Publications by authors named "George Davey-Smith"

99Publications

Relationship between smoking and ALS: Mendelian randomisation interrogation of causality.

J Neurol Neurosurg Psychiatry 2020 Aug 26. Epub 2020 Aug 26.

Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London, UK

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http://dx.doi.org/10.1136/jnnp-2020-323316DOI Listing
August 2020

Evaluating shared genetic influences on nonsyndromic cleft lip/palate and oropharyngeal neoplasms.

Genet Epidemiol 2020 Jul 24. Epub 2020 Jul 24.

Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1002/gepi.22343DOI Listing
July 2020

Investigating attention-deficit hyperactivity disorder and autism spectrum disorder traits in the general population: What happens in adult life?

J Child Psychol Psychiatry 2020 Jul 14. Epub 2020 Jul 14.

Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1111/jcpp.13297DOI Listing
July 2020

A Mendelian randomization study of the causal association between anxiety phenotypes and schizophrenia.

Am J Med Genet B Neuropsychiatr Genet 2020 Sep 24;183(6):360-369. Epub 2020 Jun 24.

Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1002/ajmg.b.32808DOI Listing
September 2020

Shielding from covid-19 should be stratified by risk.

BMJ 2020 05 28;369:m2063. Epub 2020 May 28.

Winton Centre for Risk and Evidence Communication, Centre for Mathematical Sciences, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1136/bmj.m2063DOI Listing
May 2020

Assessment of a causal relationship between body mass index and atopic dermatitis.

J Allergy Clin Immunol 2020 May 17. Epub 2020 May 17.

Skin Research Group, School of Medicine, University of Dundee, Dundee, United Kingdom; Department of Dermatology, Ninewells Hospital and Medical School, Dundee, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2020.04.050DOI Listing
May 2020

Population phenomena inflate genetic associations of complex social traits.

Sci Adv 2020 Apr 15;6(16):eaay0328. Epub 2020 Apr 15.

Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.

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http://dx.doi.org/10.1126/sciadv.aay0328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159920PMC
April 2020

A cross-disorder PRS-pheWAS of 5 major psychiatric disorders in UK Biobank.

PLoS Genet 2020 05 11;16(5):e1008185. Epub 2020 May 11.

MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1008185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274459PMC
May 2020

Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study.

BMJ 2020 May 6;369:m1203. Epub 2020 May 6.

MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.1136/bmj.m1203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201936PMC
May 2020

Mendelian randomization applied to pharmaceutical use: the case of metformin and lung cancer.

Int J Epidemiol 2020 May 1. Epub 2020 May 1.

MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1093/ije/dyaa059DOI Listing
May 2020

Early Metabolic Features of Genetic Liability to Type 2 Diabetes: Cohort Study With Repeated Metabolomics Across Early Life.

Diabetes Care 2020 Jul 28;43(7):1537-1545. Epub 2020 Apr 28.

Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, U.K.

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http://dx.doi.org/10.2337/dc19-2348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305012PMC
July 2020

Reply to: "Methodological issues regarding: "A third of nonfasting plasma cholesterol is in remnant lipoproteins: Lipoprotein subclass profiling in 9293 individuals".

Atherosclerosis 2020 06 9;302:57-58. Epub 2020 Apr 9.

Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark; The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2020.03.027DOI Listing
June 2020

UK case control study of smoking and risk of amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2020 05 17;21(3-4):222-227. Epub 2020 Apr 17.

School of Psychological Science, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1080/21678421.2019.1706580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261396PMC
May 2020

UK case control study of smoking and risk of amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2020 05 17;21(3-4):222-227. Epub 2020 Apr 17.

School of Psychological Science, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1080/21678421.2019.1706580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261396PMC
May 2020

ADHD and depression: investigating a causal explanation.

Psychol Med 2020 Apr 6:1-8. Epub 2020 Apr 6.

Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1017/S0033291720000665DOI Listing
April 2020

Correlation without a cause: an epidemiological odyssey.

Int J Epidemiol 2020 02;49(1):4-14

Institute for Global Health, University College London, London, UK.

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http://dx.doi.org/10.1093/ije/dyaa016DOI Listing
February 2020

Genetic liability to schizophrenia is associated with exposure to traumatic events in childhood.

Psychol Med 2020 Apr 1:1-8. Epub 2020 Apr 1.

