Publications by authors named "Georg Lenz"

100Publications

The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.

Proc Natl Acad Sci U S A 2020 Oct 5;117(42):26328-26339. Epub 2020 Oct 5.

Department of Microenvironmental Regulation in Autoimmunity and Cancer, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany;

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http://dx.doi.org/10.1073/pnas.2008883117DOI Listing
October 2020

Sequential therapy with inotuzumab ozogamicin, CD19 CAR T cells, and blinatumomab in an elderly patient with relapsed acute lymphoblastic leukemia.

Ann Hematol 2020 Aug 22. Epub 2020 Aug 22.

Department of Medicine A, Hematology and Oncology, University of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.

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http://dx.doi.org/10.1007/s00277-020-04227-8DOI Listing
August 2020

Blinatumomab or Inotuzumab Ozogamicin as Bridge to Allogeneic Stem Cell Transplantation for Relapsed or Refractory B-lineage Acute Lymphoblastic Leukemia: A Retrospective Single-Center Analysis.

Clin Lymphoma Myeloma Leuk 2020 Oct 3;20(10):e724-e733. Epub 2020 Jun 3.

Department of Medicine A - Hematology, Hemostaseology, Oncology, Pulmonology, University Hospital Münster, Münster, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2020.05.022DOI Listing
October 2020

Radiotherapy Dose and Volume De-escalation in Ocular Adnexal Lymphoma.

Anticancer Res 2020 Jul;40(7):4041-4046

Department of Radiation Oncology, University Hospital Muenster, Muenster, Germany.

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http://dx.doi.org/10.21873/anticanres.14400DOI Listing
July 2020

[Current diagnostic and therapeutic standards in aggressive B-cell lymphomas].

Dtsch Med Wochenschr 2020 02 4;145(3):151-154. Epub 2020 Feb 4.

Medizinische Klinik A für Hämatologie, Hämostaseologie, Onkologie und Pneumologie, Universitätsklinikum Münster.

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http://dx.doi.org/10.1055/a-0949-4745DOI Listing
February 2020

Lymphoma Angiogenesis Is Orchestrated by Noncanonical Signaling Pathways.

Cancer Res 2020 03 13;80(6):1316-1329. Epub 2020 Jan 13.

Translational Tumorimmunology, Max Delbrück Center for Molecular Medicine, Berlin, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-1493DOI Listing
March 2020

Dissection of gene expression datasets into clinically relevant interaction signatures via high-dimensional correlation maximization.

Nat Commun 2019 11 28;10(1):5417. Epub 2019 Nov 28.

Department of Physics, Renthof 5, University of Marburg, 35032, Marburg, Germany.

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http://dx.doi.org/10.1038/s41467-019-12713-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883077PMC
November 2019

Novel insights into the pathogenesis of molecular subtypes of diffuse large B-cell lymphoma and their clinical implications.

Expert Rev Clin Pharmacol 2019 Nov 23;12(11):1059-1067. Epub 2019 Oct 23.

Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany.

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https://www.tandfonline.com/doi/full/10.1080/17512433.2019.1
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http://dx.doi.org/10.1080/17512433.2019.1683447DOI Listing
November 2019

MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells.

Cell Rep 2019 10;29(4):873-888.e10

Research Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz-Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.09.040DOI Listing
October 2019

Low-dose total skin electron beam therapy: Quality of life improvement and clinical impact of maintenance and adjuvant treatment in patients with mycosis fungoides or Sezary syndrome.

Strahlenther Onkol 2020 Jan 7;196(1):77-84. Epub 2019 Oct 7.

Department of Radiation Oncology, University Hospital Muenster, Building A1, 1 Albert-Schweitzer-Campus, 48149, Muenster, Germany.

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http://dx.doi.org/10.1007/s00066-019-01517-7DOI Listing
January 2020

Therapeutic potential of PI3K signaling in distinct entities of B-cell lymphoma.

Expert Rev Hematol 2019 12 11;12(12):1053-1062. Epub 2019 Oct 11.

Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany.

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http://dx.doi.org/10.1080/17474086.2019.1676716DOI Listing
December 2019

Impact of radiation dose on local control and survival in extramedullary head and neck plasmacytoma.

Radiat Oncol 2019 Apr 15;14(1):63. Epub 2019 Apr 15.

Department of Radiation Oncology, University Hospital of Muenster, Albert-Schweitzer-Campus 1, Building A1, 48149, Muenster, Germany.

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http://dx.doi.org/10.1186/s13014-019-1265-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466654PMC
April 2019

Chromatin conformation analysis of primary patient tissue using a low input Hi-C method.

