George C Tsokos

George C Tsokos

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George C Tsokos

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Complement and coagulation cascades in trauma.

Acute Med Surg 2019 Oct 25;6(4):329-335. Epub 2019 Apr 25.

Department of Medicine Beth Israel Deaconess Medical Center Harvard Medical School Boston Massachusetts.

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http://dx.doi.org/10.1002/ams2.426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773636PMC
October 2019

SLAMF6 as a Regulator of Exhausted CD8 T Cells in Cancer.

Cancer Immunol Res 2019 Sep 17;7(9):1485-1496. Epub 2019 Jul 17.

Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2326-6066.CIR-18-0664DOI Listing
September 2019

Hyaluronic Acid Synthesis Contributes to Tissue Damage in Systemic Lupus Erythematosus.

Front Immunol 2019 13;10:2172. Epub 2019 Sep 13.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.02172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753633PMC
September 2019

Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus.

Front Immunol 2018 17;9:1088. Epub 2018 May 17.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.3389/fimmu.2018.01088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967272PMC
July 2019

Signaling lymphocyte activation molecule family in systemic lupus erythematosus.

Clin Immunol 2019 Jul 8;204:57-63. Epub 2018 Nov 8.

Harvard Medical School, Boston, MA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15216616183044
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http://dx.doi.org/10.1016/j.clim.2018.11.001DOI Listing
July 2019

CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells.

J Immunol 2019 Jul 13;203(1):93-104. Epub 2019 May 13.

Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136;

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http://dx.doi.org/10.4049/jimmunol.1801570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581624PMC
July 2019

Targeting Regulatory T Cells to Treat Patients With Systemic Lupus Erythematosus.

Front Immunol 2018 17;9:786. Epub 2018 Apr 17.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.3389/fimmu.2018.00786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932391PMC
June 2019

The role of IL-17 in systemic lupus erythematosus and its potential as a therapeutic target.

Expert Rev Clin Immunol 2019 Jun 25;15(6):629-637. Epub 2019 Mar 25.

c Division of Rheumatology and Clinical Immunology, Department of Medicine , Beth Israel Deaconess Medical Center, Harvard Medical School , Boston , MA , USA.

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1593141DOI Listing
June 2019

Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation.

JCI Insight 2019 Jun 20;4(12). Epub 2019 Jun 20.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston Massachusetts, USA.

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http://dx.doi.org/10.1172/jci.insight.127395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629104PMC
June 2019

Glutaminase 1 Inhibition Reduces Glycolysis and Ameliorates Lupus-Like Disease in MRL/lpr Mice and Experimental Autoimmune Encephalomyelitis.

Arthritis Rheumatol 2019 Jun 24. Epub 2019 Jun 24.

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/art.41019DOI Listing
June 2019

SLE-Associated Defects Promote Altered T Cell Function.

Crit Rev Immunol 2017 ;37(1):39-58

Department of Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

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http://www.dl.begellhouse.com/journals/2ff21abf44b19838,7906
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http://dx.doi.org/10.1615/CritRevImmunol.2018025213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314197PMC
April 2019

A new checkpoint in lupus.

Authors:
George C Tsokos

J Allergy Clin Immunol 2019 Apr 9;143(4):1351-1352. Epub 2019 Jan 9.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.12.996DOI Listing
April 2019

Complement Deposition on the Surface of RBC After Trauma Serves A Biomarker of Moderate Trauma Severity: A Prospective Study.

Shock 2019 Apr 12. Epub 2019 Apr 12.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1097/SHK.0000000000001348DOI Listing
April 2019

The immune podocyte.

Curr Opin Rheumatol 2019 Mar;31(2):167-174

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/BOR.0000000000000578DOI Listing
March 2019

PP2A enables IL-2 signaling by preserving IL-2Rβ chain expression during Treg development.

JCI Insight 2019 Mar 26;5. Epub 2019 Mar 26.

Division of Rheumatology and Clinical Immunology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/jci.insight.126294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538314PMC
March 2019

Editorial: Systemic Lupus Erythematosus and Antiphospholipid Syndrome.

Front Immunol 2019 25;10:199. Epub 2019 Feb 25.