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1017/S0033291720000537DOI Listing
April 2020

Common variation at 16p11.2 is associated with glycosuria in pregnancy: findings from a genome-wide association study in European women.

Hum Mol Genet 2020 Jul;29(12):2098-2106

Medical Research Council Integrative Epidemiology Unit, Avon Longitudinal Study of Parents and Children, Population Health Science, Bristol Medical School, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.

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http://dx.doi.org/10.1093/hmg/ddaa054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390941PMC
July 2020

Mendel's laws, Mendelian randomization and causal inference in observational data: substantive and nomenclatural issues.

Eur J Epidemiol 2020 Feb 23;35(2):99-111. Epub 2020 Mar 23.

London School of Hygiene and Tropical Medicine, London, UK.

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http://dx.doi.org/10.1007/s10654-020-00622-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125255PMC
February 2020

The Effect of Plasma Lipids and Lipid-Lowering Interventions on Bone Mineral Density: A Mendelian Randomization Study.

J Bone Miner Res 2020 Jul 12;35(7):1224-1235. Epub 2020 Mar 12.

Medical Research Council (MRC) Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1002/jbmr.3989DOI Listing
July 2020

Can education be personalised using pupils' genetic data?

Elife 2020 Mar 10;9. Epub 2020 Mar 10.

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.7554/eLife.49962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064332PMC
March 2020

Smoking, DNA Methylation, and Lung Function: a Mendelian Randomization Analysis to Investigate Causal Pathways.

Am J Hum Genet 2020 03 20;106(3):315-326. Epub 2020 Feb 20.

Medical Research Council Integrative Epidemiology Unit at the University of Bristol, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2020.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058834PMC
March 2020

Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework.

Nat Commun 2020 02 21;11(1):1010. Epub 2020 Feb 21.

MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.1038/s41467-020-14452-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035387PMC
February 2020

Plasma lipids and risk of aortic valve stenosis: a Mendelian randomization study.

Eur Heart J 2020 Feb 20. Epub 2020 Feb 20.

The George Institute for Global Health, University of Oxford, 1st Floor, Hayes House, 75 George Street, Oxford OX1 2BQ, UK.

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http://dx.doi.org/10.1093/eurheartj/ehaa070DOI Listing
February 2020

Mendelian Randomization analysis of the causal effect of adiposity on hospital costs.

J Health Econ 2020 Mar 25;70:102300. Epub 2020 Jan 25.

Population Health Sciences, University of Bristol, United Kingdom; MRC Integrative Epidemiology Unit, University of Bristol, United Kingdom; NIHR Biomedical Research Centre, University of Bristol, United Kingdom.

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http://dx.doi.org/10.1016/j.jhealeco.2020.102300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188219PMC
March 2020

Education, intelligence and Alzheimer's disease: evidence from a multivariable two-sample Mendelian randomization study.

Int J Epidemiol 2020 Jan 31. Epub 2020 Jan 31.

Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1093/ije/dyz280DOI Listing
January 2020

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome.

Nat Commun 2020 01 10;11(1):185. Epub 2020 Jan 10.

MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.1038/s41467-019-13921-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954187PMC
January 2020

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.

Sci Adv 2019 09 4;5(9):eaaw3095. Epub 2019 Sep 4.

Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.

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http://dx.doi.org/10.1126/sciadv.aaw3095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904961PMC
September 2019

Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health.

Int J Epidemiol 2019 Dec 13. Epub 2019 Dec 13.

Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1093/ije/dyz250DOI Listing
December 2019

Using Genetics to Examine a General Liability to Childhood Psychopathology.

Behav Genet 2020 07 11;50(4):213-220. Epub 2019 Dec 11.

Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Hadyn Ellis Building, Maindy Road, Cathays, Cardiff, CF24 4HQ, UK.

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http://dx.doi.org/10.1007/s10519-019-09985-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355267PMC
July 2020

Use of Mendelian Randomization to Examine Causal Inference in Osteoporosis.

Front Endocrinol (Lausanne) 2019 21;10:807. Epub 2019 Nov 21.

MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.3389/fendo.2019.00807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882110PMC
November 2019

Associations of parental age with offspring all-cause and cause-specific adult mortality.

Sci Rep 2019 11 19;9(1):17097. Epub 2019 Nov 19.

MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1038/s41598-019-52853-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864242PMC
November 2019

Genetic evidence for assortative mating on alcohol consumption in the UK Biobank.