Nat Commun 2018 11 29;9(1):4938. Epub 2018 Nov 29.

Max Planck Institute for Molecular Biomedicine, Roentgenstrasse 20, 48149, Muenster, Germany.

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http://dx.doi.org/10.1038/s41467-018-06961-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265268PMC
November 2018

Y-ibritumomab-tiuxetan as a therapeutic alternative for follicular lymphoma (FL): A single-center experience.

Eur J Haematol 2018 Oct 3;101(4):514-521. Epub 2018 Sep 3.

Department of Medicine A, Hematology, Oncology and Pulmonary Medicine, University Hospital Muenster, Muenster, Germany.

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http://dx.doi.org/10.1111/ejh.13138DOI Listing
October 2018

Allogeneic hematopoietic stem cell transplantation for T-cell lymphomas.

Blood 2018 07 26;132(3):245-253. Epub 2018 Apr 26.

Department of Medicine A, University Hospital Münster, Münster, Germany.

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http://dx.doi.org/10.1182/blood-2018-01-791335DOI Listing
July 2018

Targeting the B-cell receptor pathway in diffuse large B-cell lymphoma.

Cancer Treat Rev 2018 Apr 1;65:41-46. Epub 2018 Feb 1.

Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany; Cluster of Excellence EXC 1003, Cells in Motion, Münster, Germany.

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http://dx.doi.org/10.1016/j.ctrv.2018.01.002DOI Listing
April 2018

Ibrutinib resistance in mantle cell lymphoma: clinical, molecular and treatment aspects.

Br J Haematol 2018 05 23;181(3):306-319. Epub 2018 Jan 23.

Translational Research Laboratory, Assuta Medical Centres, Tel Aviv, Israel.

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http://dx.doi.org/10.1111/bjh.15108DOI Listing
May 2018

[Not Available].

Dtsch Med Wochenschr 2017 Oct 10;142(20):1531-1534. Epub 2017 Oct 10.

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http://dx.doi.org/10.1055/s-0043-103471DOI Listing
October 2017

Phosphatidylinositol 3-Kinase Inhibition by Copanlisib in Relapsed or Refractory Indolent Lymphoma.

J Clin Oncol 2017 Dec 4;35(35):3898-3905. Epub 2017 Oct 4.

Martin Dreyling, Ludwig Maximilians University of Munich, Munich; Georg Lenz, University Hospital Münster, Münster; Marius Giurescu, Karl Köchert, Henrik Seidel, and Florian Hiemeyer, Bayer AG, Berlin, Germany; Armando Santoro, Humanitas Clinical and Research Center, Rozzano; Pier Luigi Zinzani, University of Bologna, Bologna, Italy; Luigina Mollica, Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada; Sirpa Leppä, Helsinki University Central Hospital Cancer Center, Helsinki, Finland; George A. Follows, Addenbrooke's Hospital, Cambridge, United Kingdom; Won Seog Kim, Samsung Medical Center, Seoul, South Korea; Arnon Nagler, Tel Aviv University, Tel HaShomer, Israel; Panayiotis Panayiotidis, National and Kapodistrian University of Athens, Athens, Greece; Judit Demeter, Semmelweis University, Budapest, Hungary; Muhit Özcan, Ankara University School of Medicine, Ankara, Turkey; Marina Kosinova, Kemerovo Regional Clinical Hospital, Kemerovo, Russian Federation; Krimo Bouabdallah, University Hospital of Bordeaux, Pessac; Franck Morschhauser, Hôpital Claude Huriez, Lille, France; Don A. Stevens, Norton Cancer Institute, Louisville, KY; David Trevarthen, Comprehensive Cancer Care and Research Institute of Colorado, Englewood, CO; and Lisa Cupit, Li Liu, Carol Peña, Shuxin Yin, Jose Garcia-Vargas, and Barrett H. Childs, Bayer HealthCare Pharmaceuticals, Whippany, NJ.

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http://dx.doi.org/10.1200/JCO.2017.75.4648DOI Listing
December 2017

Clinical Impact of the Cell-of-Origin Classification and the MYC/ BCL2 Dual Expresser Status in Diffuse Large B-Cell Lymphoma Treated Within Prospective Clinical Trials of the German High-Grade Non-Hodgkin's Lymphoma Study Group.

J Clin Oncol 2017 Aug 19;35(22):2515-2526. Epub 2017 May 19.