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.00199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398508PMC
February 2019

TARGETING TARGETED TREATMENT FOR IMMUNE AND NON-IMMUNE KIDNEY DISEASES.

Trans Am Clin Climatol Assoc 2019 ;130:88-99

BOSTON, MASSACHUSETTS.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735968PMC
January 2019

Regulatory T cells in the treatment of disease.

Nat Rev Drug Discov 2018 11 12;17(11):823-844. Epub 2018 Oct 12.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/doifinder/10.1038/nrd.2018.148
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http://dx.doi.org/10.1038/nrd.2018.148DOI Listing
November 2018

Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells.

Front Immunol 2018 1;9:2113. Epub 2018 Oct 1.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.3389/fimmu.2018.02113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176098PMC
October 2018

Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17 differentiation.

Proc Natl Acad Sci U S A 2018 09 27;115(37):9288-9293. Epub 2018 Aug 27.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215

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http://dx.doi.org/10.1073/pnas.1805717115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140513PMC
September 2018

CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease.

J Clin Invest 2018 08 9;128(8):3445-3459. Epub 2018 Jul 9.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI99507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063476PMC
August 2018

Precision DNA demethylation ameliorates disease in lupus-prone mice.

JCI Insight 2018 08 23;3(16). Epub 2018 Aug 23.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/jci.insight.120880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141184PMC
August 2018

Downregulation of CD3ζ in NK Cells from Systemic Lupus Erythematosus Patients Confers a Proinflammatory Phenotype.

J Immunol 2018 05 30;200(9):3077-3086. Epub 2018 Mar 30.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.4049/jimmunol.1700588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048443PMC
May 2018

Recent developments in systemic lupus erythematosus pathogenesis and applications for therapy.

Curr Opin Rheumatol 2018 03;30(2):222-228

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center.

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http://dx.doi.org/10.1097/BOR.0000000000000474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050980PMC
March 2018

New insights into the role of renal resident cells in the pathogenesis of lupus nephritis.

Korean J Intern Med 2018 03 12;33(2):284-289. Epub 2018 Jan 12.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.3904/kjim.2017.383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840601PMC
March 2018

Transcriptional factor ICER promotes glutaminolysis and the generation of Th17 cells.

Proc Natl Acad Sci U S A 2018 03 20;115(10):2478-2483. Epub 2018 Feb 20.

Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215

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http://dx.doi.org/10.1073/pnas.1714717115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877961PMC
March 2018

The serine/threonine protein phosphatase 2A controls autoimmunity.

Clin Immunol 2018 01 21;186:38-42. Epub 2017 Jul 21.

Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States.

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http://dx.doi.org/10.1016/j.clim.2017.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776067PMC
January 2018

T cells and IL-17 in lupus nephritis.

Clin Immunol 2017 12 21;185:95-99. Epub 2016 Apr 21.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15216616163006
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074925PMC
http://dx.doi.org/10.1016/j.clim.2016.04.010DOI Listing
December 2017

IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury.

J Immunol 2017 10 6;199(8):2921-2929. Epub 2017 Sep 6.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.4049/jimmunol.1700655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807067PMC
October 2017

C3a Enhances the Formation of Intestinal Organoids through C3aR1.

Front Immunol 2017 4;8:1046. Epub 2017 Sep 4.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.3389/fimmu.2017.01046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591398PMC
September 2017

Immune cell signaling in autoimmune diseases.

Clin Immunol 2017 08 19;181:1-8. Epub 2017 May 19.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.05.015DOI Listing
August 2017

IL-23 Limits the Production of IL-2 and Promotes Autoimmunity in Lupus.

J Immunol 2017 08 23;199(3):903-910. Epub 2017 Jun 23.

Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston 02215, MA

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http://dx.doi.org/10.4049/jimmunol.1700418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526729PMC
August 2017

Fat T cells go to the joint.

Authors:
George C Tsokos

Nat Immunol 2017 08;18(9):955-956

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ni.3810DOI Listing
August 2017

Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective.

Trends Mol Med 2017 07 13;23(7):615-635. Epub 2017 Jun 13.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2017.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650102PMC
July 2017

T cells and autoimmune kidney disease.

