/14712598.2018.1
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http://dx.doi.org/10.1080/14712598.2018.1404572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841470PMC
February 2018

Two reassortant types of highly pathogenic H5N8 avian influenza virus from wild birds in Central China in 2016.

Emerg Microbes Infect 2018 Feb 7;7(1):14. Epub 2018 Feb 7.

CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, Hubei, China.

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http://dx.doi.org/10.1038/s41426-017-0012-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837153PMC
February 2018

The Global Virome Project.

Science 2018 Feb;359(6378):872-874

The list of author affiliations is provided in the supplementary materials.

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February 2018

Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab.

Protein Cell 2018 01;9(1):135-139

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.

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http://dx.doi.org/10.1007/s13238-017-0412-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777972PMC
January 2018

China in action: national strategies to combat against emerging infectious diseases.

Sci China Life Sci 2017 12 7;60(12):1383-1385. Epub 2017 Sep 7.

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

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http://dx.doi.org/10.1007/s11427-017-9141-3DOI Listing
December 2017

CTL immunogenicity of Rv3615c antigen and diagnostic performances of an ESAT-6/CFP-10/Rv3615c antigen cocktail for Mycobacterium tuberculosis infection.

Tuberculosis (Edinb) 2017 12 2;107:5-12. Epub 2017 Aug 2.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, 102206, China. Electronic address:

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http://dx.doi.org/10.1016/j.tube.2017.07.011DOI Listing
December 2017

Both structure and function of human monoclonal antibodies contribute to enhancement of Zika virus infectivity in vitro.

Sci China Life Sci 2017 12 10;60(12):1396-1398. Epub 2017 Nov 10.

CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai, 200031, China.

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http://dx.doi.org/10.1007/s11427-017-9192-0DOI Listing
December 2017

Conserved peptides enhance immune efficiency of inactive vaccines against emerging avian influenza viruses in chicken.

Sci China Life Sci 2017 12 8;60(12):1340-1347. Epub 2017 Sep 8.

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 100052, China.

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http://dx.doi.org/10.1007/s11427-017-9153-2DOI Listing
December 2017

Pathogen genomic surveillance elucidates the origins, transmission and evolution of emerging viral agents in China.

Sci China Life Sci 2017 12 28;60(12):1317-1330. Epub 2017 Nov 28.

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, 102206, China.

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December 2017

Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus.

Sci China Life Sci 2017 12 29;60(12):1403-1406. Epub 2017 Nov 29.

Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China.

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December 2017

Human T-cell immunity against the emerging and re-emerging viruses.

Sci China Life Sci 2017 12 29;60(12):1307-1316. Epub 2017 Nov 29.

Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of People's Republic of China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

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http://dx.doi.org/10.1007/s11427-017-9241-3DOI Listing
December 2017

CASCIRE surveillance network and work on avian influenza viruses.

Sci China Life Sci 2017 12 1;60(12):1386-1391. Epub 2017 Dec 1.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing, 100101, China.

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http://dx.doi.org/10.1007/s11427-017-9251-2DOI Listing
December 2017

The persistent prevalence and evolution of cross-family recombinant coronavirus GCCDC1 among a bat population: a two-year follow-up.

Sci China Life Sci 2017 12 1;60(12):1357-1363. Epub 2017 Dec 1.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.

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http://dx.doi.org/10.1007/s11427-017-9263-6DOI Listing
December 2017

Infectious disease trends in China since the SARS outbreak.

Lancet Infect Dis 2017 11;17(11):1113-1115

Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(17)30579-0DOI Listing
November 2017

Hemagglutinin-specific CD4 T-cell responses following 2009-pH1N1 inactivated split-vaccine inoculation in humans.

Vaccine 2017 10 13;35(42):5644-5652. Epub 2017 Sep 13.

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen, China. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2017.08.061DOI Listing
October 2017

Structures of human-infecting fusogens support a common ancestor with insect baculovirus.

Proc Natl Acad Sci U S A 2017 10 4;114(42):E8905-E8912. Epub 2017 Oct 4.

Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1706125114
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651748PMC
October 2017

An mRNA-based vaccine strategy against Zika.

Cell Res 2017 09 11;27(9):1077-1078. Epub 2017 Apr 11.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

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http://www.nature.com/doifinder/10.1038/cr.2017.53
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September 2017

Conserved Vδ1 Binding Geometry in a Setting of Locus-Disparate pHLA Recognition by δ/αβ T Cell Receptors (TCRs): Insight into Recognition of HIV Peptides by TCRs.

