Georg Breier

Georg Breier

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Georg Breier

Georg Breier

Publications by authors named "Georg Breier"

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PHD3 Acts as Tumor Suppressor in Mouse Osteosarcoma and Influences Tumor Vascularization via PDGF-C Signaling.

Cancers (Basel) 2018 Dec 6;10(12). Epub 2018 Dec 6.

Division of Medical Biology, Department of Psychiatry and Psychotherapy, TU Dresden, 01307 Dresden, Germany.

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http://dx.doi.org/10.3390/cancers10120496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316346PMC
December 2018

Heparanase and Thrombin: Common Signalling Pathways in Melanoma Cells?

Authors:
Georg Breier

Thromb Haemost 2018 Oct 1;118(10):1688-1689. Epub 2018 Oct 1.

Division of Medical Biology, Department of Psychiatry and Psychotherapy, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.

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http://dx.doi.org/10.1055/s-0038-1673329DOI Listing
October 2018

The expression of VE-cadherin in breast cancer cells modulates cell dynamics as a function of tumor differentiation and promotes tumor-endothelial cell interactions.

Histochem Cell Biol 2018 Jan 15;149(1):15-30. Epub 2017 Nov 15.

Institute of Anatomy and Vascular Biology, Westfälische Wilhelms-Universität Münster, Vesaliusweg 2-4, 48149, Münster, Germany.

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http://dx.doi.org/10.1007/s00418-017-1619-8DOI Listing
January 2018

Angiogenesis in metabolic-vascular disease.

Thromb Haemost 2017 06 8;117(7):1289-1295. Epub 2017 Jun 8.

Triantafyllos Chavakis, Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany, E-mail:

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http://dx.doi.org/10.1160/TH17-05-0325DOI Listing
June 2017

Receptor tyrosine kinase inhibitors: Are they real tumor killers?

Int J Cancer 2016 Feb 11;138(3):540-54. Epub 2015 Mar 11.

Institute of Pathology, Technical University Dresden, Dresden, Germany.

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http://dx.doi.org/10.1002/ijc.29499DOI Listing
February 2016

Adipocyte-Specific Hypoxia-Inducible Factor 2α Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation.

Mol Cell Biol 2016 02 16;36(3):376-93. Epub 2015 Nov 16.

Department of Clinical Pathobiochemistry, Medical Faculty, Technische Universität Dresden, Dresden, Germany Institute of Clinical Chemistry and Laboratory Medicine, Medical Faculty, Technische Universität Dresden, Dresden, Germany Center for Regenerative Therapies Dresden, Dresden, Germany Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, TU Dresden, Dresden, and German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany

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http://dx.doi.org/10.1128/MCB.00430-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719429PMC
February 2016

Endothelial cadherins in cancer.

Cell Tissue Res 2014 Mar 12;355(3):523-7. Epub 2014 Mar 12.

Institute of Pathology, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany,

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http://dx.doi.org/10.1007/s00441-014-1851-7DOI Listing
March 2014

A role for prolyl hydroxylase domain proteins in hippocampal synaptic plasticity.

Hippocampus 2013 Oct 6;23(10):861-72. Epub 2013 Jun 6.

UCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, 4, Ireland.

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http://dx.doi.org/10.1002/hipo.22142DOI Listing
October 2013

Lack of vascular endothelial growth factor receptor-2/Flk1 signaling does not affect substantia nigra development.

Neurosci Lett 2013 Oct 29;553:142-7. Epub 2013 Aug 29.

Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology, Dresden, Germany; Center for Regenerative Therapies Dresden, Dresden University of Technology, Dresden, Germany; German Centre for Neurodegenerative Diseases (DZNE) Dresden, Dresden University of Technology, Dresden, Germany.

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http://dx.doi.org/10.1016/j.neulet.2013.08.031DOI Listing
October 2013

Spatial regulation of VEGF receptor endocytosis in angiogenesis.

Nat Cell Biol 2013 Mar 27;15(3):249-60. Epub 2013 Jan 27.

Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Muenster, Faculty of Medicine, D-48149 Muenster, Germany.

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http://www.nature.com/articles/ncb2679
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http://dx.doi.org/10.1038/ncb2679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901019PMC
March 2013

Identification of a clonally expanding haematopoietic compartment in bone marrow.

EMBO J 2013 Jan 27;32(2):219-30. Epub 2012 Nov 27.

Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, University of Münster, Münster, Germany.

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http://dx.doi.org/10.1038/emboj.2012.308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553379PMC
January 2013

Prognostic and predictive value of circulating tumor cell analysis in colorectal cancer patients.

J Transl Med 2012 Nov 13;10:222. Epub 2012 Nov 13.

Department of Molecular Biology, Zentrum für Diagnostik am Klinikum Chemnitz, Flemmingstrasse 2, 09116 Chemnitz, Germany.

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http://dx.doi.org/10.1186/1479-5876-10-222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508882PMC
November 2012

Neuron-specific prolyl-4-hydroxylase domain 2 knockout reduces brain injury after transient cerebral ischemia.