Annette M. Staiger, Heike Horn, and German Ott, Institute of Clinical Pathology, Robert-Bosch-Krankenhaus, Stuttgart; Annette M. Staiger and Heike Horn, Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart; Annette M. Staiger and Heike Horn, University of Tuebingen, Tuebingen; Marita Ziepert and Markus Löffler, Institute for Medical Informatics, Statistics and Epidemiology, Universität Leipzig, Leipzig; Thomas F.E. Barth and Peter Möller, Institute of Pathology, Universitätsklinikum Ulm, Ulm; Heinz-Wolfram Bernd and Alfred C. Feller, Haematopathologie Luebeck, Luebeck; Wolfram Klapper and Monika Szczepanowski, Institute of Pathology, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel; Monika Szczepanowski, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel; Michael Hummel and Dido Lenze, Institute of Pathology, Campus Benjamin Franklin, Charité Universitätsmedizin; Harald Stein, Pathodiagnostik Berlin, Berlin; Martin-Leo Hansmann and Sylvia Hartmann, Dr. Senckenberg Institute of Pathology, Goethe University Hospital, Frankfurt; Georg Lenz, Translational Oncology, Albert-Schweitzer-Campus 1, University Hospital Münster, and Cluster of Excellence EXC 1003, Cells in Motion, Münster; Lorenz Trümper, Georg-August Universität, Göttingen; Norbert Schmitz, Asklepios Klinik St Georg, Hamburg; Michael Pfreundschuh, Saarland University Medical School, Homburg/Saar; Andreas Rosenwald, Institute of Pathology, Universität Würzburg and Comprehensive Cancer Center Mainfranken, Würzburg, Germany; David W. Scott, Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, British Columbia, Canada; and Sergio Cogliatti, Institute of Pathology, Kantonal Hospital St Gallen, St Gallen, Switzerland.

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http://dx.doi.org/10.1200/JCO.2016.70.3660DOI Listing
August 2017

Successful second allogeneic stem cell transplantation in a patient with T-lymphoblastic leukemia (T-ALL) relapsed as myeloid sarcoma.

Ann Hematol 2017 Jul 27;96(7):1201-1203. Epub 2017 Apr 27.

Department of Medicine A, Hematology and Oncology, University of Muenster, Albert-Schweitzer-Campus 1, 48149, Muenster, Germany.

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http://link.springer.com/10.1007/s00277-017-3000-3
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http://dx.doi.org/10.1007/s00277-017-3000-3DOI Listing
July 2017

Deciphering Ibrutinib Resistance in Chronic Lymphocytic Leukemia.

Authors:
Georg Lenz

J Clin Oncol 2017 05 14;35(13):1451-1452. Epub 2017 Mar 14.

Georg Lenz, University Hospital Münster and Cells in Motion, Münster, Germany.

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http://dx.doi.org/10.1200/JCO.2016.72.0102DOI Listing
May 2017

Mature aggressive B-cell lymphoma across age groups - molecular advances and therapeutic implications.

Expert Rev Hematol 2017 Feb 26;10(2):123-135. Epub 2016 Dec 26.

a Pediatric Hematology and Oncology , University Hospital Muenster , Muenster , Germany.

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http://dx.doi.org/10.1080/17474086.2017.1271318DOI Listing
February 2017

The molecular pathogenesis of mantle cell lymphoma.

Leuk Lymphoma 2017 07 28;58(7):1530-1537. Epub 2016 Nov 28.

a Department of Translational Oncology , University Hospital Münster , Münster , Germany.

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http://dx.doi.org/10.1080/10428194.2016.1248965DOI Listing
July 2017

Epileptic seizures and rhinocerebral mucormycosis during blinatumomab treatment in a patient with biphenotypic acute leukemia.

Ann Hematol 2017 Jan 3;96(1):151-153. Epub 2016 Oct 3.

Department of Medicine A/Hematology and Oncology, University of Muenster, Albert-Schweitzer-Campus 1, D-48149, Muenster, Germany.

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http://dx.doi.org/10.1007/s00277-016-2837-1DOI Listing
January 2017

Splenic Marginal Zone Granulocytes Acquire an Accentuated Neutrophil B-Cell Helper Phenotype in Chronic Lymphocytic Leukemia.

Cancer Res 2016 09 3;76(18):5253-65. Epub 2016 Aug 3.

Department of Hematology, Oncology and Tumorimmunology, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany. Department of Hematology, Oncology and Tumorimmunology, Charité-University Medicine Berlin, Berlin, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3486DOI Listing
September 2016

Novel NF-κB regulator in ABC DLBCL.

Authors:
Georg Lenz

Blood 2016 06;127(23):2785-6

UNIVERSITY HOSPITAL MÜNSTER; CELLS IN MOTION.