Nat Rev Nephrol 2017 06 13;13(6):329-343. Epub 2017 Mar 13.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, CLS-937, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nrneph.2017.34DOI Listing
June 2017

Downregulation of miR-200a-3p, Targeting CtBP2 Complex, Is Involved in the Hypoproduction of IL-2 in Systemic Lupus Erythematosus-Derived T Cells.

J Immunol 2017 06 24;198(11):4268-4276. Epub 2017 Apr 24.

Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700 8558, Japan; and.

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http://dx.doi.org/10.4049/jimmunol.1601705DOI Listing
June 2017

Microglia-dependent synapse loss in type I interferon-mediated lupus.

Nature 2017 06 14;546(7659):539-543. Epub 2017 Jun 14.

Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature22821DOI Listing
June 2017

Aneurysm of the ascending aorta in systemic lupus erythematosus: Case report and review of the literature.

Eur J Rheumatol 2017 Jun 1;4(2):133-135. Epub 2017 Jun 1.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://www.eurjrheumatol.org/sayilar/210/buyuk/133-1352.pdf
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http://dx.doi.org/10.5152/eurjrheum.2017.17066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473449PMC
June 2017

DNA methylation in systemic lupus erythematosus.

Epigenomics 2017 04 25;9(4):505-525. Epub 2016 Nov 25.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.2217/epi-2016-0096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040049PMC
April 2017

Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in Mice.

J Immunol 2017 03 16;198(5):1846-1854. Epub 2017 Jan 16.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.4049/jimmunol.1501145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321845PMC
March 2017

Intracellular Activation of Complement 3 Is Responsible for Intestinal Tissue Damage during Mesenteric Ischemia.

J Immunol 2017 01 2;198(2):788-797. Epub 2016 Dec 2.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.4049/jimmunol.1502287DOI Listing
January 2017

T cells in Systemic Lupus Erythematosus.

Curr Opin Immunol 2016 12 13;43:32-38. Epub 2016 Sep 13.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2016.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125867PMC
December 2016

Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification.

Ann Rheum Dis 2016 Nov 25;75(11):2014-2021. Epub 2016 Jan 25.

Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA Department of Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2015-20814
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http://dx.doi.org/10.1136/annrheumdis-2015-208140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959992PMC
November 2016

Low-Dose IL-2 in the Treatment of Lupus.

Curr Rheumatol Rep 2016 11;18(11):68

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, CLS-937, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s11926-016-0617-5DOI Listing
November 2016

What rheumatologists need to know about innate lymphocytes.

Nat Rev Rheumatol 2016 11 2;12(11):658-668. Epub 2016 Sep 2.

Manchester Collaborative Centre for Inflammation Research (MCCIR), The University of Manchester, Grafton Street, Manchester M13 9NT, UK.

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http://dx.doi.org/10.1038/nrrheum.2016.140DOI Listing
November 2016

New insights into the immunopathogenesis of systemic lupus erythematosus.

Nat Rev Rheumatol 2016 11;12(12):716-730

Division of Allergy and Immunology, The Children's Hospital of Philadelphia, The University of Pennsylvania Perelman School of Medicine, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nrrheum.2016.186DOI Listing
November 2016

Pin1-Targeted Therapy for Systemic Lupus Erythematosus.

Arthritis Rheumatol 2016 10;68(10):2503-13

Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, and Institute for Translational Medicine and Fujian Medical University, Fuzhou, China.

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http://dx.doi.org/10.1002/art.39741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493308PMC
October 2016

The role of Syk in cutaneous lupus erythematosus.

Exp Dermatol 2016 09 19;25(9):674-5. Epub 2016 Aug 19.

Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/exd.13018DOI Listing
September 2016

Complement Activation in Trauma Patients Alters Platelet Function.

Shock 2016 09;46(3 Suppl 1):83-8

*Departments of Medicine and Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts †Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts ‡Institute of Surgical Research, San Antonio, Texas.

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http://dx.doi.org/10.1097/SHK.0000000000000675DOI Listing
September 2016

C1 Inhibitor Limits Organ Injury and Prolongs Survival in Swine Subjected to Battlefield Simulated Injury.