Nat Commun 2019 11 19;10(1):5039. Epub 2019 Nov 19.

Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1038/s41467-019-12424-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864067PMC
November 2019

Using the MR-Base platform to investigate risk factors and drug targets for thousands of phenotypes.

Wellcome Open Res 2019 7;4:113. Epub 2019 Nov 7.

Medical Research Council Integrative, Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.12688/wellcomeopenres.15334.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694718PMC
November 2019

On the Use of the Lasso for Instrumental Variables Estimation with Some Invalid Instruments.

J Am Stat Assoc 2019 13;114(527):1339-1350. Epub 2018 Nov 13.

MRC Integrative Epidemiology Unit, Bristol, United Kingdom.

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http://dx.doi.org/10.1080/01621459.2018.1498346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817329PMC
November 2018

Associations of autozygosity with a broad range of human phenotypes.

Authors:
David W Clark Yukinori Okada Kristjan H S Moore Dan Mason Nicola Pirastu Ilaria Gandin Hannele Mattsson Catriona L K Barnes Kuang Lin Jing Hua Zhao Patrick Deelen Rebecca Rohde Claudia Schurmann Xiuqing Guo Franco Giulianini Weihua Zhang Carolina Medina-Gomez Robert Karlsson Yanchun Bao Traci M Bartz Clemens Baumbach Ginevra Biino Matthew J Bixley Marco Brumat Jin-Fang Chai Tanguy Corre Diana L Cousminer Annelot M Dekker David A Eccles Kristel R van Eijk Christian Fuchsberger He Gao Marine Germain Scott D Gordon Hugoline G de Haan Sarah E Harris Edith Hofer Alicia Huerta-Chagoya Catherine Igartua Iris E Jansen Yucheng Jia Tim Kacprowski Torgny Karlsson Marcus E Kleber Shengchao Alfred Li Ruifang Li-Gao Anubha Mahajan Koichi Matsuda Karina Meidtner Weihua Meng May E Montasser Peter J van der Most Matthias Munz Teresa Nutile Teemu Palviainen Gauri Prasad Rashmi B Prasad Tallapragada Divya Sri Priyanka Federica Rizzi Erika Salvi Bishwa R Sapkota Daniel Shriner Line Skotte Melissa C Smart Albert Vernon Smith Ashley van der Spek Cassandra N Spracklen Rona J Strawbridge Salman M Tajuddin Stella Trompet Constance Turman Niek Verweij Clara Viberti Lihua Wang Helen R Warren Robyn E Wootton Lisa R Yanek Jie Yao Noha A Yousri Wei Zhao Adebowale A Adeyemo Saima Afaq Carlos Alberto Aguilar-Salinas Masato Akiyama Matthew L Albert Matthew A Allison Maris Alver Tin Aung Fereidoun Azizi Amy R Bentley Heiner Boeing Eric Boerwinkle Judith B Borja Gert J de Borst Erwin P Bottinger Linda Broer Harry Campbell Stephen Chanock Miao-Li Chee Guanjie Chen Yii-Der I Chen Zhengming Chen Yen-Feng Chiu Massimiliano Cocca Francis S Collins Maria Pina Concas Janie Corley Giovanni Cugliari Rob M van Dam Anna Damulina Maryam S Daneshpour Felix R Day Graciela E Delgado Klodian Dhana Alexander S F Doney Marcus Dörr Ayo P Doumatey Nduna Dzimiri S Sunna Ebenesersdóttir Joshua Elliott Paul Elliott Ralf Ewert Janine F Felix Krista Fischer Barry I Freedman Giorgia Girotto Anuj Goel Martin Gögele Mark O Goodarzi Mariaelisa Graff Einat Granot-Hershkovitz Francine Grodstein Simonetta Guarrera Daniel F Gudbjartsson Kamran Guity Bjarni Gunnarsson Yu Guo Saskia P Hagenaars Christopher A Haiman Avner Halevy Tamara B Harris Mehdi Hedayati David A van Heel Makoto Hirata Imo Höfer Chao Agnes Hsiung Jinyan Huang Yi-Jen Hung M Arfan Ikram Anuradha Jagadeesan Pekka Jousilahti Yoichiro Kamatani Masahiro Kanai Nicola D Kerrison Thorsten Kessler Kay-Tee Khaw Chiea Chuen Khor Dominique P V de Kleijn Woon-Puay Koh Ivana Kolcic Peter Kraft Bernhard K Krämer Zoltán Kutalik Johanna Kuusisto Claudia Langenberg Lenore J Launer Deborah A Lawlor I-Te Lee Wen-Jane Lee Markus M Lerch Liming Li Jianjun Liu Marie Loh Stephanie J London Stephanie Loomis Yingchang Lu Jian'an Luan Reedik Mägi Ani W Manichaikul Paolo Manunta Gísli Másson Nana Matoba Xue W Mei Christa Meisinger Thomas Meitinger Massimo Mezzavilla Lili Milani Iona Y Millwood Yukihide Momozawa Amy