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http://dx.doi.org/10.1182/blood-2016-03-704254DOI Listing
June 2016

Approaching resistance to ibrutinib in diffuse large B-cell lymphoma.

Leuk Lymphoma 2016 11;57(6):1254-5. Epub 2016 Apr 11.

a Department of Medicine A, Division of Translational Oncology , University Hospital Münster , Münster , Germany ;

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http://dx.doi.org/10.3109/10428194.2015.1136742DOI Listing
August 2016

Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-κB and JNK activation.

Proc Natl Acad Sci U S A 2015 Dec 14;112(52):E7230-8. Epub 2015 Dec 14.

Institut für Klinische Chemie und Pathobiochemie, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany; German Cancer Consortium, 69120 Heidelberg, Germany; German Center for Infection Research, 81675 München, Germany

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http://dx.doi.org/10.1073/pnas.1507459112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702996PMC
December 2015

XI. Management of paediatric and adult non-Hodgkin lymphoma: what lessons can each teach the other?

Hematol Oncol 2015 Jun;33 Suppl 1:62-6

Translational Oncology, Department of Medicine A, University Hospital Münster, Münster, Germany.

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http://dx.doi.org/10.1002/hon.2219DOI Listing
June 2015

Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-Cell Lymphoma and Its Therapeutic Implications.

Authors:
Georg Lenz

Cancers (Basel) 2015 May 22;7(2):811-22. Epub 2015 May 22.

Translational Oncology, Department of Medicine A, Albert-Schweitzer Campus 1, University Hospital Münster, 48149 Münster, Germany.

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http://dx.doi.org/10.3390/cancers7020812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491687PMC
May 2015

Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas.

Chem Biol 2015 Jan 31;22(1):129-38. Epub 2014 Dec 31.

Research Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.10.021DOI Listing
January 2015

Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma.

Blood 2015 Jan 30;125(1):124-32. Epub 2014 Oct 30.

Department of Medicine A, Translational Oncology, Albert-Schweitzer Campus 1, University Hospital Münster, Münster, Germany; Department of Hematology, Oncology, and Tumor Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Cells in Motion Cluster of Excellence, Münster, Germany;

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http://dx.doi.org/10.1182/blood-2014-08-594507DOI Listing
January 2015

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma.

Proc Natl Acad Sci U S A 2014 Oct 6;111(42):E4513-22. Epub 2014 Oct 6.

Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany; Hematology, Oncology, and Tumor Immunology, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;

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http://dx.doi.org/10.1073/pnas.1406985111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210307PMC
October 2014

Targeting B-cell lymphomas with inhibitors of the MALT1 paracaspase.

Curr Opin Chem Biol 2014 Dec 4;23:47-55. Epub 2014 Oct 4.

Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cbpa.2014.09.025DOI Listing
December 2014

Waldenstrom macroglobulinemia: genetics dictates clinical course.

Authors:
Georg Lenz

Blood 2014 May;123(18):2750-1

CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN.

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http://dx.doi.org/10.1182/blood-2014-03-558973DOI Listing
May 2014

PI3K/AKT addiction in subsets of diffuse large B-cell lymphoma.

Cell Cycle 2013 Nov 23;12(21):3347-8. Epub 2013 Sep 23.

Department of Hematology, Oncology and Tumor Immunology; Charité - Universitätsmedizin Berlin; Berlin, Germany.

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http://dx.doi.org/10.4161/cc.26575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895419PMC
November 2013

Novel therapeutic targets in diffuse large B-cell lymphoma.

Authors:
Georg Lenz

EJC Suppl 2013 Sep;11(2):262-3

Charité - Universitätsmedizin Berlin, Department of Hematology, Oncology and Tumor Immunology, Berlin, Germany.

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http://dx.doi.org/10.1016/j.ejcsup.2013.07.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041475PMC
September 2013

The protease activity of the paracaspase MALT1 is controlled by monoubiquitination.

Nat Immunol 2013 Apr 17;14(4):337-45. Epub 2013 Feb 17.

Department of Biochemistry, Center of Immunity and Infection, University of Lausanne, Epalinges, Switzerland.

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http://www.nature.com/articles/ni.2540
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http://dx.doi.org/10.1038/ni.2540DOI Listing
April 2013

Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.

Cancer Cell 2012 Dec;22(6):825-37

Research Unit Cellular Signal Integration, Helmholtz Zentrum München-German Research Center for Environmental Health, Institute of Molecular Toxicology and Pharmacology, Ingolstädter Landstrasse. 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1016/j.ccr.2012.11.002DOI Listing
December 2012