J Virol 2017 Sep 10;91(17). Epub 2017 Aug 10.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

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http://dx.doi.org/10.1128/JVI.00725-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553175PMC
September 2017

Crystal Structure of the Marburg Virus Nucleoprotein Core Domain Chaperoned by a VP35 Peptide Reveals a Conserved Drug Target for Filovirus.

J Virol 2017 09 24;91(18). Epub 2017 Aug 24.

Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China

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http://jvi.asm.org/lookup/doi/10.1128/JVI.00996-17
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571254PMC
September 2017

Epidemiology, Evolution, and Pathogenesis of H7N9 Influenza Viruses in Five Epidemic Waves since 2013 in China.

Trends Microbiol 2017 09 19;25(9):713-728. Epub 2017 Jul 19.

Animal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, China; Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou, Jiangsu, 225009, China; Jiangsu Research Centre of Engineering and Technology for Prevention and Control of Poultry Disease, Yangzhou, Jiangsu, 225009, China. Electronic address:

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http://dx.doi.org/10.1016/j.tim.2017.06.008DOI Listing
September 2017

Clinical Evaluation of Ebola Virus Disease Therapeutics.

Trends Mol Med 2017 09 17;23(9):820-830. Epub 2017 Aug 17.

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2017.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743218PMC
September 2017

Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope.

Proc Natl Acad Sci U S A 2017 09 21;114(36):E7564-E7573. Epub 2017 Aug 21.

Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;

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http://dx.doi.org/10.1073/pnas.1705176114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594662PMC
September 2017

Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity.

Front Pharmacol 2017 19;8:653. Epub 2017 Sep 19.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of SciencesBeijing, China.

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http://dx.doi.org/10.3389/fphar.2017.00653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610691PMC
September 2017

Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies.

Oncotarget 2017 Sep 19;8(40):67129-67139. Epub 2017 May 19.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.18632/oncotarget.18004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620161PMC
September 2017

Preliminary Epidemiologic Assessment of Human Infections With Highly Pathogenic Avian Influenza A(H5N6) Virus, China.

Clin Infect Dis 2017 Aug;65(3):383-388

WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China.

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http://dx.doi.org/10.1093/cid/cix334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848334PMC
August 2017

Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4.

Cell Rep 2017 08;20(5):1201-1214

Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China; Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China; School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 101408, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.07.028DOI Listing
August 2017

Structure of the S1 subunit C-terminal domain from bat-derived coronavirus HKU5 spike protein.

Virology 2017 07 19;507:101-109. Epub 2017 Apr 19.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen 518112, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310003, China; Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2017.04.016DOI Listing
July 2017

Can China achieve a one-third reduction in premature mortality from non-communicable diseases by 2030?

BMC Med 2017 07 11;15(1):132. Epub 2017 Jul 11.

National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Nanwei Road 27, Xicheng District, Beijing, China.

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http://bmcmedicine.biomedcentral.com/articles/10.1186/s12916
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504650PMC
July 2017

The antibiotic resistome: gene flow in environments, animals and human beings.

Front Med 2017 Jun 13;11(2):161-168. Epub 2017 May 13.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.

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http://dx.doi.org/10.1007/s11684-017-0531-xDOI Listing
June 2017

Development of a reverse transcription quantitative polymerase chain reaction-based assay for broad coverage detection of African and Asian Zika virus lineages.

Virol Sin 2017 Jun 19;32(3):199-206. Epub 2017 May 19.

Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, 518112, China.

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http://dx.doi.org/10.1007/s12250-017-3958-yDOI Listing
June 2017

Structural basis of nectin-1 recognition by pseudorabies virus glycoprotein D.

PLoS Pathog 2017 May 19;13(5):e1006314. Epub 2017 May 19.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1371/journal.ppat.1006314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453625PMC
May 2017

Virus genomes reveal factors that spread and sustained the Ebola epidemic.

Nature 2017 04 12;544(7650):309-315. Epub 2017 Apr 12.

Institute of Evolutionary Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3FL, UK.

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http://dx.doi.org/10.1038/nature22040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712493PMC
April 2017

A47 Origin and possible genetic recombination of the middle east respiratory syndrome coronavirus from the first imported case in china: phylogenetics and coalescence analysis.

Virus Evol 2017 Mar 5;3(Suppl 1). Epub 2017 Mar 5.

Key Laboratory of Medical Virology Ministry of Health, National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention, Beijing, China.

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http://dx.doi.org/10.1093/ve/vew036.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566081PMC
March 2017

Seeing is believing: anti-PD-1/PD-L1 monoclonal antibodies in action for checkpoint blockade tumor immunotherapy.

Signal Transduct Target Ther 2016 25;1:16029. Epub 2016 Nov 25.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

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http://www.nature.com/articles/sigtrans201629
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November 2016