Moore Pierre-Emmanuel Morange Hortensia Moreno-Macías Trevor A Mori Alanna C Morrison Taulant Muka Yoshinori Murakami Alison D Murray Renée de Mutsert Josyf C Mychaleckyj Mike A Nalls Matthias Nauck Matt J Neville Ilja M Nolte Ken K Ong Lorena Orozco Sandosh Padmanabhan Gunnar Pálsson James S Pankow Cristian Pattaro Alison Pattie Ozren Polasek Neil Poulter Peter P Pramstaller Lluis Quintana-Murci Katri Räikkönen Sarju Ralhan Dabeeru C Rao Wouter van Rheenen Stephen S Rich Paul M Ridker Cornelius A Rietveld Antonietta Robino Frank J A van Rooij Daniela Ruggiero Yasaman Saba Charumathi Sabanayagam Maria Sabater-Lleal Cinzia Felicita Sala Veikko Salomaa Kevin Sandow Helena Schmidt Laura J Scott William R Scott Bahareh Sedaghati-Khayat Bengt Sennblad Jessica van Setten Peter J Sever Wayne H-H Sheu Yuan Shi Smeeta Shrestha Sharvari Rahul Shukla Jon K Sigurdsson Timo Tonis Sikka Jai Rup Singh Blair H Smith Alena Stančáková Alice Stanton John M Starr Lilja Stefansdottir Leon Straker Patrick Sulem Gardar Sveinbjornsson Morris A Swertz Adele M Taylor Kent D Taylor Natalie Terzikhan Yih-Chung Tham Gudmar Thorleifsson Unnur Thorsteinsdottir Annika Tillander Russell P Tracy Teresa Tusié-Luna Ioanna Tzoulaki Simona Vaccargiu Jagadish Vangipurapu Jan H Veldink Veronique Vitart Uwe Völker Eero Vuoksimaa Salma M Wakil Melanie Waldenberger Gurpreet S Wander Ya Xing Wang Nicholas J Wareham Sarah Wild Chittaranjan S Yajnik Jian-Min Yuan Lingyao Zeng Liang Zhang Jie Zhou Najaf Amin Folkert W Asselbergs Stephan J L Bakker Diane M Becker Benjamin Lehne David A Bennett Leonard H van den Berg Sonja I Berndt Dwaipayan Bharadwaj Lawrence F Bielak Murielle Bochud Mike Boehnke Claude Bouchard Jonathan P Bradfield Jennifer A Brody Archie Campbell Shai Carmi Mark J Caulfield David Cesarini John C Chambers Giriraj Ratan Chandak Ching-Yu Cheng Marina Ciullo Marilyn Cornelis Daniele Cusi George Davey Smith Ian J Deary Rajkumar Dorajoo Cornelia M van Duijn David Ellinghaus Jeanette Erdmann Johan G Eriksson Evangelos Evangelou Michele K Evans Jessica D Faul Bjarke Feenstra Mary Feitosa Sylvain Foisy Andre Franke Yechiel Friedlander Paolo Gasparini Christian Gieger Clicerio Gonzalez Philippe Goyette Struan F A Grant Lyn R Griffiths Leif Groop Vilmundur Gudnason Ulf Gyllensten Hakon Hakonarson Anders Hamsten Pim van der Harst Chew-Kiat Heng Andrew A Hicks Hagit Hochner Heikki Huikuri Steven C Hunt Vincent W V Jaddoe Philip L De Jager Magnus Johannesson Åsa Johansson Jost B Jonas J Wouter Jukema Juhani Junttila Jaakko Kaprio Sharon L R Kardia Fredrik Karpe Meena Kumari Markku Laakso Sander W van der Laan Jari Lahti Matthias Laudes Rodney A Lea Wolfgang Lieb Thomas Lumley Nicholas G Martin Winfried März Giuseppe Matullo Mark I McCarthy Sarah E Medland Tony R Merriman Andres Metspalu Brian F Meyer Karen L Mohlke Grant W Montgomery Dennis Mook-Kanamori Patricia B Munroe Kari E North Dale R Nyholt Jeffery R O'connell Carole Ober Albertine J Oldehinkel Walter Palmas Colin Palmer Gerard G Pasterkamp Etienne Patin Craig E Pennell Louis Perusse Patricia A Peyser Mario Pirastu Tinca J C Polderman David J Porteous Danielle Posthuma Bruce M Psaty John D Rioux Fernando Rivadeneira Charles Rotimi Jerome I Rotter Igor Rudan Hester M Den Ruijter Dharambir K Sanghera Naveed Sattar Reinhold Schmidt Matthias B Schulze Heribert Schunkert Robert A Scott Alan R Shuldiner Xueling Sim Neil Small Jennifer A Smith Nona Sotoodehnia E-Shyong Tai Alexander Teumer Nicholas J Timpson Daniela Toniolo David-Alexandre Tregouet Tiinamaija Tuomi Peter Vollenweider Carol A Wang David R Weir John B Whitfield Cisca Wijmenga Tien-Yin Wong John Wright Jingyun Yang Lei Yu Babette S Zemel Alan B Zonderman Markus Perola Patrik K E Magnusson André G Uitterlinden Jaspal S Kooner Daniel I Chasman Ruth J F Loos Nora Franceschini Lude Franke Chris S Haley Caroline Hayward Robin G Walters John R B Perry Tōnu Esko Agnar Helgason Kari Stefansson Peter K Joshi Michiaki Kubo James F Wilson