Stroke 2012 Oct 28;43(10):2748-56. Epub 2012 Aug 28.

Institute of Physiology and Pathophysiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany.

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.112.669598
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http://dx.doi.org/10.1161/STROKEAHA.112.669598DOI Listing
October 2012

Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C.

Int J Cancer 2012 Sep 3;131(5):E603-13. Epub 2012 Jan 3.

Department of Pathology, University of Technology Dresden, Germany.

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http://dx.doi.org/10.1002/ijc.27360DOI Listing
September 2012

Propanolol and angiogenesis inhibition in hereditary haemorrhagic telangiectasia.

Authors:
Georg Breier

Thromb Haemost 2012 Jul 25;108(1):1-2. Epub 2012 May 25.

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http://dx.doi.org/10.1160/TH12-05-0312DOI Listing
July 2012

Multimarker gene analysis of circulating tumor cells in pancreatic cancer patients: a feasibility study.

Oncology 2012 20;82(1):3-10. Epub 2012 Jan 20.

Department of Pathology, Technische Universität Dresden, Dresden, Germany.

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http://dx.doi.org/10.1159/000335479DOI Listing
April 2012

Mechanoinduction of lymph vessel expansion.

EMBO J 2012 Feb 13;31(4):788-804. Epub 2011 Dec 13.

Institute of Metabolic Physiology, Heinrich-Heine University, Düsseldorf, Germany.

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http://dx.doi.org/10.1038/emboj.2011.456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280555PMC
February 2012

HIF prolyl hydroxylase-2 inhibition diminishes tumor growth through matrix metalloproteinase-induced TGFβ activation.

Cancer Biol Ther 2012 Feb;13(4):216-23

Institute of Pathology, University of Technology, Dresden, Germany.

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http://dx.doi.org/10.4161/cbt.13.4.18830DOI Listing
February 2012

Multimarker Analysis of Circulating Tumor Cells in Peripheral Blood of Metastatic Breast Cancer Patients: A Step Forward in Personalized Medicine.

Breast Care (Basel) 2012 Feb 21;7(1):7-12. Epub 2012 Feb 21.

Department of Pathology, Faculty of Medicine Carl Gustav Carus, University of Dresden, Klinikum Chemnitz, Germany.

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http://dx.doi.org/10.1159/000336548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335359PMC
February 2012

Parameter estimation with a novel gradient-based optimization method for biological lattice-gas cellular automaton models.

J Math Biol 2011 Jul 1;63(1):173-200. Epub 2010 Oct 1.

Department for Innovative Methods of Computing, Center for Information Services and High Performance Computing, Technische Universität Dresden, Nöthnitzer Strasse 46, 01062 Dresden, Germany.

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http://dx.doi.org/10.1007/s00285-010-0366-4DOI Listing
July 2011

Inhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGFβ.

Cancer Res 2011 May 24;71(9):3306-16. Epub 2011 Mar 24.

Department of Pathology, Dresden University of Technology, Dresden, Saxony, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3838DOI Listing
May 2011

Spatiotemporal expression of flk-1 in pulmonary epithelial cells during lung development.

Am J Respir Cell Mol Biol 2008 Aug 6;39(2):163-70. Epub 2008 Mar 6.

University of Giessen Lung Center, Department of Internal Medicine, University Hospital Giessen, Giessen, Germany.

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http://dx.doi.org/10.1165/rcmb.2007-0231OCDOI Listing
August 2008

Tracking adult neovascularization during ischemia and inflammation using Vegfr2-LacZ reporter mice.

J Vasc Res 2008 16;45(5):437-44. Epub 2008 Apr 16.

Department of Dermatology, Eberhard Karls University, Tuebingen, Germany.

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https://www.karger.com/Article/FullText/126106
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http://dx.doi.org/10.1159/000126106DOI Listing
August 2008

A novel Flk1-TVA transgenic mouse model for gene delivery to angiogenic vasculature.

Transgenic Res 2008 Jun 20;17(3):403-15. Epub 2007 Nov 20.

Burnham Institute for Medical Research, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, USA.

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http://link.springer.com/content/pdf/10.1007/s11248-007-9156
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http://link.springer.com/10.1007/s11248-007-9156-1
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http://dx.doi.org/10.1007/s11248-007-9156-1DOI Listing
June 2008

HIF in vascular development and tumour angiogenesis.

Novartis Found Symp 2007 ;283:126-33; discussion 133-8, 238-41

Division of Endothelial Cell Biology, Department of Pathology, University of Technology, Dresden, Germany.

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March 2008

Judah Folkman.

Thromb Haemost 2008 Feb;99(2):250

DKFZ and University of Heidelberg.

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February 2008

Lentiviral rescue of vascular endothelial growth factor receptor-2 expression in flk1-/- embryonic stem cells shows early priming of endothelial precursors.