Shock 2016 09;46(3 Suppl 1):177-88

*Chief Scientist Office, 59MDW/ST, Wilford Hall Ambulatory Surgical Center, Joint Base San Antonio-Lackland, Texas †Damage Control Resuscitation, U.S. Army Institute of Surgical Research, Joint Base San Antonio-Fort Sam Houston, Texas ‡Pharming Technologies BV, Leiden, The Netherlands §Navel Medical Research Unit, Joint Base San Antonio-Fort Sam Houston, Texas ¶Combat Casualty Care Research Program, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland ||Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts #Chemical and Biological Technologies Department, Defense Threat Reduction Agency, Fort Belvoir, Virginia.

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http://dx.doi.org/10.1097/SHK.0000000000000677DOI Listing
September 2016

Empowering Regulatory T Cells in Autoimmunity.

Trends Mol Med 2016 09 25;22(9):784-797. Epub 2016 Jul 25.

Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2016.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003773PMC
September 2016

ICER is requisite for Th17 differentiation.

Nat Commun 2016 Sep 29;7:12993. Epub 2016 Sep 29.

Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncomms12993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056420PMC
September 2016

T Cell Transcriptomes Describe Patient Subtypes in Systemic Lupus Erythematosus.

PLoS One 2015 6;10(11):e0141171. Epub 2015 Nov 6.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141171PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636226PMC
June 2016

Phosphatase PP2A is requisite for the function of regulatory T cells.

Nat Immunol 2016 May 14;17(5):556-64. Epub 2016 Mar 14.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ni.3390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837024PMC
May 2016

Serine Arginine-Rich Splicing Factor 1 (SRSF1) Contributes to the Transcriptional Activation of CD3ζ in Human T Cells.

PLoS One 2015 2;10(7):e0131073. Epub 2015 Jul 2.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131073PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489909PMC
April 2016

Metabolic control of arthritis: Switch pathways to treat.

Authors:
George C Tsokos

Sci Transl Med 2016 Mar;8(331):331fs8

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaf4953DOI Listing
March 2016

Targeting Syk in Autoimmune Rheumatic Diseases.

Front Immunol 2016 7;7:78. Epub 2016 Mar 7.

Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA , USA.

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http://dx.doi.org/10.3389/fimmu.2016.00078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779881PMC
March 2016

Systemic lupus erythematosus in 2015: Cellular and metabolic requirements of effector T cells.

Authors:
George C Tsokos

Nat Rev Rheumatol 2016 Feb 5;12(2):74-6. Epub 2016 Jan 5.

Division of Rheumatology, Beth Israel Deaconess Medical Centre, Harvard Medical School, Harvard University, 330 Brookline Avenue, CLS937 Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nrrheum.2015.178DOI Listing
February 2016

Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4+ T Cells Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice.

J Immunol 2015 Dec 11;195(12):5533-7. Epub 2015 Nov 11.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.4049/jimmunol.1501603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670795PMC
December 2015

Pathogenesis and targeted treatment of skin injury in SLE.

Nat Rev Rheumatol 2015 Nov 4;11(11):663-9. Epub 2015 Aug 4.

Division of Rheumatology, Beth Israel Deaconess Medical Centre, Harvard Medical School, Harvard University, 330 Brookline Avenue, CLS937 Boston, MA 02215, USA.

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http://dx.doi.org/10.1038/nrrheum.2015.106DOI Listing
November 2015

Complement receptor of the immunoglobulin superfamily reduces murine lupus nephritis and cutaneous disease.

Clin Immunol 2015 Oct 16;160(2):286-91. Epub 2015 May 16.

Department of Medicine, Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2015.05.006DOI Listing
October 2015

Update on the role of Interleukin 17 in rheumatologic autoimmune diseases.

Cytokine 2015 Oct 28;75(2):207-15. Epub 2015 May 28.

Rheumatology Department at Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2015.01.003DOI Listing
October 2015

Spleen tyrosine kinase (Syk) inhibitor fostamatinib limits tissue damage and fibrosis in a bleomycin-induced scleroderma mouse model.

Clin Exp Rheumatol 2015 Jul-Aug;33(4 Suppl 91):S15-22. Epub 2015 Jul 6.

Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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October 2015

Lupus-prone mice fail to raise antigen-specific T cell responses to intracellular infection.