Nat Commun 2019 10 31;10(1):4957. Epub 2019 Oct 31.

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.

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http://dx.doi.org/10.1038/s41467-019-12283-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823371PMC
October 2019

MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging.

PLoS Genet 2019 10 31;15(10):e1008353. Epub 2019 Oct 31.

MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1008353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822717PMC
October 2019

Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780,000 participants.

Mol Psychiatry 2019 Oct 25. Epub 2019 Oct 25.

Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41380-019-0535-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182503PMC
October 2019

Within family Mendelian randomization studies.

Hum Mol Genet 2019 11;28(R2):R170-R179

Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, United Kingdom.

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http://dx.doi.org/10.1093/hmg/ddz204DOI Listing
November 2019

Genetic architecture of subcortical brain structures in 38,851 individuals.

Authors:
Claudia L Satizabal Hieab H H Adams Derrek P Hibar Charles C White Maria J Knol Jason L Stein Markus Scholz Muralidharan Sargurupremraj Neda Jahanshad Gennady V Roshchupkin Albert V Smith Joshua C Bis Xueqiu Jian Michelle Luciano Edith Hofer Alexander Teumer Sven J van der Lee Jingyun Yang Lisa R Yanek Tom V Lee Shuo Li Yanhui Hu Jia Yu Koh John D Eicher Sylvane Desrivières Alejandro Arias-Vasquez Ganesh Chauhan Lavinia Athanasiu Miguel E Rentería Sungeun Kim David Hoehn Nicola J Armstrong Qiang Chen Avram J Holmes Anouk den Braber Iwona Kloszewska Micael Andersson Thomas Espeseth Oliver Grimm Lucija Abramovic Saud Alhusaini Yuri Milaneschi Martina Papmeyer Tomas Axelsson Stefan Ehrlich Roberto Roiz-Santiañez Bernd Kraemer Asta K Håberg Hannah J Jones G Bruce Pike Dan J Stein Allison Stevens Janita Bralten Meike W Vernooij Tamara B Harris Irina Filippi A Veronica Witte Tulio Guadalupe Katharina Wittfeld Thomas H Mosley James T Becker Nhat Trung Doan Saskia P Hagenaars Yasaman Saba Gabriel Cuellar-Partida Najaf Amin Saima Hilal Kwangsik Nho Nazanin Mirza-Schreiber Konstantinos Arfanakis Diane M Becker David Ames Aaron L Goldman Phil H Lee Dorret I Boomsma Simon Lovestone Sudheer Giddaluru Stephanie Le Hellard Manuel Mattheisen Marc M Bohlken Dalia Kasperaviciute Lianne Schmaal Stephen M Lawrie Ingrid Agartz Esther Walton Diana Tordesillas-Gutierrez Gareth E Davies Jean Shin Jonathan C Ipser Louis N Vinke Martine Hoogman Tianye Jia Ralph Burkhardt Marieke Klein Fabrice Crivello Deborah Janowitz Owen Carmichael Unn K Haukvik Benjamin S Aribisala Helena Schmidt Lachlan T Strike Ching-Yu Cheng Shannon L Risacher Benno Pütz Debra A Fleischman Amelia A Assareh Venkata S Mattay Randy L Buckner Patrizia Mecocci Anders M Dale Sven Cichon Marco P Boks Mar Matarin Brenda W J H Penninx