Stem Cells 2007 Dec 16;25(12):2987-95. Epub 2007 Aug 16.

Rudbeck Laboratory, Department Genetics and Pathology, Uppsala University, Dag Hammarskjöldsv. 20, 751 85 Uppsala, Sweden.

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http://dx.doi.org/10.1634/stemcells.2007-0397DOI Listing
December 2007

Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate.

Exp Cell Res 2007 Jan 19;313(1):1-9. Epub 2006 Sep 19.

Theodor-Boveri-Institute, Physiological Chemistry I, Biocenter of the University of Wurzburg, Am Hubland, 97074 Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.yexcr.2006.09.009DOI Listing
January 2007

Isolated pancreatic islets in three-dimensional matrices are responsive to stimulators and inhibitors of angiogenesis.

Cell Transplant 2006 ;15(6):489-97

Medical Clinic and Policlinic 3, Justus Liebig University, Rodthohl 6, 35392 Giessen, Germany.

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January 2007

Endothelial cell biology: an update. 5th International Symposium on the Biology of Endothelial Cells.

Thromb Haemost 2006 Jun;95(6):1025-30

Department of Vascular Endothelium and Microcirculation, Medical Faculty Carl Gustav Carus, University of Technology Dresden Fetscherstr. 74, D-01307 Dresden, Germany.

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http://dx.doi.org/10.1160/TH06-04-0190DOI Listing
June 2006

Continuous endothelial cell activation increases angiogenesis: evidence for the direct role of endothelium linking angiogenesis and inflammation.

J Vasc Res 2006 12;43(2):193-204. Epub 2006 Jan 12.

Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Ind. 46202, USA.

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http://dx.doi.org/10.1159/000090949DOI Listing
March 2006

Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development.

Blood 2006 Jan 27;107(2):584-90. Epub 2005 Sep 27.

Department of Pathology, Faculty of Medicine, University of Technology, Dresden, Germany.

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http://dx.doi.org/10.1182/blood-2005-07-3033DOI Listing
January 2006

Type I collagen limits VEGFR-2 signaling by a SHP2 protein-tyrosine phosphatase-dependent mechanism 1.

Circ Res 2006 Jan 8;98(1):45-54. Epub 2005 Dec 8.

Institute for Cancer Research and Treatment, Department of Oncological Sciences, University of Torino, Turin, Italy.

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https://www.ahajournals.org/doi/10.1161/01.RES.0000199355.32
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http://dx.doi.org/10.1161/01.RES.0000199355.32422.7bDOI Listing
January 2006

Lymphangiogenesis in regenerating tissue: is VEGF-C sufficient?

Authors:
Georg Breier

Circ Res 2005 Jun;96(11):1132-4

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http://dx.doi.org/10.1161/01.RES.0000170976.63688.caDOI Listing
June 2005

Inhibition of solid tumor growth by gene transfer of VEGF receptor-1 mutants.

Int J Cancer 2004 Sep;111(3):348-57

Department of Molecular Cell Biology, Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany.

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http://dx.doi.org/10.1002/ijc.20260DOI Listing
September 2004

Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy.

Diabetes 2004 Apr;53(4):1104-10

5th Medical Clinic, University-Clinic Mannheim, Medical Faculty of the University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.2337/diabetes.53.4.1104DOI Listing
April 2004

Endothelium-specific Cre recombinase activity in flk-1-Cre transgenic mice.

Dev Dyn 2004 Feb;229(2):312-8

Department of Molecular Cell Biology, Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany.

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http://dx.doi.org/10.1002/dvdy.10416DOI Listing
February 2004

p38 MAP kinase--a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability.

FASEB J 2003 Feb 18;17(2):262-4. Epub 2002 Dec 18.

Department of Molecular Cell Biology, Max-Planck-Institute for Physiological and Clinical Research, 61231 Bad Nauheim, Germany.

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http://dx.doi.org/10.1096/fj.02-0329fjeDOI Listing
February 2003

Angiogenesis: molecular mechanisms and functional interactions--2nd Kloster Seeon Meeting of the German Priority Research Grant "Angiogenesis".

Thromb Haemost 2003 Jan;89(1):190-7

Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Breisacher Freiburg, Germany.

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January 2003

Design of a variant of vascular endothelial growth factor-A (VEGF-A) antagonizing KDR/Flk-1 and Flt-1.

Lab Invest 2002 Apr;82(4):473-81

Department of Pathology, University Medical Center Nijmegen, The Netherlands.

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April 2002

Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2.

J Clin Invest 2002 Mar;109(6):777-85

Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 103, D-68167 Mannheim, Germany.

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http://dx.doi.org/10.1172/JCI14105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC150910PMC
March 2002

Transforming growth factor-beta and Ras regulate the VEGF/VEGF-receptor system during tumor angiogenesis.

Int J Cancer 2002 Jan;97(2):142-8

Max-Planck-Institute for Physiological and Clinical Research, Parkstrasse 1, D-61231 Bad Nauheim, Germany.

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January 2002