PLoS One 2014 31;9(10):e111382. Epub 2014 Oct 31.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111382PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216089PMC
June 2015

Programmed cell death 1 and Helios distinguish TCR-αβ+ double-negative (CD4-CD8-) T cells that derive from self-reactive CD8 T cells.

J Immunol 2015 May 30;194(9):4207-14. Epub 2015 Mar 30.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.4049/jimmunol.1402775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503929PMC
May 2015

Target it all right, but do not forget the torchbearer.

Authors:
George C Tsokos

Circulation 2015 Mar 17;131(13):1153-5. Epub 2015 Feb 17.

From Beth Israel Deaconess Medical Center, Boston, MA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.015613DOI Listing
March 2015

Impaired receptor editing and heterozygous RAG2 mutation in a patient with systemic lupus erythematosus and erosive arthritis.

J Allergy Clin Immunol 2015 Jan 11;135(1):272-3. Epub 2014 Oct 11.

Division of Immunology, Boston Children's Hospital, Boston, Mass; The Manton Center For Orphan Disease Research, Boston Children's Hospital, Boston, Mass; Harvard Stem Cell Institute, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaci.2014.07.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289116PMC
January 2015

KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3⁺ regulatory T cells in MRL/lpr mice.

Autoimmunity 2014 Nov 15;47(7):445-50. Epub 2014 May 15.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA , USA.

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http://dx.doi.org/10.3109/08916934.2014.915954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341833PMC
November 2014

The role of T cells in systemic lupus erythematosus: an update.

Curr Opin Rheumatol 2014 Sep;26(5):493-501

Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA *Christine Konya and Ziv Paz contributed equally to the writing of this article.

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https://insights.ovid.com/crossref?an=00002281-201409000-000
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http://dx.doi.org/10.1097/BOR.0000000000000082DOI Listing
September 2014

IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells.

J Immunol 2014 Sep 25;193(5):2168-77. Epub 2014 Jul 25.

Department of Medicine, Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.4049/jimmunol.1400977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135016PMC
September 2014

Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling.

Proc Natl Acad Sci U S A 2014 Sep 3;111(37):13457-62. Epub 2014 Sep 3.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1408023111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169908PMC
September 2014

Epigenetic regulation of cytokine expression in systemic lupus erythematosus with special focus on T cells.

Autoimmunity 2014 Jun 24;47(4):234-41. Epub 2014 Apr 24.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts , USA.

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http://www.tandfonline.com/doi/full/10.3109/08916934.2013.80
Publisher Site
http://dx.doi.org/10.3109/08916934.2013.801462DOI Listing
June 2014

C4d deposits on the surface of RBCs in trauma patients and interferes with their function.

Crit Care Med 2014 May;42(5):e364-72

1Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. 2Department of Biomedical Engineering, Tulane University, New Orleans, LA. 3Institute of Surgical Research, San Antonio, TX.

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http://dx.doi.org/10.1097/CCM.0000000000000231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099476PMC
May 2014

Engagement of SLAMF2/CD48 prolongs the time frame of effective T cell activation by supporting mature dendritic cell survival.

J Immunol 2014 May 26;192(9):4436-42. Epub 2014 Mar 26.

Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115.

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http://dx.doi.org/10.4049/jimmunol.1302909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017928PMC
May 2014

Transcription factor Ikaros represses protein phosphatase 2A (PP2A) expression through an intronic binding site.

J Biol Chem 2014 May 1;289(20):13751-7. Epub 2014 Apr 1.

From the Department of Medicine, Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115 and

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http://dx.doi.org/10.1074/jbc.M114.558197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022849PMC
May 2014

Ubiquitination regulates expression of the serine/arginine-rich splicing factor 1 (SRSF1) in normal and systemic lupus erythematosus (SLE) T cells.

J Biol Chem 2014 Feb 24;289(7):4126-34. Epub 2013 Dec 24.

From the Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215.

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http://dx.doi.org/10.1074/jbc.M113.518662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924278PMC
February 2014

A T cell gene expression panel for the diagnosis and monitoring of disease activity in patients with systemic lupus erythematosus.

Clin Immunol 2014 Feb 16;150(2):192-200. Epub 2013 Dec 16.

Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2013.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932542PMC
February 2014