Vince D Calhoun M Mallar Chakravarty Andre F Marquand Christine Macare Shahrzad Kharabian Masouleh Jaap Oosterlaan Philippe Amouyel Katrin Hegenscheid Jerome I Rotter Andrew J Schork David C M Liewald Greig I de Zubicaray Tien Yin Wong Li Shen Philipp G Sämann Henry Brodaty Joshua L Roffman Eco J C de Geus Magda Tsolaki Susanne Erk Kristel R van Eijk Gianpiero L Cavalleri Nic J A van der Wee Andrew M McIntosh Randy L Gollub Kazima B Bulayeva Manon Bernard Jennifer S Richards Jayandra J Himali Markus Loeffler Nanda Rommelse Wolfgang Hoffmann Lars T Westlye Maria C Valdés Hernández Narelle K Hansell Theo G M van Erp Christiane Wolf John B J Kwok Bruno Vellas Andreas Heinz Loes M Olde Loohuis Norman Delanty Beng-Choon Ho Christopher R K Ching Elena Shumskaya Baljeet Singh Albert Hofman Dennis van der Meer Georg Homuth Bruce M Psaty Mark E Bastin Grant W Montgomery Tatiana M Foroud Simone Reppermund Jouke-Jan Hottenga Andrew Simmons Andreas Meyer-Lindenberg Wiepke Cahn Christopher D Whelan Marjolein M J van Donkelaar Qiong Yang Norbert Hosten Robert C Green Anbupalam Thalamuthu Sebastian Mohnke Hilleke E Hulshoff Pol Honghuang Lin Clifford R Jack Peter R Schofield Thomas W Mühleisen Pauline Maillard Steven G Potkin Wei Wen Evan Fletcher Arthur W Toga Oliver Gruber Matthew Huentelman George Davey Smith Lenore J Launer Lars Nyberg Erik G Jönsson Benedicto Crespo-Facorro Nastassja Koen Douglas N Greve André G Uitterlinden Daniel R Weinberger Vidar M Steen Iryna O Fedko Nynke A Groenewold Wiro J Niessen Roberto Toro Christophe Tzourio William T Longstreth M Kamran Ikram Jordan W Smoller Marie-Jose van Tol Jessika E Sussmann Tomas Paus Hervé Lemaître Matthias L Schroeter Bernard Mazoyer Ole A Andreassen Florian Holsboer Chantal Depondt Dick J Veltman Jessica A Turner Zdenka Pausova Gunter Schumann Daan van Rooij Srdjan Djurovic Ian J Deary Katie L McMahon Bertram Müller-Myhsok Rachel M Brouwer Hilkka Soininen Massimo Pandolfo Thomas H Wassink Joshua W Cheung Thomas Wolfers Jean-Luc Martinot Marcel P Zwiers Matthias Nauck Ingrid Melle Nicholas G Martin Ryota Kanai Eric Westman René S Kahn Sanjay M Sisodiya Tonya White Arvin Saremi Hans van Bokhoven Han G Brunner Henry Völzke Margaret J Wright Dennis van 't Ent Markus M Nöthen Roel A Ophoff Jan K Buitelaar Guillén Fernández Perminder S Sachdev Marcella Rietschel Neeltje E M van Haren Simon E Fisher Alexa S Beiser Clyde Francks Andrew J Saykin Karen A Mather Nina Romanczuk-Seiferth Catharina A Hartman Anita L DeStefano Dirk J Heslenfeld Michael W Weiner Henrik Walter Pieter J Hoekstra Paul A Nyquist Barbara Franke David A Bennett Hans J Grabe Andrew D Johnson Christopher Chen Cornelia M van Duijn Oscar L Lopez Myriam Fornage Joanna M Wardlaw Reinhold Schmidt Charles DeCarli Philip L De Jager Arno Villringer Stéphanie Debette Vilmundur Gudnason Sarah E Medland Joshua M Shulman Paul M Thompson Sudha Seshadri M Arfan Ikram

Nat Genet 2019 11 21;51(11):1624-1636. Epub 2019 Oct 21.

Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1038/s41588-019-0511-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055269PMC
November 2019

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study.

Authors:
Tao Huang Tiange Wang Yan Zheng Christina Ellervik Xiang Li Meng Gao Zhe Fang Jin-Fang Chai Tarun Veer S Ahluwalia Yujie Wang Trudy Voortman Raymond Noordam Alexis Frazier-Wood Markus Scholz Emily Sonestedt Masato Akiyama Rajkumar Dorajoo Ang Zhou Tuomas O Kilpeläinen Marcus E Kleber Sarah R Crozier Keith M Godfrey Rozenn Lemaitre Janine F Felix Yuan Shi Preeti Gupta Chiea-Chuen Khor Terho Lehtimäki Carol A Wang Carla M T Tiesler Elisabeth Thiering Marie Standl Peter Rzehak Eirini Marouli Meian He Cécile Lecoeur Dolores Corella Chao-Qiang Lai Luis A Moreno Niina Pitkänen Colin A Boreham Tao Zhang Seang Mei Saw Paul M Ridker Mariaelisa Graff Frank J A van Rooij Andre G Uitterlinden Albert Hofman Diana van Heemst Frits R Rosendaal Renée de Mutsert Ralph Burkhardt Christina-Alexandra Schulz Ulrika Ericson Yoichiro Kamatani Jian-Min Yuan Chris Power Torben Hansen Thorkild I A Sørensen Anne Tjønneland Kim Overvad Graciela Delgado Cyrus Cooper Luc Djousse Fernando Rivadeneira Karen Jameson Wanting Zhao Jianjun Liu Nanette R Lee Olli Raitakari Mika Kähönen Jorma Viikari Veit Grote Jean-Paul Langhendries Berthold Koletzko Joaquin Escribano Elvira Verduci George Dedoussis Caizheng Yu Yih Chung Tham Blanche Lim Sing Hui Lim Philippe Froguel Beverley Balkau Nadia R Fink Rebecca K Vinding Astrid Sevelsted Hans Bisgaard Oscar Coltell Jean Dallongeville Frédéric Gottrand Katja Pahkala Harri Niinikoski Elina Hyppönen Oluf Pedersen Winfried März Hazel Inskip Vincent W V Jaddoe Elaine Dennison Tien Yin Wong Charumathi Sabanayagam E-Shyong Tai Karen L Mohlke David A Mackey Dariusz Gruszfeld Panagiotis Deloukas Katherine L Tucker Frédéric Fumeron Klaus Bønnelykke Peter Rossing Ramon Estruch Jose M Ordovas Donna K Arnett Aline Meirhaeghe Philippe Amouyel Ching-Yu Cheng Xueling Sim Yik Ying Teo Rob M van Dam Woon-Puay Koh Marju Orho-Melander Markus Loeffler Michiaki Kubo Joachim Thiery Dennis O Mook-Kanamori Dariush Mozaffarian Bruce M Psaty Oscar H Franco Tangchun Wu Kari E North George Davey Smith Jorge E Chavarro Daniel I Chasman Lu Qi

JAMA Netw Open 2019 09 4;2(9):e1910915. Epub 2019 Sep 4.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamanetworkopen.2019.10915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755534PMC
September 2019

Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health.

Elife 2019 09 17;8. Epub 2019 Sep 17.

Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.7554/eLife.43990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748790PMC
September 2019

A Rare Mutation in SMAD9 Associated With High Bone Mass Identifies the SMAD-Dependent BMP Signaling Pathway as a Potential Anabolic Target for Osteoporosis.

J Bone Miner Res 2020 01 14;35(1):92-105. Epub 2019 Nov 14.

Faculty of Health, Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Australia.

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http://dx.doi.org/10.1002/jbmr.3875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004081PMC
January 2020

Introducing M-GCTA a Software Package to Estimate Maternal (or Paternal) Genetic Effects on Offspring Phenotypes.

Behav Genet 2020 01 6;50(1):51-66. Epub 2019 Sep 6.

University of Queensland Diamantina Institute, University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1007/s10519-019-09969-4DOI Listing
January 2020

Identifying and Validating New Drug Targets for Stroke and Beyond: Can Mendelian Randomization Help?

Circulation 2019 09 3;140(10):831-835. Epub 2019 Sep 3.

Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom (G.D.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.042005DOI Listing
September 2019

Variation of all-cause and cause-specific mortality with body mass index in one million Swedish parent-son pairs: An instrumental variable analysis.

PLoS Med 2019 08 9;16(8):e1002868. Epub 2019 Aug 9.

Population Health Sciences, Bristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.1002868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688790PMC
August 2019

Correction to: Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?

Hum Genet 2020 01;139(1):43-44

MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.1007/s00439-019-02051-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050561PMC
January 2020

Masked hypertension and submaximal exercise blood pressure among adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC).

Scand J Med Sci Sports 2020 Jan 22;30(1):25-30. Epub 2019 Aug 22.

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.

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http://dx.doi.org/10.1111/sms.13525DOI Listing
January 2020

Availability of public databases for triangulation of findings.

Proc Natl Acad Sci U S A 2019 08 23;116(32):15766-15767. Epub 2019 Jul 23.

National Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University of Bristol, Oakfield House, Bristol BS8 2BN, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1908893116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689894PMC
August 2019

How humans can contribute to Mendelian randomization analyses.

Int J Epidemiol 2019 06;48(3):661-664

MRC Integrative Epidemiology Unit, School of Social and Community Medicine, Bristol, UK.

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http://dx.doi.org/10.1093/ije/dyz152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739231PMC
June 2019

Commentary: Orienting causal relationships between two phenotypes using bidirectional Mendelian randomization.

Int J Epidemiol 2019 06;48(3):907-911

MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.

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http://dx.doi.org/10.1093/ije/dyz149DOI Listing
June 2019

Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic disease.

Hum Mol Genet 2019 10;28(19):3293-3300

MRC Integrative Epidemiology Unit, Population Health Sciences Institute, University of Bristol, Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.1093/hmg/ddz155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859431PMC
October 2019

Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour.

Nat Commun 2019 07 3;10(1):2949. Epub 2019 Jul 3.

MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.1038/s41467-019-10679-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610141PMC
July 2019

An integrative approach to detect epigenetic mechanisms that putatively mediate the influence of lifestyle exposures on disease susceptibility.

Int J Epidemiol 2019 06;48(3):887-898

MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.

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http://dx.doi.org/10.1093/ije/dyz119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659375PMC
June 2019

Comment on the Relationship Between Common Variant Schizophrenia Liability and Number of Offspring in the UK Biobank.

Am J Psychiatry 2019 07;176(7):573-574

Medical Research Council Integrative Epidemiology Unit (Lawn, Sallis, Wootton, Davey Smith, Davies, Hemani, Fraser, Munafò), School of Psychological Science (Lawn, Sallis, Wootton, Penton-Voak, Munafò), and Bristol Medical School (Sallis, Taylor, Davey Smith, Davies, Fraser), University of Bristol, Bristol, United Kingdom; National Institute for Health Research Biomedical Research Center, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, United Kingdom (Taylor).

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http://dx.doi.org/10.1176/appi.ajp.2019.19010071DOI Listing
July 2019

Identifying Novel Types of Irritability Using a Developmental Genetic Approach.

Am J Psychiatry 2019 08 1;176(8):635-642. Epub 2019 Jul 1.

The Division of Psychological Medicine and Clinical Neurosciences, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, Wales, United Kingdom (Riglin, Eyre, A.K. Thapar, O'Donovan, A. Thapar); the Emotion and Development Branch, NIMH, Bethesda, Md. (Stringaris, Leibenluft, Pine); and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom (Tilling, Smith).

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http://dx.doi.org/10.1176/appi.ajp.2019.18101134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677571PMC
August 2019

A Birth Cohort Study on the Genetic Modification of the Association of Prenatal Methylmercury With Child Cognitive Development.

Am J Epidemiol 2019 10;188(10):1784-1793

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1093/aje/kwz156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768817PMC
October 2019